Human cis-acting elements regulating escape from X-chromosome inactivation function in mouse

• Published in: Human molecular genetics Vol. 27; no. 7; pp. 1252 - 1262
• Main Authors: Peeters, Samantha B, Korecki, Andrea J, Simpson, Elizabeth M, Brown, Carolyn J
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.04.2018
• Subjects: Animals; Female; Humans; Male; Mice; Mice, Transgenic; Nuclear Proteins - genetics; Nuclear Proteins - metabolism; Sex Characteristics; Transcription Factors - genetics; Transcription Factors - metabolism; X Chromosome - genetics; X Chromosome - metabolism; X Chromosome Inactivation

Abstract A long-standing question concerning X-chromosome inactivation (XCI) has been how some genes avoid the otherwise stable chromosome-wide heterochromatinization of the inactive X chromosome. As 20% or more of human X-linked genes escape from inactivation, such genes are an important contributo...