Podophyllotoxin mediates hepatic toxicity via the C5a/C5aR/ROS/NLRP3 and cGMP/PKG/mTOR axis in rats based on toxicological evidence chain (TEC) concept by phosphoproteomic analysis - Liu, Chuanxin; Huang, Xiaobin; Kong, Jiao; Li, Xuejiao; Wang, Yuming; Zhang, Fangfang; Duan, Jiajia (Ecotoxicology and environmental safety, 2025)
Keywords: Animals; C5a/C5aR/ROS/NLRP3 axis; CGMP/PKG/mTOR/NLRP3 axis; Chemical and Drug Induced Liver Injury - metabolism; Hepatotoxicity; Liver - drug effects; Male; NLR Family, Pyrin Domain-Containing 3 Protein - metabolism; Phosphorylated proteomics; Podophyllotoxin; Podophyllotoxin - toxicity; Proteomics; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species - metabolism; Signal Transduction - drug effects; TOR Serine-Threonine Kinases - metabolism; Toxicological evidence chain (TEC) concept; Phosphorylated proteomics; CGMP/PKG/mTOR/NLRP3 axis; Toxicological evidence chain (TEC) concept; Podophyllotoxin; C5a/C5aR/ROS/NLRP3 axis; Hepatotoxicity