Heterogeneity in endothelial cells and widespread venous arterialization during early vascular development in mammals

• Published in: Cell research Vol. 32; no. 4; pp. 333 - 348
• Main Authors: Hou, Siyuan, Li, Zongcheng, Dong, Ji, Gao, Yun, Chang, Zhilin, Ding, Xiaochen, Li, Shuaili, Li, Yunqiao, Zeng, Yang, Xin, Qian, Wang, Baihan, Ni, Yanli, Ning, Xiaowei, Hu, Yuqiong, Fan, Xiaoying, Hou, Yu, Li, Xianlong, Wen, Lu, Zhou, Bin, Liu, Bing, Tang, Fuchou, Lan, Yu
• Format: Journal Article
• Language: English
• Published: Singapore Springer Singapore 01.04.2022; Nature Publishing Group
• Subjects: 13/1; 13/31; 13/51; 14/32; 631/136; 631/80; 64/110; 64/60; Angiogenesis; Animals; Biomedical and Life Sciences; Capillaries; Cell Biology; Cell Differentiation; Computer applications; Embryogenesis; Embryonic growth stage; Endothelial Cells; Heterogeneity; Humans; Life Sciences; Mammals; Mice; Neovascularization, Pathologic; Recombinase; Transcriptomics

Arteriogenesis rather than unspecialized capillary expansion is critical for restoring effective circulation to compromised tissues in patients. Deciphering the origin and specification of arterial endothelial cells during embryonic development will shed light on the understanding of adult arterioge...