Umbilical cord tissue is a robust source for mesenchymal stem cells with enhanced myogenic differentiation potential compared to cord blood

• Published in: Scientific reports Vol. 10; no. 1; p. 18978
• Main Authors: Mishra, Shivangi, Sevak, Jayesh Kumar, Das, Anamica, Arimbasseri, G. Aneeshkumar, Bhatnagar, Shinjini, Gopinath, Suchitra D.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 04.11.2020; Nature Publishing Group
• Subjects: 631/337; 631/532; Antigens, CD34 - metabolism; CD105 antigen; CD34 antigen; CD45 antigen; CD90 antigen; Cell culture; Cell Culture Techniques; Cell Differentiation; Cell Proliferation; Cells, Cultured; Comparative analysis; Cord blood; Endoglin - metabolism; Female; Fetal Blood - cytology; Fetal Blood - immunology; Fetuses; Gene Expression Profiling - methods; Gene Expression Regulation; Genetic Markers; Humanities and Social Sciences; Humans; Leukocyte Common Antigens - metabolism; Mesenchymal stem cells; Mesenchymal Stem Cells - cytology; Mesenchymal Stem Cells - immunology; multidisciplinary; Muscle Development; Muscle, Skeletal - chemistry; Muscle, Skeletal - cytology; Pregnancy; Science; Science (multidisciplinary); Senescence; Sequence Analysis, RNA; Skeletal muscle; Stem cells; Surface markers; Term Birth; Therapeutic applications; Thy-1 Antigens - metabolism; Umbilical cord; Umbilical Cord - cytology; Umbilical Cord - immunology

Differentiation of mesenchymal stem cells (MSCs) derived from two different sources of fetal tissues such as umbilical cord blood (UCB) and tissue (UCT) into skeletal muscle have remained underexplored. Here, we present a comparative analysis of UCB and UCT MSCs, in terms of surface markers, prolife...