L233P mutation in the bovine leukemia virus Tax protein depresses endothelial cell recruitment and tumorigenesis in athymic nude mice

• Published in: Archives of virology Vol. 164; no. 5; pp. 1343 - 1351
• Main Authors: Mori, Hiroshi, Tomiyasu, Takafumi, Nishiyama, Kanako, Matsumoto, Maiko, Osawa, Yoshiaki, Okazaki, Katsunori
• Format: Journal Article
• Language: English
• Published: Vienna Springer Vienna 01.05.2019; Springer Nature B.V
• Subjects: Amino acids; Angiogenesis; Biomedical and Life Sciences; Biomedicine; blood vessels; Bovine leukemia virus; Bovine leukosis; carcinogenesis; cattle; cell lines; chemoattractants; Chemotaxis; Endothelial cells; fibroblasts; human umbilical vein endothelial cells; Infectious Diseases; Leukemia; Leukemogenesis; Lymphoma; Medical Microbiology; mice; mutation; neoplasm cells; neoplasms; Original Article; Progenitor cells; rats; Stem cells; Tax protein; Tumorigenesis; Tumors; Umbilical vein; Vascularization; Virology; viruses; Xenografts

Bovine leukemia virus (BLV) can be divided into two categories based on the amino acid at position 233 in the Tax protein, which probably plays a crucial role in leukemogenesis. We show here that a rat fibroblast cell line stably expressing L233-Tax formed significantly larger tumors than P233-Tax-e...