The lncRNA Locus Handsdown Regulates Cardiac Gene Programs and Is Essential for Early Mouse Development

• Published in: Developmental cell Vol. 50; no. 5; pp. 644 - 657.e8
• Main Authors: Ritter, Nicole, Ali, Tamer, Kopitchinski, Nina, Schuster, Peggy, Beisaw, Arica, Hendrix, David A., Schulz, Marcel H., Müller-McNicoll, Michaela, Dimmeler, Stefanie, Grote, Phillip
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 09.09.2019
• Subjects: Animals; cardiac development; Cell Differentiation; Cells, Cultured; Gene Expression Regulation, Developmental; Hand2; Haploinsufficiency; Heart - embryology; LncRNA; Mice; Mice, Inbred C57BL; Mouse Embryonic Stem Cells - cytology; Mouse Embryonic Stem Cells - metabolism; Myocytes, Cardiac - cytology; Myocytes, Cardiac - metabolism; RNA, Long Noncoding - genetics; RNA, Long Noncoding - metabolism; TAD; LncRNA; haploinsufficiency; cardiac development; TAD; Hand2

Precisely controlled gene regulatory networks are required during embryonic development to give rise to various structures, including those of the cardiovascular system. Long non-coding RNA (lncRNA) loci are known to be important regulators of these genetic programs. We have identified a novel and e...