Class I HDAC inhibitors enhance antitumor efficacy and persistence of CAR-T cells by activation of the Wnt pathway - Zhu, Meng; Han, Yingli; Gu, Tianning; Wang, Rui; Si, Xiaohui; Kong, Delin; Zhao, Peng; Wang, Xiujian; Li, Jinxin; Zhai, Xingyuan; Yu, Zebin; Lu, Huan; et al. (Cell reports (Cambridge), 2024)
Keywords: Aminopyridines; Animals; Benzamides - pharmacology; CAR-T; Cell Line, Tumor; CP: Cancer; exhaustion; HDAC inhibitors; Histone Deacetylase 1 - metabolism; Histone Deacetylase Inhibitors - pharmacology; Humans; Immunotherapy, Adoptive - methods; memory T cell subsets; Mice; Receptors, Chimeric Antigen - metabolism; T-Lymphocytes - drug effects; T-Lymphocytes - immunology; T-Lymphocytes - metabolism; Wnt signaling pathway; Wnt Signaling Pathway - drug effects; exhaustion; HDAC inhibitors; Wnt signaling pathway; CAR-T; CP: Cancer; memory T cell subsets