Enhanced metastatic potential in the MB49 urothelial carcinoma model

• Published in: Scientific reports Vol. 9; no. 1; p. 7425
• Main Authors: Liu, Yu-Ru, Yin, Peng-Nien, Silvers, Christopher R., Lee, Yi-Fen
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 15.05.2019; Nature Publishing Group
• Subjects: 13; 13/106; 45; 45/77; 631/67/589/1336; 64; 64/60; 692/4025/1334; 96; Animals; Bladder cancer; Cell culture; Cell Line, Tumor; Cloning; Epithelial-Mesenchymal Transition; Gene Expression Regulation, Neoplastic - genetics; Genes, Neoplasm; Humanities and Social Sciences; Integrin beta1 - genetics; Lung Neoplasms - secondary; Male; Metastases; Metastasis; Mice; Mice, Inbred C57BL; multidisciplinary; Neoplasm Metastasis - pathology; Neoplasm Transplantation; Real-Time Polymerase Chain Reaction; Science; Science (multidisciplinary); Therapeutic applications; Tumors; Twist-Related Protein 1 - genetics; Urinary Bladder Neoplasms - pathology; Urothelial carcinoma; Urothelium - pathology

Recent data suggest that patients with a basal/stem-like bladder cancer (BC) subtype tend to have metastatic disease, but this is unconfirmed. Here we report the identification of murine MB49 cell line sub-clones with stem-like characteristics in culture. Subcutaneous implantation of S2 and S4 MB49...