Macroalgal protein hydrolysates from Palmaria palmata influence the ‘incretin effect’ in vitro via DPP-4 inhibition and upregulation of insulin, GLP-1 and GIP secretion

• Published in: European journal of nutrition Vol. 60; no. 8; pp. 4439 - 4452
• Main Authors: McLaughlin, C. M., Harnedy-Rothwell, P. A., Lafferty, R. A., Sharkey, S., Parthsarathy, V., Allsopp, P. J., McSorley, E. M., FitzGerald, R. J., O’Harte, F. P. M.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.12.2021; Springer Nature B.V
• Subjects: Animals; Antidiabetics; Bioavailability; Biological activity; Blood Glucose; Calcium (intracellular); Chemistry; Chemistry and Materials Science; Diabetes; Diabetes mellitus; Diabetes Mellitus, Experimental; Gastric Inhibitory Polypeptide; Glucagon-Like Peptide 1; Glucose tolerance; Hydrolysates; Incretins; Insulin; Insulin - metabolism; Insulin secretion; Intracellular; Membrane potential; Mice; Nutrition; Original Contribution; Palmaria palmata; Protein Hydrolysates; Proteins; Satiety; Seaweeds; Secretion; Streptozocin; Subtilisin; Up-Regulation; Type 2 diabetes; Dulse; Protein hydrolysate; Dipeptidylpeptidase-4; Antidiabetic; Incretin secretion; Palmaria palmata

Purpose This study investigated metabolic benefits of protein hydrolysates from the macroalgae Palmaria palmata , previously shown to inhibit dipeptidylpeptidase-4 (DPP-4) activity in vitro. Methods Previously, Alcalase/Flavourzyme-produced P. palmata protein hydrolysate (PPPH) improved glycaemia an...