Biochemical mechanisms of tributyltin chloride-induced cell toxicity in Sertoli cells

• Published in: Ecotoxicology and environmental safety Vol. 255; p. 114725
• Main Authors: Chen, Pengchen, Chen, Junhui, Zhang, Wei, Tang, Li, Cheng, Guangqing, Li, Huiying, Fan, Tianyun, Wang, Jigang, Zhong, Wenbin, Song, Yali
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 15.04.2023; Elsevier
• Subjects: Apoptosis; Autophagy; Endoplasmic Reticulum Stress; Humans; Male; Sertoli cell; Sertoli Cells; Spermatogenesis; Thyroid Gland; Trialkyltin Compounds - toxicity; Tributyltin chloride; Sertoli cell; Tributyltin chloride; Autophagy; Endoplasmic reticulum stress

Tributyltin chloride (TBTCL) is a widely used fungicide and heat stabilizer in compositions of PVC. TBTCL has been detected in human bodies and potentially causes harmful effects on humans’ thyroid, cardiovascular and other organs. As one of the first examples of endocrine disruptors, the toxicity e...