DHHC4 and DHHC5 Facilitate Fatty Acid Uptake by Palmitoylating and Targeting CD36 to the Plasma Membrane

• Published in: Cell reports (Cambridge) Vol. 26; no. 1; pp. 209 - 221.e5
• Main Authors: Wang, Juan, Hao, Jian-Wei, Wang, Xu, Guo, Huiling, Sun, Hui-Hui, Lai, Xiao-Ying, Liu, Li-Ying, Zhu, Mingxia, Wang, Hao-Yan, Li, Yi-Fan, Yu, Li-Yang, Xie, Changchuan, Wang, Hong-Rui, Mo, Wei, Zhou, Hai-Meng, Chen, Shuai, Liang, Guosheng, Zhao, Tong-Jin
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 02.01.2019
• Subjects: 3T3-L1 Cells; Acyltransferases - metabolism; Adipose Tissue - metabolism; Amino Acid Sequence; Animals; Biological Transport; CD36; CD36 Antigens - metabolism; Cell Membrane - metabolism; DHHC4; DHHC5; fatty acid uptake; Fatty Acids - metabolism; HEK293 Cells; Humans; Lipoylation; Male; Membrane Proteins - metabolism; Mice; Mice, Inbred C57BL; Mice, Knockout; protein palmitoylation; Transfection; CD36; fatty acid uptake; DHHC4; DHHC5; protein palmitoylation

Fatty acid uptake is the first step in fatty acid utilization, but it remains unclear how the process is regulated. Protein palmitoylation is a fatty acyl modification that plays a key regulatory role in protein targeting and trafficking; however, its function in regulating fatty acid metabolism is...