Oncogenic D816V-KIT signaling in mast cells causes persistent IL-6 production

• Published in: Haematologica (Roma) Vol. 105; no. 1; pp. 124 - 135
• Main Authors: Tobío, Araceli, Bandara, Geethani, Morris, Denise A, Kim, Do-Kyun, O'Connell, Michael P, Komarow, Hirsh D, Carter, Melody C, Smrz, Daniel, Metcalfe, Dean D, Olivera, Ana
• Format: Journal Article
• Language: English
• Published: Italy Ferrata Storti Foundation 01.01.2020
• Subjects: Humans; Interleukin-6 - genetics; Mast Cells; Mastocytosis, Systemic - diagnosis; Mastocytosis, Systemic - genetics; Mutation; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-kit - genetics

Persistent dysregulation of IL-6 production and signaling have been implicated in the pathology of various cancers. In systemic mastocytosis, increased serum levels of IL-6 associate with disease severity and progression, although the mechanisms involved are not well understood. Since systemic masto...