Pseudomonas pyocyanin inhibits wound repair by inducing premature cellular senescence: Role for p38 mitogen-activated protein kinase

• Published in: Burns Vol. 35; no. 4; pp. 500 - 508
• Main Authors: Muller, Michael, Li, Zhe, Maitz, Peter K.M
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 01.06.2009; Elsevier
• Subjects: Bandages - microbiology; beta-Galactosidase - analysis; Biological and medical sciences; Burns; Burns - complications; Burns - microbiology; Cell Proliferation; Cells, Cultured; Cellular senescence; Cellular Senescence - drug effects; Critical Care; Fibroblast; Fibroblasts - drug effects; Fibroblasts - physiology; Humans; Medical sciences; Mitogen-activated protein kinase; Oxidative stress; Oxidative Stress - drug effects; p38 Mitogen-Activated Protein Kinases - pharmacology; Pseudomonas aeruginosa; Pseudomonas aeruginosa - pathogenicity; Pseudomonas Infections - microbiology; Pseudomonas Infections - prevention & control; Pyocyanin; Pyocyanine - adverse effects; Pyocyanine - analysis; Tissue remodeling; Traumas. Diseases due to physical agents; Virulence; Virulence Factors - adverse effects; Wound Healing - drug effects; Wound Healing - physiology; Wound repair; Wound repair; Oxidative stress; Pyocyanin; Cellular senescence; Tissue remodeling; Mitogen-activated protein kinase; Pseudomonas aeruginosa; Burns; Fibroblast; Pseudomonadales; Premature; Skin disease; Senescence; Enzyme; Transferases; Wound; Burn; Bacteria; Pseudomonadaceae; Repair

Abstract Pseudomonas aeruginosa is an important nosocomial pathogen of burn wounds. Pyocyanin, a virulence factor produced by the bacterium, induces persistent intracellular oxidative stress and premature senescence in mammalian cells. Our aims were to evaluate pyocyanin levels in infected wound dre...