The impacts of probiotics in eradication therapy of Helicobacter pylori

• Published in: Archives of microbiology Vol. 204; no. 12; p. 692
• Main Authors: Bai, Xiaofen, Zhu, Minjie, He, Yajun, Wang, Tengyan, Tian, Da, Shu, Jianchang
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.12.2022; Springer Nature B.V
• Subjects: Anti-Bacterial Agents - adverse effects; Antibiotic resistance; Antibiotics; Apoptosis; Archives & records; Autophagy; Biochemistry; Biomedical and Life Sciences; Biotechnology; Cell Biology; Clinical trials; Dietary supplements; Digestive system diseases; Disease; Drug resistance; Dysbacteriosis; Ecology; Eradication; Gastric cancer; Gastritis; Gastroenterology; Gastrointestinal Microbiome; Gene expression; Health hazards; Helicobacter Infections - drug therapy; Helicobacter pylori; Hospitals; Humans; Infections; Life Sciences; Microbial Ecology; Microbiology; Mini Review; Pathogenesis; Peptic ulcers; Probiotics; Probiotics - therapeutic use; Proteins; Side effects; Therapy; Ulcers; Virulence; Eradication therapy; Helicobacter pylori; Probiotics
• ISSN: 0302-8933; 1432-072X
• DOI: 10.1007/s00203-022-03314-w

Helicobacter pylori ( H. pylori ) is a well-known pathogen that infects approximately half of the world’s population. It is a pathogenic agent with potential health hazards related to diverse diseases, especially digestive diseases, such as chronic gastritis, peptic ulcer, and gastric carcinoma. In clinical, antibiotics are commonly applied in eradication therapy of  H. pylori . However, the increase in antibiotic resistance and side effects has induced the failure of eradication therapy. Recent studies have shown that probiotic supplementation has promising application prospects. It can restore the gastrointestinal microbiota balance and prevent dysbacteriosis caused by antibiotics. Furthermore, it has been reported to have direct or indirect inhibitory effects on  H. pylori . Probiotics may have a beneficial effect on  H. pylori  eradication. However, the strain, dosages, duration times, and safety of probiotic supplementation need further study before clinical applications.