TRIM5α Restricts Flavivirus Replication by Targeting the Viral Protease for Proteasomal Degradation

• Published in: Cell reports (Cambridge) Vol. 27; no. 11; pp. 3269 - 3283.e6
• Main Authors: Chiramel, Abhilash I., Meyerson, Nicholas R., McNally, Kristin L., Broeckel, Rebecca M., Montoya, Vanessa R., Méndez-Solís, Omayra, Robertson, Shelly J., Sturdevant, Gail L., Lubick, Kirk J., Nair, Vinod, Youseff, Brian H., Ireland, Robin M., Bosio, Catharine M., Kim, Kyusik, Luban, Jeremy, Hirsch, Vanessa M., Taylor, R. Travis, Bouamr, Fadila, Sawyer, Sara L., Best, Sonja M.
• Format: Journal Article
• Language: English
• Published: United States Elsevier 11.06.2019
• Subjects: Animals; Antiviral Restriction Factors; Cats; Chlorocebus aethiops; Dendritic Cells - metabolism; Dendritic Cells - virology; Flavivirus - pathogenicity; Flavivirus - physiology; Flavivirus Infections - metabolism; Flavivirus Infections - virology; HEK293 Cells; Humans; Peptide Hydrolases - metabolism; Proteasome Endopeptidase Complex - metabolism; Protein Binding; Proteolysis; Substrate Specificity; Tripartite Motif Proteins - metabolism; Ubiquitin-Protein Ligases - metabolism; Ubiquitination; Vero Cells; Viral Proteins - metabolism; Virus Replication; TRIM5α; retrovirus; restriction factor; interferon; interferon stimulated genes; flavivirus; tick-borne encephalitis virus

Tripartite motif-containing protein 5α (TRIM5α) is a cellular antiviral restriction factor that prevents early events in retrovirus replication. The activity of TRIM5α is thought to be limited to retroviruses as a result of highly specific interactions with capsid lattices. In contrast to this curre...