Multiparametric imaging hippocampal neurodegeneration and functional connectivity with simultaneous PET/MRI in Alzheimer’s disease

• Published in: European journal of nuclear medicine and molecular imaging Vol. 47; no. 10; pp. 2440 - 2452
• Main Authors: Yan, Shaozhen, Zheng, Chaojie, Cui, Bixiao, Qi, Zhigang, Zhao, Zhilian, An, Yanhong, Qiao, Liyan, Han, Ying, Zhou, Yun, Lu, Jie
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.09.2020; Springer Nature B.V
• Subjects: Alzheimer Disease - diagnostic imaging; Alzheimer's disease; Brain mapping; Cardiology; Cerebellum; Cognitive ability; Cognitive Dysfunction - diagnostic imaging; Cortex (parietal); Dentate gyrus; Fluorine isotopes; Fluorodeoxyglucose F18; Frontal gyrus; Functional magnetic resonance imaging; Head movement; Hippocampus; Hippocampus - diagnostic imaging; Humans; Hypometabolism; Imaging; Magnetic Resonance Imaging; Mapping; Medical imaging; Medicine; Medicine & Public Health; Morphometry; Neural networks; Neurodegeneration; Neurodegenerative diseases; Neuroimaging; Neurology; Nuclear Medicine; Oncology; Original; Original Article; Orthopedics; Positron emission; Positron emission tomography; Radiology; Subiculum; Substantia grisea; Tomography; Hippocampal subregions; Alzheimer’s disease; Neurodegeneration; Voxel-based morphometric analysis; Hybrid PET/MRI

Purpose The objective of this study is to investigate the hippocampal neurodegeneration and its associated aberrant functions in mild cognitive impairment (MCI) and Alzheimer’s disease (AD) patients using simultaneous PET/MRI. Methods Forty-two cognitively normal controls (NC), 38 MCI, and 22 AD pat...