Long-term effect of diuretic-based therapy on fatal outcomes in subjects with isolated systolic hypertension with and without diabetes

• Published in: The American journal of cardiology Vol. 95; no. 1; pp. 29 - 35
• Main Authors: Kostis, John B., Wilson, Alan C., Freudenberger, Ronald S., Cosgrove, Nora M., Pressel, Sara L., Davis, Barry R.
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 2005; Elsevier; Elsevier Limited
• Subjects: Aged; Biological and medical sciences; Cardiology; Cardiology. Vascular system; Chlorthalidone - therapeutic use; Clinical outcomes; Diabetes; Diabetes Mellitus - etiology; Diabetes Mellitus - mortality; Diabetes. Impaired glucose tolerance; Diuretics - therapeutic use; Double-Blind Method; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Female; Follow-Up Studies; Humans; Hypertension; Hypertension - complications; Hypertension - drug therapy; Hypertension - mortality; Hypertension - physiopathology; Male; Medical sciences; Medical treatment; Mortality; Systole; Time Factors; Endocrinopathy; Diuretic; Human; Systolic hypertension; Prognosis; Treatment; Diabetes mellitus; Evolution; Long term

Diuretic-based antihypertensive therapy is associated with the development of diabetes but with improved clinical outcomes. It has been proposed that the duration of clinical trials has been too short to detect the adverse effects of diabetes. We assessed the long-term mortality rate of subjects in...