Connexin43 carboxyl-terminal peptides reduce scar progenitor and promote regenerative healing following skin wounding

Gap-junctional connexin43 (Cx43) has roles in multiple aspects of skin wound healing -– including scarring. The aim here was to study the effects of a cell-permeant peptide from the Cx43 carboxyl-terminus (CT) on scarring and regeneration following cutaneous injury. The effects of Cx43 CT peptide we...

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Published inRegenerative medicine Vol. 4; no. 2; pp. 205 - 223
Main Authors Ghatnekar, Gautam S, O ’Quinn, Michael P, Jourdan, L Jane, Gurjarpadhye, Abhijit A, Draughn, Robert L, Gourdie, Robert G
Format Journal Article
LanguageEnglish
Published England Future Medicine Ltd 01.03.2009
Subjects
Animals
Cicatrix - pathology
Cicatrix - prevention & control
Connexin 43 - therapeutic use
Cx43
gap junctions
Mice
Peptide Fragments - therapeutic use
Regeneration
regenerative medicine
scar prevention
Skin - injuries
Swine
wound healing
Wound Healing - drug effects
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Abstract Gap-junctional connexin43 (Cx43) has roles in multiple aspects of skin wound healing -– including scarring. The aim here was to study the effects of a cell-permeant peptide from the Cx43 carboxyl-terminus (CT) on scarring and regeneration following cutaneous injury. The effects of Cx43 CT peptide were studied in mouse and pig models of cutaneous injury. The parameters assessed included neutrophil density, wound closure, granulation, regeneration and skin tensile properties. Cx43 CT-peptide prompted decreases in area of scar progenitor tissue and promoted restoration of dermal histoarchitecture and mechanical strength following wounding of skin. These changes in healing were preceded by peptide-induced reduction in inflammatory neutrophil infiltration and alterations in the organization of epidermal Cx43, including increased connexon aggregation. Cx43 CT peptide promotes regenerative healing of cutaneous wounds and may have applications in tissues other than skin, including heart, cornea and spinal cord.
AbstractList AIMGap-junctional connexin43 (Cx43) has roles in multiple aspects of skin wound healing - including scarring. The aim here was to study the effects of a cell-permeant peptide from the Cx43 carboxyl-terminus (CT) on scarring and regeneration following cutaneous injury. MATERIALS & METHODSThe effects of Cx43 CT peptide were studied in mouse and pig models of cutaneous injury. The parameters assessed included neutrophil density, wound closure, granulation, regeneration and skin tensile properties. RESULTSCx43 CT-peptide prompted decreases in area of scar progenitor tissue and promoted restoration of dermal histoarchitecture and mechanical strength following wounding of skin. These changes in healing were preceded by peptide-induced reduction in inflammatory neutrophil infiltration and alterations in the organization of epidermal Cx43, including increased connexon aggregation. CONCLUSIONCx43 CT peptide promotes regenerative healing of cutaneous wounds and may have applications in tissues other than skin, including heart, cornea and spinal cord.
Gap-junctional connexin43 (Cx43) has roles in multiple aspects of skin wound healing -– including scarring. The aim here was to study the effects of a cell-permeant peptide from the Cx43 carboxyl-terminus (CT) on scarring and regeneration following cutaneous injury. The effects of Cx43 CT peptide were studied in mouse and pig models of cutaneous injury. The parameters assessed included neutrophil density, wound closure, granulation, regeneration and skin tensile properties. Cx43 CT-peptide prompted decreases in area of scar progenitor tissue and promoted restoration of dermal histoarchitecture and mechanical strength following wounding of skin. These changes in healing were preceded by peptide-induced reduction in inflammatory neutrophil infiltration and alterations in the organization of epidermal Cx43, including increased connexon aggregation. Cx43 CT peptide promotes regenerative healing of cutaneous wounds and may have applications in tissues other than skin, including heart, cornea and spinal cord.
Aim: Gap-junctional connexin43 (Cx43) has roles in multiple aspects of skin wound healing -- including scarring. The aim here was to study the effects of a cell-permeant peptide from the Cx43 carboxyl-terminus (CT) on scarring and regeneration following cutaneous injury. Materials & methods: The effects of Cx43 CT peptide were studied in mouse and pig models of cutaneous injury. The parameters assessed included neutrophil density, wound closure, granulation, regeneration and skin tensile properties. Results: Cx43 CT-peptide prompted decreases in area of scar progenitor tissue and promoted restoration of dermal histoarchitecture and mechanical strength following wounding of skin. These changes in healing were preceded by peptide-induced reduction in inflammatory neutrophil infiltration and alterations in the organization of epidermal Cx43, including increased connexon aggregation. Conclusion: Cx43 CT peptide promotes regenerative healing of cutaneous wounds and may have applications in tissues other than skin, including heart, cornea and spinal cord.
Author Draughn, Robert L
O ’Quinn, Michael P
Jourdan, L Jane
Gurjarpadhye, Abhijit A
Gourdie, Robert G
Ghatnekar, Gautam S
AuthorAffiliation 3Departments of Cell Biology & Anatomy, Medical University of South Carolina, 171 Ashley Avenue, Charleston, SC 29425-22204, USA. gourdier@musc.edu
5Pediatric Cardiology, Medical University of South Carolina, Charleston, SC, USA
2FirstString Research Inc., North Charleston, SC, USA
6Clemson-Medical University of South Carolina Joint Bioengineering Program, Medical University of South Carolina, Charleston, SC, USA
1Comparative Medicine, Medical University of South Carolina, Charleston, SC, USA
4Materials Science, Medical University of South Carolina, Charleston, SC, USA
AuthorAffiliation_xml – name: 3Departments of Cell Biology & Anatomy, Medical University of South Carolina, 171 Ashley Avenue, Charleston, SC 29425-22204, USA. gourdier@musc.edu
– name: 6Clemson-Medical University of South Carolina Joint Bioengineering Program, Medical University of South Carolina, Charleston, SC, USA
– name: 1Comparative Medicine, Medical University of South Carolina, Charleston, SC, USA
– name: 4Materials Science, Medical University of South Carolina, Charleston, SC, USA
– name: 5Pediatric Cardiology, Medical University of South Carolina, Charleston, SC, USA
– name: 2FirstString Research Inc., North Charleston, SC, USA
– name: 5 Pediatric Cardiology, Medical, University of South Carolina, Charleston, SC, USA
– name: 3 Departments of Cell Biology, & Anatomy, Medical University, of South Carolina, 171 Ashley, Avenue, Charleston, SC 29425-22204, USA, Tel.: +1 843 792 8181; Fax: +1 843 792 0664; E-mail: gourdier@musc.edu
– name: 6 Clemson-Medical University, of South Carolina Joint, Bioengineering Program, Medical University of South, Carolina, Charleston, SC, USA
– name: 4 Materials Science, Medical, University of South Carolina, Charleston, SC, USA
– name: 1 Comparative Medicine, Medical University of South, Carolina, Charleston, SC, USA
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Author_xml – sequence: 1
  givenname: Gautam S
  surname: Ghatnekar
  fullname: Ghatnekar, Gautam S
– sequence: 2
  givenname: Michael P
  surname: O ’Quinn
  fullname: O ’Quinn, Michael P
– sequence: 3
  givenname: L Jane
  surname: Jourdan
  fullname: Jourdan, L Jane
– sequence: 4
  givenname: Abhijit A
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  surname: Draughn
  fullname: Draughn, Robert L
– sequence: 6
  givenname: Robert G
  surname: Gourdie
  fullname: Gourdie, Robert G
BackLink https://www.ncbi.nlm.nih.gov/pubmed/19317641$$D View this record in MEDLINE/PubMed
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Snippet Gap-junctional connexin43 (Cx43) has roles in multiple aspects of skin wound healing -– including scarring. The aim here was to study the effects of a...
Gap-junctional connexin43 (Cx43) has roles in multiple aspects of skin wound healing - including scarring. The aim here was to study the effects of a...
Aim: Gap-junctional connexin43 (Cx43) has roles in multiple aspects of skin wound healing -- including scarring. The aim here was to study the effects of a...
AIMGap-junctional connexin43 (Cx43) has roles in multiple aspects of skin wound healing - including scarring. The aim here was to study the effects of a...
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StartPage 205
SubjectTerms Animals
Cicatrix - pathology
Cicatrix - prevention & control
Connexin 43 - therapeutic use
Cx43
gap junctions
Mice
Peptide Fragments - therapeutic use
Regeneration
regenerative medicine
scar prevention
Skin - injuries
Swine
wound healing
Wound Healing - drug effects
Title Connexin43 carboxyl-terminal peptides reduce scar progenitor and promote regenerative healing following skin wounding
URI http://dx.doi.org/10.2217/17460751.4.2.205
https://www.ncbi.nlm.nih.gov/pubmed/19317641
https://www.proquest.com/docview/751996947
https://search.proquest.com/docview/67070002
https://pubmed.ncbi.nlm.nih.gov/PMC2720252
Volume 4
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