Oxycodone in the Opioid Epidemic: High ‘Liking’, ‘Wanting’, and Abuse Liability

It is estimated that nearly a third of people who abuse drugs started with prescription opioid medicines. Approximately, 11.5 million Americans used prescription drugs recreationally in 2016, and in 2018, 46,802 Americans died as the result of an opioid overdose, including prescription opioids, hero...

Full description

Saved in:
Bibliographic Details
Published inCellular and molecular neurobiology Vol. 41; no. 5; pp. 899 - 926
Main Authors Kibaly, Cherkaouia, Alderete, Jacob A., Liu, Steven H., Nasef, Hazem S., Law, Ping-Yee, Evans, Christopher J., Cahill, Catherine M.
Format Journal Article
LanguageEnglish
Published New York Springer US 01.07.2021
Springer Nature B.V
Subjects
Analgesics, Opioid - administration & dosage
Analgesics, Opioid - adverse effects
Animals
Behavior, Addictive - epidemiology
Behavior, Addictive - psychology
Biomedical and Life Sciences
Biomedicine
Cell Biology
Drug abuse
Drug overdose
Fentanyl
Heroin
Humans
Intravenous administration
Mesolimbic system
Morphine
Narcotics
Neurobiology
Neurosciences
Opioid Epidemic
Opioid receptors
Opioid-Related Disorders - epidemiology
Opioid-Related Disorders - psychology
Overdose
Oxycodone
Oxycodone - administration & dosage
Oxycodone - adverse effects
Pain
Pain - drug therapy
Pain - epidemiology
Pain - psychology
Pharmacodynamics
Pharmacokinetics
Prescription drugs
Reinforcement
Review Paper
Reward
Likability
Incentive salience
Dopamine
Allosteric site
Oxycodone
Online AccessGet full text

Cover

Abstract It is estimated that nearly a third of people who abuse drugs started with prescription opioid medicines. Approximately, 11.5 million Americans used prescription drugs recreationally in 2016, and in 2018, 46,802 Americans died as the result of an opioid overdose, including prescription opioids, heroin, and illicitly manufactured fentanyl (National Institutes on Drug Abuse (2020) Opioid Overdose Crisis. https://www.drugabuse.gov/drugs-abuse/opioids/opioid-overdose-crisis . Accessed 06 June 2020). Yet physicians will continue to prescribe oral opioids for moderate-to-severe pain in the absence of alternative therapeutics, underscoring the importance in understanding how drug choice can influence detrimental outcomes. One of the opioid prescription medications that led to this crisis is oxycodone, where misuse of this drug has been rampant. Being one of the most highly prescribed opioid medications for treating moderate-to-severe pain as reflected in the skyrocketed increase in retail sales of 866% between 1997 and 2007, oxycodone was initially suggested to be less addictive than morphine. The false-claimed non-addictive formulation of oxycodone, OxyContin, further contributed to the opioid crisis. Abuse was often carried out by crushing the pills for immediate burst release, typically by nasal insufflation, or by liquefying the pills for intravenous injection. Here, we review oxycodone pharmacology and abuse liability as well as present the hypothesis that oxycodone may exhibit a unique pharmacology that contributes to its high likability and abuse susceptibility. We will discuss various mechanisms that likely contribute to the high abuse rate of oxycodone including clinical drug likability, pharmacokinetics, pharmacodynamics, differences in its actions within mesolimbic reward circuity compared to other opioids, and the possibility of differential molecular and cellular receptor interactions that contribute to its selective effects. We will also discuss marketing strategies and drug difference that likely contributes to the oxycodone opioid use disorders and addiction.
AbstractList It is estimated that nearly a third of people who abuse drugs started with prescription opioid medicines. Approximately, 11.5 million Americans used prescription drugs recreationally in 2016, and in 2018, 46,802 Americans died as the result of an opioid overdose, including prescription opioids, heroin, and illicitly manufactured fentanyl (National Institutes on Drug Abuse (2020) Opioid Overdose Crisis. https://www.drugabuse.gov/drugs-abuse/opioids/opioid-overdose-crisis . Accessed 06 June 2020). Yet physicians will continue to prescribe oral opioids for moderate-to-severe pain in the absence of alternative therapeutics, underscoring the importance in understanding how drug choice can influence detrimental outcomes. One of the opioid prescription medications that led to this crisis is oxycodone, where misuse of this drug has been rampant. Being one of the most highly prescribed opioid medications for treating moderate-to-severe pain as reflected in the skyrocketed increase in retail sales of 866% between 1997 and 2007, oxycodone was initially suggested to be less addictive than morphine. The false-claimed non-addictive formulation of oxycodone, OxyContin, further contributed to the opioid crisis. Abuse was often carried out by crushing the pills for immediate burst release, typically by nasal insufflation, or by liquefying the pills for intravenous injection. Here, we review oxycodone pharmacology and abuse liability as well as present the hypothesis that oxycodone may exhibit a unique pharmacology that contributes to its high likability and abuse susceptibility. We will discuss various mechanisms that likely contribute to the high abuse rate of oxycodone including clinical drug likability, pharmacokinetics, pharmacodynamics, differences in its actions within mesolimbic reward circuity compared to other opioids, and the possibility of differential molecular and cellular receptor interactions that contribute to its selective effects. We will also discuss marketing strategies and drug difference that likely contributes to the oxycodone opioid use disorders and addiction.It is estimated that nearly a third of people who abuse drugs started with prescription opioid medicines. Approximately, 11.5 million Americans used prescription drugs recreationally in 2016, and in 2018, 46,802 Americans died as the result of an opioid overdose, including prescription opioids, heroin, and illicitly manufactured fentanyl (National Institutes on Drug Abuse (2020) Opioid Overdose Crisis. https://www.drugabuse.gov/drugs-abuse/opioids/opioid-overdose-crisis . Accessed 06 June 2020). Yet physicians will continue to prescribe oral opioids for moderate-to-severe pain in the absence of alternative therapeutics, underscoring the importance in understanding how drug choice can influence detrimental outcomes. One of the opioid prescription medications that led to this crisis is oxycodone, where misuse of this drug has been rampant. Being one of the most highly prescribed opioid medications for treating moderate-to-severe pain as reflected in the skyrocketed increase in retail sales of 866% between 1997 and 2007, oxycodone was initially suggested to be less addictive than morphine. The false-claimed non-addictive formulation of oxycodone, OxyContin, further contributed to the opioid crisis. Abuse was often carried out by crushing the pills for immediate burst release, typically by nasal insufflation, or by liquefying the pills for intravenous injection. Here, we review oxycodone pharmacology and abuse liability as well as present the hypothesis that oxycodone may exhibit a unique pharmacology that contributes to its high likability and abuse susceptibility. We will discuss various mechanisms that likely contribute to the high abuse rate of oxycodone including clinical drug likability, pharmacokinetics, pharmacodynamics, differences in its actions within mesolimbic reward circuity compared to other opioids, and the possibility of differential molecular and cellular receptor interactions that contribute to its selective effects. We will also discuss marketing strategies and drug difference that likely contributes to the oxycodone opioid use disorders and addiction.
It is estimated that nearly a third of people who abuse drugs started with prescription opioid medicines. Approximately, 11.5 million Americans used prescription drugs recreationally in 2016, and in 2018, 46,802 Americans died as the result of an opioid overdose, including prescription opioids, heroin and illicitly manufactured fentanyl 1 . Yet, physicians will continue to prescribe oral opioids for moderate to severe pain in the absence of alternative therapeutics, underscoring the importance in understanding how drug choice can influence detrimental outcomes. One of the opioid prescription medications that led to this crisis is oxycodone, where misuse of this drug has been rampant. Being one of the most highly prescribed opioid medications for treating moderate to severe pain as reflected in the skyrocketed increase in retail sales of 866% between 1997-2007, oxycodone was initially suggested to be less addictive than morphine. The false claimed non-addictive formulation of oxycodone, OxyContin further contributed to the opioid crisis. Abuse was often carried out by crushing the pills for immediate burst release, typically by nasal insufflation, or by liquefying the pills for intravenous injection. Here we review oxycodone pharmacology and abuse liability as well as present the hypothesis that oxycodone may exhibit a unique pharmacology that contributes to its high likeability and abuse susceptibility. We will discuss various mechanisms that likely contribute to the high abuse rate of oxycodone including clinical drug likeability, pharmacokinetics, pharmacodynamics, differences in its actions within mesolimbic reward circuity compared to other opioids, and the possibility of differential molecular and cellular receptor interactions that contribute to its selective effects. We will also discuss marketing strategies and drug difference that likely contributes to the oxycodone opioid use disorders and addiction.
It is estimated that nearly a third of people who abuse drugs started with prescription opioid medicines. Approximately, 11.5 million Americans used prescription drugs recreationally in 2016, and in 2018, 46,802 Americans died as the result of an opioid overdose, including prescription opioids, heroin, and illicitly manufactured fentanyl (National Institutes on Drug Abuse (2020) Opioid Overdose Crisis. https://www.drugabuse.gov/drugs-abuse/opioids/opioid-overdose-crisis. Accessed 06 June 2020). Yet physicians will continue to prescribe oral opioids for moderate-to-severe pain in the absence of alternative therapeutics, underscoring the importance in understanding how drug choice can influence detrimental outcomes. One of the opioid prescription medications that led to this crisis is oxycodone, where misuse of this drug has been rampant. Being one of the most highly prescribed opioid medications for treating moderate-to-severe pain as reflected in the skyrocketed increase in retail sales of 866% between 1997 and 2007, oxycodone was initially suggested to be less addictive than morphine. The false-claimed non-addictive formulation of oxycodone, OxyContin, further contributed to the opioid crisis. Abuse was often carried out by crushing the pills for immediate burst release, typically by nasal insufflation, or by liquefying the pills for intravenous injection. Here, we review oxycodone pharmacology and abuse liability as well as present the hypothesis that oxycodone may exhibit a unique pharmacology that contributes to its high likability and abuse susceptibility. We will discuss various mechanisms that likely contribute to the high abuse rate of oxycodone including clinical drug likability, pharmacokinetics, pharmacodynamics, differences in its actions within mesolimbic reward circuity compared to other opioids, and the possibility of differential molecular and cellular receptor interactions that contribute to its selective effects. We will also discuss marketing strategies and drug difference that likely contributes to the oxycodone opioid use disorders and addiction.
It is estimated that nearly a third of people who abuse drugs started with prescription opioid medicines. Approximately, 11.5 million Americans used prescription drugs recreationally in 2016, and in 2018, 46,802 Americans died as the result of an opioid overdose, including prescription opioids, heroin, and illicitly manufactured fentanyl (National Institutes on Drug Abuse (2020) Opioid Overdose Crisis. https://www.drugabuse.gov/drugs-abuse/opioids/opioid-overdose-crisis . Accessed 06 June 2020). Yet physicians will continue to prescribe oral opioids for moderate-to-severe pain in the absence of alternative therapeutics, underscoring the importance in understanding how drug choice can influence detrimental outcomes. One of the opioid prescription medications that led to this crisis is oxycodone, where misuse of this drug has been rampant. Being one of the most highly prescribed opioid medications for treating moderate-to-severe pain as reflected in the skyrocketed increase in retail sales of 866% between 1997 and 2007, oxycodone was initially suggested to be less addictive than morphine. The false-claimed non-addictive formulation of oxycodone, OxyContin, further contributed to the opioid crisis. Abuse was often carried out by crushing the pills for immediate burst release, typically by nasal insufflation, or by liquefying the pills for intravenous injection. Here, we review oxycodone pharmacology and abuse liability as well as present the hypothesis that oxycodone may exhibit a unique pharmacology that contributes to its high likability and abuse susceptibility. We will discuss various mechanisms that likely contribute to the high abuse rate of oxycodone including clinical drug likability, pharmacokinetics, pharmacodynamics, differences in its actions within mesolimbic reward circuity compared to other opioids, and the possibility of differential molecular and cellular receptor interactions that contribute to its selective effects. We will also discuss marketing strategies and drug difference that likely contributes to the oxycodone opioid use disorders and addiction.
Author Law, Ping-Yee
Evans, Christopher J.
Kibaly, Cherkaouia
Liu, Steven H.
Nasef, Hazem S.
Cahill, Catherine M.
Alderete, Jacob A.
AuthorAffiliation 1 Department of Psychiatry and Biobehavioral Sciences, Jane & Terry Semel Institute for Neuroscience and Human Behavior, Shirley and Stefan Hatos Center for Neuropharmacology, University of California, Los Angeles, CA, USA
AuthorAffiliation_xml – name: 1 Department of Psychiatry and Biobehavioral Sciences, Jane & Terry Semel Institute for Neuroscience and Human Behavior, Shirley and Stefan Hatos Center for Neuropharmacology, University of California, Los Angeles, CA, USA
Author_xml – sequence: 1
  givenname: Cherkaouia
  orcidid: 0000-0003-3071-9801
  surname: Kibaly
  fullname: Kibaly, Cherkaouia
  email: ckibaly@g.ucla.edu
  organization: Department of Psychiatry and Biobehavioral Sciences, Jane & Terry Semel Institute for Neuroscience and Human Behavior, Shirley and Stefan Hatos Center for Neuropharmacology, University of California
– sequence: 2
  givenname: Jacob A.
  surname: Alderete
  fullname: Alderete, Jacob A.
  organization: Department of Psychiatry and Biobehavioral Sciences, Jane & Terry Semel Institute for Neuroscience and Human Behavior, Shirley and Stefan Hatos Center for Neuropharmacology, University of California
– sequence: 3
  givenname: Steven H.
  surname: Liu
  fullname: Liu, Steven H.
  organization: Department of Psychiatry and Biobehavioral Sciences, Jane & Terry Semel Institute for Neuroscience and Human Behavior, Shirley and Stefan Hatos Center for Neuropharmacology, University of California
– sequence: 4
  givenname: Hazem S.
  surname: Nasef
  fullname: Nasef, Hazem S.
  organization: Department of Psychiatry and Biobehavioral Sciences, Jane & Terry Semel Institute for Neuroscience and Human Behavior, Shirley and Stefan Hatos Center for Neuropharmacology, University of California
– sequence: 5
  givenname: Ping-Yee
  orcidid: 0000-0002-5364-1093
  surname: Law
  fullname: Law, Ping-Yee
  organization: Department of Psychiatry and Biobehavioral Sciences, Jane & Terry Semel Institute for Neuroscience and Human Behavior, Shirley and Stefan Hatos Center for Neuropharmacology, University of California
– sequence: 6
  givenname: Christopher J.
  orcidid: 0000-0003-0940-8224
  surname: Evans
  fullname: Evans, Christopher J.
  organization: Department of Psychiatry and Biobehavioral Sciences, Jane & Terry Semel Institute for Neuroscience and Human Behavior, Shirley and Stefan Hatos Center for Neuropharmacology, University of California
– sequence: 7
  givenname: Catherine M.
  orcidid: 0000-0001-6936-5524
  surname: Cahill
  fullname: Cahill, Catherine M.
  email: cmcahill@g.ucla.edu
  organization: Department of Psychiatry and Biobehavioral Sciences, Jane & Terry Semel Institute for Neuroscience and Human Behavior, Shirley and Stefan Hatos Center for Neuropharmacology, University of California
BackLink https://www.ncbi.nlm.nih.gov/pubmed/33245509$$D View this record in MEDLINE/PubMed
BookMark eNp9kc1u1DAUhS1URKeFF2CBIrFhQeDajuMxC6SqKhRppNmAurQc_8zckrGHOEFk18eA1-uTkGHaAl10ZV35O8fn-hyRg5iiJ-Q5hTcUQL7NFISkJTAogQLl5fiIzKiQvKznHA7IDJhkZcUrOCRHOV8CgAIQT8gh56wSAtSMXCx_jDa5ybjAWPRrXyy3mNAVZ1t0foP2XXGOq3VxffVzgV8xrq6vfr3eTRcm9rejia44aYbsiwWaBlvsx6fkcTBt9s9uzmPy5cPZ59PzcrH8-On0ZFHaSlZ96echWMt95ZR3IDxTTVOLWkEwVimgjvkAhvImcCmUdY2COkhwgTpuBJX8mLzf-26HZuOd9bHvTKu3HW5MN-pkUP9_E3GtV-m7nlMhKGOTwasbgy59G3zu9Qaz9W1rok9D1qyqRcVVDWpCX95DL9PQxWk9zQTnvOZc7gxf_JvoLsrtn08A2wO2Szl3PtwhFPSuWL0vVk_F6j_F6nESze-JLPamx7TbCtuHpXwvzdM7ceW7v7EfUP0GkiW7Yg
CitedBy_id crossref_primary_10_1016_j_bjae_2023_05_007
crossref_primary_10_1093_ijnp_pyaf005
crossref_primary_10_3390_ijms25094845
crossref_primary_10_5847_wjem_j_1920_8642_2024_002
crossref_primary_10_1111_adb_13148
crossref_primary_10_3389_fnbeh_2023_1143373
crossref_primary_10_3389_fncir_2022_983323
crossref_primary_10_3390_jpm12111772
crossref_primary_10_1007_s10571_021_01097_0
crossref_primary_10_1016_j_bpsgos_2025_100450
crossref_primary_10_1097_MD_0000000000032427
crossref_primary_10_3389_fpsyt_2023_1229439
crossref_primary_10_3390_v14040669
crossref_primary_10_3389_fphar_2022_1029073
crossref_primary_10_1016_j_pbb_2024_173771
crossref_primary_10_3389_fphar_2023_1163976
crossref_primary_10_1016_j_mpaic_2024_12_006
crossref_primary_10_3390_metabo15020095
crossref_primary_10_1523_JNEUROSCI_0595_22_2022
crossref_primary_10_1016_j_biomaterials_2024_122758
crossref_primary_10_1080_17512433_2024_2343915
crossref_primary_10_1016_j_disamonth_2025_101853
crossref_primary_10_1111_gbb_70009
crossref_primary_10_1186_s12871_024_02429_5
crossref_primary_10_1111_add_16261
crossref_primary_10_1007_s12630_022_02210_7
crossref_primary_10_12677_acm_2025_151058
crossref_primary_10_3390_jcm13226644
crossref_primary_10_1016_j_cptl_2022_09_012
crossref_primary_10_1016_j_jgo_2024_101772
crossref_primary_10_1016_j_therap_2024_11_008
crossref_primary_10_1111_aas_14388
crossref_primary_10_1097_j_pain_0000000000003155
crossref_primary_10_1021_acsmedchemlett_2c00455
crossref_primary_10_1124_pharmrev_121_000506
crossref_primary_10_1016_j_jep_2023_116877
crossref_primary_10_1016_j_jdent_2022_104254
crossref_primary_10_1016_j_trac_2022_116828
crossref_primary_10_1111_anae_15972
crossref_primary_10_1007_s00702_024_02765_3
crossref_primary_10_1111_anae_16069
crossref_primary_10_2196_50013
crossref_primary_10_1111_bph_15832
crossref_primary_10_1007_s00414_022_02890_2
crossref_primary_10_1016_j_pbb_2021_173294
crossref_primary_10_1097_ADM_0000000000001405
crossref_primary_10_3389_fphar_2023_1127735
crossref_primary_10_1002_jcph_1923
crossref_primary_10_1111_gbb_12770
Cites_doi 10.1016/s0196-9781(00)00250-3
10.1124/jpet.117.243030
10.1523/JNEUROSCI.4205-06.2007
10.1111/pme.12918
10.3109/00952990.2011.643994
10.1016/s0006-8993(03)03170-6
10.1093/pm/pnw344
10.1038/nn2006
10.1523/JNEUROSCI.2144-14.2014
10.1101/460048
10.1124/jpet.106.113167
10.5812/aapm.4529
10.1016/j.ejphar.2007.12.008
10.1097/MD.0000000000013385
10.1038/nrn.2016.165
10.1124/dmd.32.4.447
10.1016/s1090-3801(98)90020-9
10.1016/j.neuron.2017.12.022
10.3389/fpsyg.2018.01647
10.1097/MLR.0000000000000126
10.1038/nn.3699
10.1523/JNEUROSCI.12-02-00483.1992
10.1016/j.neuropharm.2019.02.007
10.1038/ncomms10702
10.1016/j.neuroscience.2006.06.067
10.1073/pnas.1705753114
10.1371/journal.pone.0042365
10.1146/annurev.pharmtox.40.1.389
10.1016/j.clinthera.2015.08.014
10.2147/JMDH.S166915
10.1016/j.coph.2008.12.014
10.1038/scientificamerican0304-78
10.1073/pnas.1101920108
10.1016/j.neuroscience.2018.11.042
10.1126/science.aac4690
10.1016/j.ejphar.2007.10.020
10.1097/AJP.0b013e318167a087
10.1111/j.1365-2125.1991.tb03942.x
10.1016/j.anclin.2017.01.022
10.1038/nn.2984
10.1037//0735-7044.103.1.36
10.1016/j.drugalcdep.2008.11.013
10.1177/0269216311401948
10.1038/s41386-020-0643-x
10.1007/s00213-011-2557-0
10.1523/JNEUROSCI.0740-06.2006
10.1038/1731231a0
10.1007/s00213-015-4027-6
10.1016/j.phrs.2016.05.034
10.1038/s41386-020-0679-y
10.1126/scitranslmed.aar3483
10.1097/ALN.0b013e318164cf9e
10.1017/s0140525x00020306
10.1007/s00213-012-2864-0
10.1038/s41386-018-0211-9
10.1016/j.jpain.2005.05.004
10.1038/253563a0
10.1056/NEJMc1204141
10.1111/j.1365-2982.2004.00513.x
10.1016/j.brainresrev.2007.10.008
10.1111/j.1526-4637.2009.00736.x
10.1523/JNEUROSCI.1902-05.2005
10.3390/proteomes6040039
10.1016/s0149-7634(00)00051-8
10.1016/S0952-8180(96)00212-7
10.1186/s12871-018-0583-8
10.1002/ana.410350716
10.1124/jpet.105.094276
10.1038/nature12944
10.1523/JNEUROSCI.0274-19.2019
10.1016/j.drugalcdep.2012.12.006
10.1016/j.tins.2012.06.007
10.1126/scisignal.aac9177
10.1124/jpet.117.241042
10.1073/pnas.92.26.12304
10.1001/jamapsychiatry.2014.3043
10.1002/9781118384404
10.1007/978-1-4939-2914-6_15
10.1016/j.drugalcdep.2015.12.026
10.2147/JPR.S217563
10.3389/fnana.2010.00150
10.1213/ane.0b013e3181605a15
10.1074/jbc.M110.177089
10.1016/0304-3959(90)91131-2
10.1093/brain/awq138
10.1097/00000542-200610000-00027
10.3389/fphar.2020.01078
10.1016/j.brainres.2005.12.066
10.1038/sj.npp.1301471
10.1378/chest.102.1.270
10.1016/j.pharmthera.2017.10.008
10.1097/j.pain.0000000000000363
10.1126/science.278.5335.52
10.1101/574434
10.2147/JPR.S21965
10.1186/1477-7517-8-29
10.1007/s40264-018-0660-4
10.1007/s00213-003-1540-9
10.1016/j.drugalcdep.2014.02.006
10.1124/mol.119.115956
10.1523/JNEUROSCI.2329-05.2005
10.1097/j.pain.0000000000001517
10.1111/j.1526-4637.2012.01380.x
10.1016/0885-3924(96)00050-4
10.1097/ALN.0000000000002031
10.1002/syn.20489
10.1002/(SICI)1097-0142(19970401)79:7<1428::AID-CNCR21>3.0.CO;2-0
10.1111/bph.15004
10.1200/JCO.1998.16.10.3222
10.1038/nn872
10.1016/j.biopsych.2019.10.020
10.1523/JNEUROSCI.2444-15.2015
10.1016/j.neubiorev.2010.02.001
10.1007/s00213-007-0937-2
10.1177/0269881116689257
10.1021/acs.jmedchem.5b00007
10.1016/j.neuron.2012.02.016
10.1073/pnas.1415013111
10.1038/srep31748
10.1007/s00213-005-0023-6
10.5055/jom.2015.0299
10.1124/pr.112.005942
10.1177/1087057114542975
10.1016/0165-0173(93)90013-p
10.1037/0735-7044.105.1.3
10.1016/j.clpt.2006.01.009
10.1111/cns.12827
10.1016/j.ijpharm.2016.06.012
10.2147/SAR.S24800
10.1007/s11916-019-0751-7
10.1016/j.neuroscience.2015.06.033
10.1111/j.1600-0773.1992.tb00441.x
10.1038/nn.3694
10.1002/jcph.235
10.1016/s0006-8993(00)02102-8
10.1177/0269881114548436
10.1021/acs.jcim.5b00388
10.2147/JPR.S171013
10.1016/j.ejpain.2008.11.006
10.1111/pme.12391
10.1016/j.tips.2006.09.006
10.1002/pds.1989
10.1016/0304-3959(95)00017-M
10.1371/journal.pone.0001506
10.1016/j.pmr.2014.12.001
10.1016/j.pain.2006.08.009
10.1073/pnas.85.14.5274
10.1007/s00213-012-2954-z
10.1016/j.pain.2009.10.026
10.1016/S1877-8860(09)70005-9
10.1111/bph.13823
10.1016/j.bbr.2015.01.023
10.1080/10550490701375293
10.2165/11593390-000000000-00000
10.1016/j.neubiorev.2016.01.006
10.1016/j.neuron.2015.02.018
10.1523/JNEUROSCI.4458-13.2014
10.1073/pnas.1105418108
10.2174/157015906778520773
10.1093/brain/124.9.1720
10.1371/journal.pone.0217371
10.1111/papr.12801
10.1523/JNEUROSCI.4331-05.2006
10.1124/jpet.114.213694
10.1098/rstb.1971.0102
10.1016/j.pain.2007.03.022
10.1016/j.drugalcdep.2007.02.012
10.1523/JNEUROSCI.10-09-02996.1990
10.1002/jgm.1514
10.1213/ane.0b013e3181b0f0bb
10.1124/jpet.112.194308
10.1016/s1522-8649(03)50051-8
10.1093/cercor/13.10.1064
10.1038/nature11111
10.1111/ejn.12733
10.3389/fpsyt.2018.00119
10.1021/acschemneuro.7b00090
10.1096/fasebj.2019.33.1_supplement.666.5
10.1016/j.ejphar.2019.04.009
10.1016/j.ejphar.2006.02.002
10.1037/xan0000090
10.1016/j.jpainsymman.2005.01.010
10.1073/pnas.1300393110
10.1124/mol.106.022376
10.2174/187152708786927813
10.1254/jphs.09139fp
10.1186/1746-160X-1-14
10.1523/JNEUROSCI.5996-09.2010
10.1016/s0304-3959(97)00072-9
10.1002/pds.1276
10.1016/j.neubiorev.2012.04.005
10.1016/S0009-9236(96)90024-7
10.1016/s0376-8716(03)00003-6
10.2217/pmt-2016-0067
10.1101/2020.08.31.276253
10.1146/annurev.neuro.29.051605.113009
10.1111/jcpt.12461
10.1634/theoncologist.11-2-217
10.1124/mol.59.1.30
10.1007/s00213-018-4931-7
10.1385/1-59259-358-5:443
10.1523/jneurosci.23-32-10331.2003
10.1073/pnas.1000751107
10.1016/j.jsat.2017.03.006
10.1056/NEJMsa1406143
10.1007/s40122-019-0122-4
10.1007/s10571-020-00816-3
10.1007/s40265-018-1007-2
10.1037/amp0000059
10.1016/0306-4522(92)90389-j
10.1111/j.1460-9568.2006.04689.x
10.3390/ijms21030847
10.1016/s0149-7634(99)00072-x
10.1124/mol.117.109561
10.1155/2012/265605
10.1054/bjoc.2001.1680
10.1037/pha0000028
10.1016/j.neuron.2010.11.022
10.1185/030079908x253708
10.1016/j.neuropharm.2017.11.026
10.1111/j.1399-6576.1991.tb03364.x
10.1146/annurev.psych.54.101601.145237
10.1007/s00210-006-0033-x
10.1016/s0304-3959(03)00160-x
10.1111/j.1440-1681.2007.04821.x
10.1073/pnas.75.4.1713
10.1124/mol.107.039842
10.1042/AN20110063
10.1523/JNEUROSCI.20-19-07489.2000
10.1124/mol.119.119321
10.1016/j.cellsig.2009.12.003
10.1152/jn.00204.2010
10.1212/wnl.50.6.1837
10.3389/fnins.2016.00471
10.1016/j.pain.2013.07.025
10.1038/npp.2014.188
10.1007/s13181-012-0263-x
10.1111/j.1526-4637.2007.00359.x
10.1111/j.1360-0443.2011.03635.x
10.1523/JNEUROSCI.3370-12.2012
10.1016/j.pbb.2019.172778
10.1073/pnas.76.11.5626
10.1097/ALN.0000000000003441
10.1038/sj.bjc.6601365
10.1016/s0091-3057(96)00240-7
10.1016/s0304-3959(97)00093-6
10.1111/ejn.12709
10.36076/ppj.2014/17/E119
10.2105/AJPH.2007.131714
10.1080/J354v20n04_06
10.7554/eLife.01936
10.5414/cp201646
10.1038/clpt.1990.85
10.1002/(SICI)1098-2396(199910)34:1<1::AID-SYN1>3.0.CO;2-H
10.2147/DDDT.S188728
10.1021/acsptsci.9b00021
10.1523/JNEUROSCI.2628-11.2011
10.1038/sj.npp.1301479
10.1021/acschemneuro.9b00274
10.12688/f1000research.8369.1
10.1016/j.neuron.2014.04.030
10.1126/science.278.5335.63
10.1038/npp.2014.96
10.1038/sj.bjp.0700942
10.1016/j.drugpo.2013.10.004
10.1124/jpet.103.058602
10.1097/FBP.0b013e328363d1c4
10.1038/nature10954
ContentType Journal Article
Copyright Springer Science+Business Media, LLC, part of Springer Nature 2020
Springer Science+Business Media, LLC, part of Springer Nature 2020.
Copyright_xml – notice: Springer Science+Business Media, LLC, part of Springer Nature 2020
– notice: Springer Science+Business Media, LLC, part of Springer Nature 2020.
DBID AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
7X8
5PM
DOI 10.1007/s10571-020-01013-y
DatabaseName CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
MEDLINE - Academic
PubMed Central (Full Participant titles)
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
MEDLINE - Academic
DatabaseTitleList MEDLINE - Academic


MEDLINE
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Anatomy & Physiology
EISSN 1573-6830
EndPage 926
ExternalDocumentID PMC8155122
33245509
10_1007_s10571_020_01013_y
Genre Journal Article
Review
GrantInformation_xml – fundername: U.S. Department of Defense
  grantid: W81XWH-15-1-0435
  funderid: http://dx.doi.org/10.13039/100000005
– fundername: National Institutes of Health
  grantid: R01DA041781; 1UG3TR003148-01; 2P50 DA005010
  funderid: http://dx.doi.org/10.13039/100000002
– fundername: NIH HHS
  grantid: 1UG3TR003148-01
– fundername: NIH HHS
  grantid: R01DA041781
– fundername: NIDA NIH HHS
  grantid: P50 DA005010
– fundername: NCATS NIH HHS
  grantid: UG3 TR003148
– fundername: NIH HHS
  grantid: 2P50 DA005010
– fundername: NIDA NIH HHS
  grantid: R01 DA041781
– fundername: U.S. Department of Defense
  grantid: W81XWH-15-1-0435
GroupedDBID ---
-4W
-56
-5G
-BR
-EM
-Y2
-~C
-~X
.86
.GJ
.VR
06C
06D
0R~
0VY
1N0
1SB
2.D
203
28-
29B
29~
2J2
2JN
2JY
2KG
2KM
2LR
2P1
2VQ
2~H
30V
3SX
4.4
406
408
409
40D
40E
53G
5GY
5QI
5RE
5VS
67N
67Z
6NX
78A
8UJ
95-
95.
95~
96X
AAAVM
AABHQ
AAHNG
AAIAL
AAJKR
AAJSJ
AAKKN
AANXM
AANZL
AARHV
AARTL
AATVU
AAUYE
AAWCG
AAYIU
AAYQN
AAYTO
AAYZH
ABAKF
ABBBX
ABBXA
ABDZT
ABECU
ABEEZ
ABFTV
ABHLI
ABHQN
ABIVO
ABJNI
ABJOX
ABKCH
ABKTR
ABMNI
ABMOR
ABMQK
ABNWP
ABPLI
ABQBU
ABQSL
ABSXP
ABTEG
ABTHY
ABTKH
ABTMW
ABULA
ABWNU
ABXPI
ACACY
ACBXY
ACGFS
ACHSB
ACHXU
ACKNC
ACMDZ
ACMLO
ACOKC
ACOMO
ACPRK
ACULB
ACZOJ
ADHHG
ADHIR
ADIMF
ADINQ
ADKNI
ADKPE
ADRFC
ADTPH
ADURQ
ADYFF
ADYPR
ADZKW
AEBTG
AEFIE
AEFQL
AEGAL
AEGNC
AEJHL
AEJRE
AEKMD
AENEX
AEOHA
AEPYU
AESKC
AETLH
AEVLU
AEXYK
AFBBN
AFEXP
AFGCZ
AFGXO
AFLOW
AFQWF
AFWTZ
AFZKB
AGAYW
AGDGC
AGGDS
AGJBK
AGMZJ
AGQEE
AGQMX
AGRTI
AGWIL
AGWZB
AGYKE
AHAVH
AHBYD
AHKAY
AHSBF
AHYZX
AIAKS
AIIXL
AILAN
AITGF
AJBLW
AJRNO
AJZVZ
AKMHD
ALMA_UNASSIGNED_HOLDINGS
ALWAN
AMKLP
AMXSW
AMYLF
AMYQR
AOCGG
ARMRJ
ASPBG
AVWKF
AXYYD
AZFZN
B-.
BA0
BBWZM
BDATZ
BGNMA
C24
C6C
CAG
COF
CS3
CSCUP
DDRTE
DL5
DNIVK
DPUIP
DU5
EBD
EBLON
EBS
EIOEI
EJD
EMOBN
EN4
EPAXT
ESBYG
F5P
FEDTE
FERAY
FFXSO
FIGPU
FINBP
FNLPD
FRRFC
FSGXE
FWDCC
G-Y
G-Z
GGCAI
GGRSB
GJIRD
GNWQR
GQ6
GQ7
GQ8
GXS
H13
HF~
HG5
HG6
HMJXF
HQYDN
HRMNR
HVGLF
HZ~
I09
IHE
IJ-
IKXTQ
ITM
IWAJR
IXC
IZIGR
IZQ
I~X
I~Z
J-C
J0Z
JBSCW
JCJTX
JZLTJ
KDC
KOV
KOW
KPH
LAK
LLZTM
M4Y
MA-
MVM
N2Q
NB0
NDZJH
NPVJJ
NQJWS
NU0
O9-
O93
O9G
O9I
O9J
OAM
OVD
P19
P2P
PF0
PT5
QOK
QOR
QOS
R4E
R89
R9I
RHV
RNI
RNS
ROL
RPX
RRX
RSV
RZC
RZE
RZK
S16
S1Z
S26
S27
S28
S3A
S3B
SAP
SBL
SBY
SCLPG
SDH
SDM
SHX
SISQX
SNE
SNPRN
SNX
SOHCF
SOJ
SPISZ
SRMVM
SSLCW
SSXJD
STPWE
SV3
SZN
T13
T16
TEORI
TN5
TSG
TSK
TSV
TUC
U2A
U9L
UG4
UOJIU
UTJUX
UZXMN
VC2
VFIZW
W23
W48
WJK
WK6
WK8
YLTOR
Z45
Z7U
Z82
Z87
Z8O
Z8V
Z91
ZGI
ZMTXR
ZOVNA
~A9
~EX
~KM
AAFWJ
AASML
AAYXX
ABDBE
ABFSG
ACSTC
ADHKG
AEZWR
AFHIU
AGQPQ
AHPBZ
AHWEU
AIXLP
AYFIA
CITATION
RPM
CGR
CUY
CVF
ECM
EIF
NPM
7X8
5PM
ID FETCH-LOGICAL-c474t-e8ffcc3e4d9ed05e29bb65690fac9901d2ef0a13bf3759cdb906f70df1d3a5173
IEDL.DBID U2A
ISSN 0272-4340
1573-6830
IngestDate Thu Aug 21 18:41:16 EDT 2025
Fri Jul 11 15:20:35 EDT 2025
Wed Aug 27 13:26:39 EDT 2025
Mon Jul 21 06:02:55 EDT 2025
Thu Apr 24 23:11:23 EDT 2025
Tue Jul 01 01:40:22 EDT 2025
Fri Feb 21 02:49:21 EST 2025
IsDoiOpenAccess false
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 5
Keywords Likability
Incentive salience
Dopamine
Allosteric site
Oxycodone
Language English
License Terms of use and reuse: academic research for non-commercial purposes, see here for full terms. https://www.springer.com/aam-terms-v1
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c474t-e8ffcc3e4d9ed05e29bb65690fac9901d2ef0a13bf3759cdb906f70df1d3a5173
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ObjectType-Review-3
content type line 23
These authors contributed equally to the work.
ORCID 0000-0003-3071-9801
0000-0003-0940-8224
0000-0001-6936-5524
0000-0002-5364-1093
OpenAccessLink https://www.ncbi.nlm.nih.gov/pmc/articles/8155122
PMID 33245509
PQID 2533363372
PQPubID 2043780
PageCount 28
ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_8155122
proquest_miscellaneous_2465439609
proquest_journals_2533363372
pubmed_primary_33245509
crossref_primary_10_1007_s10571_020_01013_y
crossref_citationtrail_10_1007_s10571_020_01013_y
springer_journals_10_1007_s10571_020_01013_y
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2021-07-01
PublicationDateYYYYMMDD 2021-07-01
PublicationDate_xml – month: 07
  year: 2021
  text: 2021-07-01
  day: 01
PublicationDecade 2020
PublicationPlace New York
PublicationPlace_xml – name: New York
– name: Netherlands
PublicationTitle Cellular and molecular neurobiology
PublicationTitleAbbrev Cell Mol Neurobiol
PublicationTitleAlternate Cell Mol Neurobiol
PublicationYear 2021
Publisher Springer US
Springer Nature B.V
Publisher_xml – name: Springer US
– name: Springer Nature B.V
References Cicero, Ellis, Paradis, Ortbal (CR54) 2010; 19
Bostrom, Hammarlund-Udenaes, Simonsson (CR30) 2008; 108
Zheng, Loh, Law (CR283) 2008; 73
Yang, de Jong, Tak, Peck, Bateup, Lammel (CR271) 2018; 97
Kalso (CR119) 2005; 29
Ohbuchi, Miyagi, Suzuki, Mizuhara, Mizuno, Omiya, Yamamoto, Warabi, Sudo, Yokoyama, Miyano, Hirokawa, Uezono (CR188) 2016; 6
Dart, Surratt, Cicero, Parrino, Severtson, Bucher-Bartelson, Green (CR66) 2015; 372
Small, Zatorre, Dagher, Evans, Jones-Gotman (CR229) 2001; 124
Maincent, Zhang (CR162) 2016; 510
Tepper, Tecuapetla, Koos, Ibanez-Sandoval (CR241) 2010; 4
Watson, Babul (CR255) 1998; 50
Cremeans, Gruley, Kyle, Ko (CR64) 2012; 343
Walentiny, Moisa, Beardsley (CR254) 2019; 150
Di Chiara, Imperato (CR73) 1988; 85
Katz, Fernandez, Chang, Benoit, Butler (CR124) 2008; 24
Kalso, Vainio (CR120) 1990; 47
Pontieri, Tanda, Di Chiara (CR204) 1995; 92
King, Reid, Forbes, Hanks (CR129) 2011; 25
Miyazaki, Choi, Rubas, Anand, Ali, Evans, Gursahani, Hennessy, Kim, McWeeney, Pfeiffer, Quach, Gauvin, Riley, Riggs, Gogas, Zalevsky, Doberstein (CR173) 2017; 363
Backlund, Lindgren, Kajimoto, Rosenberg (CR9) 1997; 9
Caraceni, Brunelli, Rocco, Minghetti (CR44) 2013; 79
Emery, Bates, Wellman, Eitan (CR77) 2015; 284
Ford, Mark, Williams (CR84) 2006; 26
Gould, Gunter, Bubser, Matthews, Teal, Ragland, Bridges, Garrison, Winder, Lindsley, Jones (CR89) 2019; 10
Zhang, Zhang, Hang, Liu (CR282) 2020; 11
Nielsen, Ross, Lotfipour, Saini, Edwards, Smith (CR186) 2007; 132
Kringelbach, O'Doherty, Rolls, Andrews (CR134) 2003; 13
Litman, Pagan, Cicero (CR151) 2018; 128
Matsui, Jarvie, Robinson, Hentges, Williams (CR168) 2014; 82
Webster, Henningfield, Buchhalter, Siddhanti, Lu, Odinecs, Di Fonzo, Eldon (CR259) 2018; 19
CR167
Lemberg, Kontinen, Siiskonen, Viljakka, Yli-Kauhaluoma, Korpi, Kalso (CR144) 2006; 105
Altarifi, David, Muchhala, Blough, Akbarali, Negus (CR5) 2017; 31
Hagen, Babul (CR94) 1997; 79
Hu, Calo, Guerrini, Ko (CR104) 2010; 148
Cone, Giordano, Weingarten (CR61) 2013; 131
Livingston, Stanczyk, Burford, Alt, Canals, Traynor (CR155) 2018; 93
Deeks (CR71) 2018; 78
Maddocks, Somogyi, Abbott, Hayball, Parker (CR161) 1996; 12
Comer, Walker, Collins (CR58) 2005; 181
Steiner, Glaser, Hawilo, Berridge (CR237) 2001; 25
de Guglielmo, Matzeu, Kononoff, Mattioni, Martin-Fardon, George (CR69) 2017; 362
Di Giannuario, Pieretti (CR74) 2000; 21
Morales, Margolis (CR176) 2017; 18
Cicero, Inciardi, Munoz (CR53) 2005; 6
Lefevre, Pisansky, Toddes, Baruffaldi, Pravetoni, Tian, Kono, Rothwell (CR143) 2020
Robinson, Berridge (CR215) 2003; 54
Lynch, Nicholson, Dance, Morgan, Foley (CR158) 2010; 60
Lenz, Sandvik, Qvigstad, Bjerkelund, Raeder (CR147) 2009; 109
Cahill (CR41) 2020
Ostlund, LeBlanc, Kosheleff, Wassum, Maidment (CR192) 2014; 39
Fenalti, Giguere, Katritch, Huang, Thompson, Cherezov, Roth, Stevens (CR83) 2014; 506
Werling, Brown, Puttfarcken, Cox (CR260) 1986; 30
Ibanez-Sandoval, Tecuapetla, Unal, Shah, Koos, Tepper (CR106) 2010; 30
Kim, Ahn, Shin, Park, Choi, Kang (CR128) 2018; 97
Kapitzke, Vetter, Cabot (CR122) 2005; 1
Smith, Javed, Elzey, Dewey (CR232) 2003; 985
Nesse, Berridge (CR183) 1997; 278
Nozaki, Saitoh, Kamei (CR187) 2006; 535
Lalovic, Kharasch, Hoffer, Risler, Liu-Chen, Shen (CR138) 2006; 79
Margolis, Hjelmstad, Fujita, Fields (CR165) 2014; 34
Kaiko, Benziger, Fitzmartin, Burke, Reder, Goldenheim (CR118) 1996; 59
Webster, Bath, Medve, Marmon, Stoddard (CR258) 2012; 13
Lemberg, Siiskonen, Kontinen, Yli-Kauhaluoma, Kalso (CR145) 2008; 106
Willuhn, Burgeno, Groblewski, Phillips (CR263) 2014; 17
Zheng, Chu, Zhang, Loh, Law (CR284) 2011; 286
Margolis, Toy, Himmels, Morales, Fields (CR164) 2012; 7
Yang, Yeh, Yeh, Xi, Loh, Law, Tao (CR270) 2016; 111
Blume, Lichtshtein, Boone (CR29) 1979; 76
MacKillop, de Wit (CR160) 2013
Wise (CR265) 1985; 8
Conibear, Kelly (CR62) 2019; 96
Pool, Sennwald, Delplanque, Brosch, Sander (CR205) 2016; 63
Carlson, Nahhas, Martins, Daniulaityte (CR45) 2016; 160
Smith, Gabra, Smith, Redwood, Dewey (CR233) 2007; 127
Wirz, Wartenberg, Nadstawek (CR264) 2005; 1
Bisignano, Burford, Shang, Marlow, Livingston, Fenton, Rockwell, Budenholzer, Traynor, Gerritz, Alt, Filizola (CR26) 2015; 55
Pecina, Berridge (CR197) 2005; 25
Orlowski, Wateska (CR190) 1992; 102
Tian, Xu, Fang, Mogil, Grisel, Grandy, Han (CR242) 1997; 120
Nguyen, Grant, Taffe (CR185) 2019
Ding, Kiguchi, Yasuda, Daga, Polgar, Lu, Czoty, Kishioka, Zaveri, Ko (CR75) 2018
Kemp, Powell (CR125) 1971; 262
Chan, Edwards, Wyse, Smith (CR49) 2008; 35
Ikemoto (CR108) 2010; 35
Severino, Shadfar, Hakimian, Crane, Singh, Heinzerling, Walwyn (CR222) 2018; 9
Vander Weele, Porter-Stransky, Mabrouk, Lovic, Singer, Kennedy, Aragona (CR248) 2014; 40
Minami, Hasegawa, Ito, Nakamura, Tomii, Matsumoto, Orita, Matsushima, Miyoshi, Masuno, Torii, Koike, Shimada, Kanemasa, Kihara, Narita, Suzuki, Kato (CR172) 2009; 111
Pollini, Banta-Green, Cuevas-Mota, Metzner, Teshale, Garfein (CR203) 2011; 2
Codd, Shank, Schupsky, Raffa (CR57) 1995; 274
Svingos, Clarke, Pickel (CR238) 1999; 34
Kim, Ganesan, Luo, Wu, Park, Huang, Chen, Ding (CR127) 2015; 350
Nestler, Malenka (CR184) 2004; 290
Pappagallo, Campbell (CR193) 1994; 35
Ma, Cepeda, Chatta, Franklin, Evans, Levine (CR159) 2012
Raff, Belbachir, El-Tallawy, Ho, Nagtalon, Salti, Seo, Tantri, Wang, Wang, Buemio, Gutierrez, Hadjiat (CR208) 2019; 8
Cone, Darwin, Buchwald, Gorodetzky (CR60) 1983; 11
Wade, Vendruscolo, Schlosburg, Hernandez, Koob (CR253) 2015; 40
Berridge, Robinson (CR20) 2016; 71
Poyhia, Olkkola, Seppala, Kalso (CR207) 1991; 32
Song, Zou, Liu, Guo (CR236) 2010; 12
Anselme, Robinson (CR6) 2016; 42
Young, Havens (CR273) 2012; 107
Jullié, Gondin, von Zastrow, Canals (CR116) 2020; 98
Meredith, Agolia, Arts, Groenewegen, Zahm (CR171) 1992; 50
Yang, Yeh, Loh, Law, Wang, Tao (CR272) 2019; 852
Cicero, Ellis (CR52) 2015; 72
Kathmann, Flau, Redmer, Trankle, Schlicker (CR123) 2006; 372
Ballantyne (CR11) 2015; 26
Siegal, Carlson, Kenne, Swora (CR227) 2003; 67
Livingston, Traynor (CR153) 2014; 111
Brauer, De Wit (CR32) 1997; 56
Butler, Black, Cassidy, Dailey, Budman (CR39) 2011; 8
Riley, Eisenberg, Muller-Schwefe, Drewes, Arendt-Nielsen (CR213) 2008; 24
Hirsch, Proescholdbell, Bronson, Dasgupta (CR102) 2014; 15
Bruera, Belzile, Pituskin, Fainsinger, Darke, Harsanyi, Babul, Ford (CR34) 1998; 16
Bertekap, Burford, Li, Alt (CR25) 2015; 1335
Olson, Duron, Womer, Fell, Streicher (CR189) 2019; 14
Grau, Dasgupta, Harvey, Irwin, Givens, Kinzly, Heimer (CR91) 2007; 16
Lutfy, Eitan, Bryant, Yang, Saliminejad, Walwyn, Kieffer, Takeshima, Carroll, Maidment, Evans (CR157) 2003; 23
Grim, Acevedo-Canabal, Bohn (CR92) 2020; 87
Moradi, Esmaeili, Shoar, Safari (CR175) 2012; 1
Guo, Deng, Lu, Zhao (CR93) 2018; 18
Smith, Berridge, Aldridge (CR234) 2011; 108
Zacny, Gutierrez (CR276) 2008; 9
Paulozzi, Budnitz, Xi (CR195) 2006; 15
Castro, Berridge (CR47) 2014; 34
Caprioli, Calu, Shaham (CR43) 2014; 17
Berridge, Venier, Robinson (CR22) 1989; 103
Butler, Fernandez, Chang, Benoit, Morey, Black, Katz (CR38) 2010; 11
Kopruszinski, Swiokla, Lee, Navratilova, VanderVeen, Yang, Liu, Miyazaki, Schmidt, Zalevsky, Porreca (CR132) 2020
Chu, Zheng, Zhang, Loh, Law (CR51) 2010; 22
Blume (CR28) 1978; 75
Kenny, Chen, Kitamura, Markou, Koob (CR126) 2006; 26
Defalque, Wright (CR72) 2003; 21
CR210
Ventola (CR250) 2011; 36
Yu, Li, Duan, Xu, Li, Tan, Yan (CR274) 2020; 40
Kalso, Poyhia, Onnela, Linko, Tigerstedt, Tammisto (CR121) 1991; 35
Taylor, Raffa, Pergolizzi (CR239) 2012; 5
Lauretti, Oliveira, Pereira (CR139) 2003; 89
Heiskanen, Kalso (CR100) 1997; 73
Shimura, Imaoka, Yamamoto (CR224) 2006; 23
Nasseef, Singh, Ehrlich, McNicholas, Park, Ma, Kulkarni, Kieffer, Darcq (CR181) 2019; 2
De Schepper, Cremonini, Park, Camilleri (CR70) 2004; 16
Ehrich, Messinger, Knakal, Kuhar, Schattauer, Bruchas, Zweifel, Kieffer, Phillips, Chavkin (CR76) 2015; 35
Ross, Smith (CR217) 1997; 73
Labouèbe, Lomazzi, Cruz, Creton, Lujan, Li, Yanagawa, Obata, Watanabe, Wickman, Boyer, Slesinger, Luscher (CR136) 2007; 10
Melief, Miyatake, Bruchas, Chavkin (CR170) 2010; 107
Sheik Amamuddy, Veldman, Manyumwa, Khairallah, Agajanian, Oluyemi, Verkhivker, Tastan Bishop (CR223) 2020
Caldwell, Hale, Boyd, Hague, Iwan, Shi, Lacouture (CR42) 1999; 26
Wu, Lu, Cao (CR268) 2019; 13
Abel, Penson, Joffe, Schapira, Chabner, Lynch (CR1) 2006; 11
Viscusi, Skobieranda, Soergel, Cook, Burt, Singla (CR252) 2019; 12
Van Zee (CR246) 2009; 99
Ito, Dalley, Howes, Robbins, Everitt (CR110) 2000; 20
Bayer, Pickel (CR13) 1990; 10
Zhou, Li, Zhang, Zhang, Zhu, Shen (CR285) 2012; 221
Comer, Sullivan, Whittington, Vosburg, Kowalczyk (CR59) 2008; 33
Williams, Ingram, Henderson, Chavkin, von Zastrow, Schulz, Koch, Evans, Christie (CR262) 2013; 65
Hinkle, Dedkov, Buono, Ferraro (CR101) 2019
Rosenblum, Parrino, Schnoll, Fong, Maxwell, Cleland, Magura, Haddox (CR216) 2007; 90
Webster, Johnson, Stauffer, Setnik, Ciric (CR257) 2011; 11
Phillips, Robinson, Stuber, Carelli, Wightman (CR200) 2003; 79
Koob, Le Moal (CR131) 1997; 278
Kuypers, Desousafernandesperna, Dolder, Toennes, Theunissen, Mason, Hutten, Ramaekers (CR135) 2018; 235
Berrios, Stamatakis, Kantak, McElligott, Judson, Aita, Rougie, Stuber, Philpot (CR24) 2016; 7
Alexander, Mannion, Weingarten, Fanelli, Stiles (CR4) 2014; 138
Pasternak, Snyder (CR194) 1975; 253
Pitman, Puil, Borgland (CR201) 2014; 40
Smith, Hopp, Mundin, Bond, Bailey, Woodward, Bell (CR235) 2012; 50
Johnson, North (CR113) 1992; 12
Singla, Skobieranda, Soergel, Salamea, Burt, Demitrack, Viscusi (CR228) 2019; 19
Lalovic, Phillips, Risler, Howald, Shen (CR137) 2004; 32
CR46
Linz, Christoph, Tzschentke, Koch, Schiene, Gautrois, Schroder, Kogel, Beier, Englberger, Schunk, De Vry, Jahnel, Frosch (CR150) 2014; 349
Childress, Ehrman, Wang, Li, Sciortino, Hakun, Jens, Suh, Listerud, Marquez, Franklin, Langleben, Detre, O'Brien (CR50) 2008; 3
Emery, Bates, Wellman, Eitan (CR78) 2016; 17
Berridge (CR18) 2018; 9
Gavin, Tremper, Smith, Williams, Brooker (CR87) 2017; 7
Liu, Pickens, Burma, Ibarra-Lecue, Yang, Xue, Cook, Hakimian, Severino, Lueptow, Komarek, Taylor, Olmstead, Carroll, Bass, Andrews, Walwyn, Trang, Evans, Leslie, Cahill (CR152) 2019; 39
Bourdy, Barrot (CR31) 2012; 35
Osgood, Eaton, Trudeau, K
RA Pollini (1013_CR203) 2011; 2
Y Shirayama (1013_CR226) 2006; 4
P Bisignano (1013_CR26) 2015; 55
JM Ehrich (1013_CR76) 2015; 35
KC Berridge (1013_CR21) 1991; 105
JT Williams (1013_CR262) 2013; 65
DC Castro (1013_CR48) 2017; 114
J Chu (1013_CR51) 2010; 22
KPC Kuypers (1013_CR135) 2018; 235
JA Adler (1013_CR2) 2018; 11
K Linz (1013_CR150) 2014; 349
KK Lemberg (1013_CR145) 2008; 106
NK Singla (1013_CR228) 2019; 19
EE Codd (1013_CR57) 1995; 274
SD Comer (1013_CR58) 2005; 181
MP Davis (1013_CR67) 2012; 2012
T Miyazaki (1013_CR173) 2017; 363
A Di Giannuario (1013_CR74) 2000; 21
HF Fraser (1013_CR86) 1961; 133
S Pecina (1013_CR197) 2005; 25
EB Margolis (1013_CR165) 2014; 34
ST Frank (1013_CR85) 2008; 62
YI Hser (1013_CR103) 2017; 77
YY Ma (1013_CR159) 2012
J Upadhyay (1013_CR245) 2010; 133
R Poyhia (1013_CR207) 1991; 32
Z Song (1013_CR236) 2010; 12
CL Ventola (1013_CR250) 2011; 36
E Bruera (1013_CR34) 1998; 16
HA Siegal (1013_CR227) 2003; 67
RC Malenka (1013_CR163) 2009
H Yang (1013_CR271) 2018; 97
CM Cahill (1013_CR41) 2020
J MacKillop (1013_CR160) 2013
CK Nielsen (1013_CR186) 2007; 132
A Hirsch (1013_CR102) 2014; 15
B Lalovic (1013_CR138) 2006; 79
KC Berridge (1013_CR20) 2016; 71
J Markman (1013_CR166) 2019; 160
R Buynak (1013_CR40) 2015; 37
TM Hansen (1013_CR98) 2018; 24
RB Rothman (1013_CR218) 2007; 320
KA Pitman (1013_CR201) 2014; 40
CJ Lobb (1013_CR156) 2010; 104
R Poyhia (1013_CR206) 1992; 70
LL Werling (1013_CR260) 1986; 30
R van Zessen (1013_CR247) 2012; 73
SF Butler (1013_CR39) 2011; 8
AL Connors (1013_CR63) 2009; 73
Y Zhou (1013_CR285) 2012; 221
PP Yang (1013_CR272) 2019; 852
CJ Evans (1013_CR80) 2016
1013_CR167
E Kalso (1013_CR121) 1991; 35
I Maddocks (1013_CR161) 1996; 12
SE Hyman (1013_CR105) 2006; 29
L Webster (1013_CR259) 2018; 19
TJ Cicero (1013_CR55) 2012; 367
JH Tian (1013_CR242) 1997; 120
I Willuhn (1013_CR263) 2014; 17
CP Watson (1013_CR255) 1998; 50
JP Orlowski (1013_CR190) 1992; 102
LM Yager (1013_CR269) 2015; 301
JP Zacny (1013_CR276) 2008; 9
M Zhang (1013_CR281) 1998; 285
CM Vander Weele (1013_CR248) 2014; 40
A Dahan (1013_CR65) 2020; 133
J Berrios (1013_CR24) 2016; 7
M Morales (1013_CR176) 2017; 18
SW Johnson (1013_CR113) 1992; 12
R Ito (1013_CR110) 2000; 20
PP Yang (1013_CR270) 2016; 111
LH Brauer (1013_CR32) 1997; 56
EA Johnson (1013_CR114) 2006; 70
J Witteman (1013_CR266) 2015; 232
TS Shippenberg (1013_CR225) 2008; 7
JP Zacny (1013_CR278) 2008; 196
KK Lemberg (1013_CR144) 2006; 105
RM Nesse (1013_CR183) 1997; 278
ER Viscusi (1013_CR252) 2019; 12
JD Woolley (1013_CR267) 2006; 143
JP Zacny (1013_CR277) 2009; 101
T Shimura (1013_CR224) 2006; 23
EM Jutkiewicz (1013_CR117) 2019; 33
AH Beckett (1013_CR14) 1954; 173
P Mucci-LoRusso (1013_CR178) 1998; 2
CL Wade (1013_CR253) 2015; 40
SJ King (1013_CR129) 2011; 25
K Smith (1013_CR235) 2012; 50
M Pappagallo (1013_CR193) 1994; 35
NT Burford (1013_CR37) 2015; 58
M Narita (1013_CR180) 2008; 33
S Pecina (1013_CR196) 2000; 863
AB Fawzi (1013_CR82) 2001; 59
M Bercovitch (1013_CR15) 2006; 20
M Raff (1013_CR208) 2019; 8
TE Robinson (1013_CR215) 2003; 54
K Moore (1013_CR174) 2016; 10
SC Iriah (1013_CR109) 2019; 398
Y Yu (1013_CR274) 2020; 40
EM Peckham (1013_CR198) 2006; 316
LE Grau (1013_CR91) 2007; 16
DA Pena (1013_CR199) 2018
PE Phillips (1013_CR200) 2003; 79
M Jalabert (1013_CR111) 2011; 108
TJ Cicero (1013_CR54) 2010; 19
A Kliewer (1013_CR130) 2020; 177
JL Plummer (1013_CR202) 1990; 40
D Jullié (1013_CR116) 2020; 98
G Di Chiara (1013_CR73) 1988; 85
C Hinkle (1013_CR101) 2019
A Matsui (1013_CR168) 2014; 82
LR Webster (1013_CR258) 2012; 13
M Backlund (1013_CR9) 1997; 9
O Ibanez-Sandoval (1013_CR106) 2010; 30
KE Livingston (1013_CR155) 2018; 93
JE Steiner (1013_CR237) 2001; 25
S Granier (1013_CR90) 2012; 485
EB Margolis (1013_CR164) 2012; 7
AE Conibear (1013_CR62) 2019; 96
CG Jang (1013_CR112) 2013; 225
KC Berridge (1013_CR23) 2009; 9
ML Halls (1013_CR95) 2016; 9
ML Kringelbach (1013_CR133) 2010
SB Ostlund (1013_CR192) 2014; 39
H Zheng (1013_CR283) 2008; 73
K Lutfy (1013_CR157) 2003; 23
H Zheng (1013_CR284) 2011; 286
M Leyton (1013_CR149) 2010
GE Meredith (1013_CR171) 1992; 50
AA Altarifi (1013_CR5) 2017; 31
B Setnik (1013_CR221) 2015; 11
JM Tepper (1013_CR240) 2008; 58
JM Tepper (1013_CR241) 2010; 4
SM Gorka (1013_CR88) 2014; 28
CM Cremeans (1013_CR64) 2012; 343
DF English (1013_CR79) 2011; 15
FB Ross (1013_CR217) 1997; 73
SS Liu (1013_CR152) 2019; 39
NT Burford (1013_CR36) 2014; 19
KE Livingston (1013_CR154) 2018; 175
S Atluri (1013_CR8) 2014; 17
CP Bailey (1013_CR10) 2006; 27
A Rosenblum (1013_CR216) 2007; 90
KM Olson (1013_CR189) 2019; 14
E Bostrom (1013_CR30) 2008; 108
KS Smith (1013_CR234) 2011; 108
PJ Kenny (1013_CR126) 2006; 26
CP Ford (1013_CR84) 2006; 26
1013_CR210
L Zhang (1013_CR282) 2020; 11
H Ding (1013_CR75) 2018
NX Tritsch (1013_CR243) 2014; 3
GW Pasternak (1013_CR194) 1975; 253
MK Kim (1013_CR128) 2018; 97
M Moradi (1013_CR175) 2012; 1
JM Kemp (1013_CR125) 1971; 262
GR Lauretti (1013_CR139) 2003; 89
K Minami (1013_CR172) 2009; 111
J Zacny (1013_CR279) 2003; 69
KC Berridge (1013_CR17) 2000; 24
DC Castro (1013_CR47) 2014; 34
P Anselme (1013_CR6) 2016; 42
SC Harris (1013_CR99) 2014; 54
A Van Zee (1013_CR246) 2009; 99
D Kapitzke (1013_CR122) 2005; 1
E Kalso (1013_CR120) 1990; 47
RW Gould (1013_CR89) 2019; 10
O Ibanez-Sandoval (1013_CR107) 2011; 31
PA Lester (1013_CR148) 2006; 1073–1074
K Ohbuchi (1013_CR188) 2016; 6
K Lee (1013_CR142) 2018; 43
KK Lemberg (1013_CR146) 2009; 1
RS Litman (1013_CR151) 2018; 128
ER Viscusi (1013_CR251) 2016; 157
RG Carlson (1013_CR45) 2016; 160
TW Grim (1013_CR92) 2020; 87
J Wu (1013_CR268) 2019; 13
FL Smith (1013_CR232) 2003; 985
D Remillard (1013_CR212) 2019; 23
H Neelakantan (1013_CR182) 2015; 23
DF Zech (1013_CR280) 1995; 63
GA Abel (1013_CR1) 2006; 11
NA Hagen (1013_CR94) 1997; 79
S Ikemoto (1013_CR108) 2010; 35
EM Lefevre (1013_CR143) 2020
ES Bromberg-Martin (1013_CR33) 2010; 68
RJ Defalque (1013_CR72) 2003; 21
ML Kringelbach (1013_CR134) 2003; 13
JD Nguyen (1013_CR185) 2019
AM Young (1013_CR273) 2012; 107
KS Smith (1013_CR230) 2005; 25
JC Ballantyne (1013_CR11) 2015; 26
EJ Cone (1013_CR60) 1983; 11
TE Robinson (1013_CR214) 1993; 18
JD Jones (1013_CR115) 2019; 186
T Saigusa (1013_CR220) 2008; 581
J Maincent (1013_CR162) 2016; 510
E Pool (1013_CR205) 2016; 63
DM Walentiny (1013_CR254) 2019; 150
RF Kaiko (1013_CR118) 1996; 59
R Bourdy (1013_CR31) 2012; 35
J Riley (1013_CR213) 2008; 24
JR Caldwell (1013_CR42) 1999; 26
VE Bayer (1013_CR13) 1990; 10
AJ Blume (1013_CR28) 1978; 75
DL Murphy (1013_CR179) 2018; 41
G Fenalti (1013_CR83) 2014; 506
Y Aono (1013_CR7) 2008; 580
GW Hanks (1013_CR97) 2001; 84
DM Small (1013_CR229) 2001; 124
G de Guglielmo (1013_CR69) 2017; 362
TM Tzschentke (1013_CR244) 2018; 129
NT Burford (1013_CR35) 2013; 110
PD Gavin (1013_CR87) 2017; 7
KC Berridge (1013_CR19) 2015; 86
T Heiskanen (1013_CR100) 1997; 73
RA Wise (1013_CR265) 1985; 8
B Lalovic (1013_CR137) 2004; 32
SH Ahmed (1013_CR3) 2002; 5
LJ Paulozzi (1013_CR195) 2006; 15
TJ Cicero (1013_CR56) 2013; 154
ED Deeks (1013_CR71) 2018; 78
LR Webster (1013_CR257) 2011; 11
KE Livingston (1013_CR153) 2014; 111
MA Emery (1013_CR78) 2016; 17
JP Zacny (1013_CR275) 2003; 170
O Sheik Amamuddy (1013_CR223) 2020
AJ Blume (1013_CR29) 1979; 76
M Kathmann (1013_CR123) 2006; 372
M Remesic (1013_CR211) 2017; 8
SD Bergese (1013_CR16) 2019; 12
KS Smith (1013_CR231) 2007; 27
SD Comer (1013_CR59) 2008; 33
KC Berridge (1013_CR18) 2018; 9
H Lenz (1013_CR147) 2009; 109
1013_CR302
GF Koob (1013_CR131) 1997; 278
S Wirz (1013_CR264) 2005; 1
AT Caraceni (1013_CR44) 2013; 79
KK Guo (1013_CR93) 2018; 18
1013_CR301
1013_CR300
KC Berridge (1013_CR22) 1989; 103
EJ Cone (1013_CR61) 2013; 131
PJ Vaysse (1013_CR249) 1987; 241
N Katz (1013_CR124) 2008; 24
D Caprioli (1013_CR43) 2014; 17
JI Kim (1013_CR127) 2015; 350
PY Law (1013_CR141) 2000; 40
MA Emery (1013_CR77) 2015; 284
X Ruan (1013_CR219) 2017; 35
E Hu (1013_CR104) 2010; 148
H de Wit (1013_CR68) 2012; 36
S Chan (1013_CR49) 2008; 35
L Alexander (1013_CR4) 2014; 138
ME Morean (1013_CR177) 2013; 227
RB Raffa (1013_CR209) 2017; 42
SF Butler (1013_CR38) 2010; 11
DM McMillan (1013_CR169) 2018; 184
CP Watson (1013_CR256) 2003; 105
HU De Schepper (1013_CR70) 2004; 16
KM Fain (1013_CR81) 2014; 52
EJ Nestler (1013_CR184) 2004; 290
G Labouèbe (1013_CR136) 2007; 10
C Nozaki (1013_CR187) 2006; 535
FE Pontieri (1013_CR204) 1995; 92
E Kalso (1013_CR119) 2005; 29
PY Law (1013_CR140) 1983; 24
AL Svingos (1013_CR238) 1999; 34
TJ Cicero (1013_CR53) 2005; 6
CA Blackwood (1013_CR27) 2020
RL Bertekap (1013_CR25) 2015; 1335
FL Smith (1013_CR233) 2007; 127
AR Childress (1013_CR50) 2008; 3
CM Kopruszinski (1013_CR132) 2020
AL Severino (1013_CR222) 2018; 9
RC Dart (1013_CR66) 2015; 372
R Taylor Jr (1013_CR239) 2012; 5
TJ Cicero (1013_CR52) 2015; 72
K Hamunen (1013_CR96) 2009; 13
R Wightman (1013_CR261) 2012; 8
1013_CR46
MT Nasseef (1013_CR181) 2019; 2
WJ Lynch (1013_CR158) 2010; 60
EJ Melief (1013_CR170) 2010; 107
ED Osgood (1013_CR191) 2012; 38
M Barrot (1013_CR12) 2012; 32
References_xml – volume: 21
  start-page: 1125
  issue: 7
  year: 2000
  end-page: 1130
  ident: CR74
  article-title: Nociceptin differentially affects morphine-induced dopamine release from the nucleus accumbens and nucleus caudate in rats
  publication-title: Peptides
  doi: 10.1016/s0196-9781(00)00250-3
– volume: 363
  start-page: 104
  issue: 1
  year: 2017
  end-page: 113
  ident: CR173
  article-title: NKTR-181: a novel mu-opioid analgesic with inherently low abuse potential
  publication-title: J Pharmacol Exp Ther
  doi: 10.1124/jpet.117.243030
– volume: 27
  start-page: 1594
  issue: 7
  year: 2007
  end-page: 1605
  ident: CR231
  article-title: Opioid limbic circuit for reward: interaction between hedonic hotspots of nucleus accumbens and ventral pallidum
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.4205-06.2007
– volume: 17
  start-page: 908
  issue: 5
  year: 2016
  end-page: 914
  ident: CR78
  article-title: Differential effects of oxycodone, hydrocodone, and morphine on activation levels of signaling molecules
  publication-title: Pain Med
  doi: 10.1111/pme.12918
– volume: 38
  start-page: 166
  issue: 2
  year: 2012
  end-page: 170
  ident: CR191
  article-title: A brief survey to characterize oxycodone abuse patterns in adolescents enrolled in two substance abuse recovery high schools
  publication-title: Am J Drug Alcohol Abuse
  doi: 10.3109/00952990.2011.643994
– volume: 985
  start-page: 78
  issue: 1
  year: 2003
  end-page: 88
  ident: CR232
  article-title: The expression of a high level of morphine antinociceptive tolerance in mice involves both PKC and PKA
  publication-title: Brain Res
  doi: 10.1016/s0006-8993(03)03170-6
– volume: 19
  start-page: 307
  issue: 2
  year: 2018
  end-page: 318
  ident: CR259
  article-title: Human abuse potential of the new opioid analgesic molecule NKTR-181 compared with oxycodone
  publication-title: Pain Med
  doi: 10.1093/pm/pnw344
– volume: 10
  start-page: 1559
  issue: 12
  year: 2007
  end-page: 1568
  ident: CR136
  article-title: RGS2 modulates coupling between GABAB receptors and GIRK channels in dopamine neurons of the ventral tegmental area
  publication-title: Nat Neurosci
  doi: 10.1038/nn2006
– ident: CR167
– volume: 34
  start-page: 14707
  issue: 44
  year: 2014
  end-page: 14716
  ident: CR165
  article-title: Direct bidirectional mu-opioid control of midbrain dopamine neurons
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.2144-14.2014
– year: 2019
  ident: CR185
  article-title: Paradoxical changes in brain reward status during opioid self-administration in a novel test of the negative reinforcement hypothesis
  publication-title: bioRxiv
  doi: 10.1101/460048
– volume: 320
  start-page: 801
  issue: 2
  year: 2007
  end-page: 810
  ident: CR218
  article-title: Salvinorin A: allosteric interactions at the mu-opioid receptor
  publication-title: J Pharmacol Exp Ther
  doi: 10.1124/jpet.106.113167
– volume: 1
  start-page: 262
  issue: 4
  year: 2012
  end-page: 264
  ident: CR175
  article-title: Use of oxycodone in pain management
  publication-title: Anesth Pain Med
  doi: 10.5812/aapm.4529
– volume: 581
  start-page: 276
  issue: 3
  year: 2008
  end-page: 282
  ident: CR220
  article-title: Role of GABA B receptors in the endomorphin-1-, but not endomorphin-2-, induced dopamine efflux in the nucleus accumbens of freely moving rats
  publication-title: Eur J Pharmacol
  doi: 10.1016/j.ejphar.2007.12.008
– volume: 97
  start-page: e13385
  issue: 49
  year: 2018
  ident: CR128
  article-title: Comparison of analgesic efficacy of oxycodone and fentanyl after total hip replacement surgery: a randomized controlled trial
  publication-title: Medicine (Baltimore)
  doi: 10.1097/MD.0000000000013385
– volume: 18
  start-page: 73
  issue: 2
  year: 2017
  end-page: 85
  ident: CR176
  article-title: Ventral tegmental area: cellular heterogeneity, connectivity and behaviour
  publication-title: Nat Rev Neurosci
  doi: 10.1038/nrn.2016.165
– volume: 32
  start-page: 447
  issue: 4
  year: 2004
  end-page: 454
  ident: CR137
  article-title: Quantitative contribution of CYP2D6 and CYP3A to oxycodone metabolism in human liver and intestinal microsomes
  publication-title: Drug Metab Dispos
  doi: 10.1124/dmd.32.4.447
– volume: 2
  start-page: 239
  issue: 3
  year: 1998
  end-page: 249
  ident: CR178
  article-title: Controlled-release oxycodone compared with controlled-release morphine in the treatment of cancer pain: a randomized, double-blind, parallel-group study
  publication-title: Eur J Pain
  doi: 10.1016/s1090-3801(98)90020-9
– volume: 97
  start-page: 434
  issue: 2
  year: 2018
  end-page: 449
  ident: CR271
  article-title: Nucleus accumbens subnuclei regulate motivated behavior via direct inhibition and disinhibition of VTA dopamine subpopulations
  publication-title: Neuron
  doi: 10.1016/j.neuron.2017.12.022
– volume: 9
  start-page: 1647
  year: 2018
  ident: CR18
  article-title: Evolving concepts of emotion and motivation
  publication-title: Front Psychol
  doi: 10.3389/fpsyg.2018.01647
– volume: 52
  start-page: 291
  issue: 4
  year: 2014
  end-page: 293
  ident: CR81
  article-title: Mind the gap: understanding the effects of pharmaceutical direct-to-consumer advertising
  publication-title: Med Care
  doi: 10.1097/MLR.0000000000000126
– volume: 17
  start-page: 644
  issue: 5
  year: 2014
  end-page: 646
  ident: CR43
  article-title: Loss of phasic dopamine: a new addiction marker?
  publication-title: Nat Neurosci
  doi: 10.1038/nn.3699
– volume: 12
  start-page: 483
  issue: 2
  year: 1992
  end-page: 488
  ident: CR113
  article-title: Opioids excite dopamine neurons by hyperpolarization of local interneurons
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.12-02-00483.1992
– volume: 150
  start-page: 210
  year: 2019
  end-page: 216
  ident: CR254
  article-title: Oxycodone-like discriminative stimulus effects of fentanyl-related emerging drugs of abuse in mice
  publication-title: Neuropharmacology
  doi: 10.1016/j.neuropharm.2019.02.007
– volume: 7
  start-page: 10702
  year: 2016
  ident: CR24
  article-title: Loss of UBE3A from TH-expressing neurons suppresses GABA co-release and enhances VTA-NAc optical self-stimulation
  publication-title: Nat Commun
  doi: 10.1038/ncomms10702
– volume: 143
  start-page: 309
  issue: 1
  year: 2006
  end-page: 317
  ident: CR267
  article-title: Nucleus accumbens opioids regulate flavor-based preferences in food consumption
  publication-title: Neuroscience
  doi: 10.1016/j.neuroscience.2006.06.067
– volume: 24
  start-page: 413
  issue: 3
  year: 1983
  end-page: 424
  ident: CR140
  article-title: Opiate receptor down-regulation and desensitization in neuroblastoma X glioma NG108-15 hybrid cells are two separate cellular adaptation processes
  publication-title: Mol Pharmacol
– volume: 114
  start-page: E9125
  issue: 43
  year: 2017
  end-page: E9134
  ident: CR48
  article-title: Opioid and orexin hedonic hotspots in rat orbitofrontal cortex and insula
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.1705753114
– volume: 7
  start-page: e42365
  issue: 7
  year: 2012
  ident: CR164
  article-title: Identification of rat ventral tegmental area GABAergic neurons
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0042365
– volume: 40
  start-page: 389
  year: 2000
  end-page: 430
  ident: CR141
  article-title: Molecular mechanisms and regulation of opioid receptor signaling
  publication-title: Annu Rev Pharmacol Toxicol
  doi: 10.1146/annurev.pharmtox.40.1.389
– volume: 37
  start-page: 2420
  issue: 11
  year: 2015
  end-page: 2438
  ident: CR40
  article-title: Long-term safety and efficacy of tapentadol extended release following up to 2 years of treatment in patients with moderate to severe, chronic pain: results of an open-label extension trial
  publication-title: Clin Ther
  doi: 10.1016/j.clinthera.2015.08.014
– volume: 11
  start-page: 323
  year: 2018
  end-page: 332
  ident: CR2
  article-title: An overview of abuse-deterrent opioids and recommendations for practical patient care
  publication-title: J Multidiscip Healthc
  doi: 10.2147/JMDH.S166915
– volume: 9
  start-page: 65
  issue: 1
  year: 2009
  end-page: 73
  ident: CR23
  article-title: Dissecting components of reward: 'liking', 'wanting', and learning
  publication-title: Curr Opin Pharmacol
  doi: 10.1016/j.coph.2008.12.014
– volume: 290
  start-page: 78
  issue: 3
  year: 2004
  end-page: 85
  ident: CR184
  article-title: The addicted brain
  publication-title: Sci Am
  doi: 10.1038/scientificamerican0304-78
– volume: 108
  start-page: E255
  issue: 27
  year: 2011
  end-page: 264
  ident: CR234
  article-title: Disentangling pleasure from incentive salience and learning signals in brain reward circuitry
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.1101920108
– volume: 398
  start-page: 88
  year: 2019
  end-page: 101
  ident: CR109
  article-title: Oxycodone exposure: a magnetic resonance imaging study in response to acute and chronic oxycodone treatment in rats
  publication-title: Neuroscience
  doi: 10.1016/j.neuroscience.2018.11.042
– volume: 350
  start-page: 102
  issue: 6256
  year: 2015
  end-page: 106
  ident: CR127
  article-title: Aldehyde dehydrogenase 1a1 mediates a GABA synthesis pathway in midbrain dopaminergic neurons
  publication-title: Science
  doi: 10.1126/science.aac4690
– volume: 580
  start-page: 87
  issue: 1–2
  year: 2008
  end-page: 94
  ident: CR7
  article-title: Role of GABAA receptors in the endomorphin-1-, but not endomorphin-2-, induced dopamine efflux in the nucleus accumbens of freely moving rats
  publication-title: Eur J Pharmacol
  doi: 10.1016/j.ejphar.2007.10.020
– volume: 24
  start-page: 528
  issue: 6
  year: 2008
  end-page: 535
  ident: CR124
  article-title: Internet-based survey of nonmedical prescription opioid use in the United States
  publication-title: Clin J Pain
  doi: 10.1097/AJP.0b013e318167a087
– volume: 32
  start-page: 516
  issue: 4
  year: 1991
  end-page: 518
  ident: CR207
  article-title: The pharmacokinetics of oxycodone after intravenous injection in adults
  publication-title: Br J Clin Pharmacol
  doi: 10.1111/j.1365-2125.1991.tb03942.x
– volume: 35
  start-page: e163
  issue: 2
  year: 2017
  end-page: e174
  ident: CR219
  article-title: Revisiting Oxycodone Analgesia: A Review And Hypothesis
  publication-title: Anesthesiol Clin
  doi: 10.1016/j.anclin.2017.01.022
– volume: 15
  start-page: 123
  issue: 1
  year: 2011
  end-page: 130
  ident: CR79
  article-title: GABAergic circuits mediate the reinforcement-related signals of striatal cholinergic interneurons
  publication-title: Nat Neurosci
  doi: 10.1038/nn.2984
– volume: 103
  start-page: 36
  issue: 1
  year: 1989
  end-page: 45
  ident: CR22
  article-title: Taste reactivity analysis of 6-hydroxydopamine-induced aphagia: implications for arousal and anhedonia hypotheses of dopamine function
  publication-title: Behav Neurosci
  doi: 10.1037//0735-7044.103.1.36
– volume: 101
  start-page: 107
  issue: 1–2
  year: 2009
  end-page: 114
  ident: CR277
  article-title: Within-subject comparison of the psychopharmacological profiles of oral hydrocodone and oxycodone combination products in non-drug-abusing volunteers
  publication-title: Drug Alcohol Depend
  doi: 10.1016/j.drugalcdep.2008.11.013
– volume: 25
  start-page: 454
  issue: 5
  year: 2011
  end-page: 470
  ident: CR129
  article-title: A systematic review of oxycodone in the management of cancer pain
  publication-title: Palliat Med
  doi: 10.1177/0269216311401948
– year: 2020
  ident: CR143
  article-title: Interruption of continuous opioid exposure exacerbates drug-evoked adaptations in the mesolimbic dopamine system
  publication-title: Neuropsychopharmacology
  doi: 10.1038/s41386-020-0643-x
– volume: 67
  start-page: 942
  issue: 5
  year: 2003
  end-page: 945
  ident: CR227
  article-title: Probable relationship between opioid abuse and heroin use
  publication-title: Am Fam Physician
– volume: 221
  start-page: 171
  issue: 1
  year: 2012
  end-page: 176
  ident: CR285
  article-title: Behavioural approach tendencies to heroin-related stimuli in abstinent heroin abusers
  publication-title: Psychopharmacology (Berl)
  doi: 10.1007/s00213-011-2557-0
– volume: 26
  start-page: 5894
  issue: 22
  year: 2006
  end-page: 5900
  ident: CR126
  article-title: Conditioned withdrawal drives heroin consumption and decreases reward sensitivity
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.0740-06.2006
– volume: 173
  start-page: 1231
  issue: 4417
  year: 1954
  end-page: 1232
  ident: CR14
  article-title: Stereochemistry of certain analgesics
  publication-title: Nature
  doi: 10.1038/1731231a0
– volume: 232
  start-page: 3685
  issue: 20
  year: 2015
  end-page: 3696
  ident: CR266
  article-title: Cue reactivity and its relation to craving and relapse in alcohol dependence: a combined laboratory and field study
  publication-title: Psychopharmacology (Berl)
  doi: 10.1007/s00213-015-4027-6
– volume: 111
  start-page: 867
  year: 2016
  end-page: 876
  ident: CR270
  article-title: Activation of delta-opioid receptor contributes to the antinociceptive effect of oxycodone in mice
  publication-title: Pharmacol Res
  doi: 10.1016/j.phrs.2016.05.034
– year: 2020
  ident: CR41
  article-title: Opioid dose regimen shapes mesolimbic adaptations
  publication-title: Neuropsychopharmacology
  doi: 10.1038/s41386-020-0679-y
– year: 2018
  ident: CR75
  article-title: A bifunctional nociceptin and mu opioid receptor agonist is analgesic without opioid side effects in nonhuman primates
  publication-title: Sci Transl Med
  doi: 10.1126/scitranslmed.aar3483
– volume: 108
  start-page: 495
  issue: 3
  year: 2008
  end-page: 505
  ident: CR30
  article-title: Blood–brain barrier transport helps to explain discrepancies in in vivo potency between oxycodone and morphine
  publication-title: Anesthesiology
  doi: 10.1097/ALN.0b013e318164cf9e
– volume: 79
  start-page: 906
  issue: 8
  year: 2013
  end-page: 914
  ident: CR44
  article-title: Trends in opioid analgesics sales to community pharmacies and hospitals in Italy (2000–2010)
  publication-title: Minerva Anestesiol
– volume: 8
  start-page: 178
  year: 1985
  end-page: 186
  ident: CR265
  article-title: The anhedonia hypothesis: Mark III
  publication-title: Behav Brain Sci
  doi: 10.1017/s0140525x00020306
– volume: 225
  start-page: 753
  issue: 3
  year: 2013
  end-page: 763
  ident: CR112
  article-title: A dysphoric-like state during early withdrawal from extended access to methamphetamine self-administration in rats
  publication-title: Psychopharmacology (Berl)
  doi: 10.1007/s00213-012-2864-0
– volume: 43
  start-page: 2606
  issue: 13
  year: 2018
  end-page: 2614
  ident: CR142
  article-title: The gut microbiota mediates reward and sensory responses associated with regimen-selective morphine dependence
  publication-title: Neuropsychopharmacology
  doi: 10.1038/s41386-018-0211-9
– volume: 73
  start-page: 243
  issue: 1
  year: 2009
  end-page: 282
  ident: CR63
  article-title: Big bad pharma: an ethical analysis of physician-directed and consumer-directed marketing tactics
  publication-title: Albany Law Rev
– volume: 6
  start-page: 662
  issue: 10
  year: 2005
  end-page: 672
  ident: CR53
  article-title: Trends in abuse of Oxycontin and other opioid analgesics in the United States: 2002–2004
  publication-title: J Pain
  doi: 10.1016/j.jpain.2005.05.004
– volume: 253
  start-page: 563
  issue: 5492
  year: 1975
  end-page: 565
  ident: CR194
  article-title: Identification of novel high affinity opiate receptor binding in rat brain
  publication-title: Nature
  doi: 10.1038/253563a0
– volume: 367
  start-page: 187
  issue: 2
  year: 2012
  end-page: 189
  ident: CR55
  article-title: Effect of abuse-deterrent formulation of OxyContin
  publication-title: N Engl J Med
  doi: 10.1056/NEJMc1204141
– volume: 16
  start-page: 383
  issue: 4
  year: 2004
  end-page: 394
  ident: CR70
  article-title: Opioids and the gut: pharmacology and current clinical experience
  publication-title: Neurogastroenterol Motil
  doi: 10.1111/j.1365-2982.2004.00513.x
– volume: 58
  start-page: 272
  issue: 2
  year: 2008
  end-page: 281
  ident: CR240
  article-title: Feedforward and feedback inhibition in neostriatal GABAergic spiny neurons
  publication-title: Brain Res Rev
  doi: 10.1016/j.brainresrev.2007.10.008
– volume: 11
  start-page: 67
  issue: 1
  year: 2010
  end-page: 80
  ident: CR38
  article-title: Measuring attractiveness for abuse of prescription opioids
  publication-title: Pain Med
  doi: 10.1111/j.1526-4637.2009.00736.x
– volume: 25
  start-page: 8637
  issue: 38
  year: 2005
  end-page: 8649
  ident: CR230
  article-title: The ventral pallidum and hedonic reward: neurochemical maps of sucrose "liking" and food intake
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.1902-05.2005
– year: 2018
  ident: CR199
  article-title: Exploring morphine-triggered PKC-targets and their interaction with signaling pathways leading to pain via TrkA
  publication-title: Proteomes
  doi: 10.3390/proteomes6040039
– volume: 25
  start-page: 53
  issue: 1
  year: 2001
  end-page: 74
  ident: CR237
  article-title: Comparative expression of hedonic impact: affective reactions to taste by human infants and other primates
  publication-title: Neurosci Biobehav Rev
  doi: 10.1016/s0149-7634(00)00051-8
– volume: 9
  start-page: 30
  issue: 1
  year: 1997
  end-page: 35
  ident: CR9
  article-title: Comparison of epidural morphine and oxycodone for pain after abdominal surgery
  publication-title: J Clin Anesth
  doi: 10.1016/S0952-8180(96)00212-7
– volume: 18
  start-page: 132
  issue: 1
  year: 2018
  ident: CR93
  article-title: Comparison of analgesic effect of oxycodone and morphine on patients with moderate and advanced cancer pain: a meta-analysis
  publication-title: BMC Anesthesiol
  doi: 10.1186/s12871-018-0583-8
– volume: 35
  start-page: S54
  year: 1994
  end-page: 56
  ident: CR193
  article-title: Chronic opioid therapy as alternative treatment for post-herpetic neuralgia
  publication-title: Ann Neurol
  doi: 10.1002/ana.410350716
– volume: 316
  start-page: 1195
  issue: 3
  year: 2006
  end-page: 1201
  ident: CR198
  article-title: Comparison of the antinociceptive response to morphine and morphine-like compounds in male and female Sprague-Dawley rats
  publication-title: J Pharmacol Exp Ther
  doi: 10.1124/jpet.105.094276
– volume: 506
  start-page: 191
  issue: 7487
  year: 2014
  end-page: 196
  ident: CR83
  article-title: Molecular control of delta-opioid receptor signalling
  publication-title: Nature
  doi: 10.1038/nature12944
– volume: 274
  start-page: 1263
  issue: 3
  year: 1995
  end-page: 1270
  ident: CR57
  article-title: Serotonin and norepinephrine uptake inhibiting activity of centrally acting analgesics: structural determinants and role in antinociception
  publication-title: J Pharmacol Exp Ther
– volume: 39
  start-page: 4162
  issue: 21
  year: 2019
  end-page: 4178
  ident: CR152
  article-title: Kappa opioid receptors drive a tonic aversive component of chronic pain
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.0274-19.2019
– volume: 131
  start-page: 100
  issue: 1–2
  year: 2013
  end-page: 105
  ident: CR61
  article-title: An iterative model for in vitro laboratory assessment of tamper deterrent formulations
  publication-title: Drug Alcohol Depend
  doi: 10.1016/j.drugalcdep.2012.12.006
– volume: 35
  start-page: 681
  issue: 11
  year: 2012
  end-page: 690
  ident: CR31
  article-title: A new control center for dopaminergic systems: pulling the VTA by the tail
  publication-title: Trends Neurosci
  doi: 10.1016/j.tins.2012.06.007
– volume: 9
  start-page: 16
  issue: 414
  year: 2016
  ident: CR95
  article-title: Plasma membrane localization of the mu-opioid receptor controls spatiotemporal signaling
  publication-title: Sci Signal
  doi: 10.1126/scisignal.aac9177
– volume: 362
  start-page: 378
  issue: 3
  year: 2017
  end-page: 384
  ident: CR69
  article-title: Cebranopadol blocks the escalation of cocaine intake and conditioned reinstatement of cocaine seeking in rats
  publication-title: J Pharmacol Exp Ther
  doi: 10.1124/jpet.117.241042
– volume: 92
  start-page: 12304
  issue: 26
  year: 1995
  end-page: 12308
  ident: CR204
  article-title: Intravenous cocaine, morphine, and amphetamine preferentially increase extracellular dopamine in the "shell" as compared with the "core" of the rat nucleus accumbens
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.92.26.12304
– volume: 72
  start-page: 424
  issue: 5
  year: 2015
  end-page: 430
  ident: CR52
  article-title: Abuse-deterrent formulations and the prescription opioid abuse epidemic in the United States: lessons learned from OxyContin
  publication-title: JAMA Psychiatry
  doi: 10.1001/jamapsychiatry.2014.3043
– year: 2013
  ident: CR160
  publication-title: The Wiley-Blackwell handbook of addiction psychopharmacology
  doi: 10.1002/9781118384404
– volume: 1335
  start-page: 223
  year: 2015
  end-page: 240
  ident: CR25
  article-title: High-throughput screening for allosteric modulators of GPCRs
  publication-title: Methods Mol Biol
  doi: 10.1007/978-1-4939-2914-6_15
– volume: 160
  start-page: 127
  year: 2016
  end-page: 134
  ident: CR45
  article-title: Predictors of transition to heroin use among initially non-opioid dependent illicit pharmaceutical opioid users: A natural history study
  publication-title: Drug Alcohol Depend
  doi: 10.1016/j.drugalcdep.2015.12.026
– volume: 12
  start-page: 3113
  year: 2019
  end-page: 3126
  ident: CR16
  article-title: ATHENA: a phase 3, open-label study of the safety and effectiveness of oliceridine (TRV130), a G-protein selective agonist at the micro-opioid receptor, in patients with moderate to severe acute pain requiring parenteral opioid therapy
  publication-title: J Pain Res
  doi: 10.2147/JPR.S217563
– volume: 4
  start-page: 150
  year: 2010
  ident: CR241
  article-title: Heterogeneity and diversity of striatal GABAergic interneurons
  publication-title: Front Neuroanat
  doi: 10.3389/fnana.2010.00150
– volume: 106
  start-page: 463
  issue: 2
  year: 2008
  end-page: 470
  ident: CR145
  article-title: Pharmacological characterization of noroxymorphone as a new opioid for spinal analgesia
  publication-title: Anesth Analg
  doi: 10.1213/ane.0b013e3181605a15
– volume: 286
  start-page: 12724
  issue: 14
  year: 2011
  end-page: 12733
  ident: CR284
  article-title: Modulating micro-opioid receptor phosphorylation switches agonist-dependent signaling as reflected in PKCepsilon activation and dendritic spine stability
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M110.177089
– volume: 1
  start-page: 279
  issue: 4
  year: 2005
  end-page: 297
  ident: CR122
  article-title: Endogenous opioid analgesia in peripheral tissues and the clinical implications for pain control
  publication-title: Ther Clin Risk Manag
– volume: 60
  start-page: 177
  issue: 3
  year: 2010
  end-page: 188
  ident: CR158
  article-title: Animal models of substance abuse and addiction: implications for science, animal welfare, and society
  publication-title: Comp Med
– ident: CR302
– volume: 40
  start-page: 339
  issue: 3
  year: 1990
  end-page: 347
  ident: CR202
  article-title: Influence of polarity on dose-response relationships of intrathecal opioids in rats
  publication-title: Pain
  doi: 10.1016/0304-3959(90)91131-2
– volume: 133
  start-page: 2098
  issue: Pt7
  year: 2010
  end-page: 2114
  ident: CR245
  article-title: Alterations in brain structure and functional connectivity in prescription opioid-dependent patients
  publication-title: Brain
  doi: 10.1093/brain/awq138
– volume: 105
  start-page: 801
  issue: 4
  year: 2006
  end-page: 812
  ident: CR144
  article-title: Antinociception by spinal and systemic oxycodone: why does the route make a difference? In vitro and in vivo studies in rats
  publication-title: Anesthesiology
  doi: 10.1097/00000542-200610000-00027
– volume: 11
  start-page: 1078
  year: 2020
  ident: CR282
  article-title: Mu opioid receptor heterodimers emerge as novel therapeutic targets: recent progress and future perspective
  publication-title: Front Pharmacol
  doi: 10.3389/fphar.2020.01078
– volume: 1073–1074
  start-page: 290
  year: 2006
  end-page: 296
  ident: CR148
  article-title: Comparison of the in vitro efficacy of mu, delta, kappa and ORL1 receptor agonists and non-selective opioid agonists in dog brain membranes
  publication-title: Brain Res
  doi: 10.1016/j.brainres.2005.12.066
– volume: 33
  start-page: 1097
  issue: 5
  year: 2008
  end-page: 1112
  ident: CR180
  article-title: Comparative pharmacological profiles of morphine and oxycodone under a neuropathic pain-like state in mice: evidence for less sensitivity to morphine
  publication-title: Neuropsychopharmacology
  doi: 10.1038/sj.npp.1301471
– volume: 102
  start-page: 270
  issue: 1
  year: 1992
  end-page: 273
  ident: CR190
  article-title: The effects of pharmaceutical firm enticements on physician prescribing patterns. There's no such thing as a free lunch
  publication-title: Chest
  doi: 10.1378/chest.102.1.270
– volume: 184
  start-page: 189
  year: 2018
  end-page: 200
  ident: CR169
  article-title: CYP-mediated drug metabolism in the brain impacts drug response
  publication-title: Pharmacol Ther
  doi: 10.1016/j.pharmthera.2017.10.008
– volume: 157
  start-page: 264
  issue: 1
  year: 2016
  end-page: 272
  ident: CR251
  article-title: A randomized, phase 2 study investigating TRV130, a biased ligand of the mu-opioid receptor, for the intravenous treatment of acute pain
  publication-title: Pain
  doi: 10.1097/j.pain.0000000000000363
– volume: 278
  start-page: 52
  issue: 5335
  year: 1997
  end-page: 58
  ident: CR131
  article-title: Drug abuse: hedonic homeostatic dysregulation
  publication-title: Science
  doi: 10.1126/science.278.5335.52
– year: 2019
  ident: CR101
  article-title: Colocalization of MOR1 and GAD67 in mouse nucleus accumbens
  publication-title: bioRxiv
  doi: 10.1101/574434
– volume: 5
  start-page: 77
  year: 2012
  end-page: 87
  ident: CR239
  article-title: Controlled release formulation of oxycodone in patients with moderate to severe chronic osteoarthritis: a critical review of the literature
  publication-title: J Pain Res
  doi: 10.2147/JPR.S21965
– volume: 8
  start-page: 29
  year: 2011
  ident: CR39
  article-title: Abuse risks and routes of administration of different prescription opioid compounds and formulations
  publication-title: Harm Reduct J
  doi: 10.1186/1477-7517-8-29
– volume: 41
  start-page: 787
  issue: 8
  year: 2018
  end-page: 795
  ident: CR179
  article-title: Comparative rates of mortality and serious adverse effects among commonly prescribed opioid analgesics
  publication-title: Drug Saf
  doi: 10.1007/s40264-018-0660-4
– volume: 30
  start-page: 90
  issue: 2
  year: 1986
  end-page: 95
  ident: CR260
  article-title: Sodium regulation of agonist binding at opioid receptors. II. Effects of sodium replacement on opioid binding in guinea pig cortical membranes
  publication-title: Mol Pharmacol
– volume: 170
  start-page: 242
  issue: 3
  year: 2003
  end-page: 254
  ident: CR275
  article-title: Characterizing the subjective, psychomotor, and physiological effects of oral oxycodone in non-drug-abusing volunteers
  publication-title: Psychopharmacology (Berl)
  doi: 10.1007/s00213-003-1540-9
– volume: 138
  start-page: 1
  year: 2014
  end-page: 6
  ident: CR4
  article-title: Development and impact of prescription opioid abuse deterrent formulation technologies
  publication-title: Drug Alcohol Depend
  doi: 10.1016/j.drugalcdep.2014.02.006
– volume: 96
  start-page: 542
  issue: 5
  year: 2019
  end-page: 549
  ident: CR62
  article-title: A biased view of mu-opioid receptors?
  publication-title: Mol Pharmacol
  doi: 10.1124/mol.119.115956
– volume: 25
  start-page: 11777
  issue: 50
  year: 2005
  end-page: 11786
  ident: CR197
  article-title: Hedonic hot spot in nucleus accumbens shell: where do mu-opioids cause increased hedonic impact of sweetness?
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.2329-05.2005
– volume: 160
  start-page: 1374
  issue: 6
  year: 2019
  end-page: 1382
  ident: CR166
  article-title: SUMMIT-07: a randomized trial of NKTR-181, a new molecular entity, full mu-opioid receptor agonist for chronic low-back pain
  publication-title: Pain
  doi: 10.1097/j.pain.0000000000001517
– volume: 13
  start-page: 790
  issue: 6
  year: 2012
  end-page: 801
  ident: CR258
  article-title: Randomized, double-blind, placebo-controlled study of the abuse potential of different formulations of oral oxycodone
  publication-title: Pain Med
  doi: 10.1111/j.1526-4637.2012.01380.x
– volume: 12
  start-page: 182
  issue: 3
  year: 1996
  end-page: 189
  ident: CR161
  article-title: Attenuation of morphine-induced delirium in palliative care by substitution with infusion of oxycodone
  publication-title: J Pain Symptom Manage
  doi: 10.1016/0885-3924(96)00050-4
– volume: 128
  start-page: 1015
  issue: 5
  year: 2018
  end-page: 1026
  ident: CR151
  article-title: Abuse-deterrent opioid formulations
  publication-title: Anesthesiology
  doi: 10.1097/ALN.0000000000002031
– volume: 62
  start-page: 243
  issue: 4
  year: 2008
  end-page: 252
  ident: CR85
  article-title: Cocaine-induced dopamine overflow within the nucleus accumbens measured by in vivo microdialysis: a meta-analysis
  publication-title: Synapse
  doi: 10.1002/syn.20489
– volume: 79
  start-page: 1428
  issue: 7
  year: 1997
  end-page: 1437
  ident: CR94
  article-title: Comparative clinical efficacy and safety of a novel controlled-release oxycodone formulation and controlled-release hydromorphone in the treatment of cancer pain
  publication-title: Cancer
  doi: 10.1002/(SICI)1097-0142(19970401)79:7<1428::AID-CNCR21>3.0.CO;2-0
– volume: 177
  start-page: 2923
  issue: 13
  year: 2020
  end-page: 2931
  ident: CR130
  article-title: Morphine-induced respiratory depression is independent of beta-arrestin2 signalling
  publication-title: Br J Pharmacol
  doi: 10.1111/bph.15004
– volume: 16
  start-page: 3222
  issue: 10
  year: 1998
  end-page: 3229
  ident: CR34
  article-title: Randomized, double-blind, cross-over trial comparing safety and efficacy of oral controlled-release oxycodone with controlled-release morphine in patients with cancer pain
  publication-title: J Clin Oncol
  doi: 10.1200/JCO.1998.16.10.3222
– volume: 5
  start-page: 625
  issue: 7
  year: 2002
  end-page: 626
  ident: CR3
  article-title: Neurobiological evidence for hedonic allostasis associated with escalating cocaine use
  publication-title: Nat Neurosci
  doi: 10.1038/nn872
– volume: 87
  start-page: 15
  issue: 1
  year: 2020
  end-page: 21
  ident: CR92
  article-title: Toward directing opioid receptor signaling to refine opioid therapeutics
  publication-title: Biol Psychiatry
  doi: 10.1016/j.biopsych.2019.10.020
– volume: 35
  start-page: 12917
  issue: 37
  year: 2015
  end-page: 12931
  ident: CR76
  article-title: Kappa opioid receptor-induced aversion requires p38 MAPK activation in VTA dopamine neurons
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.2444-15.2015
– volume: 35
  start-page: 129
  issue: 2
  year: 2010
  end-page: 50
  ident: CR108
  article-title: Brain reward circuitry beyond the mesolimbic dopamine system: a neurobiological theory
  publication-title: Neurosci Biobehav Rev
  doi: 10.1016/j.neubiorev.2010.02.001
– volume: 196
  start-page: 105
  issue: 1
  year: 2008
  end-page: 116
  ident: CR278
  article-title: Within-subject comparison of the psychopharmacological profiles of oral oxycodone and oral morphine in non-drug-abusing volunteers
  publication-title: Psychopharmacology (Berl)
  doi: 10.1007/s00213-007-0937-2
– volume: 31
  start-page: 730
  issue: 6
  year: 2017
  end-page: 739
  ident: CR5
  article-title: Effects of acute and repeated treatment with the biased mu opioid receptor agonist TRV130 (oliceridine) on measures of antinociception, gastrointestinal function, and abuse liability in rodents
  publication-title: J Psychopharmacol
  doi: 10.1177/0269881116689257
– volume: 58
  start-page: 4220
  issue: 10
  year: 2015
  end-page: 4229
  ident: CR37
  article-title: Discovery, synthesis, and molecular pharmacology of selective positive allosteric modulators of the delta-opioid receptor
  publication-title: J Med Chem
  doi: 10.1021/acs.jmedchem.5b00007
– volume: 73
  start-page: 1184
  issue: 6
  year: 2012
  end-page: 1194
  ident: CR247
  article-title: Activation of VTA GABA neurons disrupts reward consumption
  publication-title: Neuron
  doi: 10.1016/j.neuron.2012.02.016
– volume: 111
  start-page: 18369
  issue: 51
  year: 2014
  end-page: 18374
  ident: CR153
  article-title: Disruption of the Na+ ion binding site as a mechanism for positive allosteric modulation of the mu-opioid receptor
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.1415013111
– volume: 6
  start-page: 31748
  year: 2016
  ident: CR188
  article-title: Ignavine: a novel allosteric modulator of the mu opioid receptor
  publication-title: Sci Rep
  doi: 10.1038/srep31748
– volume: 181
  start-page: 664
  issue: 4
  year: 2005
  end-page: 675
  ident: CR58
  article-title: Buprenorphine/naloxone reduces the reinforcing and subjective effects of heroin in heroin-dependent volunteers
  publication-title: Psychopharmacology (Berl)
  doi: 10.1007/s00213-005-0023-6
– volume: 11
  start-page: 463
  issue: 6
  year: 2015
  end-page: 473
  ident: CR221
  article-title: Self-reports of prescription opioid abuse and diversion among recreational opioid users in a Canadian and a United States city
  publication-title: J Opioid Manag
  doi: 10.5055/jom.2015.0299
– volume: 65
  start-page: 223
  issue: 1
  year: 2013
  end-page: 254
  ident: CR262
  article-title: Regulation of mu-opioid receptors: desensitization, phosphorylation, internalization, and tolerance
  publication-title: Pharmacol Rev
  doi: 10.1124/pr.112.005942
– volume: 19
  start-page: 1255
  issue: 9
  year: 2014
  end-page: 1265
  ident: CR36
  article-title: Identification of selective agonists and positive allosteric modulators for micro- and delta-opioid receptors from a single high-throughput screen
  publication-title: J Biomol Screen
  doi: 10.1177/1087057114542975
– volume: 18
  start-page: 247
  issue: 3
  year: 1993
  end-page: 291
  ident: CR214
  article-title: The neural basis of drug craving: an incentive-sensitization theory of addiction
  publication-title: Brain Res Brain Res Rev
  doi: 10.1016/0165-0173(93)90013-p
– volume: 105
  start-page: 3
  issue: 1
  year: 1991
  end-page: 14
  ident: CR21
  article-title: What psychological process mediates feeding evoked by electrical stimulation of the lateral hypothalamus?
  publication-title: Behav Neurosci
  doi: 10.1037/0735-7044.105.1.3
– volume: 79
  start-page: 461
  issue: 5
  year: 2006
  end-page: 479
  ident: CR138
  article-title: Pharmacokinetics and pharmacodynamics of oral oxycodone in healthy human subjects: role of circulating active metabolites
  publication-title: Clin Pharmacol Ther
  doi: 10.1016/j.clpt.2006.01.009
– volume: 24
  start-page: 820
  issue: 9
  year: 2018
  end-page: 827
  ident: CR98
  article-title: Differential effects of oxycodone and venlafaxine on resting state functional connectivity-A randomized placebo-controlled magnetic resonance imaging study
  publication-title: CNS Neurosci Ther
  doi: 10.1111/cns.12827
– volume: 510
  start-page: 57
  issue: 1
  year: 2016
  end-page: 72
  ident: CR162
  article-title: Recent advances in abuse-deterrent technologies for the delivery of opioids
  publication-title: Int J Pharm
  doi: 10.1016/j.ijpharm.2016.06.012
– volume: 40
  start-page: 2
  year: 2020
  ident: CR274
  article-title: The pro- and anti-cancer effects of oxycodone are associated with epithelial growth factor receptor level in cancer cells
  publication-title: Biosci Rep
– volume: 2
  start-page: 173
  issue: 1
  year: 2011
  end-page: 180
  ident: CR203
  article-title: Problematic use of prescription-type opioids prior to heroin use among young heroin injectors
  publication-title: Subst Abuse Rehabil
  doi: 10.2147/SAR.S24800
– volume: 23
  start-page: 15
  issue: 2
  year: 2019
  ident: CR212
  article-title: Oxycodone's unparalleled addictive potential: is it time for a moratorium?
  publication-title: Curr Pain Headache Rep
  doi: 10.1007/s11916-019-0751-7
– volume: 301
  start-page: 529
  year: 2015
  end-page: 541
  ident: CR269
  article-title: The ins and outs of the striatum: role in drug addiction
  publication-title: Neuroscience
  doi: 10.1016/j.neuroscience.2015.06.033
– volume: 70
  start-page: 125
  issue: 2
  year: 1992
  end-page: 130
  ident: CR206
  article-title: Antinociceptive effects and central nervous system depression caused by oxycodone and morphine in rats
  publication-title: Pharmacol Toxicol
  doi: 10.1111/j.1600-0773.1992.tb00441.x
– volume: 17
  start-page: 704
  issue: 5
  year: 2014
  end-page: 709
  ident: CR263
  article-title: Excessive cocaine use results from decreased phasic dopamine signaling in the striatum
  publication-title: Nat Neurosci
  doi: 10.1038/nn.3694
– volume: 54
  start-page: 468
  issue: 4
  year: 2014
  end-page: 477
  ident: CR99
  article-title: Abuse potential, pharmacokinetics, pharmacodynamics, and safety of intranasally administered crushed oxycodone HCl abuse-deterrent controlled-release tablets in recreational opioid users
  publication-title: J Clin Pharmacol
  doi: 10.1002/jcph.235
– volume: 863
  start-page: 71
  issue: 1–2
  year: 2000
  end-page: 86
  ident: CR196
  article-title: Opioid site in nucleus accumbens shell mediates eating and hedonic 'liking' for food: map based on microinjection Fos plumes
  publication-title: Brain Res
  doi: 10.1016/s0006-8993(00)02102-8
– ident: CR301
– volume: 28
  start-page: 1115
  issue: 12
  year: 2014
  end-page: 1124
  ident: CR88
  article-title: Opioid modulation of resting-state anterior cingulate cortex functional connectivity
  publication-title: J Psychopharmacol
  doi: 10.1177/0269881114548436
– volume: 55
  start-page: 1836
  issue: 9
  year: 2015
  end-page: 43
  ident: CR26
  article-title: Ligand-based discovery of a new scaffold for allosteric modulation of the mu-opioid receptor
  publication-title: J Chem Inf Model
  doi: 10.1021/acs.jcim.5b00388
– volume: 12
  start-page: 927
  year: 2019
  end-page: 943
  ident: CR252
  article-title: APOLLO-1: a randomized placebo and active-controlled phase III study investigating oliceridine (TRV130), a G protein-biased ligand at the micro-opioid receptor, for management of moderate-to-severe acute pain following bunionectomy
  publication-title: J Pain Res
  doi: 10.2147/JPR.S171013
– volume: 13
  start-page: 954
  issue: 9
  year: 2009
  end-page: 962
  ident: CR96
  article-title: Trends in opioid consumption in the Nordic countries 2002–2006
  publication-title: Eur J Pain
  doi: 10.1016/j.ejpain.2008.11.006
– volume: 15
  start-page: 1187
  issue: 7
  year: 2014
  end-page: 1195
  ident: CR102
  article-title: Prescription histories and dose strengths associated with overdose deaths
  publication-title: Pain Med
  doi: 10.1111/pme.12391
– volume: 27
  start-page: 558
  issue: 11
  year: 2006
  end-page: 565
  ident: CR10
  article-title: How important is protein kinase C in mu-opioid receptor desensitization and morphine tolerance?
  publication-title: Trends Pharmacol Sci
  doi: 10.1016/j.tips.2006.09.006
– volume: 19
  start-page: 1057
  issue: 10
  year: 2010
  end-page: 1063
  ident: CR54
  article-title: Determinants of fentanyl and other potent micro opioid agonist misuse in opioid-dependent individuals
  publication-title: Pharmacoepidemiol Drug Saf
  doi: 10.1002/pds.1989
– volume: 63
  start-page: 65
  issue: 1
  year: 1995
  end-page: 76
  ident: CR280
  article-title: Validation of World Health Organization Guidelines for cancer pain relief: a 10-year prospective study
  publication-title: Pain
  doi: 10.1016/0304-3959(95)00017-M
– volume: 3
  start-page: e1506
  issue: 1
  year: 2008
  ident: CR50
  article-title: Prelude to passion: limbic activation by "unseen" drug and sexual cues
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0001506
– volume: 26
  start-page: 201
  issue: 2
  year: 2015
  end-page: 218
  ident: CR11
  article-title: Opioid therapy in chronic pain
  publication-title: Phys Med Rehabil Clin N Am
  doi: 10.1016/j.pmr.2014.12.001
– volume: 127
  start-page: 129
  issue: 1–2
  year: 2007
  end-page: 139
  ident: CR233
  article-title: Determination of the role of conventional, novel and atypical PKC isoforms in the expression of morphine tolerance in mice
  publication-title: Pain
  doi: 10.1016/j.pain.2006.08.009
– volume: 85
  start-page: 5274
  issue: 14
  year: 1988
  end-page: 5278
  ident: CR73
  article-title: Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.85.14.5274
– volume: 227
  start-page: 177
  issue: 1
  year: 2013
  end-page: 192
  ident: CR177
  article-title: The drug effects questionnaire: psychometric support across three drug types
  publication-title: Psychopharmacology (Berl)
  doi: 10.1007/s00213-012-2954-z
– volume: 148
  start-page: 107
  issue: 1
  year: 2010
  end-page: 113
  ident: CR104
  article-title: Long-lasting antinociceptive spinal effects in primates of the novel nociceptin/orphanin FQ receptor agonist UFP-112
  publication-title: Pain
  doi: 10.1016/j.pain.2009.10.026
– volume: 1
  start-page: S18
  year: 2009
  end-page: S23
  ident: CR146
  article-title: Pharmacology of oxycodone: does it explain why oxycodone has become a bestselling strong opioid?
  publication-title: Scand J Pain
  doi: 10.1016/S1877-8860(09)70005-9
– volume: 175
  start-page: 2846
  issue: 14
  year: 2018
  end-page: 2856
  ident: CR154
  article-title: Allostery at opioid receptors: modulation with small molecule ligands
  publication-title: Br J Pharmacol
  doi: 10.1111/bph.13823
– ident: CR210
– volume: 284
  start-page: 37
  year: 2015
  end-page: 41
  ident: CR77
  article-title: Differential effects of oxycodone, hydrocodone, and morphine on the responses of D2/D3 dopamine receptors
  publication-title: Behav Brain Res
  doi: 10.1016/j.bbr.2015.01.023
– volume: 16
  start-page: 166
  issue: 3
  year: 2007
  end-page: 173
  ident: CR91
  article-title: Illicit use of opioids: is OxyContin a "gateway drug"?
  publication-title: Am J Addict
  doi: 10.1080/10550490701375293
– volume: 11
  start-page: 259
  issue: 3
  year: 2011
  end-page: 275
  ident: CR257
  article-title: Impact of intravenous naltrexone on intravenous morphine-induced high, drug liking, and euphoric effects in experienced, nondependent male opioid users
  publication-title: Drugs R D
  doi: 10.2165/11593390-000000000-00000
– volume: 63
  start-page: 124
  year: 2016
  end-page: 142
  ident: CR205
  article-title: Measuring wanting and liking from animals to humans: a systematic review
  publication-title: Neurosci Biobehav Rev
  doi: 10.1016/j.neubiorev.2016.01.006
– volume: 86
  start-page: 646
  issue: 3
  year: 2015
  end-page: 664
  ident: CR19
  article-title: Pleasure systems in the brain
  publication-title: Neuron
  doi: 10.1016/j.neuron.2015.02.018
– volume: 34
  start-page: 4239
  issue: 12
  year: 2014
  end-page: 4250
  ident: CR47
  article-title: Opioid hedonic hotspot in nucleus accumbens shell: mu, delta, and kappa maps for enhancement of sweetness "liking" and "wanting"
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.4458-13.2014
– volume: 108
  start-page: 16446
  issue: 39
  year: 2011
  end-page: 16450
  ident: CR111
  article-title: Neuronal circuits underlying acute morphine action on dopamine neurons
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.1105418108
– volume: 4
  start-page: 277
  issue: 4
  year: 2006
  end-page: 291
  ident: CR226
  article-title: Neurochemistry of the nucleus accumbens and its relevance to depression and antidepressant action in rodents
  publication-title: Curr Neuropharmacol
  doi: 10.2174/157015906778520773
– volume: 124
  start-page: 1720
  year: 2001
  end-page: 1733
  ident: CR229
  article-title: Changes in brain activity related to eating chocolate: from pleasure to aversion
  publication-title: Brain
  doi: 10.1093/brain/124.9.1720
– volume: 14
  start-page: e0217371
  issue: 6
  year: 2019
  ident: CR189
  article-title: Comprehensive molecular pharmacology screening reveals potential new receptor interactions for clinically relevant opioids
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0217371
– volume: 19
  start-page: 715
  issue: 7
  year: 2019
  end-page: 731
  ident: CR228
  article-title: APOLLO-2: A Randomized, Placebo and Active-Controlled Phase III Study Investigating Oliceridine (TRV130), a G Protein-Biased Ligand at the mu-Opioid Receptor, for Management of Moderate to Severe Acute Pain Following Abdominoplasty
  publication-title: Pain Pract
  doi: 10.1111/papr.12801
– volume: 26
  start-page: 2788
  issue: 10
  year: 2006
  end-page: 2797
  ident: CR84
  article-title: Properties and opioid inhibition of mesolimbic dopamine neurons vary according to target location
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.4331-05.2006
– volume: 349
  start-page: 535
  issue: 3
  year: 2014
  end-page: 548
  ident: CR150
  article-title: Cebranopadol: a novel potent analgesic nociceptin/orphanin FQ peptide and opioid receptor agonist
  publication-title: J Pharmacol Exp Ther
  doi: 10.1124/jpet.114.213694
– volume: 262
  start-page: 383
  issue: 845
  year: 1971
  end-page: 401
  ident: CR125
  article-title: The structure of the caudate nucleus of the cat: light and electron microscopy
  publication-title: Philos Trans R Soc Lond B Biol Sci
  doi: 10.1098/rstb.1971.0102
– volume: 132
  start-page: 289
  issue: 3
  year: 2007
  end-page: 300
  ident: CR186
  article-title: Oxycodone and morphine have distinctly different pharmacological profiles: radioligand binding and behavioural studies in two rat models of neuropathic pain
  publication-title: Pain
  doi: 10.1016/j.pain.2007.03.022
– volume: 90
  start-page: 64
  issue: 1
  year: 2007
  end-page: 71
  ident: CR216
  article-title: Prescription opioid abuse among enrollees into methadone maintenance treatment
  publication-title: Drug Alcohol Depend
  doi: 10.1016/j.drugalcdep.2007.02.012
– volume: 10
  start-page: 2996
  issue: 9
  year: 1990
  end-page: 3013
  ident: CR13
  article-title: Ultrastructural localization of tyrosine hydroxylase in the rat ventral tegmental area: relationship between immunolabeling density and neuronal associations
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.10-09-02996.1990
– volume: 12
  start-page: 873
  issue: 11
  year: 2010
  end-page: 880
  ident: CR236
  article-title: Gene knockdown with lentiviral vector-mediated intrathecal RNA interference of protein kinase C gamma reverses chronic morphine tolerance in rats
  publication-title: J Gene Med
  doi: 10.1002/jgm.1514
– volume: 109
  start-page: 1279
  issue: 4
  year: 2009
  end-page: 1283
  ident: CR147
  article-title: A comparison of intravenous oxycodone and intravenous morphine in patient-controlled postoperative analgesia after laparoscopic hysterectomy
  publication-title: Anesth Analg
  doi: 10.1213/ane.0b013e3181b0f0bb
– volume: 343
  start-page: 72
  issue: 1
  year: 2012
  end-page: 81
  ident: CR64
  article-title: Roles of mu-opioid receptors and nociceptin/orphanin FQ peptide receptors in buprenorphine-induced physiological responses in primates
  publication-title: J Pharmacol Exp Ther
  doi: 10.1124/jpet.112.194308
– volume: 21
  start-page: 12
  issue: 4
  year: 2003
  end-page: 14
  ident: CR72
  article-title: Scophedal (SEE) was it a fad or a miracle drug?
  publication-title: Bull Anesth Hist
  doi: 10.1016/s1522-8649(03)50051-8
– volume: 133
  start-page: 371
  year: 1961
  end-page: 387
  ident: CR86
  article-title: Methods for evaluating addiction liability. (A) "Attitude" of opiate addicts toward opiate-like drugs. (B) a short-term "direct" addiction test
  publication-title: J Pharmacol Exp Ther
– volume: 13
  start-page: 1064
  issue: 10
  year: 2003
  end-page: 1071
  ident: CR134
  article-title: Activation of the human orbitofrontal cortex to a liquid food stimulus is correlated with its subjective pleasantness
  publication-title: Cereb Cortex
  doi: 10.1093/cercor/13.10.1064
– volume: 485
  start-page: 400
  issue: 7398
  year: 2012
  end-page: 404
  ident: CR90
  article-title: Structure of the delta-opioid receptor bound to naltrindole
  publication-title: Nature
  doi: 10.1038/nature11111
– start-page: 222
  year: 2010
  end-page: 243
  ident: CR149
  article-title: The neurobiology of desire: dopamine and the regulation of mood and motivational states in humans
  publication-title: Pleasures of the brain
– volume: 40
  start-page: 3472
  issue: 10
  year: 2014
  end-page: 34780
  ident: CR201
  article-title: GABA(B) modulation of dopamine release in the nucleus accumbens core
  publication-title: Eur J Neurosci
  doi: 10.1111/ejn.12733
– volume: 9
  start-page: 119
  year: 2018
  ident: CR222
  article-title: Pain therapy guided by purpose and perspective in light of the opioid epidemic
  publication-title: Front Psychiatry
  doi: 10.3389/fpsyt.2018.00119
– volume: 8
  start-page: 1147
  issue: 6
  year: 2017
  end-page: 1158
  ident: CR211
  article-title: Recent advances in the realm of allosteric modulators for opioid receptors for future therapeutics
  publication-title: ACS Chem Neurosci
  doi: 10.1021/acschemneuro.7b00090
– volume: 33
  start-page: 6665
  issue: S1
  year: 2019
  ident: CR117
  article-title: The opioid receptor positive allosteric modulator BMS-986187 enhances some, but not all, delta-opioid receptor mediated behaviors
  publication-title: FASEB J
  doi: 10.1096/fasebj.2019.33.1_supplement.666.5
– volume: 852
  start-page: 265
  year: 2019
  end-page: 273
  ident: CR272
  article-title: Delta-opioid receptor antagonist naltrindole reduces oxycodone addiction and constipation in mice
  publication-title: Eur J Pharmacol
  doi: 10.1016/j.ejphar.2019.04.009
– volume: 535
  start-page: 145
  issue: 1–3
  year: 2006
  end-page: 151
  ident: CR187
  article-title: Characterization of the antinociceptive effects of oxycodone in diabetic mice
  publication-title: Eur J Pharmacol
  doi: 10.1016/j.ejphar.2006.02.002
– volume: 42
  start-page: 123
  issue: 2
  year: 2016
  end-page: 140
  ident: CR6
  article-title: "Wanting," "liking," and their relation to consciousness
  publication-title: J Exp Psychol Anim Learn Cogn
  doi: 10.1037/xan0000090
– volume: 29
  start-page: S47
  year: 2005
  end-page: 56
  ident: CR119
  article-title: Oxycodone
  publication-title: J Pain Symptom Manage
  doi: 10.1016/j.jpainsymman.2005.01.010
– volume: 110
  start-page: 10830
  issue: 26
  year: 2013
  end-page: 5
  ident: CR35
  article-title: Discovery of positive allosteric modulators and silent allosteric modulators of the mu-opioid receptor
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.1300393110
– volume: 26
  start-page: 862
  issue: 4
  year: 1999
  end-page: 869
  ident: CR42
  article-title: Treatment of osteoarthritis pain with controlled release oxycodone or fixed combination oxycodone plus acetaminophen added to nonsteroidal antiinflammatory drugs: a double blind, randomized, multicenter, placebo controlled trial
  publication-title: J Rheumatol
– volume: 70
  start-page: 676
  issue: 2
  year: 2006
  end-page: 685
  ident: CR114
  article-title: Agonist-selective mechanisms of mu-opioid receptor desensitization in human embryonic kidney 293 cells
  publication-title: Mol Pharmacol
  doi: 10.1124/mol.106.022376
– volume: 36
  start-page: 669
  issue: 10
  year: 2011
  end-page: 684
  ident: CR250
  article-title: Direct-to-consumer pharmaceutical advertising: therapeutic or toxic?
  publication-title: P T
– volume: 7
  start-page: 442
  issue: 5
  year: 2008
  end-page: 453
  ident: CR225
  article-title: Targeting endogenous mu- and delta-opioid receptor systems for the treatment of drug addiction
  publication-title: CNS Neurol Disord Drug Targets
  doi: 10.2174/187152708786927813
– volume: 111
  start-page: 60
  issue: 1
  year: 2009
  end-page: 72
  ident: CR172
  article-title: Morphine, oxycodone, and fentanyl exhibit different analgesic profiles in mouse pain models
  publication-title: J Pharmacol Sci
  doi: 10.1254/jphs.09139fp
– volume: 1
  start-page: 14
  year: 2005
  ident: CR264
  article-title: Pain management procedures used by dental and maxillofacial surgeons: an investigation with special regard to odontalgia
  publication-title: Head Face Med
  doi: 10.1186/1746-160X-1-14
– volume: 30
  start-page: 6999
  issue: 20
  year: 2010
  end-page: 7016
  ident: CR106
  article-title: Electrophysiological and morphological characteristics and synaptic connectivity of tyrosine hydroxylase-expressing neurons in adult mouse striatum
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.5996-09.2010
– volume: 73
  start-page: 37
  issue: 1
  year: 1997
  end-page: 45
  ident: CR100
  article-title: Controlled-release oxycodone and morphine in cancer related pain
  publication-title: Pain
  doi: 10.1016/s0304-3959(97)00072-9
– volume: 15
  start-page: 618
  issue: 9
  year: 2006
  end-page: 627
  ident: CR195
  article-title: Increasing deaths from opioid analgesics in the United States
  publication-title: Pharmacoepidemiol Drug Saf
  doi: 10.1002/pds.1276
– volume: 36
  start-page: 1565
  year: 2012
  end-page: 1576
  ident: CR68
  article-title: Do initial responses to drugs predict future use or abuse?
  publication-title: Neurosci Biobehav Rev
  doi: 10.1016/j.neubiorev.2012.04.005
– volume: 59
  start-page: 52
  issue: 1
  year: 1996
  end-page: 61
  ident: CR118
  article-title: Pharmacokinetic-pharmacodynamic relationships of controlled-release oxycodone
  publication-title: Clin Pharmacol Ther
  doi: 10.1016/S0009-9236(96)90024-7
– volume: 69
  start-page: 215
  issue: 3
  year: 2003
  end-page: 232
  ident: CR279
  article-title: College on Problems of Drug Dependence taskforce on prescription opioid non-medical use and abuse: position statement
  publication-title: Drug Alcohol Depend
  doi: 10.1016/s0376-8716(03)00003-6
– volume: 7
  start-page: 255
  issue: 4
  year: 2017
  end-page: 267
  ident: CR87
  article-title: Transdermal oxycodone patch for the treatment of postherpetic neuralgia: a randomized, double-blind, controlled trial
  publication-title: Pain Manag
  doi: 10.2217/pmt-2016-0067
– year: 2020
  ident: CR27
  article-title: Oxycodone self-administration activates the mitogen-activated protein kinase/mitogen- and stress-activated protein kinase (MAPK-MSK) signaling pathway in the rat dorsal striatum
  publication-title: bioRxiv
  doi: 10.1101/2020.08.31.276253
– volume: 29
  start-page: 565
  year: 2006
  end-page: 598
  ident: CR105
  article-title: Neural mechanisms of addiction: the role of reward-related learning and memory
  publication-title: Annu Rev Neurosci
  doi: 10.1146/annurev.neuro.29.051605.113009
– volume: 42
  start-page: 8
  issue: 1
  year: 2017
  end-page: 17
  ident: CR209
  article-title: Cebranopadol: novel dual opioid/NOP receptor agonist analgesic
  publication-title: J Clin Pharm Ther
  doi: 10.1111/jcpt.12461
– volume: 11
  start-page: 217
  issue: 2
  year: 2006
  end-page: 226
  ident: CR1
  article-title: Direct-to-consumer advertising in oncology
  publication-title: Oncologist
  doi: 10.1634/theoncologist.11-2-217
– volume: 59
  start-page: 30
  issue: 1
  year: 2001
  end-page: 7
  ident: CR82
  article-title: SCH-202676: an allosteric modulator of both agonist and antagonist binding to G protein-coupled receptors
  publication-title: Mol Pharmacol
  doi: 10.1124/mol.59.1.30
– volume: 235
  start-page: 2349
  issue: 8
  year: 2018
  end-page: 2356
  ident: CR135
  article-title: Drug liking and wanting, not impulsive action or reflection is increased by 4-fluoroamphetamine
  publication-title: Psychopharmacology (Berl)
  doi: 10.1007/s00213-018-4931-7
– volume: 79
  start-page: 443
  year: 2003
  end-page: 464
  ident: CR200
  article-title: Real-time measurements of phasic changes in extracellular dopamine concentration in freely moving rats by fast-scan cyclic voltammetry
  publication-title: Methods Mol Med
  doi: 10.1385/1-59259-358-5:443
– volume: 23
  start-page: 10331
  issue: 32
  year: 2003
  end-page: 10337
  ident: CR157
  article-title: Buprenorphine-induced antinociception is mediated by mu-opioid receptors and compromised by concomitant activation of opioid receptor-like receptors
  publication-title: J Neurosci
  doi: 10.1523/jneurosci.23-32-10331.2003
– volume: 107
  start-page: 11608
  issue: 25
  year: 2010
  end-page: 11613
  ident: CR170
  article-title: Ligand-directed c-Jun N-terminal kinase activation disrupts opioid receptor signaling
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.1000751107
– volume: 77
  start-page: 26
  year: 2017
  end-page: 30
  ident: CR103
  article-title: Chronic pain among patients with opioid use disorder: results from electronic health records data
  publication-title: J Subst Abuse Treat
  doi: 10.1016/j.jsat.2017.03.006
– volume: 372
  start-page: 241
  issue: 3
  year: 2015
  end-page: 248
  ident: CR66
  article-title: Trends in opioid analgesic abuse and mortality in the United States
  publication-title: N Engl J Med
  doi: 10.1056/NEJMsa1406143
– volume: 8
  start-page: 19
  issue: 1
  year: 2019
  end-page: 39
  ident: CR208
  article-title: Intravenous oxycodone versus other intravenous strong opioids for acute postoperative pain control: a systematic review of randomized controlled trials
  publication-title: Pain Ther
  doi: 10.1007/s40122-019-0122-4
– year: 2020
  ident: CR132
  article-title: Preclinical assessment of the analgesic pharmacology of NKTR-181 in rodents
  publication-title: Cell Mol Neurobiol
  doi: 10.1007/s10571-020-00816-3
– volume: 78
  start-page: 1805
  issue: 17
  year: 2018
  end-page: 1816
  ident: CR71
  article-title: Tapentadol prolonged release: a review in pain management
  publication-title: Drugs
  doi: 10.1007/s40265-018-1007-2
– volume: 71
  start-page: 670
  issue: 8
  year: 2016
  end-page: 679
  ident: CR20
  article-title: Liking, wanting, and the incentive-sensitization theory of addiction
  publication-title: Am Psychol
  doi: 10.1037/amp0000059
– volume: 50
  start-page: 149
  issue: 1
  year: 1992
  end-page: 162
  ident: CR171
  article-title: Morphological differences between projection neurons of the core and shell in the nucleus accumbens of the rat
  publication-title: Neuroscience
  doi: 10.1016/0306-4522(92)90389-j
– volume: 23
  start-page: 1596
  issue: 6
  year: 2006
  end-page: 1604
  ident: CR224
  article-title: Neurochemical modulation of ingestive behavior in the ventral pallidum
  publication-title: Eur J Neurosci
  doi: 10.1111/j.1460-9568.2006.04689.x
– year: 2020
  ident: CR223
  article-title: Integrated computational approaches and tools for allosteric drug discovery
  publication-title: Int J Mol Sci
  doi: 10.3390/ijms21030847
– volume: 24
  start-page: 173
  issue: 2
  year: 2000
  end-page: 198
  ident: CR17
  article-title: Measuring hedonic impact in animals and infants: microstructure of affective taste reactivity patterns
  publication-title: Neurosci Biobehav Rev
  doi: 10.1016/s0149-7634(99)00072-x
– volume: 93
  start-page: 157
  issue: 2
  year: 2018
  end-page: 167
  ident: CR155
  article-title: Pharmacologic evidence for a putative conserved allosteric site on opioid receptors
  publication-title: Mol Pharmacol
  doi: 10.1124/mol.117.109561
– volume: 2012
  start-page: 265605
  year: 2012
  ident: CR67
  article-title: Drug management of visceral pain: concepts from basic research
  publication-title: Pain Res Treat
  doi: 10.1155/2012/265605
– ident: CR46
– volume: 84
  start-page: 587
  issue: 5
  year: 2001
  end-page: 593
  ident: CR97
  article-title: Morphine and alternative opioids in cancer pain: the EAPC recommendations
  publication-title: Br J Cancer
  doi: 10.1054/bjoc.2001.1680
– volume: 23
  start-page: 217
  issue: 4
  year: 2015
  end-page: 227
  ident: CR182
  article-title: Discriminative stimulus effects of morphine and oxycodone in the absence and presence of acetic acid in male and female C57Bl/6 mice
  publication-title: Exp Clin Psychopharmacol
  doi: 10.1037/pha0000028
– volume: 68
  start-page: 815
  issue: 5
  year: 2010
  end-page: 834
  ident: CR33
  article-title: Dopamine in motivational control: rewarding, aversive, and alerting
  publication-title: Neuron
  doi: 10.1016/j.neuron.2010.11.022
– volume: 24
  start-page: 175
  issue: 1
  year: 2008
  end-page: 192
  ident: CR213
  article-title: Oxycodone: a review of its use in the management of pain
  publication-title: Curr Med Res Opin
  doi: 10.1185/030079908x253708
– volume: 129
  start-page: 100
  year: 2018
  end-page: 108
  ident: CR244
  article-title: Mu-opioid peptide (MOP) and nociceptin/orphanin FQ peptide (NOP) receptor activation both contribute to the discriminative stimulus properties of cebranopadol in the rat
  publication-title: Neuropharmacology
  doi: 10.1016/j.neuropharm.2017.11.026
– volume: 35
  start-page: 642
  issue: 7
  year: 1991
  end-page: 646
  ident: CR121
  article-title: Intravenous morphine and oxycodone for pain after abdominal surgery
  publication-title: Acta Anaesthesiol Scand
  doi: 10.1111/j.1399-6576.1991.tb03364.x
– volume: 54
  start-page: 25
  year: 2003
  end-page: 53
  ident: CR215
  article-title: Addiction
  publication-title: Annu Rev Psychol
  doi: 10.1146/annurev.psych.54.101601.145237
– volume: 372
  start-page: 354
  issue: 5
  year: 2006
  end-page: 361
  ident: CR123
  article-title: Cannabidiol is an allosteric modulator at mu- and delta-opioid receptors
  publication-title: Naunyn Schmiedebergs Arch Pharmacol
  doi: 10.1007/s00210-006-0033-x
– start-page: 202
  year: 2010
  end-page: 221
  ident: CR133
  article-title: The hedonic brain: A functional neuroanatomy of human pleasure
  publication-title: Pleasures of the brain
– volume: 105
  start-page: 71
  issue: 1–2
  year: 2003
  end-page: 78
  ident: CR256
  article-title: Controlled-release oxycodone relieves neuropathic pain: a randomized controlled trial in painful diabetic neuropathy
  publication-title: Pain
  doi: 10.1016/s0304-3959(03)00160-x
– volume: 35
  start-page: 295
  issue: 3
  year: 2008
  end-page: 302
  ident: CR49
  article-title: Sex differences in the pharmacokinetics, oxidative metabolism and oral bioavailability of oxycodone in the Sprague-Dawley rat
  publication-title: Clin Exp Pharmacol Physiol
  doi: 10.1111/j.1440-1681.2007.04821.x
– volume: 75
  start-page: 1713
  issue: 4
  year: 1978
  end-page: 1717
  ident: CR28
  article-title: Interaction of ligands with the opiate receptors of brain membranes: regulation by ions and nucleotides
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.75.4.1713
– volume: 73
  start-page: 178
  issue: 1
  year: 2008
  end-page: 190
  ident: CR283
  article-title: Beta-arrestin-dependent mu-opioid receptor-activated extracellular signal-regulated kinases (ERKs) Translocate to Nucleus in Contrast to G protein-dependent ERK activation
  publication-title: Mol Pharmacol
  doi: 10.1124/mol.107.039842
– year: 2012
  ident: CR159
  article-title: Regional and cell-type-specific effects of DAMGO on striatal D1 and D2 dopamine receptor-expressing medium-sized spiny neurons
  publication-title: ASN Neuro
  doi: 10.1042/AN20110063
– volume: 20
  start-page: 7489
  issue: 19
  year: 2000
  end-page: 7495
  ident: CR110
  article-title: Dissociation in conditioned dopamine release in the nucleus accumbens core and shell in response to cocaine cues and during cocaine-seeking behavior in rats
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.20-19-07489.2000
– volume: 98
  start-page: 425
  issue: 4
  year: 2020
  end-page: 432
  ident: CR116
  article-title: Opioid pharmacology under the microscope
  publication-title: Mol Pharmacol
  doi: 10.1124/mol.119.119321
– volume: 22
  start-page: 684
  issue: 4
  year: 2010
  end-page: 696
  ident: CR51
  article-title: Agonist-dependent mu-opioid receptor signaling can lead to heterologous desensitization
  publication-title: Cell Signal
  doi: 10.1016/j.cellsig.2009.12.003
– volume: 104
  start-page: 403
  issue: 1
  year: 2010
  end-page: 413
  ident: CR156
  article-title: A dynamic role for GABA receptors on the firing pattern of midbrain dopaminergic neurons
  publication-title: J Neurophysiol
  doi: 10.1152/jn.00204.2010
– volume: 285
  start-page: 908
  issue: 2
  year: 1998
  end-page: 914
  ident: CR281
  article-title: Intake of high-fat food is selectively enhanced by mu opioid receptor stimulation within the nucleus accumbens
  publication-title: J Pharmacol Exp Ther
– volume: 50
  start-page: 1837
  issue: 6
  year: 1998
  end-page: 1841
  ident: CR255
  article-title: Efficacy of oxycodone in neuropathic pain: a randomized trial in postherpetic neuralgia
  publication-title: Neurology
  doi: 10.1212/wnl.50.6.1837
– volume: 10
  start-page: 471
  year: 2016
  ident: CR174
  article-title: BOLD imaging in awake wild-Type and mu-Opioid receptor knock-out mice reveals on-target activation maps in response to oxycodone
  publication-title: Front Neurosci
  doi: 10.3389/fnins.2016.00471
– volume: 154
  start-page: 2639
  issue: 12
  year: 2013
  end-page: 2648
  ident: CR56
  article-title: Factors influencing the selection of hydrocodone and oxycodone as primary opioids in substance abusers seeking treatment in the United States
  publication-title: Pain
  doi: 10.1016/j.pain.2013.07.025
– volume: 40
  start-page: 421
  issue: 2
  year: 2015
  end-page: 428
  ident: CR253
  article-title: Compulsive-like responding for opioid analgesics in rats with extended access
  publication-title: Neuropsychopharmacology
  doi: 10.1038/npp.2014.188
– volume: 8
  start-page: 335
  issue: 4
  year: 2012
  end-page: 340
  ident: CR261
  article-title: Likeability and abuse liability of commonly prescribed opioids
  publication-title: J Med Toxicol
  doi: 10.1007/s13181-012-0263-x
– volume: 9
  start-page: 433
  issue: 4
  year: 2008
  end-page: 443
  ident: CR276
  article-title: Subjective, psychomotor, and physiological effects profile of hydrocodone/acetaminophen and oxycodone/acetaminophen combination products
  publication-title: Pain Med
  doi: 10.1111/j.1526-4637.2007.00359.x
– volume: 107
  start-page: 587
  issue: 3
  year: 2012
  end-page: 596
  ident: CR273
  article-title: Transition from first illicit drug use to first injection drug use among rural Appalachian drug users: a cross-sectional comparison and retrospective survival analysis
  publication-title: Addiction
  doi: 10.1111/j.1360-0443.2011.03635.x
– volume: 32
  start-page: 14094
  issue: 41
  year: 2012
  end-page: 14101
  ident: CR12
  article-title: Braking dopamine systems: a new GABA master structure for mesolimbic and nigrostriatal functions
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.3370-12.2012
– volume: 186
  start-page: 172778
  year: 2019
  ident: CR115
  article-title: Assessing the contribution of opioid- and dopamine-related genetic polymorphisms to the abuse liability of oxycodone
  publication-title: Pharmacol Biochem Behav
  doi: 10.1016/j.pbb.2019.172778
– volume: 76
  start-page: 5626
  issue: 11
  year: 1979
  end-page: 5630
  ident: CR29
  article-title: Coupling of opiate receptors to adenylate cyclase: requirement for Na+ and GTP
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.76.11.5626
– volume: 133
  start-page: 559
  issue: 3
  year: 2020
  end-page: 568
  ident: CR65
  article-title: Benefit and risk evaluation of biased mu-receptor agonist oliceridine versus morphine
  publication-title: Anesthesiology
  doi: 10.1097/ALN.0000000000003441
– volume: 89
  start-page: 2027
  issue: 11
  year: 2003
  end-page: 2030
  ident: CR139
  article-title: Comparison of sustained-release morphine with sustained-release oxycodone in advanced cancer patients
  publication-title: Br J Cancer
  doi: 10.1038/sj.bjc.6601365
– volume: 56
  start-page: 265
  issue: 2
  year: 1997
  end-page: 272
  ident: CR32
  article-title: High dose pimozide does not block amphetamine-induced euphoria in normal volunteers
  publication-title: Pharmacol Biochem Behav
  doi: 10.1016/s0091-3057(96)00240-7
– volume: 73
  start-page: 151
  issue: 2
  year: 1997
  end-page: 157
  ident: CR217
  article-title: The intrinsic antinociceptive effects of oxycodone appear to be kappa-opioid receptor mediated
  publication-title: Pain
  doi: 10.1016/s0304-3959(97)00093-6
– volume: 40
  start-page: 3041
  issue: 7
  year: 2014
  end-page: 3054
  ident: CR248
  article-title: Rapid dopamine transmission within the nucleus accumbens: dramatic difference between morphine and oxycodone delivery
  publication-title: Eur J Neurosci
  doi: 10.1111/ejn.12709
– volume: 17
  start-page: E119
  issue: 2
  year: 2014
  end-page: 128
  ident: CR8
  article-title: Assessment of the trends in medical use and misuse of opioid analgesics from 2004 to 2011
  publication-title: Pain Physician
  doi: 10.36076/ppj.2014/17/E119
– volume: 99
  start-page: 221
  issue: 2
  year: 2009
  end-page: 227
  ident: CR246
  article-title: The promotion and marketing of oxycontin: commercial triumph, public health tragedy
  publication-title: Am J Public Health
  doi: 10.2105/AJPH.2007.131714
– volume: 20
  start-page: 33
  issue: 4
  year: 2006
  end-page: 39
  ident: CR15
  article-title: High dose controlled-release oxycodone in hospice care
  publication-title: J Pain Palliat Care Pharmacother
  doi: 10.1080/J354v20n04_06
– ident: CR300
– volume: 3
  start-page: e01936
  year: 2014
  ident: CR243
  article-title: Midbrain dopamine neurons sustain inhibitory transmission using plasma membrane uptake of GABA, not synthesis
  publication-title: Elife
  doi: 10.7554/eLife.01936
– volume: 50
  start-page: 360
  issue: 5
  year: 2012
  end-page: 367
  ident: CR235
  article-title: Low absolute bioavailability of oral naloxone in healthy subjects
  publication-title: Int J Clin Pharmacol Ther
  doi: 10.5414/cp201646
– volume: 47
  start-page: 639
  issue: 5
  year: 1990
  end-page: 646
  ident: CR120
  article-title: Morphine and oxycodone hydrochloride in the management of cancer pain
  publication-title: Clin Pharmacol Ther
  doi: 10.1038/clpt.1990.85
– volume: 34
  start-page: 1
  issue: 1
  year: 1999
  end-page: 10
  ident: CR238
  article-title: Localization of the delta-opioid receptor and dopamine transporter in the nucleus accumbens shell: implications for opiate and psychostimulant cross-sensitization
  publication-title: Synapse
  doi: 10.1002/(SICI)1098-2396(199910)34:1<1::AID-SYN1>3.0.CO;2-H
– volume: 13
  start-page: 365
  year: 2019
  end-page: 372
  ident: CR268
  article-title: Different effects of oxycodone and remifentanil in patients undergoing ultrasound-guided percutaneous radiofrequency ablation of hepatic cancer: a randomized trial
  publication-title: Drug Des Devel Ther
  doi: 10.2147/DDDT.S188728
– volume: 2
  start-page: 264
  issue: 4
  year: 2019
  end-page: 274
  ident: CR181
  article-title: Oxycodone-mediated activation of the mu opioid receptor reduces whole brain functional connectivity in mice
  publication-title: ACS Pharmacol Transl Sci
  doi: 10.1021/acsptsci.9b00021
– volume: 31
  start-page: 16757
  issue: 46
  year: 2011
  end-page: 16769
  ident: CR107
  article-title: A novel functionally distinct subtype of striatal neuropeptide Y interneuron
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.2628-11.2011
– volume: 33
  start-page: 1179
  issue: 5
  year: 2008
  end-page: 1191
  ident: CR59
  article-title: Abuse liability of prescription opioids compared to heroin in morphine-maintained heroin abusers
  publication-title: Neuropsychopharmacology
  doi: 10.1038/sj.npp.1301479
– volume: 10
  start-page: 3740
  issue: 8
  year: 2019
  end-page: 3750
  ident: CR89
  article-title: Acute negative allosteric modulation of M5 muscarinic acetylcholine receptors inhibits oxycodone self-Administration and cue-induced reactivity with no effect on antinociception
  publication-title: ACS Chem Neurosci
  doi: 10.1021/acschemneuro.9b00274
– year: 2016
  ident: CR80
  article-title: Neurobiology of opioid dependence in creating addiction vulnerability
  publication-title: F1000Res
  doi: 10.12688/f1000research.8369.1
– volume: 82
  start-page: 1346
  issue: 6
  year: 2014
  end-page: 1356
  ident: CR168
  article-title: Separate GABA afferents to dopamine neurons mediate acute action of opioids, development of tolerance, and expression of withdrawal
  publication-title: Neuron
  doi: 10.1016/j.neuron.2014.04.030
– volume: 278
  start-page: 63
  issue: 5335
  year: 1997
  end-page: 66
  ident: CR183
  article-title: Psychoactive drug use in evolutionary perspective
  publication-title: Science
  doi: 10.1126/science.278.5335.63
– volume: 241
  start-page: 534
  issue: 2
  year: 1987
  end-page: 539
  ident: CR249
  article-title: Modulation of rat brain opioid receptors by cannabinoids
  publication-title: J Pharmacol Exp Ther
– volume: 39
  start-page: 2441
  issue: 10
  year: 2014
  end-page: 2449
  ident: CR192
  article-title: Phasic mesolimbic dopamine signaling encodes the facilitation of incentive motivation produced by repeated cocaine exposure
  publication-title: Neuropsychopharmacology
  doi: 10.1038/npp.2014.96
– volume: 120
  start-page: 676
  issue: 4
  year: 1997
  end-page: 680
  ident: CR242
  article-title: Bidirectional modulatory effect of orphanin FQ on morphine-induced analgesia: antagonism in brain and potentiation in spinal cord of the rat
  publication-title: Br J Pharmacol
  doi: 10.1038/sj.bjp.0700942
– start-page: 147
  year: 2009
  end-page: 148
  ident: CR163
  publication-title: Molecular neuropharmacology: a foundation for clinical neuroscience (2nd edn)
– volume: 11
  start-page: 446
  issue: 5
  year: 1983
  end-page: 450
  ident: CR60
  article-title: Oxymorphone metabolism and urinary excretion in human, rat, guinea pig, rabbit, and dog
  publication-title: Drug Metab Dispos
– volume: 349
  start-page: 535
  issue: 3
  year: 2014
  ident: 1013_CR150
  publication-title: J Pharmacol Exp Ther
  doi: 10.1124/jpet.114.213694
– volume: 7
  start-page: 255
  issue: 4
  year: 2017
  ident: 1013_CR87
  publication-title: Pain Manag
  doi: 10.2217/pmt-2016-0067
– volume: 27
  start-page: 1594
  issue: 7
  year: 2007
  ident: 1013_CR231
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.4205-06.2007
– volume: 13
  start-page: 1064
  issue: 10
  year: 2003
  ident: 1013_CR134
  publication-title: Cereb Cortex
  doi: 10.1093/cercor/13.10.1064
– volume: 24
  start-page: 820
  issue: 9
  year: 2018
  ident: 1013_CR98
  publication-title: CNS Neurosci Ther
  doi: 10.1111/cns.12827
– volume: 485
  start-page: 400
  issue: 7398
  year: 2012
  ident: 1013_CR90
  publication-title: Nature
  doi: 10.1038/nature11111
– volume: 37
  start-page: 2420
  issue: 11
  year: 2015
  ident: 1013_CR40
  publication-title: Clin Ther
  doi: 10.1016/j.clinthera.2015.08.014
– volume: 16
  start-page: 166
  issue: 3
  year: 2007
  ident: 1013_CR91
  publication-title: Am J Addict
  doi: 10.1080/10550490701375293
– volume: 40
  start-page: 421
  issue: 2
  year: 2015
  ident: 1013_CR253
  publication-title: Neuropsychopharmacology
  doi: 10.1038/npp.2014.188
– volume: 1073–1074
  start-page: 290
  year: 2006
  ident: 1013_CR148
  publication-title: Brain Res
  doi: 10.1016/j.brainres.2005.12.066
– volume: 39
  start-page: 2441
  issue: 10
  year: 2014
  ident: 1013_CR192
  publication-title: Neuropsychopharmacology
  doi: 10.1038/npp.2014.96
– volume: 58
  start-page: 4220
  issue: 10
  year: 2015
  ident: 1013_CR37
  publication-title: J Med Chem
  doi: 10.1021/acs.jmedchem.5b00007
– volume: 73
  start-page: 178
  issue: 1
  year: 2008
  ident: 1013_CR283
  publication-title: Mol Pharmacol
  doi: 10.1124/mol.107.039842
– volume: 278
  start-page: 63
  issue: 5335
  year: 1997
  ident: 1013_CR183
  publication-title: Science
  doi: 10.1126/science.278.5335.63
– volume: 59
  start-page: 52
  issue: 1
  year: 1996
  ident: 1013_CR118
  publication-title: Clin Pharmacol Ther
  doi: 10.1016/S0009-9236(96)90024-7
– volume: 278
  start-page: 52
  issue: 5335
  year: 1997
  ident: 1013_CR131
  publication-title: Science
  doi: 10.1126/science.278.5335.52
– volume: 79
  start-page: 461
  issue: 5
  year: 2006
  ident: 1013_CR138
  publication-title: Clin Pharmacol Ther
  doi: 10.1016/j.clpt.2006.01.009
– volume: 225
  start-page: 753
  issue: 3
  year: 2013
  ident: 1013_CR112
  publication-title: Psychopharmacology (Berl)
  doi: 10.1007/s00213-012-2864-0
– volume: 10
  start-page: 3740
  issue: 8
  year: 2019
  ident: 1013_CR89
  publication-title: ACS Chem Neurosci
  doi: 10.1021/acschemneuro.9b00274
– volume: 16
  start-page: 383
  issue: 4
  year: 2004
  ident: 1013_CR70
  publication-title: Neurogastroenterol Motil
  doi: 10.1111/j.1365-2982.2004.00513.x
– volume: 84
  start-page: 587
  issue: 5
  year: 2001
  ident: 1013_CR97
  publication-title: Br J Cancer
  doi: 10.1054/bjoc.2001.1680
– volume: 24
  start-page: 528
  issue: 6
  year: 2008
  ident: 1013_CR124
  publication-title: Clin J Pain
  doi: 10.1097/AJP.0b013e318167a087
– volume: 160
  start-page: 127
  year: 2016
  ident: 1013_CR45
  publication-title: Drug Alcohol Depend
  doi: 10.1016/j.drugalcdep.2015.12.026
– volume: 36
  start-page: 1565
  year: 2012
  ident: 1013_CR68
  publication-title: Neurosci Biobehav Rev
  doi: 10.1016/j.neubiorev.2012.04.005
– volume: 35
  start-page: S54
  year: 1994
  ident: 1013_CR193
  publication-title: Ann Neurol
  doi: 10.1002/ana.410350716
– volume: 52
  start-page: 291
  issue: 4
  year: 2014
  ident: 1013_CR81
  publication-title: Med Care
  doi: 10.1097/MLR.0000000000000126
– volume: 111
  start-page: 60
  issue: 1
  year: 2009
  ident: 1013_CR172
  publication-title: J Pharmacol Sci
  doi: 10.1254/jphs.09139fp
– volume: 23
  start-page: 217
  issue: 4
  year: 2015
  ident: 1013_CR182
  publication-title: Exp Clin Psychopharmacol
  doi: 10.1037/pha0000028
– volume: 32
  start-page: 447
  issue: 4
  year: 2004
  ident: 1013_CR137
  publication-title: Drug Metab Dispos
  doi: 10.1124/dmd.32.4.447
– volume: 138
  start-page: 1
  year: 2014
  ident: 1013_CR4
  publication-title: Drug Alcohol Depend
  doi: 10.1016/j.drugalcdep.2014.02.006
– volume: 581
  start-page: 276
  issue: 3
  year: 2008
  ident: 1013_CR220
  publication-title: Eur J Pharmacol
  doi: 10.1016/j.ejphar.2007.12.008
– volume: 274
  start-page: 1263
  issue: 3
  year: 1995
  ident: 1013_CR57
  publication-title: J Pharmacol Exp Ther
– volume: 105
  start-page: 801
  issue: 4
  year: 2006
  ident: 1013_CR144
  publication-title: Anesthesiology
  doi: 10.1097/00000542-200610000-00027
– volume: 227
  start-page: 177
  issue: 1
  year: 2013
  ident: 1013_CR177
  publication-title: Psychopharmacology (Berl)
  doi: 10.1007/s00213-012-2954-z
– volume: 9
  start-page: 65
  issue: 1
  year: 2009
  ident: 1013_CR23
  publication-title: Curr Opin Pharmacol
  doi: 10.1016/j.coph.2008.12.014
– volume: 863
  start-page: 71
  issue: 1–2
  year: 2000
  ident: 1013_CR196
  publication-title: Brain Res
  doi: 10.1016/s0006-8993(00)02102-8
– volume: 56
  start-page: 265
  issue: 2
  year: 1997
  ident: 1013_CR32
  publication-title: Pharmacol Biochem Behav
  doi: 10.1016/s0091-3057(96)00240-7
– volume: 50
  start-page: 149
  issue: 1
  year: 1992
  ident: 1013_CR171
  publication-title: Neuroscience
  doi: 10.1016/0306-4522(92)90389-j
– volume: 34
  start-page: 4239
  issue: 12
  year: 2014
  ident: 1013_CR47
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.4458-13.2014
– volume: 39
  start-page: 4162
  issue: 21
  year: 2019
  ident: 1013_CR152
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.0274-19.2019
– volume: 6
  start-page: 662
  issue: 10
  year: 2005
  ident: 1013_CR53
  publication-title: J Pain
  doi: 10.1016/j.jpain.2005.05.004
– volume: 111
  start-page: 18369
  issue: 51
  year: 2014
  ident: 1013_CR153
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.1415013111
– volume: 60
  start-page: 177
  issue: 3
  year: 2010
  ident: 1013_CR158
  publication-title: Comp Med
– volume: 43
  start-page: 2606
  issue: 13
  year: 2018
  ident: 1013_CR142
  publication-title: Neuropsychopharmacology
  doi: 10.1038/s41386-018-0211-9
– volume: 284
  start-page: 37
  year: 2015
  ident: 1013_CR77
  publication-title: Behav Brain Res
  doi: 10.1016/j.bbr.2015.01.023
– volume: 181
  start-page: 664
  issue: 4
  year: 2005
  ident: 1013_CR58
  publication-title: Psychopharmacology (Berl)
  doi: 10.1007/s00213-005-0023-6
– volume: 363
  start-page: 104
  issue: 1
  year: 2017
  ident: 1013_CR173
  publication-title: J Pharmacol Exp Ther
  doi: 10.1124/jpet.117.243030
– volume: 157
  start-page: 264
  issue: 1
  year: 2016
  ident: 1013_CR251
  publication-title: Pain
  doi: 10.1097/j.pain.0000000000000363
– volume: 97
  start-page: 434
  issue: 2
  year: 2018
  ident: 1013_CR271
  publication-title: Neuron
  doi: 10.1016/j.neuron.2017.12.022
– volume-title: The Wiley-Blackwell handbook of addiction psychopharmacology
  year: 2013
  ident: 1013_CR160
  doi: 10.1002/9781118384404
– volume: 1
  start-page: S18
  year: 2009
  ident: 1013_CR146
  publication-title: Scand J Pain
  doi: 10.1016/S1877-8860(09)70005-9
– volume: 26
  start-page: 5894
  issue: 22
  year: 2006
  ident: 1013_CR126
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.0740-06.2006
– volume: 30
  start-page: 6999
  issue: 20
  year: 2010
  ident: 1013_CR106
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.5996-09.2010
– volume: 41
  start-page: 787
  issue: 8
  year: 2018
  ident: 1013_CR179
  publication-title: Drug Saf
  doi: 10.1007/s40264-018-0660-4
– volume: 316
  start-page: 1195
  issue: 3
  year: 2006
  ident: 1013_CR198
  publication-title: J Pharmacol Exp Ther
  doi: 10.1124/jpet.105.094276
– ident: 1013_CR167
  doi: 10.1016/j.drugpo.2013.10.004
– volume: 40
  start-page: 389
  year: 2000
  ident: 1013_CR141
  publication-title: Annu Rev Pharmacol Toxicol
  doi: 10.1146/annurev.pharmtox.40.1.389
– volume: 7
  start-page: 10702
  year: 2016
  ident: 1013_CR24
  publication-title: Nat Commun
  doi: 10.1038/ncomms10702
– volume: 128
  start-page: 1015
  issue: 5
  year: 2018
  ident: 1013_CR151
  publication-title: Anesthesiology
  doi: 10.1097/ALN.0000000000002031
– volume: 34
  start-page: 1
  issue: 1
  year: 1999
  ident: 1013_CR238
  publication-title: Synapse
  doi: 10.1002/(SICI)1098-2396(199910)34:1<1::AID-SYN1>3.0.CO;2-H
– volume: 11
  start-page: 259
  issue: 3
  year: 2011
  ident: 1013_CR257
  publication-title: Drugs R D
  doi: 10.2165/11593390-000000000-00000
– volume: 20
  start-page: 7489
  issue: 19
  year: 2000
  ident: 1013_CR110
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.20-19-07489.2000
– volume: 70
  start-page: 125
  issue: 2
  year: 1992
  ident: 1013_CR206
  publication-title: Pharmacol Toxicol
  doi: 10.1111/j.1600-0773.1992.tb00441.x
– volume: 133
  start-page: 2098
  issue: Pt7
  year: 2010
  ident: 1013_CR245
  publication-title: Brain
  doi: 10.1093/brain/awq138
– volume: 285
  start-page: 908
  issue: 2
  year: 1998
  ident: 1013_CR281
  publication-title: J Pharmacol Exp Ther
– volume: 3
  start-page: e01936
  year: 2014
  ident: 1013_CR243
  publication-title: Elife
  doi: 10.7554/eLife.01936
– volume: 4
  start-page: 150
  year: 2010
  ident: 1013_CR241
  publication-title: Front Neuroanat
  doi: 10.3389/fnana.2010.00150
– volume: 42
  start-page: 123
  issue: 2
  year: 2016
  ident: 1013_CR6
  publication-title: J Exp Psychol Anim Learn Cogn
  doi: 10.1037/xan0000090
– volume: 23
  start-page: 15
  issue: 2
  year: 2019
  ident: 1013_CR212
  publication-title: Curr Pain Headache Rep
  doi: 10.1007/s11916-019-0751-7
– year: 2020
  ident: 1013_CR223
  publication-title: Int J Mol Sci
  doi: 10.3390/ijms21030847
– volume: 24
  start-page: 175
  issue: 1
  year: 2008
  ident: 1013_CR213
  publication-title: Curr Med Res Opin
  doi: 10.1185/030079908x253708
– volume: 54
  start-page: 468
  issue: 4
  year: 2014
  ident: 1013_CR99
  publication-title: J Clin Pharmacol
  doi: 10.1002/jcph.235
– volume: 26
  start-page: 2788
  issue: 10
  year: 2006
  ident: 1013_CR84
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.4331-05.2006
– volume: 221
  start-page: 171
  issue: 1
  year: 2012
  ident: 1013_CR285
  publication-title: Psychopharmacology (Berl)
  doi: 10.1007/s00213-011-2557-0
– volume: 25
  start-page: 454
  issue: 5
  year: 2011
  ident: 1013_CR129
  publication-title: Palliat Med
  doi: 10.1177/0269216311401948
– year: 2020
  ident: 1013_CR27
  publication-title: bioRxiv
  doi: 10.1101/2020.08.31.276253
– volume: 75
  start-page: 1713
  issue: 4
  year: 1978
  ident: 1013_CR28
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.75.4.1713
– volume: 343
  start-page: 72
  issue: 1
  year: 2012
  ident: 1013_CR64
  publication-title: J Pharmacol Exp Ther
  doi: 10.1124/jpet.112.194308
– volume: 160
  start-page: 1374
  issue: 6
  year: 2019
  ident: 1013_CR166
  publication-title: Pain
  doi: 10.1097/j.pain.0000000000001517
– volume: 25
  start-page: 53
  issue: 1
  year: 2001
  ident: 1013_CR237
  publication-title: Neurosci Biobehav Rev
  doi: 10.1016/s0149-7634(00)00051-8
– volume: 65
  start-page: 223
  issue: 1
  year: 2013
  ident: 1013_CR262
  publication-title: Pharmacol Rev
  doi: 10.1124/pr.112.005942
– volume: 104
  start-page: 403
  issue: 1
  year: 2010
  ident: 1013_CR156
  publication-title: J Neurophysiol
  doi: 10.1152/jn.00204.2010
– volume: 73
  start-page: 1184
  issue: 6
  year: 2012
  ident: 1013_CR247
  publication-title: Neuron
  doi: 10.1016/j.neuron.2012.02.016
– volume: 63
  start-page: 65
  issue: 1
  year: 1995
  ident: 1013_CR280
  publication-title: Pain
  doi: 10.1016/0304-3959(95)00017-M
– volume: 11
  start-page: 323
  year: 2018
  ident: 1013_CR2
  publication-title: J Multidiscip Healthc
  doi: 10.2147/JMDH.S166915
– year: 2020
  ident: 1013_CR143
  publication-title: Neuropsychopharmacology
  doi: 10.1038/s41386-020-0643-x
– volume: 111
  start-page: 867
  year: 2016
  ident: 1013_CR270
  publication-title: Pharmacol Res
  doi: 10.1016/j.phrs.2016.05.034
– volume: 16
  start-page: 3222
  issue: 10
  year: 1998
  ident: 1013_CR34
  publication-title: J Clin Oncol
  doi: 10.1200/JCO.1998.16.10.3222
– volume: 120
  start-page: 676
  issue: 4
  year: 1997
  ident: 1013_CR242
  publication-title: Br J Pharmacol
  doi: 10.1038/sj.bjp.0700942
– volume: 12
  start-page: 3113
  year: 2019
  ident: 1013_CR16
  publication-title: J Pain Res
  doi: 10.2147/JPR.S217563
– start-page: 202
  volume-title: Pleasures of the brain
  year: 2010
  ident: 1013_CR133
– year: 2020
  ident: 1013_CR41
  publication-title: Neuropsychopharmacology
  doi: 10.1038/s41386-020-0679-y
– volume: 19
  start-page: 307
  issue: 2
  year: 2018
  ident: 1013_CR259
  publication-title: Pain Med
  doi: 10.1093/pm/pnw344
– volume: 15
  start-page: 618
  issue: 9
  year: 2006
  ident: 1013_CR195
  publication-title: Pharmacoepidemiol Drug Saf
  doi: 10.1002/pds.1276
– volume: 372
  start-page: 241
  issue: 3
  year: 2015
  ident: 1013_CR66
  publication-title: N Engl J Med
  doi: 10.1056/NEJMsa1406143
– volume: 58
  start-page: 272
  issue: 2
  year: 2008
  ident: 1013_CR240
  publication-title: Brain Res Rev
  doi: 10.1016/j.brainresrev.2007.10.008
– volume: 85
  start-page: 5274
  issue: 14
  year: 1988
  ident: 1013_CR73
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.85.14.5274
– volume: 235
  start-page: 2349
  issue: 8
  year: 2018
  ident: 1013_CR135
  publication-title: Psychopharmacology (Berl)
  doi: 10.1007/s00213-018-4931-7
– volume: 8
  start-page: 178
  year: 1985
  ident: 1013_CR265
  publication-title: Behav Brain Sci
  doi: 10.1017/s0140525x00020306
– volume: 8
  start-page: 335
  issue: 4
  year: 2012
  ident: 1013_CR261
  publication-title: J Med Toxicol
  doi: 10.1007/s13181-012-0263-x
– volume: 86
  start-page: 646
  issue: 3
  year: 2015
  ident: 1013_CR19
  publication-title: Neuron
  doi: 10.1016/j.neuron.2015.02.018
– volume: 131
  start-page: 100
  issue: 1–2
  year: 2013
  ident: 1013_CR61
  publication-title: Drug Alcohol Depend
  doi: 10.1016/j.drugalcdep.2012.12.006
– volume: 1
  start-page: 14
  year: 2005
  ident: 1013_CR264
  publication-title: Head Face Med
  doi: 10.1186/1746-160X-1-14
– volume: 31
  start-page: 16757
  issue: 46
  year: 2011
  ident: 1013_CR107
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.2628-11.2011
– volume: 24
  start-page: 413
  issue: 3
  year: 1983
  ident: 1013_CR140
  publication-title: Mol Pharmacol
– volume: 175
  start-page: 2846
  issue: 14
  year: 2018
  ident: 1013_CR154
  publication-title: Br J Pharmacol
  doi: 10.1111/bph.13823
– volume: 290
  start-page: 78
  issue: 3
  year: 2004
  ident: 1013_CR184
  publication-title: Sci Am
  doi: 10.1038/scientificamerican0304-78
– volume: 301
  start-page: 529
  year: 2015
  ident: 1013_CR269
  publication-title: Neuroscience
  doi: 10.1016/j.neuroscience.2015.06.033
– volume: 11
  start-page: 1078
  year: 2020
  ident: 1013_CR282
  publication-title: Front Pharmacol
  doi: 10.3389/fphar.2020.01078
– volume: 33
  start-page: 6665
  issue: S1
  year: 2019
  ident: 1013_CR117
  publication-title: FASEB J
  doi: 10.1096/fasebj.2019.33.1_supplement.666.5
– volume: 2012
  start-page: 265605
  year: 2012
  ident: 1013_CR67
  publication-title: Pain Res Treat
  doi: 10.1155/2012/265605
– volume: 124
  start-page: 1720
  year: 2001
  ident: 1013_CR229
  publication-title: Brain
  doi: 10.1093/brain/124.9.1720
– volume: 506
  start-page: 191
  issue: 7487
  year: 2014
  ident: 1013_CR83
  publication-title: Nature
  doi: 10.1038/nature12944
– volume: 79
  start-page: 1428
  issue: 7
  year: 1997
  ident: 1013_CR94
  publication-title: Cancer
  doi: 10.1002/(SICI)1097-0142(19970401)79:7<1428::AID-CNCR21>3.0.CO;2-0
– volume: 8
  start-page: 1147
  issue: 6
  year: 2017
  ident: 1013_CR211
  publication-title: ACS Chem Neurosci
  doi: 10.1021/acschemneuro.7b00090
– volume: 3
  start-page: e1506
  issue: 1
  year: 2008
  ident: 1013_CR50
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0001506
– volume: 38
  start-page: 166
  issue: 2
  year: 2012
  ident: 1013_CR191
  publication-title: Am J Drug Alcohol Abuse
  doi: 10.3109/00952990.2011.643994
– volume: 186
  start-page: 172778
  year: 2019
  ident: 1013_CR115
  publication-title: Pharmacol Biochem Behav
  doi: 10.1016/j.pbb.2019.172778
– volume: 8
  start-page: 29
  year: 2011
  ident: 1013_CR39
  publication-title: Harm Reduct J
  doi: 10.1186/1477-7517-8-29
– volume: 1
  start-page: 279
  issue: 4
  year: 2005
  ident: 1013_CR122
  publication-title: Ther Clin Risk Manag
– volume: 9
  start-page: 1647
  year: 2018
  ident: 1013_CR18
  publication-title: Front Psychol
  doi: 10.3389/fpsyg.2018.01647
– volume: 108
  start-page: 495
  issue: 3
  year: 2008
  ident: 1013_CR30
  publication-title: Anesthesiology
  doi: 10.1097/ALN.0b013e318164cf9e
– volume: 50
  start-page: 360
  issue: 5
  year: 2012
  ident: 1013_CR235
  publication-title: Int J Clin Pharmacol Ther
  doi: 10.5414/cp201646
– volume: 1335
  start-page: 223
  year: 2015
  ident: 1013_CR25
  publication-title: Methods Mol Biol
  doi: 10.1007/978-1-4939-2914-6_15
– volume: 1
  start-page: 262
  issue: 4
  year: 2012
  ident: 1013_CR175
  publication-title: Anesth Pain Med
  doi: 10.5812/aapm.4529
– volume: 107
  start-page: 587
  issue: 3
  year: 2012
  ident: 1013_CR273
  publication-title: Addiction
  doi: 10.1111/j.1360-0443.2011.03635.x
– volume: 13
  start-page: 365
  year: 2019
  ident: 1013_CR268
  publication-title: Drug Des Devel Ther
  doi: 10.2147/DDDT.S188728
– volume: 89
  start-page: 2027
  issue: 11
  year: 2003
  ident: 1013_CR139
  publication-title: Br J Cancer
  doi: 10.1038/sj.bjc.6601365
– volume: 241
  start-page: 534
  issue: 2
  year: 1987
  ident: 1013_CR249
  publication-title: J Pharmacol Exp Ther
– volume: 105
  start-page: 71
  issue: 1–2
  year: 2003
  ident: 1013_CR256
  publication-title: Pain
  doi: 10.1016/s0304-3959(03)00160-x
– volume: 10
  start-page: 1559
  issue: 12
  year: 2007
  ident: 1013_CR136
  publication-title: Nat Neurosci
  doi: 10.1038/nn2006
– volume: 36
  start-page: 669
  issue: 10
  year: 2011
  ident: 1013_CR250
  publication-title: P T
– volume: 27
  start-page: 558
  issue: 11
  year: 2006
  ident: 1013_CR10
  publication-title: Trends Pharmacol Sci
  doi: 10.1016/j.tips.2006.09.006
– volume: 362
  start-page: 378
  issue: 3
  year: 2017
  ident: 1013_CR69
  publication-title: J Pharmacol Exp Ther
  doi: 10.1124/jpet.117.241042
– volume: 42
  start-page: 8
  issue: 1
  year: 2017
  ident: 1013_CR209
  publication-title: J Clin Pharm Ther
  doi: 10.1111/jcpt.12461
– volume: 8
  start-page: 19
  issue: 1
  year: 2019
  ident: 1013_CR208
  publication-title: Pain Ther
  doi: 10.1007/s40122-019-0122-4
– volume: 15
  start-page: 123
  issue: 1
  year: 2011
  ident: 1013_CR79
  publication-title: Nat Neurosci
  doi: 10.1038/nn.2984
– volume: 69
  start-page: 215
  issue: 3
  year: 2003
  ident: 1013_CR279
  publication-title: Drug Alcohol Depend
  doi: 10.1016/s0376-8716(03)00003-6
– volume: 87
  start-page: 15
  issue: 1
  year: 2020
  ident: 1013_CR92
  publication-title: Biol Psychiatry
  doi: 10.1016/j.biopsych.2019.10.020
– volume: 40
  start-page: 3041
  issue: 7
  year: 2014
  ident: 1013_CR248
  publication-title: Eur J Neurosci
  doi: 10.1111/ejn.12709
– year: 2016
  ident: 1013_CR80
  publication-title: F1000Res
  doi: 10.12688/f1000research.8369.1
– volume: 77
  start-page: 26
  year: 2017
  ident: 1013_CR103
  publication-title: J Subst Abuse Treat
  doi: 10.1016/j.jsat.2017.03.006
– volume: 73
  start-page: 37
  issue: 1
  year: 1997
  ident: 1013_CR100
  publication-title: Pain
  doi: 10.1016/s0304-3959(97)00072-9
– volume: 13
  start-page: 954
  issue: 9
  year: 2009
  ident: 1013_CR96
  publication-title: Eur J Pain
  doi: 10.1016/j.ejpain.2008.11.006
– volume: 2
  start-page: 264
  issue: 4
  year: 2019
  ident: 1013_CR181
  publication-title: ACS Pharmacol Transl Sci
  doi: 10.1021/acsptsci.9b00021
– volume: 30
  start-page: 90
  issue: 2
  year: 1986
  ident: 1013_CR260
  publication-title: Mol Pharmacol
– volume: 372
  start-page: 354
  issue: 5
  year: 2006
  ident: 1013_CR123
  publication-title: Naunyn Schmiedebergs Arch Pharmacol
  doi: 10.1007/s00210-006-0033-x
– volume: 102
  start-page: 270
  issue: 1
  year: 1992
  ident: 1013_CR190
  publication-title: Chest
  doi: 10.1378/chest.102.1.270
– volume: 47
  start-page: 639
  issue: 5
  year: 1990
  ident: 1013_CR120
  publication-title: Clin Pharmacol Ther
  doi: 10.1038/clpt.1990.85
– ident: 1013_CR300
  doi: 10.1124/jpet.103.058602
– volume: 580
  start-page: 87
  issue: 1–2
  year: 2008
  ident: 1013_CR7
  publication-title: Eur J Pharmacol
  doi: 10.1016/j.ejphar.2007.10.020
– volume: 17
  start-page: E119
  issue: 2
  year: 2014
  ident: 1013_CR8
  publication-title: Pain Physician
  doi: 10.36076/ppj.2014/17/E119
– volume: 9
  start-page: 30
  issue: 1
  year: 1997
  ident: 1013_CR9
  publication-title: J Clin Anesth
  doi: 10.1016/S0952-8180(96)00212-7
– volume: 28
  start-page: 1115
  issue: 12
  year: 2014
  ident: 1013_CR88
  publication-title: J Psychopharmacol
  doi: 10.1177/0269881114548436
– volume: 68
  start-page: 815
  issue: 5
  year: 2010
  ident: 1013_CR33
  publication-title: Neuron
  doi: 10.1016/j.neuron.2010.11.022
– volume: 99
  start-page: 221
  issue: 2
  year: 2009
  ident: 1013_CR246
  publication-title: Am J Public Health
  doi: 10.2105/AJPH.2007.131714
– volume: 23
  start-page: 10331
  issue: 32
  year: 2003
  ident: 1013_CR157
  publication-title: J Neurosci
  doi: 10.1523/jneurosci.23-32-10331.2003
– volume: 5
  start-page: 77
  year: 2012
  ident: 1013_CR239
  publication-title: J Pain Res
  doi: 10.2147/JPR.S21965
– volume: 7
  start-page: e42365
  issue: 7
  year: 2012
  ident: 1013_CR164
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0042365
– volume: 18
  start-page: 132
  issue: 1
  year: 2018
  ident: 1013_CR93
  publication-title: BMC Anesthesiol
  doi: 10.1186/s12871-018-0583-8
– volume: 18
  start-page: 247
  issue: 3
  year: 1993
  ident: 1013_CR214
  publication-title: Brain Res Brain Res Rev
  doi: 10.1016/0165-0173(93)90013-p
– start-page: 147
  volume-title: Molecular neuropharmacology: a foundation for clinical neuroscience (2nd edn)
  year: 2009
  ident: 1013_CR163
– ident: 1013_CR46
– volume: 12
  start-page: 873
  issue: 11
  year: 2010
  ident: 1013_CR236
  publication-title: J Gene Med
  doi: 10.1002/jgm.1514
– volume: 286
  start-page: 12724
  issue: 14
  year: 2011
  ident: 1013_CR284
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M110.177089
– volume: 173
  start-page: 1231
  issue: 4417
  year: 1954
  ident: 1013_CR14
  publication-title: Nature
  doi: 10.1038/1731231a0
– volume: 11
  start-page: 67
  issue: 1
  year: 2010
  ident: 1013_CR38
  publication-title: Pain Med
  doi: 10.1111/j.1526-4637.2009.00736.x
– volume: 31
  start-page: 730
  issue: 6
  year: 2017
  ident: 1013_CR5
  publication-title: J Psychopharmacol
  doi: 10.1177/0269881116689257
– volume: 50
  start-page: 1837
  issue: 6
  year: 1998
  ident: 1013_CR255
  publication-title: Neurology
  doi: 10.1212/wnl.50.6.1837
– volume: 98
  start-page: 425
  issue: 4
  year: 2020
  ident: 1013_CR116
  publication-title: Mol Pharmacol
  doi: 10.1124/mol.119.119321
– volume: 150
  start-page: 210
  year: 2019
  ident: 1013_CR254
  publication-title: Neuropharmacology
  doi: 10.1016/j.neuropharm.2019.02.007
– volume: 78
  start-page: 1805
  issue: 17
  year: 2018
  ident: 1013_CR71
  publication-title: Drugs
  doi: 10.1007/s40265-018-1007-2
– year: 2018
  ident: 1013_CR75
  publication-title: Sci Transl Med
  doi: 10.1126/scitranslmed.aar3483
– volume: 12
  start-page: 483
  issue: 2
  year: 1992
  ident: 1013_CR113
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.12-02-00483.1992
– volume: 73
  start-page: 151
  issue: 2
  year: 1997
  ident: 1013_CR217
  publication-title: Pain
  doi: 10.1016/s0304-3959(97)00093-6
– volume: 25
  start-page: 8637
  issue: 38
  year: 2005
  ident: 1013_CR230
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.1902-05.2005
– volume: 73
  start-page: 243
  issue: 1
  year: 2009
  ident: 1013_CR63
  publication-title: Albany Law Rev
– volume: 40
  start-page: 3472
  issue: 10
  year: 2014
  ident: 1013_CR201
  publication-title: Eur J Neurosci
  doi: 10.1111/ejn.12733
– volume: 12
  start-page: 927
  year: 2019
  ident: 1013_CR252
  publication-title: J Pain Res
  doi: 10.2147/JPR.S171013
– volume: 852
  start-page: 265
  year: 2019
  ident: 1013_CR272
  publication-title: Eur J Pharmacol
  doi: 10.1016/j.ejphar.2019.04.009
– volume: 107
  start-page: 11608
  issue: 25
  year: 2010
  ident: 1013_CR170
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.1000751107
– volume: 79
  start-page: 443
  year: 2003
  ident: 1013_CR200
  publication-title: Methods Mol Med
  doi: 10.1385/1-59259-358-5:443
– volume: 398
  start-page: 88
  year: 2019
  ident: 1013_CR109
  publication-title: Neuroscience
  doi: 10.1016/j.neuroscience.2018.11.042
– volume: 32
  start-page: 14094
  issue: 41
  year: 2012
  ident: 1013_CR12
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.3370-12.2012
– volume: 10
  start-page: 471
  year: 2016
  ident: 1013_CR174
  publication-title: Front Neurosci
  doi: 10.3389/fnins.2016.00471
– volume: 105
  start-page: 3
  issue: 1
  year: 1991
  ident: 1013_CR21
  publication-title: Behav Neurosci
  doi: 10.1037/0735-7044.105.1.3
– volume: 35
  start-page: 295
  issue: 3
  year: 2008
  ident: 1013_CR49
  publication-title: Clin Exp Pharmacol Physiol
  doi: 10.1111/j.1440-1681.2007.04821.x
– volume: 17
  start-page: 704
  issue: 5
  year: 2014
  ident: 1013_CR263
  publication-title: Nat Neurosci
  doi: 10.1038/nn.3694
– volume: 9
  start-page: 119
  year: 2018
  ident: 1013_CR222
  publication-title: Front Psychiatry
  doi: 10.3389/fpsyt.2018.00119
– volume: 93
  start-page: 157
  issue: 2
  year: 2018
  ident: 1013_CR155
  publication-title: Mol Pharmacol
  doi: 10.1124/mol.117.109561
– volume: 35
  start-page: 12917
  issue: 37
  year: 2015
  ident: 1013_CR76
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.2444-15.2015
– volume: 7
  start-page: 442
  issue: 5
  year: 2008
  ident: 1013_CR225
  publication-title: CNS Neurol Disord Drug Targets
  doi: 10.2174/187152708786927813
– volume: 17
  start-page: 644
  issue: 5
  year: 2014
  ident: 1013_CR43
  publication-title: Nat Neurosci
  doi: 10.1038/nn.3699
– volume: 350
  start-page: 102
  issue: 6256
  year: 2015
  ident: 1013_CR127
  publication-title: Science
  doi: 10.1126/science.aac4690
– volume: 132
  start-page: 289
  issue: 3
  year: 2007
  ident: 1013_CR186
  publication-title: Pain
  doi: 10.1016/j.pain.2007.03.022
– volume: 19
  start-page: 715
  issue: 7
  year: 2019
  ident: 1013_CR228
  publication-title: Pain Pract
  doi: 10.1111/papr.12801
– volume: 143
  start-page: 309
  issue: 1
  year: 2006
  ident: 1013_CR267
  publication-title: Neuroscience
  doi: 10.1016/j.neuroscience.2006.06.067
– volume: 59
  start-page: 30
  issue: 1
  year: 2001
  ident: 1013_CR82
  publication-title: Mol Pharmacol
  doi: 10.1124/mol.59.1.30
– year: 2012
  ident: 1013_CR159
  publication-title: ASN Neuro
  doi: 10.1042/AN20110063
– volume: 82
  start-page: 1346
  issue: 6
  year: 2014
  ident: 1013_CR168
  publication-title: Neuron
  doi: 10.1016/j.neuron.2014.04.030
– volume: 70
  start-page: 676
  issue: 2
  year: 2006
  ident: 1013_CR114
  publication-title: Mol Pharmacol
  doi: 10.1124/mol.106.022376
– volume: 63
  start-page: 124
  year: 2016
  ident: 1013_CR205
  publication-title: Neurosci Biobehav Rev
  doi: 10.1016/j.neubiorev.2016.01.006
– volume: 10
  start-page: 2996
  issue: 9
  year: 1990
  ident: 1013_CR13
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.10-09-02996.1990
– volume: 19
  start-page: 1255
  issue: 9
  year: 2014
  ident: 1013_CR36
  publication-title: J Biomol Screen
  doi: 10.1177/1087057114542975
– volume: 20
  start-page: 33
  issue: 4
  year: 2006
  ident: 1013_CR15
  publication-title: J Pain Palliat Care Pharmacother
  doi: 10.1080/J354v20n04_06
– volume: 320
  start-page: 801
  issue: 2
  year: 2007
  ident: 1013_CR218
  publication-title: J Pharmacol Exp Ther
  doi: 10.1124/jpet.106.113167
– volume: 23
  start-page: 1596
  issue: 6
  year: 2006
  ident: 1013_CR224
  publication-title: Eur J Neurosci
  doi: 10.1111/j.1460-9568.2006.04689.x
– volume: 24
  start-page: 173
  issue: 2
  year: 2000
  ident: 1013_CR17
  publication-title: Neurosci Biobehav Rev
  doi: 10.1016/s0149-7634(99)00072-x
– volume: 2
  start-page: 239
  issue: 3
  year: 1998
  ident: 1013_CR178
  publication-title: Eur J Pain
  doi: 10.1016/s1090-3801(98)90020-9
– volume: 18
  start-page: 73
  issue: 2
  year: 2017
  ident: 1013_CR176
  publication-title: Nat Rev Neurosci
  doi: 10.1038/nrn.2016.165
– volume: 108
  start-page: E255
  issue: 27
  year: 2011
  ident: 1013_CR234
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.1101920108
– volume: 62
  start-page: 243
  issue: 4
  year: 2008
  ident: 1013_CR85
  publication-title: Synapse
  doi: 10.1002/syn.20489
– volume: 253
  start-page: 563
  issue: 5492
  year: 1975
  ident: 1013_CR194
  publication-title: Nature
  doi: 10.1038/253563a0
– volume: 12
  start-page: 182
  issue: 3
  year: 1996
  ident: 1013_CR161
  publication-title: J Pain Symptom Manage
  doi: 10.1016/0885-3924(96)00050-4
– volume: 184
  start-page: 189
  year: 2018
  ident: 1013_CR169
  publication-title: Pharmacol Ther
  doi: 10.1016/j.pharmthera.2017.10.008
– year: 2019
  ident: 1013_CR101
  publication-title: bioRxiv
  doi: 10.1101/574434
– volume: 33
  start-page: 1097
  issue: 5
  year: 2008
  ident: 1013_CR180
  publication-title: Neuropsychopharmacology
  doi: 10.1038/sj.npp.1301471
– volume: 2
  start-page: 173
  issue: 1
  year: 2011
  ident: 1013_CR203
  publication-title: Subst Abuse Rehabil
  doi: 10.2147/SAR.S24800
– volume: 67
  start-page: 942
  issue: 5
  year: 2003
  ident: 1013_CR227
  publication-title: Am Fam Physician
– volume: 11
  start-page: 217
  issue: 2
  year: 2006
  ident: 1013_CR1
  publication-title: Oncologist
  doi: 10.1634/theoncologist.11-2-217
– volume: 114
  start-page: E9125
  issue: 43
  year: 2017
  ident: 1013_CR48
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.1705753114
– volume: 15
  start-page: 1187
  issue: 7
  year: 2014
  ident: 1013_CR102
  publication-title: Pain Med
  doi: 10.1111/pme.12391
– volume: 55
  start-page: 1836
  issue: 9
  year: 2015
  ident: 1013_CR26
  publication-title: J Chem Inf Model
  doi: 10.1021/acs.jcim.5b00388
– volume: 367
  start-page: 187
  issue: 2
  year: 2012
  ident: 1013_CR55
  publication-title: N Engl J Med
  doi: 10.1056/NEJMc1204141
– year: 2018
  ident: 1013_CR199
  publication-title: Proteomes
  doi: 10.3390/proteomes6040039
– year: 2020
  ident: 1013_CR132
  publication-title: Cell Mol Neurobiol
  doi: 10.1007/s10571-020-00816-3
– volume: 71
  start-page: 670
  issue: 8
  year: 2016
  ident: 1013_CR20
  publication-title: Am Psychol
  doi: 10.1037/amp0000059
– volume: 11
  start-page: 446
  issue: 5
  year: 1983
  ident: 1013_CR60
  publication-title: Drug Metab Dispos
– volume: 6
  start-page: 31748
  year: 2016
  ident: 1013_CR188
  publication-title: Sci Rep
  doi: 10.1038/srep31748
– ident: 1013_CR302
  doi: 10.1097/FBP.0b013e328363d1c4
– volume: 133
  start-page: 371
  year: 1961
  ident: 1013_CR86
  publication-title: J Pharmacol Exp Ther
– volume: 11
  start-page: 463
  issue: 6
  year: 2015
  ident: 1013_CR221
  publication-title: J Opioid Manag
  doi: 10.5055/jom.2015.0299
– volume: 129
  start-page: 100
  year: 2018
  ident: 1013_CR244
  publication-title: Neuropharmacology
  doi: 10.1016/j.neuropharm.2017.11.026
– volume: 33
  start-page: 1179
  issue: 5
  year: 2008
  ident: 1013_CR59
  publication-title: Neuropsychopharmacology
  doi: 10.1038/sj.npp.1301479
– volume: 26
  start-page: 201
  issue: 2
  year: 2015
  ident: 1013_CR11
  publication-title: Phys Med Rehabil Clin N Am
  doi: 10.1016/j.pmr.2014.12.001
– volume: 262
  start-page: 383
  issue: 845
  year: 1971
  ident: 1013_CR125
  publication-title: Philos Trans R Soc Lond B Biol Sci
  doi: 10.1098/rstb.1971.0102
– volume: 35
  start-page: e163
  issue: 2
  year: 2017
  ident: 1013_CR219
  publication-title: Anesthesiol Clin
  doi: 10.1016/j.anclin.2017.01.022
– volume: 110
  start-page: 10830
  issue: 26
  year: 2013
  ident: 1013_CR35
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.1300393110
– volume: 5
  start-page: 625
  issue: 7
  year: 2002
  ident: 1013_CR3
  publication-title: Nat Neurosci
  doi: 10.1038/nn872
– volume: 79
  start-page: 906
  issue: 8
  year: 2013
  ident: 1013_CR44
  publication-title: Minerva Anestesiol
– volume: 154
  start-page: 2639
  issue: 12
  year: 2013
  ident: 1013_CR56
  publication-title: Pain
  doi: 10.1016/j.pain.2013.07.025
– volume: 232
  start-page: 3685
  issue: 20
  year: 2015
  ident: 1013_CR266
  publication-title: Psychopharmacology (Berl)
  doi: 10.1007/s00213-015-4027-6
– volume: 17
  start-page: 908
  issue: 5
  year: 2016
  ident: 1013_CR78
  publication-title: Pain Med
  doi: 10.1111/pme.12918
– volume: 90
  start-page: 64
  issue: 1
  year: 2007
  ident: 1013_CR216
  publication-title: Drug Alcohol Depend
  doi: 10.1016/j.drugalcdep.2007.02.012
– volume: 535
  start-page: 145
  issue: 1–3
  year: 2006
  ident: 1013_CR187
  publication-title: Eur J Pharmacol
  doi: 10.1016/j.ejphar.2006.02.002
– volume: 29
  start-page: 565
  year: 2006
  ident: 1013_CR105
  publication-title: Annu Rev Neurosci
  doi: 10.1146/annurev.neuro.29.051605.113009
– volume: 109
  start-page: 1279
  issue: 4
  year: 2009
  ident: 1013_CR147
  publication-title: Anesth Analg
  doi: 10.1213/ane.0b013e3181b0f0bb
– volume: 170
  start-page: 242
  issue: 3
  year: 2003
  ident: 1013_CR275
  publication-title: Psychopharmacology (Berl)
  doi: 10.1007/s00213-003-1540-9
– volume: 177
  start-page: 2923
  issue: 13
  year: 2020
  ident: 1013_CR130
  publication-title: Br J Pharmacol
  doi: 10.1111/bph.15004
– volume: 196
  start-page: 105
  issue: 1
  year: 2008
  ident: 1013_CR278
  publication-title: Psychopharmacology (Berl)
  doi: 10.1007/s00213-007-0937-2
– volume: 103
  start-page: 36
  issue: 1
  year: 1989
  ident: 1013_CR22
  publication-title: Behav Neurosci
  doi: 10.1037//0735-7044.103.1.36
– volume: 76
  start-page: 5626
  issue: 11
  year: 1979
  ident: 1013_CR29
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.76.11.5626
– volume: 40
  start-page: 2
  year: 2020
  ident: 1013_CR274
  publication-title: Biosci Rep
– volume: 133
  start-page: 559
  issue: 3
  year: 2020
  ident: 1013_CR65
  publication-title: Anesthesiology
  doi: 10.1097/ALN.0000000000003441
– volume: 35
  start-page: 129
  issue: 2
  year: 2010
  ident: 1013_CR108
  publication-title: Neurosci Biobehav Rev
  doi: 10.1016/j.neubiorev.2010.02.001
– volume: 21
  start-page: 1125
  issue: 7
  year: 2000
  ident: 1013_CR74
  publication-title: Peptides
  doi: 10.1016/s0196-9781(00)00250-3
– volume: 4
  start-page: 277
  issue: 4
  year: 2006
  ident: 1013_CR226
  publication-title: Curr Neuropharmacol
  doi: 10.2174/157015906778520773
– volume: 985
  start-page: 78
  issue: 1
  year: 2003
  ident: 1013_CR232
  publication-title: Brain Res
  doi: 10.1016/s0006-8993(03)03170-6
– ident: 1013_CR301
  doi: 10.1038/nature10954
– year: 2019
  ident: 1013_CR185
  publication-title: bioRxiv
  doi: 10.1101/460048
– volume: 29
  start-page: S47
  year: 2005
  ident: 1013_CR119
  publication-title: J Pain Symptom Manage
  doi: 10.1016/j.jpainsymman.2005.01.010
– volume: 13
  start-page: 790
  issue: 6
  year: 2012
  ident: 1013_CR258
  publication-title: Pain Med
  doi: 10.1111/j.1526-4637.2012.01380.x
– volume: 106
  start-page: 463
  issue: 2
  year: 2008
  ident: 1013_CR145
  publication-title: Anesth Analg
  doi: 10.1213/ane.0b013e3181605a15
– volume: 14
  start-page: e0217371
  issue: 6
  year: 2019
  ident: 1013_CR189
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0217371
– volume: 40
  start-page: 339
  issue: 3
  year: 1990
  ident: 1013_CR202
  publication-title: Pain
  doi: 10.1016/0304-3959(90)91131-2
– volume: 9
  start-page: 433
  issue: 4
  year: 2008
  ident: 1013_CR276
  publication-title: Pain Med
  doi: 10.1111/j.1526-4637.2007.00359.x
– volume: 108
  start-page: 16446
  issue: 39
  year: 2011
  ident: 1013_CR111
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.1105418108
– volume: 22
  start-page: 684
  issue: 4
  year: 2010
  ident: 1013_CR51
  publication-title: Cell Signal
  doi: 10.1016/j.cellsig.2009.12.003
– volume: 9
  start-page: 16
  issue: 414
  year: 2016
  ident: 1013_CR95
  publication-title: Sci Signal
  doi: 10.1126/scisignal.aac9177
– volume: 96
  start-page: 542
  issue: 5
  year: 2019
  ident: 1013_CR62
  publication-title: Mol Pharmacol
  doi: 10.1124/mol.119.115956
– volume: 25
  start-page: 11777
  issue: 50
  year: 2005
  ident: 1013_CR197
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.2329-05.2005
– volume: 32
  start-page: 516
  issue: 4
  year: 1991
  ident: 1013_CR207
  publication-title: Br J Clin Pharmacol
  doi: 10.1111/j.1365-2125.1991.tb03942.x
– volume: 26
  start-page: 862
  issue: 4
  year: 1999
  ident: 1013_CR42
  publication-title: J Rheumatol
– volume: 72
  start-page: 424
  issue: 5
  year: 2015
  ident: 1013_CR52
  publication-title: JAMA Psychiatry
  doi: 10.1001/jamapsychiatry.2014.3043
– volume: 34
  start-page: 14707
  issue: 44
  year: 2014
  ident: 1013_CR165
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.2144-14.2014
– volume: 101
  start-page: 107
  issue: 1–2
  year: 2009
  ident: 1013_CR277
  publication-title: Drug Alcohol Depend
  doi: 10.1016/j.drugalcdep.2008.11.013
– volume: 35
  start-page: 681
  issue: 11
  year: 2012
  ident: 1013_CR31
  publication-title: Trends Neurosci
  doi: 10.1016/j.tins.2012.06.007
– volume: 21
  start-page: 12
  issue: 4
  year: 2003
  ident: 1013_CR72
  publication-title: Bull Anesth Hist
  doi: 10.1016/s1522-8649(03)50051-8
– volume: 97
  start-page: e13385
  issue: 49
  year: 2018
  ident: 1013_CR128
  publication-title: Medicine (Baltimore)
  doi: 10.1097/MD.0000000000013385
– volume: 35
  start-page: 642
  issue: 7
  year: 1991
  ident: 1013_CR121
  publication-title: Acta Anaesthesiol Scand
  doi: 10.1111/j.1399-6576.1991.tb03364.x
– start-page: 222
  volume-title: Pleasures of the brain
  year: 2010
  ident: 1013_CR149
– volume: 510
  start-page: 57
  issue: 1
  year: 2016
  ident: 1013_CR162
  publication-title: Int J Pharm
  doi: 10.1016/j.ijpharm.2016.06.012
– volume: 19
  start-page: 1057
  issue: 10
  year: 2010
  ident: 1013_CR54
  publication-title: Pharmacoepidemiol Drug Saf
  doi: 10.1002/pds.1989
– volume: 54
  start-page: 25
  year: 2003
  ident: 1013_CR215
  publication-title: Annu Rev Psychol
  doi: 10.1146/annurev.psych.54.101601.145237
– volume: 127
  start-page: 129
  issue: 1–2
  year: 2007
  ident: 1013_CR233
  publication-title: Pain
  doi: 10.1016/j.pain.2006.08.009
– volume: 148
  start-page: 107
  issue: 1
  year: 2010
  ident: 1013_CR104
  publication-title: Pain
  doi: 10.1016/j.pain.2009.10.026
– volume: 92
  start-page: 12304
  issue: 26
  year: 1995
  ident: 1013_CR204
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.92.26.12304
– ident: 1013_CR210
SSID ssj0009005
Score 2.530829
SecondaryResourceType review_article
Snippet It is estimated that nearly a third of people who abuse drugs started with prescription opioid medicines. Approximately, 11.5 million Americans used...
SourceID pubmedcentral
proquest
pubmed
crossref
springer
SourceType Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 899
SubjectTerms Analgesics, Opioid - administration & dosage
Analgesics, Opioid - adverse effects
Animals
Behavior, Addictive - epidemiology
Behavior, Addictive - psychology
Biomedical and Life Sciences
Biomedicine
Cell Biology
Drug abuse
Drug overdose
Fentanyl
Heroin
Humans
Intravenous administration
Mesolimbic system
Morphine
Narcotics
Neurobiology
Neurosciences
Opioid Epidemic
Opioid receptors
Opioid-Related Disorders - epidemiology
Opioid-Related Disorders - psychology
Overdose
Oxycodone
Oxycodone - administration & dosage
Oxycodone - adverse effects
Pain
Pain - drug therapy
Pain - epidemiology
Pain - psychology
Pharmacodynamics
Pharmacokinetics
Prescription drugs
Reinforcement
Review Paper
Reward
Title Oxycodone in the Opioid Epidemic: High ‘Liking’, ‘Wanting’, and Abuse Liability
URI https://link.springer.com/article/10.1007/s10571-020-01013-y
https://www.ncbi.nlm.nih.gov/pubmed/33245509
https://www.proquest.com/docview/2533363372
https://www.proquest.com/docview/2465439609
https://pubmed.ncbi.nlm.nih.gov/PMC8155122
Volume 41
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1Lb9QwEB5Be-GCCuWxUCojIS40kuNH3PQWoS1VKfTCquUUxS81EqQVuys1t_4M-vf6Sxg7yW6XAhJHy07seOz4G8_MNwBvNEJUyahItOU0EVakSe5onrhdLbk0qbKReP7T5-xgIg5P5WkfFDYdvN0Hk2T8U98KdpMKVV8WHKlCToL2PqzLoLvjKp6wYkm1SzvHRaZCPJCgfajMn9-xehzdwZh3XSV_s5fGY2h_Ax72-JEUncAfwT3XPIbNokHd-XtL3pLo0Rmvyjfh5PiyNah2No7UDUGkR44v6vPaknGXFtbskeDmQW6ufh7V4cr85up6J5ROqpg_IharxpJCz6eOHNUdp3f7BCb74y_vD5I-kUJihBIznHjvjeFO2NxZKh3LtUYcl1NfmWAXs8x5WqVce65kbqzOaeYVtT61vJKp4k9hrcHBPgdiJPMh1tVq60VqlaaZE9JzrqXNM81HkA7zWZqeZTwku_hWLvmRgwxKlEEZZVC2I3i3eOai49j4Z-utQUxlv9-mJUPUyjPOFRvB60U17pRg_qgadz7HNoE6jgeGvRE866S66I4jrkRdDWvUirwXDQIL92pNU59FNu7dADoZ9rszrIzlsP7-FS_-r_lLeMCCM030E96CtdmPuXuFaGimt2G9-PD143g7boJfbJYFwg
linkProvider Springer Nature
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3LbtQwFL2CsoANAspjoBQjITY0kuNHPGE3Qq0GmLabjtpdFL_USJBWzIxEdv0M-nv9kl47yUyHAhLLyE7s-Mbxufa55wK80whRJaMi0ZbTRFiRJrmjeeKGWnJpUmWj8Pz-QTaeii8n8qQLCpv1bPf-SDL-qW8Eu0mFri8LRKqQk6C5C_cQDAwDkWvKRiupXdoSF5kK8UCCdqEyf37G-nJ0C2Pepkr-dl4al6G9R_Cww49k1Br8Mdxx9RPYHNXoO39vyHsSGZ1xq3wTjg9_NgbdztqRqiaI9MjheXVWWbLbpoU1H0mgeZCri1-TKmyZX11c7oSr4zLmj4iXZW3JSC9mjkyqVtO7eQrTvd2jT-OkS6SQGKHEHAfee2O4EzZ3lkrHcq0Rx-XUlyaci1nmPC1Trj1XMjdW5zTzilqfWl7KVPFnsFFjZ18AMZL5EOtqtfUitUrTzAnpOdfS5pnmA0j78SxMpzIekl18K1b6yMEGBdqgiDYomgF8WN5z3mps_LP2Vm-moptvs4IhauUZ54oN4O2yGGdKOP4oa3e2wDpBOo4Hhb0BPG-tumyOI65EXw1L1Jq9lxWCCvd6SV2dRjXuYQCdDNvd6b-MVbf-_hYv_6_6G7g_PtqfFJPPB19fwQMWiDWRM7wFG_MfC_cakdFcb8eJcA2zRwch
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1Lb9QwELagSIgLAspjoYCREBca1fEjbritoKsCS8uBVXuL4peIBO6K7krk1p8Bf6-_hBknu9ulgMQx8iR2Mnb8jWfmG0KeG4CoijOZGSdYJp3Ms9KzMvO7Rgllc-0S8fyHg2J_It8dq-MLWfwp2n3hkuxyGpClKc52pi7sXEh8UxrMYI5BVVifoL1KrsHvOMd5PeHDFe0u64IYucbcIMn6tJk_P2N9a7qENy-HTf7mO01b0ugWudljSTrslH-bXPHxDtkcRrCjv7b0BU3RnenYfJMcHX5vLZig0dMmUkB99HDanDSO7nUlYu0riiEf9Pzsx7jB4_Pzs5_beHVUp1oS6bKOjg7N_NTTcdPxe7d3yWS09-n1ftYXVcis1HIGSgjBWuGlK71jyvPSGMB0JQu1RR-Z4z6wOhcmCK1K60zJiqCZC7kTtcq1uEc2Igz2AaFW8YB5r864IHOnDSu8VEEIo1xZGDEg-eJ7VrZnHMfCF1-qFVcy6qACHVRJB1U7IC-X90w7vo1_Sm8t1FT1a--04oBgRSGE5gPybNkMqwZdIXX0J3OQQRo5gWx7A3K_0-qyOwEYE-w2aNFr-l4KICP3ektsPidm7l0EoBz63V7MjNWw_v4WD_9P_Cm5_vHNqBq_PXj_iNzgGGOTwoe3yMbs29w_BpA0M0_SOvgFc4YLXQ
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Oxycodone+in+the+Opioid+Epidemic%3A+High+%27Liking%27%2C+%27Wanting%27%2C+and+Abuse+Liability&rft.jtitle=Cellular+and+molecular+neurobiology&rft.au=Kibaly%2C+Cherkaouia&rft.au=Alderete%2C+Jacob+A&rft.au=Liu%2C+Steven+H&rft.au=Nasef%2C+Hazem+S&rft.date=2021-07-01&rft.issn=1573-6830&rft.eissn=1573-6830&rft.volume=41&rft.issue=5&rft.spage=899&rft_id=info:doi/10.1007%2Fs10571-020-01013-y&rft.externalDBID=NO_FULL_TEXT
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0272-4340&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0272-4340&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0272-4340&client=summon