Parvimonas micra promotes colorectal tumorigenesis and is associated with prognosis of colorectal cancer patients

• Published in: Oncogene Vol. 41; no. 36; pp. 4200 - 4210
• Main Authors: Zhao, Liuyang, Zhang, Xiang, Zhou, Yunfei, Fu, Kaili, Lau, Harry Cheuk-Hay, Chun, Tommy Wai-Yiu, Cheung, Alvin Ho-Kwan, Coker, Olabisi Oluwabukola, Wei, Hong, Wu, William Ka-Kei, Wong, Sunny Hei, Sung, Joseph Jao-Yiu, To, Ka Fai, Yu, Jun
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 02.09.2022; Nature Publishing Group
• Subjects: 13/51; 631/67/1504/1885; 64/60; 692/53/2422; 82/80; 96/31; Angiogenesis; Animal models; Animals; Apoptosis; Biopsy; Carcinogenesis - genetics; CD4 antigen; Cell Biology; Cell differentiation; Cell Proliferation; Colorectal cancer; Colorectal carcinoma; Colorectal Neoplasms - pathology; Feces; Firmicutes; Gene Expression Regulation, Neoplastic; Germfree; Helper cells; Human Genetics; Humans; Interleukin 17; Interleukin 22; Interleukin 23; Interleukin-17 - metabolism; Internal Medicine; Invasiveness; Lymphocytes T; Medical prognosis; Medicine; Medicine & Public Health; Metagenomics; Metastases; Mice; Multivariate analysis; Oncology; Parvimonas micra; Patients; Phenotypes; Phreatodrobia micra; Risk factors; Signal transduction; Tumorigenesis; Wnt protein

Large-scale fecal shotgun metagenomic sequencing revealed the high abundance of Parvimonas micra in colorectal cancer (CRC) patients. We investigated the role and clinical significance of P. micra in colorectal tumorigenesis. The abundance of P. micra was examined in 309 fecal samples and 165 colon...