Several dementia subtypes and mild cognitive impairment share brain reduction of neurotransmitter precursor amino acids, impaired energy metabolism, and lipid hyperoxidation - Aquilani, Roberto; Cotta Ramusino, Matteo; Maestri, Roberto; Iadarola, Paolo; Boselli, Mirella; Perini, Giulia; Boschi, Federica; Dossena, Maurizia; Bellini, Anna; Buonocore, Daniela; Doria, Enrico; Costa, Alfredo; et al. (Frontiers in aging neuroscience, 2023)
Keywords: Alzheimer's disease; Amino acids; Body mass index; Catecholamines; Cerebrospinal fluid; cerebrospinal fluid amino acid precursors of neurotransmitters; Cognitive ability; Dementia; Dementia disorders; dementias; Dopamine; energetic substrates; Energy metabolism; Energy resources; Ethics; Frontotemporal dementia; Lactic acid; Lipid metabolism; Mental depression; Metabolism; Methionine; mild cognitive impairment; Neurodegenerative diseases; Neurology; Neuroscience; Neurotransmission; Neurotransmitters; Observational studies; Oxidative stress; Patients; Phenylalanine; Plasma levels; Protein biosynthesis; Protein synthesis; Protein turnover; Proteins; Pyruvic acid; Serotonin; Stroke; Structure-function relationships; Synaptic plasticity; Tryptophan; Vascular diseases; Italy