Enhanced descending pain facilitation in acute traumatic brain injury

• Published in: Experimental neurology Vol. 320; p. 112976
• Main Authors: Irvine, Karen-Amanda, Sahbaie, Peyman, Ferguson, Adam R., Clark, J. David
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.10.2019
• Subjects: Acute brain injury; Animals; Brain Injuries, Traumatic - complications; Brain Injuries, Traumatic - physiopathology; Hyperalgesia - etiology; Hyperalgesia - physiopathology; Male; Neuroinflammation; Ondansetron - pharmacology; Pain; Pain - etiology; Pain - physiopathology; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin 5-HT3 Receptor Antagonists - pharmacology; Spinal Cord - drug effects; Spinal Cord - metabolism; CPM; TNFα; DH; DNIC; RVM; CNS; IBA-1; Pain; LFP; TBI; PBS; Serotonin; DAB; BDNF; L4; Neuroinflammation; IL-1β; NGF; PWT; 5-HTR; GFAP; AR; CT; 5, 7-DHT/DHT; LC; PAG; VEH; Acute brain injury; SEM; Atm; 5-HT; DPI

Acute and persistent pain are recognized consequences of TBI that can enhance suffering and significantly impair rehabilitative efforts. Both experimental models and clinical studies suggest that TBI may result in an imbalance between descending pain facilitatory and inhibitory pathways. The aim of...