Identification of MST1 as a potential early detection biomarker for colorectal cancer through a proteomic approach

• Published in: Scientific reports Vol. 7; no. 1; pp. 14265 - 10
• Main Authors: Yu, Jiekai, Zhai, Xiaohui, Li, Xiaofen, Zhong, Chenhan, Guo, Cheng, Yang, Fuquan, Yuan, Ying, Zheng, Shu
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 27.10.2017; Nature Publishing Group
• Subjects: 631/67/1857; 692/53/2423; 692/699/67/1504/1885; 82/47; 82/58; 82/80; 82/83; Biomarkers; Biomarkers, Tumor - metabolism; Carcinoembryonic antigen; Case-Control Studies; Colorectal cancer; Colorectal carcinoma; Colorectal Neoplasms - diagnosis; Colorectal Neoplasms - metabolism; Colorectal Neoplasms - pathology; Desorption; Early Detection of Cancer; Enzyme-linked immunosorbent assay; Female; Gene Expression Regulation, Neoplastic; Hepatocyte Growth Factor - metabolism; Humanities and Social Sciences; Humans; Ionization; Ions; Lasers; Male; Mass spectrometry; Mass spectroscopy; Metastases; Middle Aged; multidisciplinary; Neoplasm Metastasis; Prognosis; Protein-serine/threonine kinase; Proteomics; Proto-Oncogene Proteins - metabolism; Science; Science (multidisciplinary); Scientific imaging; Western blotting

Colorectal cancer (CRC) is a common malignant neoplasm worldwide. It is important to identify new biomarkers for the early detection of CRC. In this study, magnetic beads and the Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS) platform were used to analyse...