A mouse-human phase 1 co-clinical trial of a protease-activated fluorescent probe for imaging cancer

• Published in: Science translational medicine Vol. 8; no. 320; p. 320ra4
• Main Authors: Whitley, Melodi Javid, Cardona, Diana M, Lazarides, Alexander L, Spasojevic, Ivan, Ferrer, Jorge M, Cahill, Joan, Lee, Chang-Lung, Snuderl, Matija, Blazer, 3rd, Dan G, Hwang, E Shelley, Greenup, Rachel A, Mosca, Paul J, Mito, Jeffrey K, Cuneo, Kyle C, Larrier, Nicole A, O'Reilly, Erin K, Riedel, Richard F, Eward, William C, Strasfeld, David B, Fukumura, Dai, Jain, Rakesh K, Lee, W David, Griffith, Linda G, Bawendi, Moungi G, Kirsch, David G, Brigman, Brian E
• Format: Journal Article
• Language: English
• Published: United States 06.01.2016
• Subjects: Animals; Breast Neoplasms - diagnosis; Diagnostic Imaging - methods; Disease Models, Animal; Female; Fluorescent Dyes - metabolism; Fluorescent Dyes - pharmacokinetics; Humans; Injections, Intravenous; Metabolome; Mice; Neoplasms - diagnosis; Peptide Hydrolases - metabolism; Sarcoma - diagnosis; Tissue Distribution

Local recurrence is a common cause of treatment failure for patients with solid tumors. Intraoperative detection of microscopic residual cancer in the tumor bed could be used to decrease the risk of a positive surgical margin, reduce rates of reexcision, and tailor adjuvant therapy. We used a protea...