Effects of Hepatic Impairment on the Pharmacokinetics of the Dual GIP and GLP-1 Receptor Agonist Tirzepatide - Urva, Shweta; Quinlan, Tonya; Landry, John; Ma, Xiaosu; Martin, Jennifer A.; Benson, Charles T. (Clinical pharmacokinetics, 2022)
Keywords: Antidiabetics; Area Under Curve; Diabetes; Diabetes Mellitus, Type 2 - drug therapy; Drug dosages; Ejection fraction; Enzymes; Fatty liver; Gastric Inhibitory Polypeptide - pharmacokinetics; GLP-1 receptor agonists; Glucagon; Glucagon-Like Peptide-1 Receptor - agonists; Heart failure; Hemoglobin; Humans; Hyperglycemia; Hypoglycemic Agents - pharmacokinetics; Internal Medicine; Liver; Liver Diseases - complications; Medicine; Medicine & Public Health; Metabolism; NCT; NCT03940742; Original; Original Research Article; Pharmacokinetics; Pharmacology/Toxicology; Pharmacotherapy; Polypeptides; Serum Albumin; United States--US