Salmonella enterica serovar Typhi influences inflammation and autophagy in macrophages
Salmonella enterica serovar Typhi ( S. Typhi) is a human enteropathogen that can survive in macrophages and cause systemic infection. Autophagy and inflammation are two important immune responses of macrophages that contribute to the elimination of pathogens. However, Salmonella has derived many str...
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| Published in | Brazilian journal of microbiology Vol. 53; no. 2; pp. 525 - 534 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Cham
Springer International Publishing
01.06.2022
Springer Nature B.V |
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| Abstract | Salmonella enterica
serovar Typhi (
S.
Typhi) is a human enteropathogen that can survive in macrophages and cause systemic infection. Autophagy and inflammation are two important immune responses of macrophages that contribute to the elimination of pathogens. However,
Salmonella
has derived many strategies to evade inflammation and autophagy. This study investigated inflammation-related NF-κB signaling pathways and autophagy in
S.
Typhi-infected macrophages. RNA-seq and quantitative real-time PCR indicated that mRNA levels of NF-κB signaling pathway and autophagy-related genes were dynamically influenced in
S.
Typhi-infected macrophages. Western blots revealed that
S.
Typhi activated the NF-κB signaling pathway and induced the expression of inhibitor protein IκBζ. In addition,
S
. Typhi enhanced autophagy during early stages of infection and may inhibit autophagy during late stages of infection. Thus, we propose that
S.
Typhi can influence the NF-κB signaling pathway and autophagy in macrophages. |
|---|---|
| AbstractList | Salmonella enterica
serovar Typhi (
S.
Typhi) is a human enteropathogen that can survive in macrophages and cause systemic infection. Autophagy and inflammation are two important immune responses of macrophages that contribute to the elimination of pathogens. However,
Salmonella
has derived many strategies to evade inflammation and autophagy. This study investigated inflammation-related NF-κB signaling pathways and autophagy in
S.
Typhi-infected macrophages. RNA-seq and quantitative real-time PCR indicated that mRNA levels of NF-κB signaling pathway and autophagy-related genes were dynamically influenced in
S.
Typhi-infected macrophages. Western blots revealed that
S.
Typhi activated the NF-κB signaling pathway and induced the expression of inhibitor protein IκBζ. In addition,
S
. Typhi enhanced autophagy during early stages of infection and may inhibit autophagy during late stages of infection. Thus, we propose that
S.
Typhi can influence the NF-κB signaling pathway and autophagy in macrophages. Salmonella enterica serovar Typhi (S. Typhi) is a human enteropathogen that can survive in macrophages and cause systemic infection. Autophagy and inflammation are two important immune responses of macrophages that contribute to the elimination of pathogens. However, Salmonella has derived many strategies to evade inflammation and autophagy. This study investigated inflammation-related NF-κB signaling pathways and autophagy in S. Typhi-infected macrophages. RNA-seq and quantitative real-time PCR indicated that mRNA levels of NF-κB signaling pathway and autophagy-related genes were dynamically influenced in S. Typhi-infected macrophages. Western blots revealed that S. Typhi activated the NF-κB signaling pathway and induced the expression of inhibitor protein IκBζ. In addition, S. Typhi enhanced autophagy during early stages of infection and may inhibit autophagy during late stages of infection. Thus, we propose that S. Typhi can influence the NF-κB signaling pathway and autophagy in macrophages. Salmonella enterica serovar Typhi (S. Typhi) is a human enteropathogen that can survive in macrophages and cause systemic infection. Autophagy and inflammation are two important immune responses of macrophages that contribute to the elimination of pathogens. However, Salmonella has derived many strategies to evade inflammation and autophagy. This study investigated inflammation-related NF-κB signaling pathways and autophagy in S. Typhi-infected macrophages. RNA-seq and quantitative real-time PCR indicated that mRNA levels of NF-κB signaling pathway and autophagy-related genes were dynamically influenced in S. Typhi-infected macrophages. Western blots revealed that S. Typhi activated the NF-κB signaling pathway and induced the expression of inhibitor protein IκBζ. In addition, S. Typhi enhanced autophagy during early stages of infection and may inhibit autophagy during late stages of infection. Thus, we propose that S. Typhi can influence the NF-κB signaling pathway and autophagy in macrophages.Salmonella enterica serovar Typhi (S. Typhi) is a human enteropathogen that can survive in macrophages and cause systemic infection. Autophagy and inflammation are two important immune responses of macrophages that contribute to the elimination of pathogens. However, Salmonella has derived many strategies to evade inflammation and autophagy. This study investigated inflammation-related NF-κB signaling pathways and autophagy in S. Typhi-infected macrophages. RNA-seq and quantitative real-time PCR indicated that mRNA levels of NF-κB signaling pathway and autophagy-related genes were dynamically influenced in S. Typhi-infected macrophages. Western blots revealed that S. Typhi activated the NF-κB signaling pathway and induced the expression of inhibitor protein IκBζ. In addition, S. Typhi enhanced autophagy during early stages of infection and may inhibit autophagy during late stages of infection. Thus, we propose that S. Typhi can influence the NF-κB signaling pathway and autophagy in macrophages. |
| Author | Wang, Yurou Wang, Huiyun Jiang, Haiqiang Huang, Xinxiang Zhang, Ying Xie, Zhongyi Yang, Fanfan |
| Author_xml | – sequence: 1 givenname: Huiyun surname: Wang fullname: Wang, Huiyun organization: JiangYin Hospital Affiliated to Nanjing University of Chinese Medicine – sequence: 2 givenname: Zhongyi surname: Xie fullname: Xie, Zhongyi organization: Department of Biochemistry and Molecular Biology, Jiangsu University School of Medicine – sequence: 3 givenname: Fanfan surname: Yang fullname: Yang, Fanfan organization: Department of Biochemistry and Molecular Biology, Jiangsu University School of Medicine – sequence: 4 givenname: Yurou surname: Wang fullname: Wang, Yurou organization: Department of Biochemistry and Molecular Biology, Jiangsu University School of Medicine – sequence: 5 givenname: Haiqiang surname: Jiang fullname: Jiang, Haiqiang organization: JiangYin Hospital Affiliated to Nanjing University of Chinese Medicine – sequence: 6 givenname: Xinxiang surname: Huang fullname: Huang, Xinxiang organization: Department of Biochemistry and Molecular Biology, Jiangsu University School of Medicine – sequence: 7 givenname: Ying orcidid: 0000-0002-6505-4822 surname: Zhang fullname: Zhang, Ying email: zhangyingzj85@163.com organization: Department of Biochemistry and Molecular Biology, Jiangsu University School of Medicine |
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| CitedBy_id | crossref_primary_10_1016_j_cellin_2025_100237 crossref_primary_10_1128_iai_00476_23 crossref_primary_10_1007_s00203_023_03702_w crossref_primary_10_1021_acsinfecdis_4c00001 |
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| Keywords | Inflammation Typhi Autophagy NF-κB signaling pathway Transcriptome S. Typhi |
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| Snippet | Salmonella enterica
serovar Typhi (
S.
Typhi) is a human enteropathogen that can survive in macrophages and cause systemic infection. Autophagy and... Salmonella enterica serovar Typhi (S. Typhi) is a human enteropathogen that can survive in macrophages and cause systemic infection. Autophagy and inflammation... |
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| SubjectTerms | Autophagy Bacterial and Fungal Pathogenesis - Research Paper Biomedical and Life Sciences Disseminated infection Food Microbiology Humans Immune response Infections Inflammation Life Sciences Macrophages Macrophages - microbiology Medical Microbiology Microbial Ecology Microbial Genetics and Genomics Microbiology mRNA Mycology NF-kappa B - genetics NF-κB protein Salmonella Salmonella enterica Salmonella typhi - genetics Signal transduction Signaling Western blotting |
| Title | Salmonella enterica serovar Typhi influences inflammation and autophagy in macrophages |
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