A cellular automaton model for spheroid response to radiation and hyperthermia treatments

• Published in: Scientific reports Vol. 9; no. 1; pp. 17674 - 12
• Main Authors: Brüningk, Sarah C., Ziegenhein, Peter, Rivens, Ian, Oelfke, Uwe, Haar, Gail ter
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 27.11.2019; Nature Publishing Group
• Subjects: 13/106; 14/63; 631/114/2397; 631/553/2694; 631/67/70; Cell death; Combined Modality Therapy; Computational Biology - methods; Fever; HCT116 Cells; Humanities and Social Sciences; Humans; Hyperthermia; Hyperthermia, Induced - methods; Hypoxia; Models, Biological; multidisciplinary; Neoplasms - radiotherapy; Oncology; Oxygen; Oxygenation; Science; Science (multidisciplinary); Spheroids; Spheroids, Cellular - radiation effects; Tumor Hypoxia - radiation effects; Tumors

Thermo-radiosensitisation is a promising approach for treatment of radio-resistant tumours such as those containing hypoxic subregions. Response prediction and treatment planning should account for tumour response heterogeneity, e.g. due to microenvironmental factors, and quantification of the biolo...