Gut Microbiota in Children With Cystic Fibrosis: A Taxonomic and Functional Dysbiosis
Intestinal dysbiosis has been observed in children with cystic fibrosis (CF), yet the functional consequences are poorly understood. We investigated the functional capacity of intestinal microbiota and inflammation in children with CF. Stool samples were collected from 27 children with CF and 27 age...
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Published in | Scientific reports Vol. 9; no. 1; pp. 18593 - 14 |
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Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
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London
Nature Publishing Group UK
09.12.2019
Nature Publishing Group |
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Abstract | Intestinal dysbiosis has been observed in children with cystic fibrosis (CF), yet the functional consequences are poorly understood. We investigated the functional capacity of intestinal microbiota and inflammation in children with CF. Stool samples were collected from 27 children with CF and 27 age and gender matched healthy controls (HC) (aged 0.8–18 years). Microbial communities were investigated by iTag sequencing of 16S rRNA genes and functional profiles predicted using Tax4Fun. Inflammation was measured by faecal calprotectin and M2-pyruvate kinase. Paediatric CF gastrointestinal microbiota demonstrated lower richness and diversity compared to HC. CF samples exhibited a marked taxonomic and inferred functional dysbiosis when compared to HC. In children with CF, we predicted an enrichment of genes involved in short-chain fatty acid (SCFA), antioxidant and nutrient metabolism (relevant for growth and nutrition) in CF. The notion of pro-inflammatory GI microbiota in children with CF is supported by positive correlations between intestinal inflammatory markers and both genera and functional pathways. We also observed an association between intestinal genera and both growth z-scores and FEV1%. These taxonomic and functional changes provide insights into gastrointestinal disease in children with CF and future gastrointestinal therapeutics for CF should explore the aforementioned pathways and microbial changes. |
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AbstractList | Intestinal dysbiosis has been observed in children with cystic fibrosis (CF), yet the functional consequences are poorly understood. We investigated the functional capacity of intestinal microbiota and inflammation in children with CF. Stool samples were collected from 27 children with CF and 27 age and gender matched healthy controls (HC) (aged 0.8–18 years). Microbial communities were investigated by iTag sequencing of 16S rRNA genes and functional profiles predicted using Tax4Fun. Inflammation was measured by faecal calprotectin and M2-pyruvate kinase. Paediatric CF gastrointestinal microbiota demonstrated lower richness and diversity compared to HC. CF samples exhibited a marked taxonomic and inferred functional dysbiosis when compared to HC. In children with CF, we predicted an enrichment of genes involved in short-chain fatty acid (SCFA), antioxidant and nutrient metabolism (relevant for growth and nutrition) in CF. The notion of pro-inflammatory GI microbiota in children with CF is supported by positive correlations between intestinal inflammatory markers and both genera and functional pathways. We also observed an association between intestinal genera and both growth z-scores and FEV1%. These taxonomic and functional changes provide insights into gastrointestinal disease in children with CF and future gastrointestinal therapeutics for CF should explore the aforementioned pathways and microbial changes. |
ArticleNumber | 18593 |
Author | Pickford, Russell Kaakoush, Nadeem O. Thomas, Torsten Nielsen, Shaun Coffey, Michael J. Needham, Bronwen Jaffe, Adam Ooi, Chee Y. Wemheuer, Bernd Garg, Millie |
Author_xml | – sequence: 1 givenname: Michael J. orcidid: 0000-0002-5543-9438 surname: Coffey fullname: Coffey, Michael J. organization: Discipline of Paediatrics, School of Women’s and Children’s Health, University of New South Wales – sequence: 2 givenname: Shaun surname: Nielsen fullname: Nielsen, Shaun organization: Centre for Marine Science and Innovation, School of Biological, Earth and Environmental Sciences, University of New South Wales – sequence: 3 givenname: Bernd surname: Wemheuer fullname: Wemheuer, Bernd organization: Centre for Marine Science and Innovation, School of Biological, Earth and Environmental Sciences, University of New South Wales – sequence: 4 givenname: Nadeem O. surname: Kaakoush fullname: Kaakoush, Nadeem O. organization: School of Medical Sciences, University of New South Wales – sequence: 5 givenname: Millie surname: Garg fullname: Garg, Millie organization: Discipline of Paediatrics, School of Women’s and Children’s Health, University of New South Wales – sequence: 6 givenname: Bronwen orcidid: 0000-0002-0936-1828 surname: Needham fullname: Needham, Bronwen organization: Centre for Marine Science and Innovation, School of Biological, Earth and Environmental Sciences, University of New South Wales – sequence: 7 givenname: Russell surname: Pickford fullname: Pickford, Russell organization: Bioanalytical Mass Spectrometry Facility, Mark Wainwright Analytical Centre (MWAC), University of New South Wales – sequence: 8 givenname: Adam surname: Jaffe fullname: Jaffe, Adam organization: Discipline of Paediatrics, School of Women’s and Children’s Health, University of New South Wales, Molecular and Integrative Cystic Fibrosis (miCF) Research Centre, Department of Respiratory, Sydney Children’s Hospital – sequence: 9 givenname: Torsten orcidid: 0000-0001-9557-3001 surname: Thomas fullname: Thomas, Torsten organization: Centre for Marine Science and Innovation, School of Biological, Earth and Environmental Sciences, University of New South Wales – sequence: 10 givenname: Chee Y. surname: Ooi fullname: Ooi, Chee Y. email: keith.ooi@unsw.edu.au organization: Discipline of Paediatrics, School of Women’s and Children’s Health, University of New South Wales, Molecular and Integrative Cystic Fibrosis (miCF) Research Centre, Department of Gastroenterology, Sydney Children’s Hospital |
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Snippet | Intestinal dysbiosis has been observed in children with cystic fibrosis (CF), yet the functional consequences are poorly understood. We investigated the... |
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SubjectTerms | 101/58 45/91 692/4020/1503/2745 692/699/1785/4039 Adolescent Antioxidants Antioxidants - metabolism Biomarkers - metabolism Case-Control Studies Child Child, Preschool Children Cross-Sectional Studies Cystic fibrosis Cystic Fibrosis - microbiology Dysbacteriosis Dysbiosis - microbiology Fatty Acids, Volatile - metabolism Feces Female Gastrointestinal diseases Gastrointestinal Microbiome Genera Humanities and Social Sciences Humans Infant Inflammation Intestinal microflora Intestine Male Metabolomics Microbial activity Microbiota multidisciplinary Prospective Studies Pyruvate kinase Pyruvic acid RNA, Ribosomal, 16S - metabolism rRNA 16S Science Science (multidisciplinary) Taxonomy |
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Title | Gut Microbiota in Children With Cystic Fibrosis: A Taxonomic and Functional Dysbiosis |
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