Several dementia subtypes and mild cognitive impairment share brain reduction of neurotransmitter precursor amino acids, impaired energy metabolism, and lipid hyperoxidation

• Published in: Frontiers in aging neuroscience Vol. 15; p. 1237469
• Main Authors: Aquilani, Roberto, Cotta Ramusino, Matteo, Maestri, Roberto, Iadarola, Paolo, Boselli, Mirella, Perini, Giulia, Boschi, Federica, Dossena, Maurizia, Bellini, Anna, Buonocore, Daniela, Doria, Enrico, Costa, Alfredo, Verri, Manuela
• Format: Journal Article
• Language: English
• Published: Lausanne Frontiers Research Foundation 16.08.2023; Frontiers Media S.A
• Subjects: Alzheimer's disease; Amino acids; Body mass index; Catecholamines; Cerebrospinal fluid; cerebrospinal fluid amino acid precursors of neurotransmitters; Cognitive ability; Dementia; Dementia disorders; dementias; Dopamine; energetic substrates; Energy metabolism; Energy resources; Ethics; Frontotemporal dementia; Lactic acid; Lipid metabolism; Mental depression; Metabolism; Methionine; mild cognitive impairment; Neurodegenerative diseases; Neurology; Neuroscience; Neurotransmission; Neurotransmitters; Observational studies; Oxidative stress; Patients; Phenylalanine; Plasma levels; Protein biosynthesis; Protein synthesis; Protein turnover; Proteins; Pyruvic acid; Serotonin; Stroke; Structure-function relationships; Synaptic plasticity; Tryptophan; Vascular diseases; Italy

Objective: Dementias and mild cognitive impairment (MCI) are associated with variously combined changes in the neurotransmitter system and signaling, from neurotransmitter synthesis to synaptic binding. The study tested the hypothesis that different dementia subtypes and MCI may share similar reduct...