Chromosome banding analysis and genomic microarrays are both useful but not equivalent methods for genomic complexity risk stratification in chronic lymphocytic leukemia patients

• Published in: Haematologica (Roma) Vol. 107; no. 3; pp. 593 - 603
• Main Authors: Ramos-Campoy, Silvia, Puiggros, Anna, Beà, Sílvia, Bougeon, Sandrine, Larráyoz, María José, Costa, Dolors, Parker, Helen, Rigolin, Gian Matteo, Ortega, Margarita, Blanco, María Laura, Collado, Rosa, Salgado, Rocío, Baumann, Tycho, Gimeno, Eva, Moreno, Carolina, Bosch, Francesc, Calvo, Xavier, Calasanz, María José, Cuneo, Antonio, Strefford, Jonathan C, Nguyen-Khac, Florence, Oscier, David, Haferlach, Claudia, Schoumans, Jacqueline, Espinet, Blanca
• Format: Journal Article
• Language: English
• Published: Italy Fondazione Ferrata Storti 01.03.2022; Ferrata Storti Foundation
• Subjects: Chromosome Aberrations; Chromosome Banding; Genomics; Humans; Leukemia, Lymphocytic, Chronic, B-Cell - diagnosis; Leukemia, Lymphocytic, Chronic, B-Cell - genetics; Mutation; Prognosis; Risk Assessment

Genome complexity has been associated with poor outcome in patients with chronic lymphocytic leukemia (CLL). Previous cooperative studies established five abnormalities as the cut-off that best predicts an adverse evolution by chromosome banding analysis (CBA) and genomic microarrays (GM). However,...