Molecular mechanisms of ferroptosis and relevance to inflammation

• Published in: Inflammation research Vol. 72; no. 2; pp. 281 - 299
• Main Authors: Deng, Liyan, He, Shasha, Guo, Nuoqing, Tian, Wen, Zhang, Weizhen, Luo, Lianxiang
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.02.2023; Springer Nature B.V
• Subjects: Allergology; Biomedical and Life Sciences; Biomedicine; Cell Death; Defensive behavior; Degeneration; Dermatology; Ferroptosis; Homeostasis; Humans; Immunology; Inflammation; Inflammatory diseases; Inflammatory response; Iron; Irritation; Lipid metabolism; Lipid Peroxidation; Lipids; Metabolic pathways; Mitochondria; Molecular modelling; Neurology; Pain; Pain perception; Peroxidation; Pharmacology/Toxicology; Regulatory mechanisms (biology); Review; Rheumatology; Lipid peroxidation; Ferroptosis; Iron metabolism; Mitochondria; Inflammation

Introduction Inflammation is a defensive response of the organism to irritation which is manifested by redness, swelling, heat, pain and dysfunction. The inflammatory response underlies the role of various diseases. Ferroptosis, a unique modality of cell death, driven by iron-dependent lipid peroxid...