QCT-based finite element prediction of pathologic fractures in proximal femora with metastatic lesions

• Published in: Scientific reports Vol. 9; no. 1; pp. 10305 - 9
• Main Authors: Benca, Emir, Synek, Alexander, Amini, Morteza, Kainberger, Franz, Hirtler, Lena, Windhager, Reinhard, Mayr, Winfried, Pahr, Dieter H.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 16.07.2019; Nature Publishing Group
• Subjects: 692/308/1426; 692/699/67/322/803; Aged; Aged, 80 and over; Automation; Bone diseases; Bone Neoplasms - complications; Bone Neoplasms - diagnostic imaging; Bone Neoplasms - secondary; Computed tomography; Computer applications; Female; Femoral Fractures - diagnostic imaging; Femoral Fractures - etiology; Femur; Finite Element Analysis; Fractures; Fractures, Spontaneous - diagnostic imaging; Fractures, Spontaneous - etiology; Humanities and Social Sciences; Humans; Lesions; Male; Mathematical models; Metastases; Metastasis; multidisciplinary; Patient-Specific Modeling; Patients; Science; Science (multidisciplinary); Tomography, X-Ray Computed

Predicting pathologic fractures in femora with metastatic lesions remains a clinical challenge. Currently used guidelines are inaccurate, especially to predict non-impeding fractures. This study evaluated the ability of a nonlinear quantitative computed tomography (QCT)-based homogenized voxel finit...