Drosophila clipper/CPSF 30K is a post-transcriptionally regulated nuclear protein that binds RNA containing GC clusters

• Published in: Nucleic acids research Vol. 26; no. 7; pp. 1597 - 1604
• Main Authors: Bai, C, Tolias, P.P
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.04.1998
• Subjects: Amino Acid Sequence; amino acid sequences; Animals; Base Composition; Base Sequence; binding proteins; binding sites; clp gene; Cytosine; Drosophila melanogaster; Drosophila melanogaster - genetics; Drosophila melanogaster - growth & development; embryogenesis; genbank/af033201; gene expression; Gene Expression Regulation, Developmental; Genes, Insect; genetic regulation; Guanine; Larva; messenger RNA; Mice; Molecular Sequence Data; mRNA Cleavage and Polyadenylation Factors; nucleotide sequences; post-transcriptional regulation; RNA; RNA Precursors - chemistry; RNA Precursors - metabolism; RNA Processing, Post-Transcriptional; RNA, Messenger - biosynthesis; RNA-binding proteins; RNA-Binding Proteins - biosynthesis; RNA-Binding Proteins - chemistry; Sequence Alignment; Sequence Deletion; Sequence Homology, Amino Acid; Sequence Homology, Nucleic Acid; structural genes; Substrate Specificity; transcription (genetics); Transcription, Genetic; Zebrafish; Zinc Fingers

An essential component of the mammalian pre-mRNA 3′-end processing machinery is a multimeric protein complex known as cleavage and polyadenylation specificity factor (CPSF). The Drosophila melanogaster gene, clipper (clp), encodes a homolog of the CPSF 30K subunit. We have shown previously that CLP...