Environmental Toxicant Induced Epigenetic Transgenerational Inheritance of Prostate Pathology and Stromal-Epithelial Cell Epigenome and Transcriptome Alterations: Ancestral Origins of Prostate Disease
Prostate diseases include prostate cancer, which is the second most common male neoplasia, and benign prostatic hyperplasia (BPH), which affects approximately 50% of men. The incidence of prostate disease is increasing, and some of this increase may be attributable to ancestral exposure to environme...
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Published in | Scientific reports Vol. 9; no. 1; p. 2209 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
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Nature Publishing Group UK
18.02.2019
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Abstract | Prostate diseases include prostate cancer, which is the second most common male neoplasia, and benign prostatic hyperplasia (BPH), which affects approximately 50% of men. The incidence of prostate disease is increasing, and some of this increase may be attributable to ancestral exposure to environmental toxicants and epigenetic transgenerational inheritance mechanisms. The goal of the current study was to determine the effects that exposure of gestating female rats to vinclozolin has on the epigenetic transgenerational inheritance of prostate disease, and to characterize by what molecular epigenetic mechanisms this has occurred. Gestating female rats (F0 generation) were exposed to vinclozolin during E8-E14 of gestation. F1 generation offspring were bred to produce the F2 generation, which were bred to produce the transgenerational F3 generation. The transgenerational F3 generation vinclozolin lineage males at 12 months of age had an increased incidence of prostate histopathology and abnormalities compared to the control lineage. Ventral prostate epithelial and stromal cells were isolated from F3 generation 20-day old rats, prior to the onset of pathology, and used to obtain DNA and RNA for analysis. Results indicate that there were transgenerational changes in gene expression, noncoding RNA expression, and DNA methylation in both cell types. Our results suggest that ancestral exposure to vinclozolin at a critical period of gestation induces the epigenetic transgenerational inheritance of prostate stromal and epithelial cell changes in both the epigenome and transcriptome that ultimately lead to prostate disease susceptibility and may serve as a source of the increased incidence of prostate pathology observed in recent years. |
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AbstractList | Prostate diseases include prostate cancer, which is the second most common male neoplasia, and benign prostatic hyperplasia (BPH), which affects approximately 50% of men. The incidence of prostate disease is increasing, and some of this increase may be attributable to ancestral exposure to environmental toxicants and epigenetic transgenerational inheritance mechanisms. The goal of the current study was to determine the effects that exposure of gestating female rats to vinclozolin has on the epigenetic transgenerational inheritance of prostate disease, and to characterize by what molecular epigenetic mechanisms this has occurred. Gestating female rats (F0 generation) were exposed to vinclozolin during E8-E14 of gestation. F1 generation offspring were bred to produce the F2 generation, which were bred to produce the transgenerational F3 generation. The transgenerational F3 generation vinclozolin lineage males at 12 months of age had an increased incidence of prostate histopathology and abnormalities compared to the control lineage. Ventral prostate epithelial and stromal cells were isolated from F3 generation 20-day old rats, prior to the onset of pathology, and used to obtain DNA and RNA for analysis. Results indicate that there were transgenerational changes in gene expression, noncoding RNA expression, and DNA methylation in both cell types. Our results suggest that ancestral exposure to vinclozolin at a critical period of gestation induces the epigenetic transgenerational inheritance of prostate stromal and epithelial cell changes in both the epigenome and transcriptome that ultimately lead to prostate disease susceptibility and may serve as a source of the increased incidence of prostate pathology observed in recent years. Abstract Prostate diseases include prostate cancer, which is the second most common male neoplasia, and benign prostatic hyperplasia (BPH), which affects approximately 50% of men. The incidence of prostate disease is increasing, and some of this increase may be attributable to ancestral exposure to environmental toxicants and epigenetic transgenerational inheritance mechanisms. The goal of the current study was to determine the effects that exposure of gestating female rats to vinclozolin has on the epigenetic transgenerational inheritance of prostate disease, and to characterize by what molecular epigenetic mechanisms this has occurred. Gestating female rats (F0 generation) were exposed to vinclozolin during E8-E14 of gestation. F1 generation offspring were bred to produce the F2 generation, which were bred to produce the transgenerational F3 generation. The transgenerational F3 generation vinclozolin lineage males at 12 months of age had an increased incidence of prostate histopathology and abnormalities compared to the control lineage. Ventral prostate epithelial and stromal cells were isolated from F3 generation 20-day old rats, prior to the onset of pathology, and used to obtain DNA and RNA for analysis. Results indicate that there were transgenerational changes in gene expression, noncoding RNA expression, and DNA methylation in both cell types. Our results suggest that ancestral exposure to vinclozolin at a critical period of gestation induces the epigenetic transgenerational inheritance of prostate stromal and epithelial cell changes in both the epigenome and transcriptome that ultimately lead to prostate disease susceptibility and may serve as a source of the increased incidence of prostate pathology observed in recent years. |
ArticleNumber | 2209 |
Author | Xie, Yeming Nilsson, Eric Skinner, Michael K. Klukovich, Rachel Yan, Wei Beck, Daniel Sadler-Riggleman, Ingrid |
Author_xml | – sequence: 1 givenname: Rachel orcidid: 0000-0001-5166-469X surname: Klukovich fullname: Klukovich, Rachel organization: Department of Physiology and Cell Biology, University of Nevada, Reno School of Medicine – sequence: 2 givenname: Eric surname: Nilsson fullname: Nilsson, Eric organization: Center for Reproductive Biology, School of Biological Sciences, Washington State University – sequence: 3 givenname: Ingrid surname: Sadler-Riggleman fullname: Sadler-Riggleman, Ingrid organization: Center for Reproductive Biology, School of Biological Sciences, Washington State University – sequence: 4 givenname: Daniel surname: Beck fullname: Beck, Daniel organization: Center for Reproductive Biology, School of Biological Sciences, Washington State University – sequence: 5 givenname: Yeming surname: Xie fullname: Xie, Yeming organization: Department of Physiology and Cell Biology, University of Nevada, Reno School of Medicine – sequence: 6 givenname: Wei surname: Yan fullname: Yan, Wei email: wyan@med.unr.edu organization: Department of Physiology and Cell Biology, University of Nevada, Reno School of Medicine – sequence: 7 givenname: Michael K. surname: Skinner fullname: Skinner, Michael K. email: skinner@wsu.edu organization: Center for Reproductive Biology, School of Biological Sciences, Washington State University |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30778168$$D View this record in MEDLINE/PubMed |
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Cites_doi | 10.1093/bioinformatics/btt650 10.1016/j.diff.2017.07.002 10.1002/pros.20238 10.1055/s-2006-944423 10.1210/me.2013-1207 10.1093/eepdvy010 10.1038/nmeth.1923 10.1186/gb-2012-13-10-r91 10.1080/01485010600630124 10.1016/S0898-6568(01)00205-4 10.1002/pros.20724 10.1210/endo.139.3.5821 10.1016/j.prp.2013.08.013 10.1038/nprot.2013.092 10.1038/nprot.2009.97 10.1126/science.aad7977 10.1371/journal.pone.0031901 10.1002/pros.22640 10.1002/pros.23046 10.1371/journal.pone.0059922 10.1016/j.tox.2009.06.011 10.1093/bioinformatics/btp352 10.1016/S0012-1606(02)00031-3 10.1016/j.mce.2014.09.008 10.1371/journal.pone.0102091 10.1002/bdrb.21131 10.1186/1471-2164-15-692 10.1111/j.1464-410X.1997.tb16917.x 10.1038/nprot.2008.211 10.1016/S1472-6483(10)60553-6 10.1016/j.reprotox.2017.01.008 10.1210/en.2017-00718 10.1093/bioinformatics/btp616 10.1371/journal.pone.0036129 10.1371/journal.pone.0202662 10.1371/journal.pone.0046249 10.1210/edrv-8-3-338 10.1158/1078-0432.CCR-13-1184 10.1080/15592294.2018.1521223 10.1002/aja.1001340109 10.1016/j.cell.2014.06.020 10.7150/ijbs.12468 10.1016/j.reprotox.2012.08.010 10.1371/journal.pone.0055387 10.1002/pros.20616 10.1126/science.1108190 10.1155/2014/502093 10.1186/s12864-016-2748-5 10.1016/j.reprotox.2012.11.011 10.1093/nar/gku1010 10.1186/1471-2407-12-222 10.1093/nar/gkt1076 10.1093/bioinformatics/btu170 10.1186/s13072-018-0178-0 10.1210/en.2006-0640 10.1016/j.jsbmb.2011.07.005 10.1093/gerona/gly118 10.1002/(SICI)1097-4652(199907)180:1<53::AID-JCP6>3.0.CO;2-P 10.1530/REP-07-0542 10.1093/eep/dvz008 10.1093/nar/28.1.27 10.1016/j.reprotox.2007.09.001 10.1016/j.tem.2009.12.007 10.1016/j.mce.2014.07.019 |
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References | Miyake, Lawton, Goodison, Urquidi, Rosser (CR47) 2014; 210 Marker, Donjacour, Dahiya, Cunha (CR12) 2003; 253 Festuccia (CR45) 2007; 67 Manikkam, Haque, Guerrero-Bosagna, Nilsson, Skinner (CR38) 2014; 9 Manikkam, Guerrero-Bosagna, Tracey, Haque, Skinner (CR22) 2012; 7 Bolger, Lohse, Usadel (CR55) 2014; 30 Tracey, Manikkam, Guerrero-Bosagna, Skinner (CR37) 2013; 36 Anway, Skinner (CR7) 2008; 16 Manikkam, Tracey, Guerrero-Bosagna, Skinner (CR35) 2012; 7 CR32 CR31 Ben Maamar (CR39) 2018; 4 Nilsson (CR24) 2012; 7 Scarano (CR40) 2009; 262 Skinner, Manikkam, Haque, Zhang, Savenkova (CR43) 2012; 13 Cunha (CR9) 1987; 8 Manikkam, Tracey, Guerrero-Bosagna, Skinner (CR34) 2013; 8 Vuichoud, Loughlin (CR1) 2015; 22 Huang da, Sherman, Lempicki (CR65) 2009; 4 Dakhova, Rowley, Ittmann (CR44) 2014; 20 CR6 Robinson, McCarthy, Smyth (CR59) 2010; 26 CR5 Nilsson (CR54) 2018; 13 Skinner, Guerrero-Bosagna (CR33) 2014; 15 Wang (CR41) 2017; 69 Huang (CR46) 2015; 11 Skinner (CR27) 2018; 11 Lienhard, Grimm, Morkel, Herwig, Chavez (CR58) 2014; 30 Rechavi (CR28) 2014; 158 Manikkam, Tracey, Guerrero-Bosagna, Skinner (CR36) 2012; 34 CR42 Chen (CR29) 2016; 351 Haque, Nilsson, Holder, Skinner (CR60) 2016; 17 Yu, Hsieh, Chang (CR49) 2006; 52 Itoh, Patel, Skinner (CR21) 1998; 139 Anway, Cupp, Uzumcu, Skinner (CR23) 2005; 308 Cunningham (CR62) 2015; 43 Flickinger (CR8) 1972; 134 Yan (CR26) 2014; 398 Haynes, Frydenberg, Majewski (CR11) 2001; 13 Spade (CR14) 2014; 101 Sasaki, Franco, Hayward (CR19) 2017; 96 Lee (CR20) 2014; 2014 Heindel (CR13) 2006; 24 CR15 Mi, Muruganujan, Casagrande, Thomas (CR66) 2013; 8 CR52 CR51 CR50 Li (CR57) 2009; 25 Chen (CR3) 2012; 12 Benelli, Stigliani, Minghelli, Carlone, Ferrari (CR48) 2013; 73 Hayward, Rosen, Cunha (CR18) 1997; Suppl 2 Plata Bello, Concepcion Masip (CR2) 2014; 67 Lai (CR17) 2013; 27 Langmead, Salzberg (CR56) 2012; 9 Qi (CR4) 2015; 75 Anway, Skinner (CR16) 2008; 68 Guerrero-Bosagna, Savenkova, Haque, Nilsson, Skinner (CR25) 2013; 8 Nilsson (CR30) 2018; 13 Chaudhary, Schmidt, Sadler-Riggleman (CR53) 2005; 64 Peinetti (CR10) 2018; 159 CR63 Durinck, Spellman, Birney, Huber (CR61) 2009; 4 Kanehisa (CR64) 2014; 42 MM Haque (38741_CR60) 2016; 17 38741_CR63 A Plata Bello (38741_CR2) 2014; 67 C Chen (38741_CR3) 2012; 12 JJ Heindel (38741_CR13) 2006; 24 H Li (38741_CR57) 2009; 25 38741_CR15 PC Marker (38741_CR12) 2003; 253 C Vuichoud (38741_CR1) 2015; 22 WR Scarano (38741_CR40) 2009; 262 N Itoh (38741_CR21) 1998; 139 M Lienhard (38741_CR58) 2014; 30 38741_CR6 38741_CR5 C Festuccia (38741_CR45) 2007; 67 M Manikkam (38741_CR34) 2013; 8 DJ Spade (38741_CR14) 2014; 101 MD Anway (38741_CR16) 2008; 68 MD Anway (38741_CR23) 2005; 308 M Manikkam (38741_CR38) 2014; 9 38741_CR52 38741_CR50 38741_CR51 M Manikkam (38741_CR35) 2012; 7 AM Bolger (38741_CR55) 2014; 30 H Mi (38741_CR66) 2013; 8 M Manikkam (38741_CR36) 2012; 34 O Dakhova (38741_CR44) 2014; 20 E Nilsson (38741_CR24) 2012; 7 DS Yu (38741_CR49) 2006; 52 M Kanehisa (38741_CR64) 2014; 42 O Rechavi (38741_CR28) 2014; 158 F Cunningham (38741_CR62) 2015; 43 CJ Flickinger (38741_CR8) 1972; 134 38741_CR42 M Manikkam (38741_CR22) 2012; 7 J Chaudhary (38741_CR53) 2005; 64 C Lee (38741_CR20) 2014; 2014 B Langmead (38741_CR56) 2012; 9 MD Anway (38741_CR7) 2008; 16 D Qi (38741_CR4) 2015; 75 E Nilsson (38741_CR30) 2018; 13 M Miyake (38741_CR47) 2014; 210 Y Huang (38741_CR46) 2015; 11 MK Skinner (38741_CR27) 2018; 11 KP Lai (38741_CR17) 2013; 27 X Wang (38741_CR41) 2017; 69 MK Skinner (38741_CR33) 2014; 15 Q Chen (38741_CR29) 2016; 351 E Nilsson (38741_CR54) 2018; 13 N Peinetti (38741_CR10) 2018; 159 JM Haynes (38741_CR11) 2001; 13 R Tracey (38741_CR37) 2013; 36 S Durinck (38741_CR61) 2009; 4 38741_CR32 38741_CR31 MD Robinson (38741_CR59) 2010; 26 M Ben Maamar (38741_CR39) 2018; 4 C Guerrero-Bosagna (38741_CR25) 2013; 8 MK Skinner (38741_CR43) 2012; 13 T Sasaki (38741_CR19) 2017; 96 W Huang da (38741_CR65) 2009; 4 GR Cunha (38741_CR9) 1987; 8 W Yan (38741_CR26) 2014; 398 SW Hayward (38741_CR18) 1997; Suppl 2 R Benelli (38741_CR48) 2013; 73 |
References_xml | – volume: 30 start-page: 284 year: 2014 end-page: 286 ident: CR58 article-title: MEDIPS: genome-wide differential coverage analysis of sequencing data derived from DNA enrichment experiments publication-title: Bioinformatics doi: 10.1093/bioinformatics/btt650 contributor: fullname: Chavez – volume: 96 start-page: 40 year: 2017 end-page: 48 ident: CR19 article-title: Interaction of prostate carcinoma-associated fibroblasts with human epithelial cell lines publication-title: Differentiation doi: 10.1016/j.diff.2017.07.002 contributor: fullname: Hayward – volume: 64 start-page: 253 year: 2005 end-page: 264 ident: CR53 article-title: Negative acting HLH proteins Id 1, Id 2, Id 3, and Id 4 are expressed in prostate epithelial cells publication-title: Prostate doi: 10.1002/pros.20238 contributor: fullname: Sadler-Riggleman – ident: CR51 – volume: 24 start-page: 168 year: 2006 end-page: 177 ident: CR13 article-title: Role of exposure to environmental chemicals in the developmental basis of reproductive disease and dysfunction publication-title: Semin Reprod Med doi: 10.1055/s-2006-944423 contributor: fullname: Heindel – volume: 27 start-page: 1617 year: 2013 end-page: 1631 ident: CR17 article-title: Targeting stromal androgen receptor suppresses prolactin-driven benign prostatic hyperplasia (BPH) publication-title: Mol Endocrinol doi: 10.1210/me.2013-1207 contributor: fullname: Lai – volume: 4 start-page: dvy010 issue: 1–19 year: 2018 ident: CR39 article-title: Alterations in sperm DNA methylation, non-coding RNA expression, and histone retention mediate vinclozolin-induced epigenetic transgenerational inheritance of disease. Environmental publication-title: Epigenetics doi: 10.1093/eepdvy010 contributor: fullname: Ben Maamar – volume: 9 start-page: 357 year: 2012 end-page: 359 ident: CR56 article-title: Fast gapped-read alignment with Bowtie 2 publication-title: Nature methods doi: 10.1038/nmeth.1923 contributor: fullname: Salzberg – volume: 13 year: 2012 ident: CR43 article-title: Epigenetic Transgenerational Inheritance of Somatic Transcriptomes and Epigenetic Control Regions publication-title: Genome biology doi: 10.1186/gb-2012-13-10-r91 contributor: fullname: Savenkova – volume: 52 start-page: 275 year: 2006 end-page: 281 ident: CR49 article-title: Increasing expression of GST-pi MIF, and ID1 genes in chemoresistant prostate cancer cells publication-title: Arch Androl doi: 10.1080/01485010600630124 contributor: fullname: Chang – ident: CR42 – volume: 13 start-page: 703 year: 2001 end-page: 709 ident: CR11 article-title: Testosterone- and phorbol ester-stimulated proliferation in human cultured prostatic stromal cells publication-title: Cell Signal doi: 10.1016/S0898-6568(01)00205-4 contributor: fullname: Majewski – volume: 68 start-page: 517 year: 2008 end-page: 529 ident: CR16 article-title: Transgenerational effects of the endocrine disruptor vinclozolin on the prostate transcriptome and adult onset disease publication-title: Prostate doi: 10.1002/pros.20724 contributor: fullname: Skinner – volume: 139 start-page: 1369 year: 1998 end-page: 1377 ident: CR21 article-title: Developmental and hormonal regulation of transforming growth factor-alpha and epidermal growth factor receptor gene expression in isolated prostatic epithelial and stromal cells publication-title: Endocrinology doi: 10.1210/endo.139.3.5821 contributor: fullname: Skinner – volume: 210 start-page: 74 year: 2014 end-page: 78 ident: CR47 article-title: Chemokine (C-X-C motif) ligand 1 (CXCL1) protein expression is increased in high-grade prostate cancer publication-title: Pathol Res Pract doi: 10.1016/j.prp.2013.08.013 contributor: fullname: Rosser – volume: 8 start-page: 1551 year: 2013 end-page: 1566 ident: CR66 article-title: Large-scale gene function analysis with the PANTHER classification system publication-title: Nature protocols doi: 10.1038/nprot.2013.092 contributor: fullname: Thomas – volume: 4 start-page: 1184 year: 2009 end-page: 1191 ident: CR61 article-title: Mapping identifiers for the integration of genomic datasets with the R/Bioconductor package biomaRt publication-title: Nature protocols doi: 10.1038/nprot.2009.97 contributor: fullname: Huber – volume: 351 start-page: 397 year: 2016 end-page: 400 ident: CR29 article-title: Sperm tsRNAs contribute to intergenerational inheritance of an acquired metabolic disorder publication-title: Science doi: 10.1126/science.aad7977 contributor: fullname: Chen – ident: CR15 – ident: CR50 – volume: 7 start-page: e31901 issue: 1-12 year: 2012 ident: CR22 article-title: Transgenerational actions of environmental compounds on reproductive disease and identification of epigenetic biomarkers of ancestral exposures publication-title: PloS one doi: 10.1371/journal.pone.0031901 contributor: fullname: Skinner – volume: 73 start-page: 941 year: 2013 end-page: 951 ident: CR48 article-title: Impact of CXCL1 overexpression on growth and invasion of prostate cancer cell publication-title: Prostate doi: 10.1002/pros.22640 contributor: fullname: Ferrari – volume: 75 start-page: 1662 year: 2015 end-page: 1668 ident: CR4 article-title: Trends of prostate cancer incidence and mortality in Shanghai, China from 1973 to 2009 publication-title: Prostate doi: 10.1002/pros.23046 contributor: fullname: Qi – volume: 8 start-page: e59922 issue: 1–12 year: 2013 ident: CR25 article-title: Environmentally Induced Epigenetic Transgenerational Inheritance of Altered Sertoli Cell Transcriptome and Epigenome: Molecular Etiology of Male Infertility publication-title: PloS one doi: 10.1371/journal.pone.0059922 contributor: fullname: Skinner – ident: CR32 – volume: 262 start-page: 215 year: 2009 end-page: 223 ident: CR40 article-title: Long-term effects of developmental exposure to di-n-butyl-phthalate (DBP) on rat prostate: proliferative and inflammatory disorders and a possible role of androgens publication-title: Toxicology doi: 10.1016/j.tox.2009.06.011 contributor: fullname: Scarano – ident: CR5 – volume: 25 start-page: 2078 year: 2009 end-page: 2079 ident: CR57 article-title: The Sequence Alignment/Map format and SAMtools publication-title: Bioinformatics doi: 10.1093/bioinformatics/btp352 contributor: fullname: Li – volume: 253 start-page: 165 year: 2003 end-page: 174 ident: CR12 article-title: Hormonal, cellular, and molecular control of prostatic development publication-title: Developmental biology doi: 10.1016/S0012-1606(02)00031-3 contributor: fullname: Cunha – volume: 398 start-page: 24 year: 2014 end-page: 30 ident: CR26 article-title: Potential roles of noncoding RNAs in environmental epigenetic transgenerational inheritance publication-title: Molecular and cellular endocrinology doi: 10.1016/j.mce.2014.09.008 contributor: fullname: Yan – volume: 9 start-page: e102091 issue: 1–19 year: 2014 ident: CR38 article-title: Pesticide methoxychlor promotes the epigenetic transgenerational inheritance of adult onset disease through the female germline publication-title: PloS one doi: 10.1371/journal.pone.0102091 contributor: fullname: Skinner – volume: 101 start-page: 410 year: 2014 end-page: 422 ident: CR14 article-title: Xenotransplantation models to study the effects of toxicants on human fetal tissues publication-title: Birth Defects Res B Dev Reprod Toxicol doi: 10.1002/bdrb.21131 contributor: fullname: Spade – volume: 15 year: 2014 ident: CR33 article-title: Role of CpG Deserts in the Epigenetic Transgenerational Inheritance of Differential DNA Methylation Regions publication-title: BMC Genomics doi: 10.1186/1471-2164-15-692 contributor: fullname: Guerrero-Bosagna – volume: Suppl 2 start-page: 18 year: 1997 end-page: 26 ident: CR18 article-title: Stromal-epithelial interactions in the normal and neoplastic prostate publication-title: Br J Urol 79 doi: 10.1111/j.1464-410X.1997.tb16917.x contributor: fullname: Cunha – volume: 4 start-page: 44 year: 2009 end-page: 57 ident: CR65 article-title: Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources publication-title: Nature protocols doi: 10.1038/nprot.2008.211 contributor: fullname: Lempicki – volume: 16 start-page: 23 year: 2008 end-page: 25 ident: CR7 article-title: Epigenetic programming of the germ line: effects of endocrine disruptors on the development of transgenerational disease publication-title: Reprod Biomed Online doi: 10.1016/S1472-6483(10)60553-6 contributor: fullname: Skinner – volume: 69 start-page: 60 year: 2017 end-page: 67 ident: CR41 article-title: In utero and lactational exposure to di(2-ethylhexyl) phthalate increased the susceptibility of prostate carcinogenesis in male offspring publication-title: Reproductive toxicology doi: 10.1016/j.reprotox.2017.01.008 contributor: fullname: Wang – volume: 159 start-page: 945 year: 2018 end-page: 956 ident: CR10 article-title: The Response of Prostate Smooth Muscle Cells to Testosterone Is Determined by the Subcellular Distribution of the Androgen Receptor publication-title: Endocrinology doi: 10.1210/en.2017-00718 contributor: fullname: Peinetti – volume: 26 start-page: 139 year: 2010 end-page: 140 ident: CR59 article-title: K. edgeR: a Bioconductor package for differential expression analysis of digital gene expression data publication-title: Bioinformatics doi: 10.1093/bioinformatics/btp616 contributor: fullname: Smyth – ident: CR6 – volume: 7 start-page: e36129 issue: 1–18 year: 2012 ident: CR24 article-title: Environmentally Induced Epigenetic Transgenerational Inheritance of Ovarian Disease publication-title: PloS one doi: 10.1371/journal.pone.0036129 contributor: fullname: Nilsson – ident: CR63 – volume: 13 start-page: e0202662 issue: 1–29 year: 2018 ident: CR30 article-title: Vinclozolin induced epigenetic transgenerational inheritance of pathologies and sperm epimutation biomarkers for specific diseases publication-title: PloS one doi: 10.1371/journal.pone.0202662 contributor: fullname: Nilsson – volume: 7 start-page: e46249 issue: 1–15 year: 2012 ident: CR35 article-title: Dioxin (TCDD) induces epigenetic transgenerational inheritance of adult onset disease and sperm epimutations publication-title: PloS one doi: 10.1371/journal.pone.0046249 contributor: fullname: Skinner – volume: 8 start-page: 338 year: 1987 end-page: 362 ident: CR9 article-title: The endocrinology and developmental biology of the prostate publication-title: Endocr Rev doi: 10.1210/edrv-8-3-338 contributor: fullname: Cunha – volume: 20 start-page: 100 year: 2014 end-page: 109 ident: CR44 article-title: Genes upregulated in prostate cancer reactive stroma promote prostate cancer progression publication-title: Clin Cancer Res doi: 10.1158/1078-0432.CCR-13-1184 contributor: fullname: Ittmann – volume: 13 start-page: 875 year: 2018 end-page: 895 ident: CR54 article-title: Environmental toxicant induced epigenetic transgenerational inheritance of ovarian pathology and granulosa cell epigenome and transcriptome alterations: ancestral origins of polycystic ovarian syndrome and primary ovarian insufiency. Epigenetics: official journal of the DNA Methylation publication-title: Society doi: 10.1080/15592294.2018.1521223 contributor: fullname: Nilsson – volume: 134 start-page: 107 year: 1972 end-page: 125 ident: CR8 article-title: The fine structure of the interstitial tissue of the rat prostate publication-title: Am J Anat doi: 10.1002/aja.1001340109 contributor: fullname: Flickinger – volume: 158 start-page: 277 year: 2014 end-page: 287 ident: CR28 article-title: Starvation-induced transgenerational inheritance of small RNAs in C. elegans publication-title: Cell doi: 10.1016/j.cell.2014.06.020 contributor: fullname: Rechavi – volume: 11 start-page: 948 year: 2015 end-page: 960 ident: CR46 article-title: Overexpression of FGF9 in prostate epithelial cells augments reactive stroma formation and promotes prostate cancer progression publication-title: Int J Biol Sci doi: 10.7150/ijbs.12468 contributor: fullname: Huang – ident: CR52 – ident: CR31 – volume: 34 start-page: 708 year: 2012 end-page: 719 ident: CR36 article-title: Pesticide and Insect Repellent Mixture (Permethrin and DEET) Induces Epigenetic Transgenerational Inheritance of Disease and Sperm Epimutations publication-title: Reproductive toxicology doi: 10.1016/j.reprotox.2012.08.010 contributor: fullname: Skinner – volume: 8 start-page: e55387 issue: 1–18 year: 2013 ident: CR34 article-title: Plastics Derived Endocrine Disruptors (BPA, DEHP and DBP) Induce Epigenetic Transgenerational Inheritance of Obesity, Reproductive Disease and Sperm Epimutations publication-title: PloS one doi: 10.1371/journal.pone.0055387 contributor: fullname: Skinner – volume: 67 start-page: 1255 year: 2007 end-page: 1264 ident: CR45 article-title: and effects of bicalutamide on the expression of TrkA and P75 neurotrophin receptors in prostate carcinoma publication-title: Prostate doi: 10.1002/pros.20616 contributor: fullname: Festuccia – volume: 308 start-page: 1466 year: 2005 end-page: 1469 ident: CR23 article-title: Epigenetic transgenerational actions of endocrine disruptors and male fertility publication-title: Science doi: 10.1126/science.1108190 contributor: fullname: Skinner – volume: 2014 start-page: 502093 year: 2014 ident: CR20 article-title: Role of the adjacent stroma cells in prostate cancer development and progression: synergy between TGF-beta and IGF signaling publication-title: Biomed Res Int doi: 10.1155/2014/502093 contributor: fullname: Lee – volume: 17 start-page: 411 issue: 418 year: 2016 end-page: 413 ident: CR60 article-title: Genomic Clustering of differential DNA methylated regions (epimutations) associated with the epigenetic transgenerational inheritance of disease and phenotypic variation publication-title: BMC Genomics doi: 10.1186/s12864-016-2748-5 contributor: fullname: Skinner – volume: 36 start-page: 104 year: 2013 end-page: 116 ident: CR37 article-title: Hydrocarbons (jet fuel JP-8) induce epigenetic transgenerational inheritance of obesity, reproductive disease and sperm epimutations publication-title: Reproductive toxicology doi: 10.1016/j.reprotox.2012.11.011 contributor: fullname: Skinner – volume: 43 start-page: D662 year: 2015 end-page: 669 ident: CR62 article-title: Ensembl 2015 publication-title: Nucleic acids research doi: 10.1093/nar/gku1010 contributor: fullname: Cunningham – volume: 12 year: 2012 ident: CR3 article-title: A comparative population-based study of prostate cancer incidence and mortality rates in Singapore, Sweden and Geneva, Switzerland from 1973 to 2006 publication-title: BMC Cancer doi: 10.1186/1471-2407-12-222 contributor: fullname: Chen – volume: 42 start-page: D199 year: 2014 end-page: 205 ident: CR64 article-title: Data, information, knowledge and principle: back to metabolism in KEGG publication-title: Nucleic acids research doi: 10.1093/nar/gkt1076 contributor: fullname: Kanehisa – volume: 30 start-page: 2114 year: 2014 end-page: 2120 ident: CR55 article-title: Trimmomatic: a flexible trimmer for Illumina sequence data publication-title: Bioinformatics doi: 10.1093/bioinformatics/btu170 contributor: fullname: Usadel – volume: 11 start-page: 1 issue: 8 year: 2018 end-page: 24 ident: CR27 article-title: Alterations in sperm DNA methylation, non-coding RNA and histone retention associate with DDT-induced epigenetic transgenerational inheritance of disease publication-title: Epigenetics & Chromatin doi: 10.1186/s13072-018-0178-0 contributor: fullname: Skinner – volume: 22 start-page: 1 issue: Suppl 1 year: 2015 end-page: 6 ident: CR1 article-title: Benign prostatic hyperplasia: epidemiology, economics and evaluation publication-title: Can J Urol contributor: fullname: Loughlin – volume: 67 start-page: 373 year: 2014 end-page: 382 ident: CR2 article-title: Prostate cancer epidemiology publication-title: Arch Esp Urol contributor: fullname: Concepcion Masip – ident: 38741_CR15 doi: 10.1210/en.2006-0640 – ident: 38741_CR52 doi: 10.1016/j.jsbmb.2011.07.005 – volume: 64 start-page: 253 year: 2005 ident: 38741_CR53 publication-title: Prostate doi: 10.1002/pros.20238 contributor: fullname: J Chaudhary – volume: 8 start-page: 1551 year: 2013 ident: 38741_CR66 publication-title: Nature protocols doi: 10.1038/nprot.2013.092 contributor: fullname: H Mi – volume: 398 start-page: 24 year: 2014 ident: 38741_CR26 publication-title: Molecular and cellular endocrinology doi: 10.1016/j.mce.2014.09.008 contributor: fullname: W Yan – ident: 38741_CR31 doi: 10.1093/gerona/gly118 – volume: 15 year: 2014 ident: 38741_CR33 publication-title: BMC Genomics doi: 10.1186/1471-2164-15-692 contributor: fullname: MK Skinner – volume: 73 start-page: 941 year: 2013 ident: 38741_CR48 publication-title: Prostate doi: 10.1002/pros.22640 contributor: fullname: R Benelli – ident: 38741_CR50 doi: 10.1002/(SICI)1097-4652(199907)180:1<53::AID-JCP6>3.0.CO;2-P – volume: 16 start-page: 23 year: 2008 ident: 38741_CR7 publication-title: Reprod Biomed Online doi: 10.1016/S1472-6483(10)60553-6 contributor: fullname: MD Anway – volume: 262 start-page: 215 year: 2009 ident: 38741_CR40 publication-title: Toxicology doi: 10.1016/j.tox.2009.06.011 contributor: fullname: WR Scarano – volume: 13 start-page: e0202662 issue: 1–29 year: 2018 ident: 38741_CR30 publication-title: PloS one doi: 10.1371/journal.pone.0202662 contributor: fullname: E Nilsson – volume: 36 start-page: 104 year: 2013 ident: 38741_CR37 publication-title: Reproductive toxicology doi: 10.1016/j.reprotox.2012.11.011 contributor: fullname: R Tracey – volume: 7 start-page: e46249 issue: 1–15 year: 2012 ident: 38741_CR35 publication-title: PloS one doi: 10.1371/journal.pone.0046249 contributor: fullname: M Manikkam – volume: 7 start-page: e36129 issue: 1–18 year: 2012 ident: 38741_CR24 publication-title: PloS one doi: 10.1371/journal.pone.0036129 contributor: fullname: E Nilsson – volume: 13 start-page: 875 year: 2018 ident: 38741_CR54 publication-title: Society doi: 10.1080/15592294.2018.1521223 contributor: fullname: E Nilsson – volume: 17 start-page: 411 issue: 418 year: 2016 ident: 38741_CR60 publication-title: BMC Genomics doi: 10.1186/s12864-016-2748-5 contributor: fullname: MM Haque – volume: 96 start-page: 40 year: 2017 ident: 38741_CR19 publication-title: Differentiation doi: 10.1016/j.diff.2017.07.002 contributor: fullname: T Sasaki – volume: 9 start-page: e102091 issue: 1–19 year: 2014 ident: 38741_CR38 publication-title: PloS one doi: 10.1371/journal.pone.0102091 contributor: fullname: M Manikkam – volume: 75 start-page: 1662 year: 2015 ident: 38741_CR4 publication-title: Prostate doi: 10.1002/pros.23046 contributor: fullname: D Qi – volume: 25 start-page: 2078 year: 2009 ident: 38741_CR57 publication-title: Bioinformatics doi: 10.1093/bioinformatics/btp352 contributor: fullname: H Li – ident: 38741_CR51 doi: 10.1530/REP-07-0542 – ident: 38741_CR32 doi: 10.1093/eep/dvz008 – volume: 4 start-page: 44 year: 2009 ident: 38741_CR65 publication-title: Nature protocols doi: 10.1038/nprot.2008.211 contributor: fullname: W Huang da – volume: 159 start-page: 945 year: 2018 ident: 38741_CR10 publication-title: Endocrinology doi: 10.1210/en.2017-00718 contributor: fullname: N Peinetti – volume: 43 start-page: D662 year: 2015 ident: 38741_CR62 publication-title: Nucleic acids research doi: 10.1093/nar/gku1010 contributor: fullname: F Cunningham – volume: 12 year: 2012 ident: 38741_CR3 publication-title: BMC Cancer doi: 10.1186/1471-2407-12-222 contributor: fullname: C Chen – volume: 8 start-page: e59922 issue: 1–12 year: 2013 ident: 38741_CR25 publication-title: PloS one doi: 10.1371/journal.pone.0059922 contributor: fullname: C Guerrero-Bosagna – volume: 9 start-page: 357 year: 2012 ident: 38741_CR56 publication-title: Nature methods doi: 10.1038/nmeth.1923 contributor: fullname: B Langmead – volume: 24 start-page: 168 year: 2006 ident: 38741_CR13 publication-title: Semin Reprod Med doi: 10.1055/s-2006-944423 contributor: fullname: JJ Heindel – volume: 42 start-page: D199 year: 2014 ident: 38741_CR64 publication-title: Nucleic acids research doi: 10.1093/nar/gkt1076 contributor: fullname: M Kanehisa – volume: 158 start-page: 277 year: 2014 ident: 38741_CR28 publication-title: Cell doi: 10.1016/j.cell.2014.06.020 contributor: fullname: O Rechavi – volume: 13 year: 2012 ident: 38741_CR43 publication-title: Genome biology doi: 10.1186/gb-2012-13-10-r91 contributor: fullname: MK Skinner – volume: 7 start-page: e31901 issue: 1-12 year: 2012 ident: 38741_CR22 publication-title: PloS one doi: 10.1371/journal.pone.0031901 contributor: fullname: M Manikkam – volume: 253 start-page: 165 year: 2003 ident: 38741_CR12 publication-title: Developmental biology doi: 10.1016/S0012-1606(02)00031-3 contributor: fullname: PC Marker – volume: 26 start-page: 139 year: 2010 ident: 38741_CR59 publication-title: Bioinformatics doi: 10.1093/bioinformatics/btp616 contributor: fullname: MD Robinson – volume: 308 start-page: 1466 year: 2005 ident: 38741_CR23 publication-title: Science doi: 10.1126/science.1108190 contributor: fullname: MD Anway – volume: 11 start-page: 1 issue: 8 year: 2018 ident: 38741_CR27 publication-title: Epigenetics & Chromatin doi: 10.1186/s13072-018-0178-0 contributor: fullname: MK Skinner – volume: 13 start-page: 703 year: 2001 ident: 38741_CR11 publication-title: Cell Signal doi: 10.1016/S0898-6568(01)00205-4 contributor: fullname: JM Haynes – volume: 4 start-page: dvy010 issue: 1–19 year: 2018 ident: 38741_CR39 publication-title: Epigenetics doi: 10.1093/eepdvy010 contributor: fullname: M Ben Maamar – ident: 38741_CR63 doi: 10.1093/nar/28.1.27 – volume: 4 start-page: 1184 year: 2009 ident: 38741_CR61 publication-title: Nature protocols doi: 10.1038/nprot.2009.97 contributor: fullname: S Durinck – ident: 38741_CR42 doi: 10.1016/j.reprotox.2007.09.001 – ident: 38741_CR5 doi: 10.1016/j.tem.2009.12.007 – volume: 8 start-page: e55387 issue: 1–18 year: 2013 ident: 38741_CR34 publication-title: PloS one doi: 10.1371/journal.pone.0055387 contributor: fullname: M Manikkam – ident: 38741_CR6 doi: 10.1016/j.mce.2014.07.019 – volume: 69 start-page: 60 year: 2017 ident: 38741_CR41 publication-title: Reproductive toxicology doi: 10.1016/j.reprotox.2017.01.008 contributor: fullname: X Wang – volume: Suppl 2 start-page: 18 year: 1997 ident: 38741_CR18 publication-title: Br J Urol 79 doi: 10.1111/j.1464-410X.1997.tb16917.x contributor: fullname: SW Hayward – volume: 20 start-page: 100 year: 2014 ident: 38741_CR44 publication-title: Clin Cancer Res doi: 10.1158/1078-0432.CCR-13-1184 contributor: fullname: O Dakhova – volume: 30 start-page: 2114 year: 2014 ident: 38741_CR55 publication-title: Bioinformatics doi: 10.1093/bioinformatics/btu170 contributor: fullname: AM Bolger – volume: 34 start-page: 708 year: 2012 ident: 38741_CR36 publication-title: Reproductive toxicology doi: 10.1016/j.reprotox.2012.08.010 contributor: fullname: M Manikkam – volume: 22 start-page: 1 issue: Suppl 1 year: 2015 ident: 38741_CR1 publication-title: Can J Urol contributor: fullname: C Vuichoud – volume: 101 start-page: 410 year: 2014 ident: 38741_CR14 publication-title: Birth Defects Res B Dev Reprod Toxicol doi: 10.1002/bdrb.21131 contributor: fullname: DJ Spade – volume: 30 start-page: 284 year: 2014 ident: 38741_CR58 publication-title: Bioinformatics doi: 10.1093/bioinformatics/btt650 contributor: fullname: M Lienhard – volume: 67 start-page: 373 year: 2014 ident: 38741_CR2 publication-title: Arch Esp Urol contributor: fullname: A Plata Bello – volume: 68 start-page: 517 year: 2008 ident: 38741_CR16 publication-title: Prostate doi: 10.1002/pros.20724 contributor: fullname: MD Anway – volume: 351 start-page: 397 year: 2016 ident: 38741_CR29 publication-title: Science doi: 10.1126/science.aad7977 contributor: fullname: Q Chen – volume: 134 start-page: 107 year: 1972 ident: 38741_CR8 publication-title: Am J Anat doi: 10.1002/aja.1001340109 contributor: fullname: CJ Flickinger – volume: 27 start-page: 1617 year: 2013 ident: 38741_CR17 publication-title: Mol Endocrinol doi: 10.1210/me.2013-1207 contributor: fullname: KP Lai – volume: 11 start-page: 948 year: 2015 ident: 38741_CR46 publication-title: Int J Biol Sci doi: 10.7150/ijbs.12468 contributor: fullname: Y Huang – volume: 210 start-page: 74 year: 2014 ident: 38741_CR47 publication-title: Pathol Res Pract doi: 10.1016/j.prp.2013.08.013 contributor: fullname: M Miyake – volume: 2014 start-page: 502093 year: 2014 ident: 38741_CR20 publication-title: Biomed Res Int doi: 10.1155/2014/502093 contributor: fullname: C Lee – volume: 67 start-page: 1255 year: 2007 ident: 38741_CR45 publication-title: Prostate doi: 10.1002/pros.20616 contributor: fullname: C Festuccia – volume: 52 start-page: 275 year: 2006 ident: 38741_CR49 publication-title: Arch Androl doi: 10.1080/01485010600630124 contributor: fullname: DS Yu – volume: 8 start-page: 338 year: 1987 ident: 38741_CR9 publication-title: Endocr Rev doi: 10.1210/edrv-8-3-338 contributor: fullname: GR Cunha – volume: 139 start-page: 1369 year: 1998 ident: 38741_CR21 publication-title: Endocrinology doi: 10.1210/endo.139.3.5821 contributor: fullname: N Itoh |
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Snippet | Prostate diseases include prostate cancer, which is the second most common male neoplasia, and benign prostatic hyperplasia (BPH), which affects approximately... Abstract Prostate diseases include prostate cancer, which is the second most common male neoplasia, and benign prostatic hyperplasia (BPH), which affects... |
SourceID | pubmedcentral proquest crossref pubmed springer |
SourceType | Open Access Repository Aggregation Database Index Database Publisher |
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SubjectTerms | 45 45/23 45/91 631/136/2442 692/4025/1752 Critical period Disease DNA methylation Epigenetics Epithelial cells Gene expression Gestation Heredity Humanities and Social Sciences Hyperplasia multidisciplinary Pathology Prostate Prostate cancer Ribonucleic acid RNA Science Science (multidisciplinary) Stromal cells Toxicants Vinclozolin |
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Title | Environmental Toxicant Induced Epigenetic Transgenerational Inheritance of Prostate Pathology and Stromal-Epithelial Cell Epigenome and Transcriptome Alterations: Ancestral Origins of Prostate Disease |
URI | https://link.springer.com/article/10.1038/s41598-019-38741-1 https://www.ncbi.nlm.nih.gov/pubmed/30778168 https://www.proquest.com/docview/2183176311 https://pubmed.ncbi.nlm.nih.gov/PMC6379561 |
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