Oxycodone in the Opioid Epidemic: High ‘Liking’, ‘Wanting’, and Abuse Liability

• Published in: Cellular and molecular neurobiology Vol. 41; no. 5; pp. 899 - 926
• Main Authors: Kibaly, Cherkaouia, Alderete, Jacob A., Liu, Steven H., Nasef, Hazem S., Law, Ping-Yee, Evans, Christopher J., Cahill, Catherine M.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.07.2021; Springer Nature B.V
• Subjects: Analgesics, Opioid - administration & dosage; Analgesics, Opioid - adverse effects; Animals; Behavior, Addictive - epidemiology; Behavior, Addictive - psychology; Biomedical and Life Sciences; Biomedicine; Cell Biology; Drug abuse; Drug overdose; Fentanyl; Heroin; Humans; Intravenous administration; Mesolimbic system; Morphine; Narcotics; Neurobiology; Neurosciences; Opioid Epidemic; Opioid receptors; Opioid-Related Disorders - epidemiology; Opioid-Related Disorders - psychology; Overdose; Oxycodone; Oxycodone - administration & dosage; Oxycodone - adverse effects; Pain; Pain - drug therapy; Pain - epidemiology; Pain - psychology; Pharmacodynamics; Pharmacokinetics; Prescription drugs; Reinforcement; Review Paper; Reward; Likability; Incentive salience; Dopamine; Allosteric site; Oxycodone

It is estimated that nearly a third of people who abuse drugs started with prescription opioid medicines. Approximately, 11.5 million Americans used prescription drugs recreationally in 2016, and in 2018, 46,802 Americans died as the result of an opioid overdose, including prescription opioids, hero...