Gut Microbiota in Children With Cystic Fibrosis: A Taxonomic and Functional Dysbiosis

• Published in: Scientific reports Vol. 9; no. 1; pp. 18593 - 14
• Main Authors: Coffey, Michael J., Nielsen, Shaun, Wemheuer, Bernd, Kaakoush, Nadeem O., Garg, Millie, Needham, Bronwen, Pickford, Russell, Jaffe, Adam, Thomas, Torsten, Ooi, Chee Y.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 09.12.2019; Nature Publishing Group
• Subjects: 101/58; 45/91; 692/4020/1503/2745; 692/699/1785/4039; Adolescent; Antioxidants; Antioxidants - metabolism; Biomarkers - metabolism; Case-Control Studies; Child; Child, Preschool; Children; Cross-Sectional Studies; Cystic fibrosis; Cystic Fibrosis - microbiology; Dysbacteriosis; Dysbiosis - microbiology; Fatty Acids, Volatile - metabolism; Feces; Female; Gastrointestinal diseases; Gastrointestinal Microbiome; Genera; Humanities and Social Sciences; Humans; Infant; Inflammation; Intestinal microflora; Intestine; Male; Metabolomics; Microbial activity; Microbiota; multidisciplinary; Prospective Studies; Pyruvate kinase; Pyruvic acid; RNA, Ribosomal, 16S - metabolism; rRNA 16S; Science; Science (multidisciplinary); Taxonomy

Intestinal dysbiosis has been observed in children with cystic fibrosis (CF), yet the functional consequences are poorly understood. We investigated the functional capacity of intestinal microbiota and inflammation in children with CF. Stool samples were collected from 27 children with CF and 27 age...