Mapping the cortico-striatal transcriptome in attention deficit hyperactivity disorder

• Published in: Molecular psychiatry Vol. 28; no. 2; pp. 792 - 800
• Main Authors: Sudre, Gustavo, Gildea, Derek E., Shastri, Gauri G., Sharp, Wendy, Jung, Benjamin, Xu, Qing, Auluck, Pavan K., Elnitski, Laura, Baxevanis, Andreas D., Marenco, Stefano, Shaw, Philip
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.02.2023; Nature Publishing Group
• Subjects: 38/91; 631/208; 631/378; 692/699/476/1311; Attention Deficit Disorder with Hyperactivity - metabolism; Attention deficit hyperactivity disorder; Behavioral Sciences; Biological Psychology; Brain - metabolism; Brain Mapping; Brain research; Caudate nucleus; Corpus Striatum - metabolism; Cortex (cingulate); Dissection; Gene expression; Gene mapping; Genetic diversity; Genomes; Genomics; Glutamatergic transmission; Humans; Hyperactivity; Magnetic Resonance Imaging; Medicine; Medicine & Public Health; Mental disorders; Mental health; Neostriatum; Neurodevelopmental disorders; Neurosciences; Neurotransmitters; Pharmacotherapy; Psychiatry; Quality control; Research centers; Software packages; Transcriptome - genetics; Transcriptomes; Transcriptomics

Despite advances in identifying rare and common genetic variants conferring risk for ADHD, the lack of a transcriptomic understanding of cortico-striatal brain circuitry has stymied a molecular mechanistic understanding of this disorder. To address this gap, we mapped the transcriptome of the caudat...