Macroautophagy Proteins Control MHC Class I Levels on Dendritic Cells and Shape Anti-viral CD8+ T Cell Responses

• Published in: Cell reports (Cambridge) Vol. 15; no. 5; pp. 1076 - 1087
• Main Authors: Loi, Monica, Müller, Anne, Steinbach, Karin, Niven, Jennifer, Barreira da Silva, Rosa, Paul, Petra, Ligeon, Laure-Anne, Caruso, Assunta, Albrecht, Randy A., Becker, Andrea C., Annaheim, Nicolas, Nowag, Heike, Dengjel, Jörn, García-Sastre, Adolfo, Merkler, Doron, Münz, Christian, Gannagé, Monique
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 03.05.2016; Elsevier
• Subjects: AAK1; Animals; Antigen Presentation - immunology; Autophagy - immunology; Autophagy-Related Protein 5 - genetics; Autophagy-Related Protein 7 - genetics; CD8-Positive T-Lymphocytes - immunology; Cells, Cultured; Dendritic Cells - immunology; endocytosis; Endocytosis - immunology; Histocompatibility Antigens Class I - immunology; Histocompatibility Antigens Class II - immunology; Humans; immune control; influenza; Influenza A Virus, H1N1 Subtype - immunology; LCMV; Lymphocyte Activation - immunology; Lymphocytic choriomeningitis virus - immunology; Macrophages - immunology; Mice; Mice, Inbred C57BL; Mice, Knockout; influenza; AAK1; endocytosis; LCMV; immune control

The macroautophagy machinery has been implicated in MHC class II restricted antigen presentation. Here, we report that this machinery assists in the internalization of MHC class I molecules. In the absence of the autophagy factors Atg5 and Atg7, MHC class I surface levels are elevated due to decreas...