Gene therapy for hearing loss

• Published in: Human molecular genetics Vol. 28; no. R1; pp. R65 - R79
• Main Authors: Omichi, Ryotaro, Shibata, Seiji B, Morton, Cynthia C, Smith, Richard J H
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.10.2019
• Subjects: Animals; Biomarkers; Clinical Trials as Topic; Disease Management; Disease Models, Animal; Drug Evaluation, Preclinical; Gene Expression; Genetic Predisposition to Disease; Genetic Therapy - methods; Genetic Vectors - genetics; Hearing Loss - diagnosis; Hearing Loss - genetics; Hearing Loss - therapy; Humans; Invited Review; Transgenes; Treatment Outcome

Abstract Sensorineural hearing loss (SNHL) is the most common sensory disorder. Its underlying etiologies include a broad spectrum of genetic and environmental factors that can lead to hearing loss that is congenital or late onset, stable or progressive, drug related, noise induced, age related, tra...