Antiviral Antibodies and T Cells Are Present in the Foreskin of Simian Immunodeficiency Virus-Infected Rhesus Macaques
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| Published in | Journal of Virology Vol. 86; no. 13; pp. 7098 - 7106 |
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| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
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01.07.2012
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| AbstractList | No information exists regarding immune responses to human immunodeficiency virus (HIV) infection in the foreskin or glans of the human penis, although this is a key tissue for HIV transmission. To address this gap, we characterized antiviral immune responses in foreskin of male rhesus macaques (RMs) inoculated with simian immunodeficiency virus (SIV) strain SIVmac251 by penile foreskin exposure. We found a complete population of immune cells in the foreskin and glans of normal RMs, although B cells were less common than CD4+ and CD8+ T cells. IgG-secreting cells were detected by enzyme-linked immunospot (ELISPOT) assay in cell suspensions made from the foreskin. In the foreskin and glans of SIV-infected RMs, although B cells were less common than CD4+ and CD8+ T cells, SIV-specific IgG antibody was present in foreskin secretions. In addition, cytokine-secreting SIV-specific CD8+ T cells were readily found in cell suspensions made from the foreskin. Although potential HIV target cells were found in and under the epithelium covering all penile surfaces, the presence of antiviral effector B and T cells in the foreskin suggests that vaccines may be able to elicit immunity in this critical site to protect men from acquiring HIV. Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue Spotlights in the Current Issue JVI About JVI Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy JVI RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0022-538X Online ISSN: 1098-5514 Copyright © 2014 by the American Society for Microbiology. For an alternate route to JVI .asm.org, visit: JVI ABSTRACT No information exists regarding immune responses to human immunodeficiency virus (HIV) infection in the foreskin or glans of the human penis, although this is a key tissue for HIV transmission. To address this gap, we characterized antiviral immune responses in foreskin of male rhesus macaques (RMs) inoculated with simian immunodeficiency virus (SIV) strain SIVmac251 by penile foreskin exposure. We found a complete population of immune cells in the foreskin and glans of normal RMs, although B cells were less common than CD4 + and CD8 + T cells. IgG-secreting cells were detected by enzyme-linked immunospot (ELISPOT) assay in cell suspensions made from the foreskin. In the foreskin and glans of SIV-infected RMs, although B cells were less common than CD4 + and CD8 + T cells, SIV-specific IgG antibody was present in foreskin secretions. In addition, cytokine-secreting SIV-specific CD8 + T cells were readily found in cell suspensions made from the foreskin. Although potential HIV target cells were found in and under the epithelium covering all penile surfaces, the presence of antiviral effector B and T cells in the foreskin suggests that vaccines may be able to elicit immunity in this critical site to protect men from acquiring HIV. No information exists regarding immune responses to human immunodeficiency virus (HIV) infection in the foreskin or glans of the human penis, although this is a key tissue for HIV transmission. To address this gap, we characterized antiviral immune responses in foreskin of male rhesus macaques (RMs) inoculated with simian immunodeficiency virus (SIV) strain SIVmac251 by penile foreskin exposure. We found a complete population of immune cells in the foreskin and glans of normal RMs, although B cells were less common than CD4 + and CD8 + T cells. IgG-secreting cells were detected by enzyme-linked immunospot (ELISPOT) assay in cell suspensions made from the foreskin. In the foreskin and glans of SIV-infected RMs, although B cells were less common than CD4 + and CD8 + T cells, SIV-specific IgG antibody was present in foreskin secretions. In addition, cytokine-secreting SIV-specific CD8 + T cells were readily found in cell suspensions made from the foreskin. Although potential HIV target cells were found in and under the epithelium covering all penile surfaces, the presence of antiviral effector B and T cells in the foreskin suggests that vaccines may be able to elicit immunity in this critical site to protect men from acquiring HIV. |
| Author | Michael B. McChesney Kristina Rothaeusler Huma Qureshi Christopher J. Miller Zhong-Min Ma Tracy Rourke Timothy D. Carroll |
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| Cites_doi | 10.1073/pnas.78.6.3848 10.4049/jimmunol.125.4.1678 10.1007/BF00217177 10.1309/JVHQVDJDYKM58EPH 10.1128/JVI.79.14.9228-9235.2005 10.1002/eji.200939798 10.1016/S0140-6736(07)60312-2 10.1038/mi.2010.18 10.1182/blood.V70.5.1316.1316 10.1001/jama.1987.03400060064030 10.1128/JVI.06175-11 10.2353/ajpath.2010.090926 10.1046/j.1365-2249.2002.01780.x 10.1016/S0140-6736(07)60313-4 10.1001/jama.1991.03470120066034 10.1089/aid.2004.20.972 10.1128/JVI.77.3.2214-2226.2003 10.1038/mi.2008.6 10.1016/j.jri.2009.07.005 10.1196/annals.1425.013 10.1016/S1286-4579(02)01585-X 10.1095/biolreprod.110.090423 10.1016/j.virol.2009.06.052 10.1097/01.aids.0000237364.11123.98 10.1097/01.aids.0000386729.56683.33 10.1371/journal.pmed.0020298 10.1371/journal.pone.0012756 10.4049/jimmunol.161.8.4406 10.1128/JVI.00481-10 10.1093/infdis/168.6.1404 10.1128/JVI.01433-08 10.1097/00126334-200212010-00008 10.1097/QAI.0b013e3181e243a1 10.1371/journal.pone.0002212 10.1089/aid.1995.11.719 10.1089/088922299310070 10.1097/QAD.0b013e32827b144c 10.4049/jimmunol.179.7.4732 10.1089/aid.2006.22.93 10.4161/hv.6.12.13399 10.1093/oxfordjournals.aje.a009276 10.1128/JVI.73.5.4508-4512.1999 10.1111/j.1365-2796.2008.02051.x 10.1111/j.1600-0897.2010.00941.x 10.1089/aid.2011.0090 |
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| Keywords | Virus Vertebrata Mammalia Antibody T-Lymphocyte Primates Retroviridae Simioidea Antiviral Macaca mulatta Simian immunodeficiency virus Lentivirus |
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Mendeley... No information exists regarding immune responses to human immunodeficiency virus (HIV) infection in the foreskin or glans of the human penis, although this is... ABSTRACT No information exists regarding immune responses to human immunodeficiency virus (HIV) infection in the foreskin or glans of the human penis, although... |
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| SubjectTerms | Animals Antibodies, Viral - analysis Antibodies, Viral - immunology B-Lymphocytes - immunology Biological and medical sciences CD4-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - immunology Cytokines - secretion Flow Cytometry Foreskin - chemistry Foreskin - immunology Foreskin - pathology Foreskin - virology Fundamental and applied biological sciences. Psychology Human immunodeficiency virus Immunoglobulin G - analysis Immunoglobulin G - immunology Immunohistochemistry Immunophenotyping Macaca mulatta Male Microbiology Microscopy Miscellaneous Pathogenesis and Immunity Penis - chemistry Penis - immunology Penis - pathology Penis - virology Simian Acquired Immunodeficiency Syndrome - immunology Simian Acquired Immunodeficiency Syndrome - pathology Simian Acquired Immunodeficiency Syndrome - virology Simian immunodeficiency virus Simian Immunodeficiency Virus - immunology Virology |
| Title | Antiviral Antibodies and T Cells Are Present in the Foreskin of Simian Immunodeficiency Virus-Infected Rhesus Macaques |
| URI | http://jvi.asm.org/content/86/13/7098.abstract https://www.ncbi.nlm.nih.gov/pubmed/22532691 https://search.proquest.com/docview/1019616938 https://search.proquest.com/docview/1024661801 https://pubmed.ncbi.nlm.nih.gov/PMC3416333 |
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