Multiparametric imaging hippocampal neurodegeneration and functional connectivity with simultaneous PET/MRI in Alzheimer’s disease

• Published in: European journal of nuclear medicine and molecular imaging Vol. 47; no. 10; pp. 2440 - 2452
• Main Authors: Yan, Shaozhen, Zheng, Chaojie, Cui, Bixiao, Qi, Zhigang, Zhao, Zhilian, An, Yanhong, Qiao, Liyan, Han, Ying, Zhou, Yun, Lu, Jie
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.09.2020; Springer Nature B.V
• Subjects: Alzheimer Disease - diagnostic imaging; Alzheimer's disease; Brain mapping; Cardiology; Cerebellum; Cognitive ability; Cognitive Dysfunction - diagnostic imaging; Cortex (parietal); Dentate gyrus; Fluorine isotopes; Fluorodeoxyglucose F18; Frontal gyrus; Functional magnetic resonance imaging; Head movement; Hippocampus; Hippocampus - diagnostic imaging; Humans; Hypometabolism; Imaging; Magnetic Resonance Imaging; Mapping; Medical imaging; Medicine; Medicine & Public Health; Morphometry; Neural networks; Neurodegeneration; Neurodegenerative diseases; Neuroimaging; Neurology; Nuclear Medicine; Oncology; Original; Original Article; Orthopedics; Positron emission; Positron emission tomography; Radiology; Subiculum; Substantia grisea; Tomography; Hippocampal subregions; Alzheimer’s disease; Neurodegeneration; Voxel-based morphometric analysis; Hybrid PET/MRI
• ISSN: 1619-7070; 1619-7089; 1619-7089
• DOI: 10.1007/s00259-020-04752-8

Purpose The objective of this study is to investigate the hippocampal neurodegeneration and its associated aberrant functions in mild cognitive impairment (MCI) and Alzheimer’s disease (AD) patients using simultaneous PET/MRI. Methods Forty-two cognitively normal controls (NC), 38 MCI, and 22 AD patients were enrolled in this study. All subjects underwent 18 F-FDG PET/functional MRI (fMRI) and high-resolution T1-weighted MRI scans on a hybrid GE Signa PET/MRI scanner. Neurodegeneration in hippocampus and its subregions was quantified by regional gray matter volume and 18 F-FDG standardized uptake value ratio (SUVR) relative to cerebellum. An iterative reblurred Van Cittert iteration method was used for voxelwise partial volume correction on 18 F-FDG PET images. Regional gray matter volume was estimated from voxel-based morphometric analysis with MRI. fMRI data were analyzed after slice time correction and head motion correction using statistical parametric mapping (SPM12) with DPARSF toolbox. The regions of interest including hippocampus, cornu ammonis (CA1), CA2/3/dentate gyrus (DG), and subiculum were defined in the standard MNI space. Results Patient groups had reduced SUVR, gray matter volume, and functional connectivity compared to NC in CA1, CA2/3/DG, and subiculum (AD < MCI < NC). There was a linear correlation between the left CA2/3DG gray matter volume and 18 F-FDG SUVR in AD patients ( P  < 0.001, r  = 0.737). Significant correlation was also found between left CA2/3/DG-superior medial frontal gyrus functional connectivity and left CA2/3/DG hypometabolism in patients with AD. The functional connectivity of right CA1-precuneus in patients with MCI and right subiculum-superior frontal gyrus in patients with AD was positively correlated with mini mental status examination scores ( P  < 0.05). Conclusion Our findings demonstrate that the associations existed at subregional hippocampal level between the functional connectivity measured by fMRI and neurodegeneration measured by structural MRI and 18 F-FDG PET. Our results may provide a basis for precision neuroimaging of hippocampus in AD.