A cellular automaton model for spheroid response to radiation and hyperthermia treatments
Thermo-radiosensitisation is a promising approach for treatment of radio-resistant tumours such as those containing hypoxic subregions. Response prediction and treatment planning should account for tumour response heterogeneity, e.g. due to microenvironmental factors, and quantification of the biolo...
Saved in:
| Published in | Scientific reports Vol. 9; no. 1; pp. 17674 - 12 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
London
Nature Publishing Group UK
27.11.2019
Nature Publishing Group |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Thermo-radiosensitisation is a promising approach for treatment of radio-resistant tumours such as those containing hypoxic subregions. Response prediction and treatment planning should account for tumour response heterogeneity, e.g. due to microenvironmental factors, and quantification of the biological effects induced. 3D tumour spheroids provide a physiological
in vitro
model of tumour response and a systems oncology framework for simulating spheroid response to radiation and hyperthermia is presented. Using a cellular automaton model, 3D oxygen diffusion, delivery of radiation and/or hyperthermia were simulated for many (
1
0
4
−
1
0
7
) individual cells forming a spheroid. The iterative oxygen diffusion model was compared to an analytical oxygenation model and simulations were calibrated and validated against experimental data for irradiated (0–10 Gy) and/or heated (0–240
CEM
43
) HCT116 spheroids. Despite comparable clonogenic survival, spheroid growth differed significantly following radiation or hyperthermia. This dynamic response was described well by the simulation (
R
2
> 0.85). Heat-induced cell death was implemented as a fast, proliferation-independent process, allowing reoxygenation and repopulation, whereas radiation was modelled as proliferation-dependent mitotic catastrophe. This framework stands out both through its experimental validation and its novel ability to predict spheroid response to multimodality treatment. It provides a good description of response where biological dose-weighting based on clonogenic survival alone was insufficient. |
|---|---|
| AbstractList | Thermo-radiosensitisation is a promising approach for treatment of radio-resistant tumours such as those containing hypoxic subregions. Response prediction and treatment planning should account for tumour response heterogeneity, e.g. due to microenvironmental factors, and quantification of the biological effects induced. 3D tumour spheroids provide a physiological
in vitro
model of tumour response and a systems oncology framework for simulating spheroid response to radiation and hyperthermia is presented. Using a cellular automaton model, 3D oxygen diffusion, delivery of radiation and/or hyperthermia were simulated for many (
\documentclass[12pt]{minimal}
\usepackage{amsmath}
\usepackage{wasysym}
\usepackage{amsfonts}
\usepackage{amssymb}
\usepackage{amsbsy}
\usepackage{mathrsfs}
\usepackage{upgreek}
\setlength{\oddsidemargin}{-69pt}
\begin{document}$${\bf{1}}{{\bf{0}}}^{{\bf{4}}}{\boldsymbol{-}}{\bf{1}}{{\bf{0}}}^{{\bf{7}}}$$\end{document}
1
0
4
−
1
0
7
) individual cells forming a spheroid. The iterative oxygen diffusion model was compared to an analytical oxygenation model and simulations were calibrated and validated against experimental data for irradiated (0–10 Gy) and/or heated (0–240
CEM
43
) HCT116 spheroids. Despite comparable clonogenic survival, spheroid growth differed significantly following radiation or hyperthermia. This dynamic response was described well by the simulation (
\documentclass[12pt]{minimal}
\usepackage{amsmath}
\usepackage{wasysym}
\usepackage{amsfonts}
\usepackage{amssymb}
\usepackage{amsbsy}
\usepackage{mathrsfs}
\usepackage{upgreek}
\setlength{\oddsidemargin}{-69pt}
\begin{document}$${{\bf{R}}}^{{\bf{2}}}$$\end{document}
R
2
> 0.85). Heat-induced cell death was implemented as a fast, proliferation-independent process, allowing reoxygenation and repopulation, whereas radiation was modelled as proliferation-dependent mitotic catastrophe. This framework stands out both through its experimental validation and its novel ability to predict spheroid response to multimodality treatment. It provides a good description of response where biological dose-weighting based on clonogenic survival alone was insufficient. Thermo-radiosensitisation is a promising approach for treatment of radio-resistant tumours such as those containing hypoxic subregions. Response prediction and treatment planning should account for tumour response heterogeneity, e.g. due to microenvironmental factors, and quantification of the biological effects induced. 3D tumour spheroids provide a physiological in vitro model of tumour response and a systems oncology framework for simulating spheroid response to radiation and hyperthermia is presented. Using a cellular automaton model, 3D oxygen diffusion, delivery of radiation and/or hyperthermia were simulated for many (\[{\bf{1}}{{\bf{0}}}^{{\bf{4}}}{\boldsymbol{-}}{\bf{1}}{{\bf{0}}}^{{\bf{7}}}\]) individual cells forming a spheroid. The iterative oxygen diffusion model was compared to an analytical oxygenation model and simulations were calibrated and validated against experimental data for irradiated (0–10 Gy) and/or heated (0–240 CEM43) HCT116 spheroids. Despite comparable clonogenic survival, spheroid growth differed significantly following radiation or hyperthermia. This dynamic response was described well by the simulation (\[{{\bf{R}}}^{{\bf{2}}}\] > 0.85). Heat-induced cell death was implemented as a fast, proliferation-independent process, allowing reoxygenation and repopulation, whereas radiation was modelled as proliferation-dependent mitotic catastrophe. This framework stands out both through its experimental validation and its novel ability to predict spheroid response to multimodality treatment. It provides a good description of response where biological dose-weighting based on clonogenic survival alone was insufficient. Thermo-radiosensitisation is a promising approach for treatment of radio-resistant tumours such as those containing hypoxic subregions. Response prediction and treatment planning should account for tumour response heterogeneity, e.g. due to microenvironmental factors, and quantification of the biological effects induced. 3D tumour spheroids provide a physiological in vitro model of tumour response and a systems oncology framework for simulating spheroid response to radiation and hyperthermia is presented. Using a cellular automaton model, 3D oxygen diffusion, delivery of radiation and/or hyperthermia were simulated for many ([Formula: see text]) individual cells forming a spheroid. The iterative oxygen diffusion model was compared to an analytical oxygenation model and simulations were calibrated and validated against experimental data for irradiated (0-10 Gy) and/or heated (0-240 CEM ) HCT116 spheroids. Despite comparable clonogenic survival, spheroid growth differed significantly following radiation or hyperthermia. This dynamic response was described well by the simulation ([Formula: see text] > 0.85). Heat-induced cell death was implemented as a fast, proliferation-independent process, allowing reoxygenation and repopulation, whereas radiation was modelled as proliferation-dependent mitotic catastrophe. This framework stands out both through its experimental validation and its novel ability to predict spheroid response to multimodality treatment. It provides a good description of response where biological dose-weighting based on clonogenic survival alone was insufficient. Abstract Thermo-radiosensitisation is a promising approach for treatment of radio-resistant tumours such as those containing hypoxic subregions. Response prediction and treatment planning should account for tumour response heterogeneity, e.g. due to microenvironmental factors, and quantification of the biological effects induced. 3D tumour spheroids provide a physiological in vitro model of tumour response and a systems oncology framework for simulating spheroid response to radiation and hyperthermia is presented. Using a cellular automaton model, 3D oxygen diffusion, delivery of radiation and/or hyperthermia were simulated for many ( $${\bf{1}}{{\bf{0}}}^{{\bf{4}}}{\boldsymbol{-}}{\bf{1}}{{\bf{0}}}^{{\bf{7}}}$$ 1 0 4 − 1 0 7 ) individual cells forming a spheroid. The iterative oxygen diffusion model was compared to an analytical oxygenation model and simulations were calibrated and validated against experimental data for irradiated (0–10 Gy) and/or heated (0–240 CEM 43 ) HCT116 spheroids. Despite comparable clonogenic survival, spheroid growth differed significantly following radiation or hyperthermia. This dynamic response was described well by the simulation ( $${{\bf{R}}}^{{\bf{2}}}$$ R 2 > 0.85). Heat-induced cell death was implemented as a fast, proliferation-independent process, allowing reoxygenation and repopulation, whereas radiation was modelled as proliferation-dependent mitotic catastrophe. This framework stands out both through its experimental validation and its novel ability to predict spheroid response to multimodality treatment. It provides a good description of response where biological dose-weighting based on clonogenic survival alone was insufficient. Thermo-radiosensitisation is a promising approach for treatment of radio-resistant tumours such as those containing hypoxic subregions. Response prediction and treatment planning should account for tumour response heterogeneity, e.g. due to microenvironmental factors, and quantification of the biological effects induced. 3D tumour spheroids provide a physiological in vitro model of tumour response and a systems oncology framework for simulating spheroid response to radiation and hyperthermia is presented. Using a cellular automaton model, 3D oxygen diffusion, delivery of radiation and/or hyperthermia were simulated for many ( 1 0 4 − 1 0 7 ) individual cells forming a spheroid. The iterative oxygen diffusion model was compared to an analytical oxygenation model and simulations were calibrated and validated against experimental data for irradiated (0–10 Gy) and/or heated (0–240 CEM 43 ) HCT116 spheroids. Despite comparable clonogenic survival, spheroid growth differed significantly following radiation or hyperthermia. This dynamic response was described well by the simulation ( R 2 > 0.85). Heat-induced cell death was implemented as a fast, proliferation-independent process, allowing reoxygenation and repopulation, whereas radiation was modelled as proliferation-dependent mitotic catastrophe. This framework stands out both through its experimental validation and its novel ability to predict spheroid response to multimodality treatment. It provides a good description of response where biological dose-weighting based on clonogenic survival alone was insufficient. Thermo-radiosensitisation is a promising approach for treatment of radio-resistant tumours such as those containing hypoxic subregions. Response prediction and treatment planning should account for tumour response heterogeneity, e.g. due to microenvironmental factors, and quantification of the biological effects induced. 3D tumour spheroids provide a physiological in vitro model of tumour response and a systems oncology framework for simulating spheroid response to radiation and hyperthermia is presented. Using a cellular automaton model, 3D oxygen diffusion, delivery of radiation and/or hyperthermia were simulated for many ([Formula: see text]) individual cells forming a spheroid. The iterative oxygen diffusion model was compared to an analytical oxygenation model and simulations were calibrated and validated against experimental data for irradiated (0-10 Gy) and/or heated (0-240 CEM43) HCT116 spheroids. Despite comparable clonogenic survival, spheroid growth differed significantly following radiation or hyperthermia. This dynamic response was described well by the simulation ([Formula: see text] > 0.85). Heat-induced cell death was implemented as a fast, proliferation-independent process, allowing reoxygenation and repopulation, whereas radiation was modelled as proliferation-dependent mitotic catastrophe. This framework stands out both through its experimental validation and its novel ability to predict spheroid response to multimodality treatment. It provides a good description of response where biological dose-weighting based on clonogenic survival alone was insufficient. |
| ArticleNumber | 17674 |
| Author | Brüningk, Sarah C. Ziegenhein, Peter Haar, Gail ter Oelfke, Uwe Rivens, Ian |
| Author_xml | – sequence: 1 givenname: Sarah C. orcidid: 0000-0003-3176-1032 surname: Brüningk fullname: Brüningk, Sarah C. email: sarah.brueningk@icr.ac.uk organization: Joint Department of Physics at The Institute of Cancer Research and the Royal Marsden NHS Foundation Trust – sequence: 2 givenname: Peter orcidid: 0000-0003-4703-8623 surname: Ziegenhein fullname: Ziegenhein, Peter organization: Joint Department of Physics at The Institute of Cancer Research and the Royal Marsden NHS Foundation Trust – sequence: 3 givenname: Ian surname: Rivens fullname: Rivens, Ian organization: Joint Department of Physics at The Institute of Cancer Research and the Royal Marsden NHS Foundation Trust – sequence: 4 givenname: Uwe surname: Oelfke fullname: Oelfke, Uwe organization: Joint Department of Physics at The Institute of Cancer Research and the Royal Marsden NHS Foundation Trust – sequence: 5 givenname: Gail ter surname: Haar fullname: Haar, Gail ter organization: Joint Department of Physics at The Institute of Cancer Research and the Royal Marsden NHS Foundation Trust |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/31776398$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9kc1O3TAQha0KVCjlBbqoLHXTTYrHP4m9qYRQW5CQ2LSLriwnmXCDEju1HQRvX18upbQLvLGl-eacGZ83ZM8Hj4S8A_YJmNAnSYIyumJgKiUBmuruFTnkTKqKC873nr0PyHFKN6wcxY0E85ocCGiaWhh9SH6e0g6naZ1cpG7NYXY5eDqHHic6hEjTssEYxp5GTEvwCWkONLp-dHksoPM93dwvGHPB5tHRHNHlGX1Ob8n-4KaEx4_3Efnx9cv3s_Pq8urbxdnpZdXJRuZq0G3jGICWNVegNZOtahirQZiO67ZlaBjWbSt6BkIMzeBYq3qUojYoXaPEEfm8013Wdsa-K97RTXaJ4-zivQ1utP9W_Lix1-HW1lqDVFAEPj4KxPBrxZTtPKbtpziPYU2WCzDSqFptvT78h96ENfqy3gMFWgmzpfiO6mJIKeLwNAwwuw3P7sKzJTz7EJ69K03vn6_x1PInqgKIHZBKyV9j_Ov9guxvL8yoPw |
| CitedBy_id | crossref_primary_10_1186_s40824_022_00280_8 crossref_primary_10_3390_cancers15215284 crossref_primary_10_3390_mi15060689 crossref_primary_10_3390_jpm11080818 crossref_primary_10_1155_2020_1737318 crossref_primary_10_1038_s41598_021_99507_2 crossref_primary_10_1088_1361_6560_abd4f9 crossref_primary_10_1016_j_jconrel_2022_04_045 crossref_primary_10_1016_j_jtbi_2023_111462 crossref_primary_10_3390_cancers15235645 crossref_primary_10_1016_j_physrep_2021_05_001 crossref_primary_10_3390_cancers13133168 crossref_primary_10_3389_fonc_2022_811415 crossref_primary_10_1002_cso2_1018 crossref_primary_10_1109_JPROC_2021_3136715 crossref_primary_10_1039_D3NH00305A |
| Cites_doi | 10.1111/j.1582-4934.2011.01258.x 10.1080/02656736.2017.1341059 10.1038/srep30689 10.1016/j.canlet.2015.02.047 10.1016/j.radphyschem.2016.01.018 10.3389/fonc.2012.00116 10.1016/j.cmpb.2004.07.003 10.1016/j.clon.2007.03.015 10.1002/ijc.20596 10.1016/j.bpj.2014.08.031 10.1093/jnci/56.6.1243 10.1080/02656736.2017.1320812 10.1016/0014-4827(72)90265-0 10.1371/journal.pone.0153692 10.1088/2057-1976/1/4/045209 10.1152/physiol.00016 10.1016/j.molcel.2010.10.006 10.1111/j.1743-6109.2008.01122.x.Endothelial 10.1016/0360-3016(90)90227-b 10.1016/j.radphyschem.2015.11.031 10.1142/S0219525902000572 10.1007/s10237-015-0755-0 10.1259/0007-1285-62-740-679 10.1007/s10441-010-9118-5 10.1152/physiol.00036.2016 10.1126/science.2451290 10.1016/j.pharmthera.2016.03.013 10.1080/02656730500532028 10.1016/j.ijrobp.2004.03.005 10.2307/3574911 10.1371/journal.pone.0161239 10.1016/j.jrras.2015.03.003 10.3892/ol.2017.5697 10.1093/jnci/58.6.1837 10.1098/rsif.2017.0681 10.1016/0014-2964(74)90009-7 10.1016/j.bbrc.2013.08.093 10.1098/rsif.2013.1124 10.1080/09553009114550711 10.1016/j.ijrobp.2013.11.212 10.1080/09553000010024687 10.1111/cas.13178 10.1115/1.4027272 10.1007/978-3-540-30479-1_46 10.1371/journal.pcbi.1003295 10.1088/1367-2630/14/5/055008 10.1007/978-3-662-47221-7 |
| ContentType | Journal Article |
| Copyright | The Author(s) 2019 2019. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
| Copyright_xml | – notice: The Author(s) 2019 – notice: 2019. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
| DBID | C6C CGR CUY CVF ECM EIF NPM AAYXX CITATION 3V. 7X7 7XB 88A 88E 88I 8FE 8FH 8FI 8FJ 8FK ABUWG AFKRA AZQEC BBNVY BENPR BHPHI CCPQU DWQXO FYUFA GHDGH GNUQQ HCIFZ K9. LK8 M0S M1P M2P M7P PIMPY PQEST PQQKQ PQUKI PRINS Q9U 7X8 5PM |
| DOI | 10.1038/s41598-019-54117-x |
| DatabaseName | SpringerOpen Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef ProQuest Central (Corporate) Health & Medical Collection ProQuest Central (purchase pre-March 2016) Biology Database (Alumni Edition) Medical Database (Alumni Edition) Science Database (Alumni Edition) ProQuest SciTech Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central ProQuest Central Essentials Biological Science Collection AUTh Library subscriptions: ProQuest Central Natural Science Collection ProQuest One Community College ProQuest Central Korea Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) ProQuest Biological Science Collection Health & Medical Collection (Alumni Edition) PML(ProQuest Medical Library) Science Database Biological Science Database Publicly Available Content Database ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China ProQuest Central Basic MEDLINE - Academic PubMed Central (Full Participant titles) |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef Publicly Available Content Database ProQuest Central Student ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest Natural Science Collection ProQuest Central China ProQuest Biology Journals (Alumni Edition) ProQuest Central Health Research Premium Collection Health and Medicine Complete (Alumni Edition) Natural Science Collection ProQuest Central Korea Biological Science Collection ProQuest Medical Library (Alumni) ProQuest Science Journals (Alumni Edition) ProQuest Biological Science Collection ProQuest Central Basic ProQuest Science Journals ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) Biological Science Database ProQuest SciTech Collection ProQuest Hospital Collection (Alumni) ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition ProQuest One Academic ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | Publicly Available Content Database MEDLINE CrossRef MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: C6C name: SpringerOpen url: http://www.springeropen.com/ sourceTypes: Publisher – sequence: 2 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 4 dbid: BENPR name: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Biology |
| EISSN | 2045-2322 |
| EndPage | 12 |
| ExternalDocumentID | 10_1038_s41598_019_54117_x 31776398 |
| Genre | Research Support, Non-U.S. Gov't Journal Article |
| GrantInformation_xml | – fundername: Cancer Research UK (CRUK) grantid: C33589/A19727 funderid: https://doi.org/10.13039/501100000289 – fundername: Cancer Research UK grantid: 16464 – fundername: Cancer Research UK grantid: 19727 – fundername: ; grantid: C33589/A19727 |
| GroupedDBID | 0R~ 3V. 4.4 53G 5VS 7X7 88A 88E 88I 8FE 8FH 8FI 8FJ AAFWJ AAJSJ AAKDD ABDBF ABUWG ACGFS ACSMW ADBBV ADRAZ AENEX AFKRA AJTQC ALIPV ALMA_UNASSIGNED_HOLDINGS AOIJS AZQEC BAWUL BBNVY BCNDV BENPR BHPHI BPHCQ BVXVI C6C CCPQU DIK DWQXO EBD EBLON EBS EJD ESX FYUFA GNUQQ GROUPED_DOAJ GX1 HCIFZ HH5 HMCUK HYE KQ8 LK8 M0L M1P M2P M48 M7P M~E NAO OK1 PIMPY PQQKQ PROAC PSQYO RIG RNT RNTTT RPM SNYQT UKHRP CGR CUY CVF ECM EIF NPM AAYXX AFPKN CITATION 7XB 8FK K9. PQEST PQUKI PRINS Q9U 7X8 5PM |
| ID | FETCH-LOGICAL-c474t-f8b7a0118462518804b57006139c28bb0e90e6bb3d0133f7fa0b5de4369e4a753 |
| IEDL.DBID | RPM |
| ISSN | 2045-2322 |
| IngestDate | Tue Sep 17 20:32:43 EDT 2024 Fri Oct 25 23:14:37 EDT 2024 Thu Oct 10 17:53:40 EDT 2024 Fri Aug 23 01:26:59 EDT 2024 Tue Oct 29 09:29:01 EDT 2024 Fri Oct 11 20:45:47 EDT 2024 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Language | English |
| License | Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c474t-f8b7a0118462518804b57006139c28bb0e90e6bb3d0133f7fa0b5de4369e4a753 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| ORCID | 0000-0003-4703-8623 0000-0003-3176-1032 |
| OpenAccessLink | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6881451/ |
| PMID | 31776398 |
| PQID | 2319185395 |
| PQPubID | 2041939 |
| PageCount | 12 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_6881451 proquest_miscellaneous_2319495655 proquest_journals_2319185395 crossref_primary_10_1038_s41598_019_54117_x pubmed_primary_31776398 springer_journals_10_1038_s41598_019_54117_x |
| PublicationCentury | 2000 |
| PublicationDate | 2019-11-27 |
| PublicationDateYYYYMMDD | 2019-11-27 |
| PublicationDate_xml | – month: 11 year: 2019 text: 2019-11-27 day: 27 |
| PublicationDecade | 2010 |
| PublicationPlace | London |
| PublicationPlace_xml | – name: London – name: England |
| PublicationTitle | Scientific reports |
| PublicationTitleAbbrev | Sci Rep |
| PublicationTitleAlternate | Sci Rep |
| PublicationYear | 2019 |
| Publisher | Nature Publishing Group UK Nature Publishing Group |
| Publisher_xml | – name: Nature Publishing Group UK – name: Nature Publishing Group |
| References | Kampinga, Dikomey (CR1) 2001; 77 Brüningk (CR7) 2017; 34 Duval (CR16) 2017; 32 Song, Najjar, Diller (CR24) 2014; 136 CR37 CR36 Schwachöfer (CR12) 1990; 19 Zacharaki, Stamatakos, Nikita, Uzunoglu (CR46) 2004; 76 Fowler (CR39) 1989; 62 Richter, Haslbeck, Buchner (CR25) 2010; 40 Desouky, Ding, Zhou (CR40) 2015; 8 Asayesh, Changizi, Eyvazzadeh (CR21) 2016; 120 Kampinga (CR26) 2006; 22 Freeman, Dewey (CR50) 1977; 58 van Leeuwen (CR6) 2018; 34 Kok (CR8) 2014; 88 Sugahara (CR3) 2008; 24 Sendoel, Hengartner (CR33) 2014; 29 Grimes, Partridge (CR32) 2015; 1 Durand, Sutherland (CR13) 1972; 71 Durand (CR22) 1978; 75 Lauber (CR17) 2015; 368 CR47 CR43 Dikomey, Jung (CR5) 1991; 59 CR42 Lücke-Huhle, Dertinger (CR23) 1977; 13 Gomes (CR45) 2016; 11 Otani (CR48) 2016; 6 Chopard, Ouared, Deutsch, Hatzikirou, Wolf-Gladrow (CR51) 2010; 58 Nath, Devi (CR14) 2016; 163 Kaida, Miura (CR9) 2013; 439 Sutherland (CR11) 1988; 240 Grimes, Kelly, Bloch, Partridge (CR31) 2014; 11 Grimes (CR44) 2016; 11 Sankar (CR15) 2017; 13 Onozato, Kaida, Harada, Miura (CR10) 2017; 108 Delarue (CR35) 2014; 107 Brüningk (CR30) 2018; 15 Moreira, Deutsch (CR27) 2002; 5 Lauber, Ernst, Orth, Herrmann, Belka (CR18) 2012; 2 Pawlik, Keyomarsi (CR2) 2004; 59 Wartenberg (CR19) 2005; 113 Overgaard (CR49) 1976; 56 CR29 CR28 Mahdavi, Yahyapour, Nikoofar (CR20) 2016; 123 Gerweck, Gillette, Dewey (CR41) 1974; 10 Horsman, Overgaard (CR4) 2007; 19 Carreau, Hafny-Rahbi, Matejuk (CR38) 2011; 15 Mascheroni (CR34) 2016; 15 M Delarue (54117_CR35) 2014; 107 A Carreau (54117_CR38) 2011; 15 54117_CR47 A Sendoel (54117_CR33) 2014; 29 SR Mahdavi (54117_CR20) 2016; 123 O Desouky (54117_CR40) 2015; 8 HH Kampinga (54117_CR26) 2006; 22 A Gomes (54117_CR45) 2016; 11 54117_CR42 54117_CR43 RE Durand (54117_CR13) 1972; 71 EI Zacharaki (54117_CR46) 2004; 76 JF Fowler (54117_CR39) 1989; 62 HP Kok (54117_CR8) 2014; 88 J Moreira (54117_CR27) 2002; 5 DR Grimes (54117_CR31) 2014; 11 T Sugahara (54117_CR3) 2008; 24 Y Onozato (54117_CR10) 2017; 108 54117_CR37 J Schwachöfer (54117_CR12) 1990; 19 54117_CR36 K Lauber (54117_CR17) 2015; 368 PS Sankar (54117_CR15) 2017; 13 P Mascheroni (54117_CR34) 2016; 15 K Duval (54117_CR16) 2017; 32 S Brüningk (54117_CR30) 2018; 15 HH Kampinga (54117_CR1) 2001; 77 RM Sutherland (54117_CR11) 1988; 240 RE Durand (54117_CR22) 1978; 75 C Lücke-Huhle (54117_CR23) 1977; 13 ML Freeman (54117_CR50) 1977; 58 CM van Leeuwen (54117_CR6) 2018; 34 TM Pawlik (54117_CR2) 2004; 59 AS Song (54117_CR24) 2014; 136 E Dikomey (54117_CR5) 1991; 59 54117_CR28 54117_CR29 T Asayesh (54117_CR21) 2016; 120 A Kaida (54117_CR9) 2013; 439 MR Horsman (54117_CR4) 2007; 19 B Chopard (54117_CR51) 2010; 58 K Richter (54117_CR25) 2010; 40 DR Grimes (54117_CR32) 2015; 1 J Overgaard (54117_CR49) 1976; 56 LE Gerweck (54117_CR41) 1974; 10 S Nath (54117_CR14) 2016; 163 SC Brüningk (54117_CR7) 2017; 34 M Wartenberg (54117_CR19) 2005; 113 K Otani (54117_CR48) 2016; 6 K Lauber (54117_CR18) 2012; 2 DR Grimes (54117_CR44) 2016; 11 |
| References_xml | – volume: 15 start-page: 1239 year: 2011 end-page: 1253 ident: CR38 article-title: Grillon, C. andKieda, C. Why is the partial oxygen pressure of human tissues a crucial parameter? Small molecules and hypoxia publication-title: Journal of Cellular and Molecular Medicine doi: 10.1111/j.1582-4934.2011.01258.x contributor: fullname: Matejuk – volume: 34 start-page: 1 year: 2017 end-page: 11 ident: CR7 article-title: A comprehensive model for heat-induced radio-sensitisation publication-title: International Journal of Hyperthermia. doi: 10.1080/02656736.2017.1341059 contributor: fullname: Brüningk – volume: 6 start-page: 1 year: 2016 end-page: 8 ident: CR48 article-title: Cell-cycle-controlled radiation therapy was effective for treating a murine malignant melanoma cell line in vitro and in vivo publication-title: Scientific Reports doi: 10.1038/srep30689 contributor: fullname: Otani – volume: 368 start-page: 209 year: 2015 end-page: 229 ident: CR17 article-title: Targeting the heat shock response in combination with radiotherapy: Sensitizing cancer cells to irradiation-induced cell death and heating up their immunogenicity publication-title: Cancer Letters doi: 10.1016/j.canlet.2015.02.047 contributor: fullname: Lauber – volume: 123 start-page: 20 year: 2016 end-page: 24 ident: CR20 article-title: Cytotoxic effects of hyperthermia, chemotherapy (Navelbine) and radiation on glioma spheroids publication-title: Radiation Physics and Chemistry doi: 10.1016/j.radphyschem.2016.01.018 contributor: fullname: Nikoofar – volume: 2 start-page: 1 year: 2012 end-page: 14 ident: CR18 article-title: Dying cell clearance and its impact on the outcome of tumor radiotherapy publication-title: Frontiers in Oncology doi: 10.3389/fonc.2012.00116 contributor: fullname: Belka – ident: CR29 – ident: CR42 – volume: 76 start-page: 193 year: 2004 end-page: 206 ident: CR46 article-title: Simulating growth dynamics and radiation response of avascular tumour spheroids - Model validation in the case of an EMT6/Ro multicellular spheroid publication-title: Computer Methods and Programs in Biomedicine doi: 10.1016/j.cmpb.2004.07.003 contributor: fullname: Uzunoglu – volume: 19 start-page: 418 year: 2007 end-page: 426 ident: CR4 article-title: Hyperthermia: a Potent Enhancer of Radiotherapy publication-title: Clinical Oncology doi: 10.1016/j.clon.2007.03.015 contributor: fullname: Overgaard – volume: 113 start-page: 229 year: 2005 end-page: 240 ident: CR19 article-title: Regulation of the multidrug resistance transporter P-glycoprotein in multicellular prostate tumor spheroids by hyperthermia and reactive oxygen species publication-title: International Journal of Cancer doi: 10.1002/ijc.20596 contributor: fullname: Wartenberg – volume: 107 start-page: 1821 year: 2014 end-page: 1828 ident: CR35 article-title: Article Compressive Stress Inhibits Proliferation in Tumor Spheroids through a Volume Limitation publication-title: Biophysical Journal doi: 10.1016/j.bpj.2014.08.031 contributor: fullname: Delarue – volume: 56 start-page: 1243 year: 1976 end-page: 1250 ident: CR49 article-title: Influence of extracellular ph on the viability and morphology of tumor cells exposed to hyperthermia publication-title: Journal of the National Cancer Institute doi: 10.1093/jnci/56.6.1243 contributor: fullname: Overgaard – volume: 34 start-page: 30 year: 2018 end-page: 38 ident: CR6 article-title: Measurement and analysis of the impact of time-interval, temperature and radiation dose on tumour cell survival and its application in thermoradiotherapy plan evaluation publication-title: International Journal of Hyperthermia doi: 10.1080/02656736.2017.1320812 contributor: fullname: van Leeuwen – volume: 71 start-page: 75 year: 1972 end-page: 80 ident: CR13 article-title: Effects of intercellular contact on repair of radiation damage publication-title: Experimental Cell Research doi: 10.1016/0014-4827(72)90265-0 contributor: fullname: Sutherland – volume: 11 start-page: 1 year: 2016 end-page: 19 ident: CR44 article-title: The role of oxygen in avascular tumor growth publication-title: PLoS ONE doi: 10.1371/journal.pone.0153692 contributor: fullname: Grimes – volume: 1 start-page: 045209 year: 2015 ident: CR32 article-title: A mechanistic investigation of the oxygen fixation hypothesis and oxygen enhancement ratio publication-title: Biomedical Physics and Engineering Express doi: 10.1088/2057-1976/1/4/045209 contributor: fullname: Partridge – ident: CR36 – volume: 29 start-page: 168 year: 2014 end-page: 176 ident: CR33 article-title: Apoptotic cell death under hypoxia publication-title: Physiology doi: 10.1152/physiol.00016 contributor: fullname: Hengartner – volume: 40 start-page: 253 year: 2010 end-page: 266 ident: CR25 article-title: The Heat Shock Response: Life on the Verge of Death publication-title: Molecular Cell doi: 10.1016/j.molcel.2010.10.006 contributor: fullname: Buchner – volume: 24 start-page: 123 year: 2008 end-page: 140 ident: CR3 article-title: Kadota Fund International Forum 2004. Application of thermal stress for the improvement of health, 15-18 June 2004, Awaji Yumebutai International Conference Center, Awaji Island, Hyogo, Japan. Final Report publication-title: International Journal of Hyperthermia doi: 10.1111/j.1743-6109.2008.01122.x.Endothelial contributor: fullname: Sugahara – volume: 19 start-page: 1191 year: 1990 end-page: 1197 ident: CR12 article-title: Radiosensitivity of human melanoma spheroids influenced by growth rate publication-title: International Journal of Radiation Oncology Biology Physics doi: 10.1016/0360-3016(90)90227-b contributor: fullname: Schwachöfer – volume: 120 start-page: 44 year: 2016 end-page: 48 ident: CR21 article-title: Assessment of cytotoxic damage induced by irradiation combined with hyperthermia and Gemcitabine on cultured glioblastoma spheroid cells publication-title: Radiation Physics and Chemistry doi: 10.1016/j.radphyschem.2015.11.031 contributor: fullname: Eyvazzadeh – ident: CR43 – volume: 5 start-page: 247 year: 2002 end-page: 267 ident: CR27 article-title: Cellular Automaton Models Of Tumor Development: A Critical Review publication-title: Advances in Complex Systems (ACS) doi: 10.1142/S0219525902000572 contributor: fullname: Deutsch – volume: 15 start-page: 1215 year: 2016 end-page: 1228 ident: CR34 article-title: Predicting the growth of glioblastoma multiforme spheroids using a multiphase porous media model publication-title: Biomechanics and Modeling in Mechanobiology doi: 10.1007/s10237-015-0755-0 contributor: fullname: Mascheroni – volume: 62 start-page: 679 year: 1989 end-page: 694 ident: CR39 article-title: The linear-quadratic formula and progress in fractionated radiotherapy publication-title: British Journal of Radiology doi: 10.1259/0007-1285-62-740-679 contributor: fullname: Fowler – ident: CR47 – volume: 58 start-page: 329 year: 2010 end-page: 340 ident: CR51 article-title: Lattice-Gas Cellular Automaton Models for Biology: From Fluids to Cells publication-title: Acta Biotheoretica doi: 10.1007/s10441-010-9118-5 contributor: fullname: Wolf-Gladrow – volume: 32 start-page: 266 year: 2017 end-page: 277 ident: CR16 article-title: Modeling Physiological Events in 2D vs 3D Cell Culture publication-title: Physiology doi: 10.1152/physiol.00036.2016 contributor: fullname: Duval – ident: CR37 – volume: 240 start-page: 177 year: 1988 end-page: 240 ident: CR11 article-title: Cell and Environment Interactions in Tumor Microregions: The Multicell Spheroid Model publication-title: Science doi: 10.1126/science.2451290 contributor: fullname: Sutherland – volume: 163 start-page: 94 year: 2016 end-page: 108 ident: CR14 article-title: Three-dimensional culture systems in cancer research: Focus on tumor spheroid model publication-title: Pharmacology and Therapeutics doi: 10.1016/j.pharmthera.2016.03.013 contributor: fullname: Devi – volume: 13 start-page: 23 year: 1977 end-page: 28 ident: CR23 article-title: Kinetic Response of an In Vitro "Tumour-model"(V 79 spheroids) to 42 C Hyperthermia publication-title: European Journal of Cancer doi: 10.1080/02656730500532028 contributor: fullname: Dertinger – volume: 59 start-page: 928 year: 2004 end-page: 942 ident: CR2 article-title: Role of cell cycle in mediating sensitivity to radiotherapy publication-title: International Journal of Radiation Oncology, Biology, Physics doi: 10.1016/j.ijrobp.2004.03.005 contributor: fullname: Keyomarsi – volume: 75 start-page: 373 year: 1978 end-page: 384 ident: CR22 article-title: Effects of hyperthermia on the cycling, noncycling, and hypoxic cells of irradiated and unirradiated multicell spheroids publication-title: Radiation Research doi: 10.2307/3574911 contributor: fullname: Durand – volume: 22 start-page: 191 year: 2006 end-page: 196 ident: CR26 article-title: Cell biological effects of hyperthermia alone or combined with radiation or drugs: A short introduction to newcomers in the field publication-title: International Journal of Hyperthermia doi: 10.1080/02656730500532028 contributor: fullname: Kampinga – volume: 11 start-page: 1 year: 2016 end-page: 11 ident: CR45 article-title: Oxygen partial pressure is a rate-limiting parameter for cell proliferation in 3D spheroids grown in physioxic culture condition publication-title: PLoS ONE doi: 10.1371/journal.pone.0161239 contributor: fullname: Gomes – volume: 8 start-page: 247 year: 2015 end-page: 254 ident: CR40 article-title: Targeted and non-targeted effects of ionizing radiatio publication-title: Journal of Radiation Research and Applied Sciences doi: 10.1016/j.jrras.2015.03.003 contributor: fullname: Zhou – volume: 13 start-page: 2034 year: 2017 end-page: 2044 ident: CR15 article-title: Modeling nasopharyngeal carcinoma in three dimensions (Review) publication-title: Oncology Letters doi: 10.3892/ol.2017.5697 contributor: fullname: Sankar – volume: 58 start-page: 1837 year: 1977 end-page: 1839 ident: CR50 article-title: Effect of pH on hyperthermic cell survival: Brief communication publication-title: Journal of the National Cancer Institute doi: 10.1093/jnci/58.6.1837 contributor: fullname: Dewey – volume: 15 start-page: 20170681 year: 2018 ident: CR30 article-title: Combining radiation with hyperthermia: a multiscale model informed by in vitro experiments publication-title: Journal of The Royal Society Interface doi: 10.1098/rsif.2017.0681 contributor: fullname: Brüningk – volume: 10 start-page: 691 year: 1974 end-page: 693 ident: CR41 article-title: Killing of Chinese hamster cells in vitro by heating under hypoxic or aerobic conditions publication-title: European Journal of Cancer doi: 10.1016/0014-2964(74)90009-7 contributor: fullname: Dewey – volume: 439 start-page: 453 year: 2013 end-page: 458 ident: CR9 article-title: Visualizing the effect of tumor microenvironments on radiation-induced cell kinetics in multicellular spheroids consisting of HeLa cells publication-title: Biochemical and Biophysical Research Communications doi: 10.1016/j.bbrc.2013.08.093 contributor: fullname: Miura – volume: 11 start-page: 20131124 year: 2014 ident: CR31 article-title: A method for estimating the oxygen consumption rate in multicellular tumour spheroids publication-title: Journal of The Royal Society Interface doi: 10.1098/rsif.2013.1124 contributor: fullname: Partridge – volume: 59 start-page: 815 year: 1991 end-page: 825 ident: CR5 article-title: Thermal radiosensitization in CHO cells by prior heating at 41–46C publication-title: International Journal of Radiation Biology doi: 10.1080/09553009114550711 contributor: fullname: Jung – volume: 88 start-page: 739 year: 2014 end-page: 745 ident: CR8 article-title: Quantifying the combined effect of radiation therapy and hyperthermia in terms of equivalent dose distributions publication-title: International Journal of Radiation Oncology Biology Physics doi: 10.1016/j.ijrobp.2013.11.212 contributor: fullname: Kok – volume: 77 start-page: 399 year: 2001 end-page: 408 ident: CR1 article-title: Hyperthermic radiosensitization: mode of action and clinical relevance publication-title: International Journal of Radiation Biology doi: 10.1080/09553000010024687 contributor: fullname: Dikomey – volume: 108 start-page: 704 year: 2017 end-page: 712 ident: CR10 article-title: Radiosensitivity of quiescent and proliferating cells grown as multicellular tumor spheroids publication-title: Cancer Science doi: 10.1111/cas.13178 contributor: fullname: Miura – volume: 136 start-page: 071006 year: 2014 ident: CR24 article-title: Thermally Induced Apoptosis, Necrosis, and Heat Shock Protein Expression in 3D Culture publication-title: Journal of Biomechanical Engineering doi: 10.1115/1.4027272 contributor: fullname: Diller – ident: CR28 – volume: 113 start-page: 229 year: 2005 ident: 54117_CR19 publication-title: International Journal of Cancer doi: 10.1002/ijc.20596 contributor: fullname: M Wartenberg – volume: 240 start-page: 177 year: 1988 ident: 54117_CR11 publication-title: Science doi: 10.1126/science.2451290 contributor: fullname: RM Sutherland – volume: 56 start-page: 1243 year: 1976 ident: 54117_CR49 publication-title: Journal of the National Cancer Institute doi: 10.1093/jnci/56.6.1243 contributor: fullname: J Overgaard – volume: 77 start-page: 399 year: 2001 ident: 54117_CR1 publication-title: International Journal of Radiation Biology doi: 10.1080/09553000010024687 contributor: fullname: HH Kampinga – volume: 88 start-page: 739 year: 2014 ident: 54117_CR8 publication-title: International Journal of Radiation Oncology Biology Physics doi: 10.1016/j.ijrobp.2013.11.212 contributor: fullname: HP Kok – ident: 54117_CR28 doi: 10.1007/978-3-540-30479-1_46 – volume: 15 start-page: 1239 year: 2011 ident: 54117_CR38 publication-title: Journal of Cellular and Molecular Medicine doi: 10.1111/j.1582-4934.2011.01258.x contributor: fullname: A Carreau – volume: 5 start-page: 247 year: 2002 ident: 54117_CR27 publication-title: Advances in Complex Systems (ACS) doi: 10.1142/S0219525902000572 contributor: fullname: J Moreira – ident: 54117_CR37 – volume: 13 start-page: 2034 year: 2017 ident: 54117_CR15 publication-title: Oncology Letters doi: 10.3892/ol.2017.5697 contributor: fullname: PS Sankar – volume: 1 start-page: 045209 year: 2015 ident: 54117_CR32 publication-title: Biomedical Physics and Engineering Express doi: 10.1088/2057-1976/1/4/045209 contributor: fullname: DR Grimes – volume: 15 start-page: 1215 year: 2016 ident: 54117_CR34 publication-title: Biomechanics and Modeling in Mechanobiology doi: 10.1007/s10237-015-0755-0 contributor: fullname: P Mascheroni – ident: 54117_CR47 doi: 10.1371/journal.pcbi.1003295 – volume: 120 start-page: 44 year: 2016 ident: 54117_CR21 publication-title: Radiation Physics and Chemistry doi: 10.1016/j.radphyschem.2015.11.031 contributor: fullname: T Asayesh – ident: 54117_CR43 – volume: 34 start-page: 30 year: 2018 ident: 54117_CR6 publication-title: International Journal of Hyperthermia doi: 10.1080/02656736.2017.1320812 contributor: fullname: CM van Leeuwen – volume: 13 start-page: 23 year: 1977 ident: 54117_CR23 publication-title: European Journal of Cancer doi: 10.1080/02656730500532028 contributor: fullname: C Lücke-Huhle – volume: 2 start-page: 1 year: 2012 ident: 54117_CR18 publication-title: Frontiers in Oncology doi: 10.3389/fonc.2012.00116 contributor: fullname: K Lauber – ident: 54117_CR36 doi: 10.1088/1367-2630/14/5/055008 – volume: 62 start-page: 679 year: 1989 ident: 54117_CR39 publication-title: British Journal of Radiology doi: 10.1259/0007-1285-62-740-679 contributor: fullname: JF Fowler – volume: 108 start-page: 704 year: 2017 ident: 54117_CR10 publication-title: Cancer Science doi: 10.1111/cas.13178 contributor: fullname: Y Onozato – volume: 29 start-page: 168 year: 2014 ident: 54117_CR33 publication-title: Physiology doi: 10.1152/physiol.00016 contributor: fullname: A Sendoel – volume: 10 start-page: 691 year: 1974 ident: 54117_CR41 publication-title: European Journal of Cancer doi: 10.1016/0014-2964(74)90009-7 contributor: fullname: LE Gerweck – volume: 71 start-page: 75 year: 1972 ident: 54117_CR13 publication-title: Experimental Cell Research doi: 10.1016/0014-4827(72)90265-0 contributor: fullname: RE Durand – volume: 11 start-page: 20131124 year: 2014 ident: 54117_CR31 publication-title: Journal of The Royal Society Interface doi: 10.1098/rsif.2013.1124 contributor: fullname: DR Grimes – volume: 58 start-page: 329 year: 2010 ident: 54117_CR51 publication-title: Acta Biotheoretica doi: 10.1007/s10441-010-9118-5 contributor: fullname: B Chopard – volume: 163 start-page: 94 year: 2016 ident: 54117_CR14 publication-title: Pharmacology and Therapeutics doi: 10.1016/j.pharmthera.2016.03.013 contributor: fullname: S Nath – volume: 75 start-page: 373 year: 1978 ident: 54117_CR22 publication-title: Radiation Research doi: 10.2307/3574911 contributor: fullname: RE Durand – volume: 439 start-page: 453 year: 2013 ident: 54117_CR9 publication-title: Biochemical and Biophysical Research Communications doi: 10.1016/j.bbrc.2013.08.093 contributor: fullname: A Kaida – volume: 123 start-page: 20 year: 2016 ident: 54117_CR20 publication-title: Radiation Physics and Chemistry doi: 10.1016/j.radphyschem.2016.01.018 contributor: fullname: SR Mahdavi – ident: 54117_CR42 – volume: 11 start-page: 1 year: 2016 ident: 54117_CR45 publication-title: PLoS ONE doi: 10.1371/journal.pone.0161239 contributor: fullname: A Gomes – volume: 58 start-page: 1837 year: 1977 ident: 54117_CR50 publication-title: Journal of the National Cancer Institute doi: 10.1093/jnci/58.6.1837 contributor: fullname: ML Freeman – volume: 15 start-page: 20170681 year: 2018 ident: 54117_CR30 publication-title: Journal of The Royal Society Interface doi: 10.1098/rsif.2017.0681 contributor: fullname: S Brüningk – volume: 40 start-page: 253 year: 2010 ident: 54117_CR25 publication-title: Molecular Cell doi: 10.1016/j.molcel.2010.10.006 contributor: fullname: K Richter – ident: 54117_CR29 doi: 10.1007/978-3-662-47221-7 – volume: 19 start-page: 1191 year: 1990 ident: 54117_CR12 publication-title: International Journal of Radiation Oncology Biology Physics doi: 10.1016/0360-3016(90)90227-b contributor: fullname: J Schwachöfer – volume: 34 start-page: 1 year: 2017 ident: 54117_CR7 publication-title: International Journal of Hyperthermia. doi: 10.1080/02656736.2017.1341059 contributor: fullname: SC Brüningk – volume: 59 start-page: 815 year: 1991 ident: 54117_CR5 publication-title: International Journal of Radiation Biology doi: 10.1080/09553009114550711 contributor: fullname: E Dikomey – volume: 11 start-page: 1 year: 2016 ident: 54117_CR44 publication-title: PLoS ONE doi: 10.1371/journal.pone.0153692 contributor: fullname: DR Grimes – volume: 107 start-page: 1821 year: 2014 ident: 54117_CR35 publication-title: Biophysical Journal doi: 10.1016/j.bpj.2014.08.031 contributor: fullname: M Delarue – volume: 59 start-page: 928 year: 2004 ident: 54117_CR2 publication-title: International Journal of Radiation Oncology, Biology, Physics doi: 10.1016/j.ijrobp.2004.03.005 contributor: fullname: TM Pawlik – volume: 8 start-page: 247 year: 2015 ident: 54117_CR40 publication-title: Journal of Radiation Research and Applied Sciences doi: 10.1016/j.jrras.2015.03.003 contributor: fullname: O Desouky – volume: 6 start-page: 1 year: 2016 ident: 54117_CR48 publication-title: Scientific Reports doi: 10.1038/srep30689 contributor: fullname: K Otani – volume: 32 start-page: 266 year: 2017 ident: 54117_CR16 publication-title: Physiology doi: 10.1152/physiol.00036.2016 contributor: fullname: K Duval – volume: 136 start-page: 071006 year: 2014 ident: 54117_CR24 publication-title: Journal of Biomechanical Engineering doi: 10.1115/1.4027272 contributor: fullname: AS Song – volume: 368 start-page: 209 year: 2015 ident: 54117_CR17 publication-title: Cancer Letters doi: 10.1016/j.canlet.2015.02.047 contributor: fullname: K Lauber – volume: 19 start-page: 418 year: 2007 ident: 54117_CR4 publication-title: Clinical Oncology doi: 10.1016/j.clon.2007.03.015 contributor: fullname: MR Horsman – volume: 76 start-page: 193 year: 2004 ident: 54117_CR46 publication-title: Computer Methods and Programs in Biomedicine doi: 10.1016/j.cmpb.2004.07.003 contributor: fullname: EI Zacharaki – volume: 22 start-page: 191 year: 2006 ident: 54117_CR26 publication-title: International Journal of Hyperthermia doi: 10.1080/02656730500532028 contributor: fullname: HH Kampinga – volume: 24 start-page: 123 year: 2008 ident: 54117_CR3 publication-title: International Journal of Hyperthermia doi: 10.1111/j.1743-6109.2008.01122.x.Endothelial contributor: fullname: T Sugahara |
| SSID | ssj0000529419 |
| Score | 2.4539192 |
| Snippet | Thermo-radiosensitisation is a promising approach for treatment of radio-resistant tumours such as those containing hypoxic subregions. Response prediction and... Abstract Thermo-radiosensitisation is a promising approach for treatment of radio-resistant tumours such as those containing hypoxic subregions. Response... |
| SourceID | pubmedcentral proquest crossref pubmed springer |
| SourceType | Open Access Repository Aggregation Database Index Database Publisher |
| StartPage | 17674 |
| SubjectTerms | 13/106 14/63 631/114/2397 631/553/2694 631/67/70 Cell death Combined Modality Therapy Computational Biology - methods Fever HCT116 Cells Humanities and Social Sciences Humans Hyperthermia Hyperthermia, Induced - methods Hypoxia Models, Biological multidisciplinary Neoplasms - radiotherapy Oncology Oxygen Oxygenation Science Science (multidisciplinary) Spheroids Spheroids, Cellular - radiation effects Tumor Hypoxia - radiation effects Tumors |
| SummonAdditionalLinks | – databaseName: AUTh Library subscriptions: ProQuest Central dbid: BENPR link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3NS-UwEB_WJ4IX0V0_qq5E2NsabJu0TU6iiyKCIrKCnkrSpvgOtvraB_rfO9P2VZ6i5wy0mUlmfjOZD4A_sQlyHSnBtcVLLn0ruZXC8UygNxLpTOUhVSNfXsXnt_LiLrrrA251n1Y504mtos6rjGLkh4hDNNkWHR09PXOaGkWvq_0IjQVYDNFTCEeweHJ6dX0zRFnoHUsGuq-W8YU6rNFiUVVZoHkkA1TRL_MW6RPM_Jwt-eHJtLVEZ6uw0kNIdtzJfA1-uPInLHVDJV9_wf0xo2g8pZcyM20qhKRVydqJNwwRKqupkUA1ztmkS491rKnYhFoUkIyYKXP2gM7phJDh49iwIRW9Xofbs9P__855P0CBZzKRDS-UTQyVlkr0cqjxmrTUzh4tuM5CZa3vtO9ia0WOQFAUSWF8G-VOilg7adCR2YBRWZVuC5gzhQmdjnQRC1zSyiUIDAplQqQLYuPB3xkT06euT0bavm8LlXYsT5Hlacvy9MWD3Rmf0_7O1Om7hD3YH5bxtBPTTOmqaUdDLl2ENJudWIbPIRJCZamVB8mcwAYC6qQ9v1KOH9qO2rFSNLHYg4OZaN9_6-tdbH-_ix1YDumYBQEPk10YNZOp-40IprF7_TF9A5FF8Gk priority: 102 providerName: ProQuest – databaseName: Scholars Portal Open Access Journals dbid: M48 link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LS8QwEB5EUbyIb-uLCN60um3TNjmIiLgsgp5c0FNJtikuaKvdLqz_3pmmXVkfF89JaTuPzjfNzDcAx5HyUhmKwJUanZx3NHc1D4w7CDAbCeVApD51I9_dR70-v30MH-egHXfUCHD0a2pH86T65cvZ5P3jEh3-wraMi_MRBiFqFPOkG3IPv7qIKRd8IuaiUr4G7luub19yTza9M79fugxLGFLR66SYDVU_8OfPMspvZ6l1iOquwkqDLdmVNYY1mDP5OizaaZMfG_B0xeg3PdWdMjWuCsSqRc7qUTgMoSsbEcNAMUxZaetmDasKVhJ3ASmPqTxlz5i1lgQZX4eKTWvUR5vQ7948XPfcZrKCO-Axr9xM6FhRzynH9IcY2bgmnnsM7XLgC607RnZMpHWQIkIMsjhTHR2mhgeRNFxhhrMF83mRmx1gRmXKNzKUWRTgkhQmRsSQCeXjPi9SDpy0QkzeLIFGUh98ByKx0k9Q-kkt_WTiwH4r56S1hQQhqCRYIUMHjqbL6AYkNJWbYmz3UK4X4p5tq5bp7Vp9OhDPKGy6gSi2Z1fy4XNNtR0JQaOMHThtVfv1WH-_xe6_b7QHyz4Zo-e5frwP81U5NgeIeip9WJvyJ2q4_90 priority: 102 providerName: Scholars Portal – databaseName: SpringerOpen dbid: C6C link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3fT4MwEG7MjIkvxt-i09TENyUCLdA-LovLYqJPLplPpIWS7UEwwBL9770DhsHpg889Aty1ve96ve8IuQmUm0hfMFtqWOTc0dzWnBk7ZhCN-DIWiYfVyE_PwXTGH-f-vKXJwVqYXv6eifsSHAwWgbnS9rkLOyrgxW30wdimYRyMu_MUzFhxV7Z1Mb8_2vc9G4By817kj-Ro7XMm-2SvBYt01Fj3gGyZ7JDsNO0jP4_I64jiuTteJKVqVeUAPvOM1r1tKGBRWiJlQL5MaNFchDW0ymmBZARoDaqyhC4gDC0QA74tFe0unZfHZDZ5eBlP7bZVgh3zkFd2KnSosIiUQzyDFGtcI3E9-GoZe0Jrx0jHBFqzBCAfS8NUOdpPDGeBNFxByHJCBlmemTNCjUqVZ6Qv04DBkBQmBAiQCuWBnBsoi9yulRi9N4wYUZ3JZiJqVB6ByqNa5dGHRYZrPUft6igjwJQScYL0LXLdDcO8RqWpzOSrRgaDNx9kThuzdK8DzAPbohQWCXsG6wSQM7s_ki0XNXd2IAT2JrbI3dq035_191-c_0_8gux6OO1c1_bCIRlUxcpcAnap9FU9ab8Ay0jofg priority: 102 providerName: Springer Nature |
| Title | A cellular automaton model for spheroid response to radiation and hyperthermia treatments |
| URI | https://link.springer.com/article/10.1038/s41598-019-54117-x https://www.ncbi.nlm.nih.gov/pubmed/31776398 https://www.proquest.com/docview/2319185395 https://search.proquest.com/docview/2319495655 https://pubmed.ncbi.nlm.nih.gov/PMC6881451 |
| Volume | 9 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3da9swED_6wWAvZd1XvbVBhb11bmxLsqXHLrSUQUoZK6RPRrJlGmjskjiw_fe7k-1sWdnLXgxGAsl3J9_vpLufAD6lJi61VDzUFhe5iKwIreAuLDhGI1IXqkyoGnl6k17fia8zOdsBOdTC-KT9ws7P68fFeT1_8LmVT4tiPOSJjW-nk1QpumB2vAu7aKB_hOgdoXeiRaz7ApmIq_EKnRQVksU6lCLGvzKRT6PfxKWl1bY_egYyn-dK_nVg6v3Q1Ss46AEku-gmegg7rn4NL7orJX--gfsLRnvxlFzKzLptEJA2NfP33TDEp2xFNALNvGTLLjnWsbZhSyIoIA0xU5fsAUPTJeHCxdywTSL66i3cXV1-n1yH_fUJYSEy0YaVspmhwlKBMQ7RrglLZPbov3WRKGsjpyOXWstLhIG8yioTWVk6wVPthMEw5h3s1U3tjoA5U5nEaamrlGOTVi5DWFApk2C_ODUBnA1CzJ86lozcn25zlXfSz1H6uZd-_iOA40HOeb9iVjniTE3YQcsATjfNaOskNFO7Zt31oYBOYp_3nVo2ww36DCDbUtimA_Fob7egeXk-7d6cAvg8qPb3tP79FR_-e6CP8DIhY4zjMMmOYa9drt0JQpvWjtCgZ9kI9r9c3tx-w7dJOhn5bQJ8ToUaeVP_BfN7_TM |
| link.rule.ids | 230,315,730,783,787,867,888,12070,21402,24332,27938,27939,31733,31734,33758,33759,41134,42203,43324,43819,51590,53806,53808,74081,74638 |
| linkProvider | National Library of Medicine |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Nb9QwEB2VIgQXxHcDbTESN7CaxE5in1BVtdrCbk-ttJwsO3HUPZBsN1lp-ffMJNlUSwVnW0o8Y8-8GY_fAHxObVToRAmuHR5yGTrJnRSe5wKjkUTnqojpNfLsKp3cyO_zZD4k3JqhrHJrEztDXdQ55chPEIdo8i06-ba849Q1im5XhxYaj-Ax8XARd342z8YcC91iyUgPb2VCoU4a9Ff0pizSPJERGujNrj96ADIf1kr-dWHa-aGLF_B8AJDstNf4S9jz1St40reU_P0afp4yysVTcSmz67ZGQFpXrOt3wxCfsoZoBOpFwVZ9caxnbc1WRFBAGmK2KtgthqYrwoW_FpaNhejNG7i5OL8-m_ChfQLPZSZbXiqXWXpYKjHGIdo16YjMHv23zmPlXOh16FPnRIEwUJRZaUOXFF6KVHtpMYx5C_tVXfkDYN6WNvY60WUqcEgrnyEsKJWNcV6U2gC-bIVolj1Lhulut4UyvcgNitx0IjebAA63cjbDiWnMvX4D-DQO414nodnK1-t-DgV0Cc5516tl_BziIDSVWgWQ7ShsnEA82rsj1eK249NOlaJ-xQF83ar2_rf-vYr3_1_FR3g6uZ5NzfTy6scHeBbTlosiHmeHsN-u1v4IsUzrjrsN-wf2l_H0 |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9QwEB7BViAuiDeBAkbiBtYmsZPYJ1Sgq_JaVYhK5WTZiaPugaRsslL598wk3lRLBWePlHhmPPONPQ-AV7lNKp0pwbXDQy5jJ7mTwvNSYDSS6VJVKVUjf13mRyfy02l2GvKfupBWubWJg6Gu2pLuyOeIQzT5Fp3N65AWcfxh8fb8F6cJUvTSGsZpXIe9QqJWzWDv3eHy-Nt040JvWjLRoXImFmreofeiCrNE80wmaK4vdr3TFch5NXPyr-fTwSst7sDtACfZwSj_u3DNN_fgxjhg8vd9-HHA6GaeUk2Z3fQtwtO2YcP0G4ZolXXUVKBdVWw9psp61rdsTe0KSF7MNhU7w0B1TSjx58qyKS29ewAni8Pv7494GKbAS1nIntfKFZbKTCVGPNSETTpqbY_eXJepci72Ova5c6JCUCjqoraxyyovRa69tBjUPIRZ0zb-MTBva5t6nek6F7iklS8QJNTKpkiX5DaC11smmvOxZ4YZ3rqFMiPLDbLcDCw3FxHsb_lswvnpzKW0I3g5LaPmE9Ns49vNSEPhXYY0j0axTJ9DVISGU6sIih2BTQTUVXt3pVmdDd21c6VoenEEb7aivfytf-_iyf938QJuoraaLx-Xn5_CrZQ0Lkl4WuzDrF9v_DMENr17HjT2D3k695c |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=A+cellular+automaton+model+for+spheroid+response+to+radiation+and+hyperthermia+treatments&rft.jtitle=Scientific+reports&rft.au=Br%C3%BCningk%2C+Sarah+C.&rft.au=Ziegenhein%2C+Peter&rft.au=Rivens%2C+Ian&rft.au=Oelfke%2C+Uwe&rft.date=2019-11-27&rft.pub=Nature+Publishing+Group+UK&rft.eissn=2045-2322&rft.volume=9&rft_id=info:doi/10.1038%2Fs41598-019-54117-x&rft_id=info%3Apmid%2F31776398&rft.externalDBID=PMC6881451 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2045-2322&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2045-2322&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2045-2322&client=summon |