Heterogeneity in endothelial cells and widespread venous arterialization during early vascular development in mammals

Arteriogenesis rather than unspecialized capillary expansion is critical for restoring effective circulation to compromised tissues in patients. Deciphering the origin and specification of arterial endothelial cells during embryonic development will shed light on the understanding of adult arterioge...

Full description

Saved in:
Bibliographic Details
Published inCell research Vol. 32; no. 4; pp. 333 - 348
Main Authors Hou, Siyuan, Li, Zongcheng, Dong, Ji, Gao, Yun, Chang, Zhilin, Ding, Xiaochen, Li, Shuaili, Li, Yunqiao, Zeng, Yang, Xin, Qian, Wang, Baihan, Ni, Yanli, Ning, Xiaowei, Hu, Yuqiong, Fan, Xiaoying, Hou, Yu, Li, Xianlong, Wen, Lu, Zhou, Bin, Liu, Bing, Tang, Fuchou, Lan, Yu
Format Journal Article
LanguageEnglish
Published Singapore Springer Singapore 01.04.2022
Nature Publishing Group
Subjects
13/1
13/31
13/51
14/32
631/136
631/80
64/110
64/60
Angiogenesis
Animals
Biomedical and Life Sciences
Capillaries
Cell Biology
Cell Differentiation
Computer applications
Embryogenesis
Embryonic growth stage
Endothelial Cells
Heterogeneity
Humans
Life Sciences
Mammals
Mice
Neovascularization, Pathologic
Recombinase
Transcriptomics
Online AccessGet full text

Cover

Abstract Arteriogenesis rather than unspecialized capillary expansion is critical for restoring effective circulation to compromised tissues in patients. Deciphering the origin and specification of arterial endothelial cells during embryonic development will shed light on the understanding of adult arteriogenesis. However, during early embryonic angiogenesis, the process of endothelial diversification and molecular events underlying arteriovenous fate settling remain largely unresolved in mammals. Here, we constructed the single-cell transcriptomic landscape of vascular endothelial cells (VECs) during the time window for the occurrence of key vasculogenic and angiogenic events in both mouse and human embryos. We uncovered two distinct arterial VEC types, the major artery VECs and arterial plexus VECs, and unexpectedly divergent arteriovenous characteristics among VECs that are located in morphologically undistinguishable vascular plexus intra-embryonically. Using computational prediction and further lineage tracing of venous-featured VECs with a newly developed Nr2f2 CrexER mouse model and a dual recombinase-mediated intersectional genetic approach, we revealed early and widespread arterialization from the capillaries with considerable venous characteristics. Altogether, our findings provide unprecedented and comprehensive details of endothelial heterogeneity and lineage relationships at early angiogenesis stages, and establish a new model regarding the arteriogenesis behaviors of early intra-embryonic vasculatures.
AbstractList Arteriogenesis rather than unspecialized capillary expansion is critical for restoring effective circulation to compromised tissues in patients. Deciphering the origin and specification of arterial endothelial cells during embryonic development will shed light on the understanding of adult arteriogenesis. However, during early embryonic angiogenesis, the process of endothelial diversification and molecular events underlying arteriovenous fate settling remain largely unresolved in mammals. Here, we constructed the single-cell transcriptomic landscape of vascular endothelial cells (VECs) during the time window for the occurrence of key vasculogenic and angiogenic events in both mouse and human embryos. We uncovered two distinct arterial VEC types, the major artery VECs and arterial plexus VECs, and unexpectedly divergent arteriovenous characteristics among VECs that are located in morphologically undistinguishable vascular plexus intra-embryonically. Using computational prediction and further lineage tracing of venous-featured VECs with a newly developed Nr2f2 CrexER mouse model and a dual recombinase-mediated intersectional genetic approach, we revealed early and widespread arterialization from the capillaries with considerable venous characteristics. Altogether, our findings provide unprecedented and comprehensive details of endothelial heterogeneity and lineage relationships at early angiogenesis stages, and establish a new model regarding the arteriogenesis behaviors of early intra-embryonic vasculatures.
Arteriogenesis rather than unspecialized capillary expansion is critical for restoring effective circulation to compromised tissues in patients. Deciphering the origin and specification of arterial endothelial cells during embryonic development will shed light on the understanding of adult arteriogenesis. However, during early embryonic angiogenesis, the process of endothelial diversification and molecular events underlying arteriovenous fate settling remain largely unresolved in mammals. Here, we constructed the single-cell transcriptomic landscape of vascular endothelial cells (VECs) during the time window for the occurrence of key vasculogenic and angiogenic events in both mouse and human embryos. We uncovered two distinct arterial VEC types, the major artery VECs and arterial plexus VECs, and unexpectedly divergent arteriovenous characteristics among VECs that are located in morphologically undistinguishable vascular plexus intra-embryonically. Using computational prediction and further lineage tracing of venous-featured VECs with a newly developed Nr2f2CrexER mouse model and a dual recombinase-mediated intersectional genetic approach, we revealed early and widespread arterialization from the capillaries with considerable venous characteristics. Altogether, our findings provide unprecedented and comprehensive details of endothelial heterogeneity and lineage relationships at early angiogenesis stages, and establish a new model regarding the arteriogenesis behaviors of early intra-embryonic vasculatures.
Arteriogenesis rather than unspecialized capillary expansion is critical for restoring effective circulation to compromised tissues in patients. Deciphering the origin and specification of arterial endothelial cells during embryonic development will shed light on the understanding of adult arteriogenesis. However, during early embryonic angiogenesis, the process of endothelial diversification and molecular events underlying arteriovenous fate settling remain largely unresolved in mammals. Here, we constructed the single-cell transcriptomic landscape of vascular endothelial cells (VECs) during the time window for the occurrence of key vasculogenic and angiogenic events in both mouse and human embryos. We uncovered two distinct arterial VEC types, the major artery VECs and arterial plexus VECs, and unexpectedly divergent arteriovenous characteristics among VECs that are located in morphologically undistinguishable vascular plexus intra-embryonically. Using computational prediction and further lineage tracing of venous-featured VECs with a newly developed Nr2f2 mouse model and a dual recombinase-mediated intersectional genetic approach, we revealed early and widespread arterialization from the capillaries with considerable venous characteristics. Altogether, our findings provide unprecedented and comprehensive details of endothelial heterogeneity and lineage relationships at early angiogenesis stages, and establish a new model regarding the arteriogenesis behaviors of early intra-embryonic vasculatures.
Arteriogenesis rather than unspecialized capillary expansion is critical for restoring effective circulation to compromised tissues in patients. Deciphering the origin and specification of arterial endothelial cells during embryonic development will shed light on the understanding of adult arteriogenesis. However, during early embryonic angiogenesis, the process of endothelial diversification and molecular events underlying arteriovenous fate settling remain largely unresolved in mammals. Here, we constructed the single-cell transcriptomic landscape of vascular endothelial cells (VECs) during the time window for the occurrence of key vasculogenic and angiogenic events in both mouse and human embryos. We uncovered two distinct arterial VEC types, the major artery VECs and arterial plexus VECs, and unexpectedly divergent arteriovenous characteristics among VECs that are located in morphologically undistinguishable vascular plexus intra-embryonically. Using computational prediction and further lineage tracing of venous-featured VECs with a newly developed Nr2f2CrexER mouse model and a dual recombinase-mediated intersectional genetic approach, we revealed early and widespread arterialization from the capillaries with considerable venous characteristics. Altogether, our findings provide unprecedented and comprehensive details of endothelial heterogeneity and lineage relationships at early angiogenesis stages, and establish a new model regarding the arteriogenesis behaviors of early intra-embryonic vasculatures.Arteriogenesis rather than unspecialized capillary expansion is critical for restoring effective circulation to compromised tissues in patients. Deciphering the origin and specification of arterial endothelial cells during embryonic development will shed light on the understanding of adult arteriogenesis. However, during early embryonic angiogenesis, the process of endothelial diversification and molecular events underlying arteriovenous fate settling remain largely unresolved in mammals. Here, we constructed the single-cell transcriptomic landscape of vascular endothelial cells (VECs) during the time window for the occurrence of key vasculogenic and angiogenic events in both mouse and human embryos. We uncovered two distinct arterial VEC types, the major artery VECs and arterial plexus VECs, and unexpectedly divergent arteriovenous characteristics among VECs that are located in morphologically undistinguishable vascular plexus intra-embryonically. Using computational prediction and further lineage tracing of venous-featured VECs with a newly developed Nr2f2CrexER mouse model and a dual recombinase-mediated intersectional genetic approach, we revealed early and widespread arterialization from the capillaries with considerable venous characteristics. Altogether, our findings provide unprecedented and comprehensive details of endothelial heterogeneity and lineage relationships at early angiogenesis stages, and establish a new model regarding the arteriogenesis behaviors of early intra-embryonic vasculatures.
Author Zhou, Bin
Ni, Yanli
Tang, Fuchou
Wang, Baihan
Li, Yunqiao
Wen, Lu
Fan, Xiaoying
Ding, Xiaochen
Ning, Xiaowei
Lan, Yu
Hou, Siyuan
Dong, Ji
Zeng, Yang
Chang, Zhilin
Hou, Yu
Liu, Bing
Hu, Yuqiong
Xin, Qian
Gao, Yun
Li, Shuaili
Li, Zongcheng
Li, Xianlong
Author_xml – sequence: 1
  givenname: Siyuan
  orcidid: 0000-0002-4280-0562
  surname: Hou
  fullname: Hou, Siyuan
  organization: Key Laboratory for Regenerative Medicine of Ministry of Education, Institute of Hematology, School of Medicine, Jinan University, State Key Laboratory of Experimental Hematology, Haihe Laboratory of Cell Ecosystem, Institute of Hematology, Fifth Medical Center of Chinese PLA General Hospital, Integrated Chinese and Western Medicine Postdoctoral Research Station, Jinan University
– sequence: 2
  givenname: Zongcheng
  orcidid: 0000-0002-5189-5268
  surname: Li
  fullname: Li, Zongcheng
  organization: State Key Laboratory of Experimental Hematology, Haihe Laboratory of Cell Ecosystem, Institute of Hematology, Fifth Medical Center of Chinese PLA General Hospital
– sequence: 3
  givenname: Ji
  orcidid: 0000-0002-8953-5284
  surname: Dong
  fullname: Dong, Ji
  organization: Beijing Advanced Innovation Center for Genomics and Biomedical Pioneering Innovation Center, School of Life Sciences, Peking University
– sequence: 4
  givenname: Yun
  orcidid: 0000-0003-3530-7259
  surname: Gao
  fullname: Gao, Yun
  organization: Beijing Advanced Innovation Center for Genomics and Biomedical Pioneering Innovation Center, School of Life Sciences, Peking University
– sequence: 5
  givenname: Zhilin
  surname: Chang
  fullname: Chang, Zhilin
  organization: State Key Laboratory of Proteomics, Academy of Military Medical Sciences, Academy of Military Sciences
– sequence: 6
  givenname: Xiaochen
  surname: Ding
  fullname: Ding, Xiaochen
  organization: State Key Laboratory of Proteomics, Academy of Military Medical Sciences, Academy of Military Sciences
– sequence: 7
  givenname: Shuaili
  surname: Li
  fullname: Li, Shuaili
  organization: State Key Laboratory of Proteomics, Academy of Military Medical Sciences, Academy of Military Sciences
– sequence: 8
  givenname: Yunqiao
  surname: Li
  fullname: Li, Yunqiao
  organization: State Key Laboratory of Proteomics, Academy of Military Medical Sciences, Academy of Military Sciences
– sequence: 9
  givenname: Yang
  surname: Zeng
  fullname: Zeng, Yang
  organization: State Key Laboratory of Experimental Hematology, Haihe Laboratory of Cell Ecosystem, Institute of Hematology, Fifth Medical Center of Chinese PLA General Hospital
– sequence: 10
  givenname: Qian
  surname: Xin
  fullname: Xin, Qian
  organization: State Key Laboratory of Proteomics, Academy of Military Medical Sciences, Academy of Military Sciences
– sequence: 11
  givenname: Baihan
  surname: Wang
  fullname: Wang, Baihan
  organization: State Key Laboratory of Proteomics, Academy of Military Medical Sciences, Academy of Military Sciences
– sequence: 12
  givenname: Yanli
  surname: Ni
  fullname: Ni, Yanli
  organization: State Key Laboratory of Experimental Hematology, Haihe Laboratory of Cell Ecosystem, Institute of Hematology, Fifth Medical Center of Chinese PLA General Hospital
– sequence: 13
  givenname: Xiaowei
  surname: Ning
  fullname: Ning, Xiaowei
  organization: State Key Laboratory of Proteomics, Academy of Military Medical Sciences, Academy of Military Sciences
– sequence: 14
  givenname: Yuqiong
  surname: Hu
  fullname: Hu, Yuqiong
  organization: Beijing Advanced Innovation Center for Genomics and Biomedical Pioneering Innovation Center, School of Life Sciences, Peking University
– sequence: 15
  givenname: Xiaoying
  orcidid: 0000-0002-5497-6178
  surname: Fan
  fullname: Fan, Xiaoying
  organization: Beijing Advanced Innovation Center for Genomics and Biomedical Pioneering Innovation Center, School of Life Sciences, Peking University
– sequence: 16
  givenname: Yu
  orcidid: 0000-0001-7875-7087
  surname: Hou
  fullname: Hou, Yu
  organization: Beijing Advanced Innovation Center for Genomics and Biomedical Pioneering Innovation Center, School of Life Sciences, Peking University
– sequence: 17
  givenname: Xianlong
  surname: Li
  fullname: Li, Xianlong
  organization: State Key Laboratory of Experimental Hematology, Haihe Laboratory of Cell Ecosystem, Institute of Hematology, Fifth Medical Center of Chinese PLA General Hospital
– sequence: 18
  givenname: Lu
  surname: Wen
  fullname: Wen, Lu
  organization: Beijing Advanced Innovation Center for Genomics and Biomedical Pioneering Innovation Center, School of Life Sciences, Peking University, Ministry of Education Key Laboratory of Cell Proliferation and Differentiation
– sequence: 19
  givenname: Bin
  orcidid: 0000-0001-5278-5522
  surname: Zhou
  fullname: Zhou, Bin
  organization: The State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences
– sequence: 20
  givenname: Bing
  surname: Liu
  fullname: Liu, Bing
  email: bingliu17@126.com
  organization: Key Laboratory for Regenerative Medicine of Ministry of Education, Institute of Hematology, School of Medicine, Jinan University, State Key Laboratory of Experimental Hematology, Haihe Laboratory of Cell Ecosystem, Institute of Hematology, Fifth Medical Center of Chinese PLA General Hospital, State Key Laboratory of Proteomics, Academy of Military Medical Sciences, Academy of Military Sciences
– sequence: 21
  givenname: Fuchou
  orcidid: 0000-0002-8625-7717
  surname: Tang
  fullname: Tang, Fuchou
  email: tangfuchou@pku.edu.cn
  organization: Beijing Advanced Innovation Center for Genomics and Biomedical Pioneering Innovation Center, School of Life Sciences, Peking University, Ministry of Education Key Laboratory of Cell Proliferation and Differentiation, Peking-Tsinghua Center for Life Sciences, Peking University
– sequence: 22
  givenname: Yu
  orcidid: 0000-0002-4731-5945
  surname: Lan
  fullname: Lan, Yu
  email: rainyblue_1999@126.com
  organization: Key Laboratory for Regenerative Medicine of Ministry of Education, Institute of Hematology, School of Medicine, Jinan University
BackLink https://www.ncbi.nlm.nih.gov/pubmed/35079138$$D View this record in MEDLINE/PubMed
BookMark eNp9kUuPFCEUhYkZ4zz0D7gwJG7clEJRPGpjYibqmEziRteEgls9TChooapN96-Xsmd8zGIWBALfOTncc45OYoqA0EtK3lLC1LvS0a5tG7IuIihvDk_QGZWdaqRi6qSeCaENEaQ9Reel3BLS8o7TZ-iUcSJ7ytQZWq5ghpw2EMHPe-wjhujSfAPBm4AthFCwiQ7_9A7KNoNxeAcxLfU2V2GF_MHMPkXsluzjBoPJYY93ptglmIwd7CCk7QRxXs0nM00mlOfo6Vg3eHG3X6Dvnz5-u7xqrr9-_nL54bqxnezmxoEb6dgzawflOtELYYSjI1WGkoERIUY1DFwSwayErje9MZXgjFk-8tEZdoHeH323yzCBszVFNkFvs59M3utkvP7_JfobvUk7rXrJleqrwZs7g5x-LFBmPfmyTsVEqEPQrWjbnkvJV_T1A_Q2LTnW71WqqyVQykilXv2b6E-U-0YqoI6AzamUDKO2fv494RrQB02JXsvXx_I1Wddavj5UaftAeu_-qIgdRbXd2h_kv7EfUf0CBYbGQw
CitedBy_id crossref_primary_10_1016_j_csbj_2022_09_019
crossref_primary_10_1186_s12916_024_03611_9
crossref_primary_10_1161_CIRCRESAHA_123_323956
crossref_primary_10_1161_CIRCRESAHA_123_322767
crossref_primary_10_1038_s41569_024_01103_0
crossref_primary_10_1093_schbul_sbad057
crossref_primary_10_1038_s41467_024_47434_x
crossref_primary_10_1161_CIRCRESAHA_124_324868
crossref_primary_10_1038_s41422_022_00629_7
crossref_primary_10_1038_s41422_022_00687_x
crossref_primary_10_1016_j_devcel_2024_03_003
crossref_primary_10_3389_fcell_2023_1176115
crossref_primary_10_1016_j_ejcb_2024_151473
crossref_primary_10_1016_j_yjmcc_2024_10_004
crossref_primary_10_1038_s41598_023_50148_7
crossref_primary_10_1002_advs_202203813
crossref_primary_10_1152_ajprenal_00283_2024
crossref_primary_10_1016_j_pharmthera_2023_108418
crossref_primary_10_3389_fcell_2024_1439419
crossref_primary_10_1161_HYPERTENSIONAHA_122_19427
crossref_primary_10_1038_s41569_022_00770_1
crossref_primary_10_1016_j_devcel_2024_02_010
crossref_primary_10_1016_j_stem_2024_10_015
crossref_primary_10_1016_j_celrep_2022_110621
crossref_primary_10_7554_eLife_106133
crossref_primary_10_1038_s41598_023_29779_3
crossref_primary_10_1016_j_semcdb_2023_08_005
crossref_primary_10_1002_smtd_202401588
crossref_primary_10_1016_j_cophys_2023_100691
crossref_primary_10_1186_s13619_025_00223_3
crossref_primary_10_1016_j_neo_2024_101110
crossref_primary_10_1002_advs_202409744
crossref_primary_10_1097_BS9_0000000000000199
crossref_primary_10_1242_dev_201030
crossref_primary_10_1038_s44318_024_00079_4
crossref_primary_10_3390_biomedicines12081795
crossref_primary_10_1016_j_devcel_2025_01_010
crossref_primary_10_1016_j_exphem_2024_104284
crossref_primary_10_3389_fcell_2023_1220694
crossref_primary_10_1016_j_jgg_2023_09_005
crossref_primary_10_1016_j_semcdb_2023_06_004
crossref_primary_10_1016_j_cell_2023_01_034
crossref_primary_10_1016_j_semcdb_2023_06_002
crossref_primary_10_1681_ASN_0000000000000320
crossref_primary_10_7554_eLife_102440
crossref_primary_10_1038_s41422_023_00904_1
crossref_primary_10_17802_2306_1278_2024_13_4S_73_87
crossref_primary_10_1016_j_jgg_2023_05_006
Cites_doi 10.1242/dev.058776
10.1038/s41592-018-0303-9
10.1038/nature08873
10.1002/dvdy.22706
10.1002/dvg.20687
10.1038/nbt.4096
10.1038/s41586-019-0969-x
10.1038/s41422-019-0228-6
10.1016/j.ydbio.2011.10.018
10.1016/j.chom.2015.11.002
10.1038/nmeth.2772
10.1038/nrm2183
10.1002/bies.201800198
10.1371/journal.pone.0002853
10.1038/s41586-019-0933-9
10.1038/s41556-017-0013-z
10.1093/bioinformatics/btp120
10.1182/blood.V95.5.1671.005k39_1671_1679
10.1016/j.ydbio.2016.12.010
10.1161/CIRCRESAHA.118.312981
10.1093/cvr/cvw005
10.1242/dev.093351
10.1038/nprot.2014.006
10.1161/CIRCULATIONAHA.119.041433
10.1016/j.celrep.2012.08.003
10.1016/j.cell.2015.05.047
10.1038/nature10783
10.1016/j.cell.2015.05.002
10.1126/science.1251487
10.1038/s41467-017-01742-7
10.1016/j.stem.2017.05.009
10.1089/omi.2011.0118
10.1038/nature25739
10.1002/jcp.24094
10.1242/dev.070912
10.1161/ATVBAHA.114.303929
10.1016/j.cell.2020.01.015
10.1038/nature03080
10.1038/nrm3176
10.1242/dev.119.2.295
10.1091/mbc.4.1.7
10.1242/dev.129.17.4147
10.7554/eLife.21032
10.1038/s41586-018-0288-7
10.1002/dvdy.24252
10.1126/science.aaf1204
10.1038/s41586-018-0414-6
10.1242/dev.059881
10.1038/ncomms8866
10.1038/nprot.2009.97
10.1016/j.matbio.2014.02.004
10.1186/s13059-017-1382-0
10.1126/science.aad0501
10.1038/ncb3555
10.1038/ncomms11988
10.1186/1471-213X-1-4
10.1038/nmeth.2639
10.1016/j.devcel.2011.07.001
10.1038/nrm.2017.36
10.1038/s41556-020-0475-2
10.1093/nar/gku887
10.1038/ncomms6758
10.1016/j.cardiores.2004.03.007
10.1016/j.stem.2021.01.007
10.1038/nprot.2010.113
10.1093/bioinformatics/btu638
10.1016/j.cell.2019.05.031
10.1038/nmeth.4402
10.1161/ATVBAHA.114.303218
10.1242/dev.01711
10.1161/CIRCRESAHA.121.318669
10.1038/s41586-020-3018-x
10.1080/01621459.1989.10478797
10.1038/nature18633
10.1161/CIRCRESAHA.110.233171
10.1038/nbt.4091
10.1038/ni1560
10.1038/s41467-018-06318-7
10.1161/CIRCRESAHA.116.302953
10.1182/blood-2011-12-398156
10.1038/nm.4437
10.1038/s41422-020-0300-2
10.1038/s41587-020-0591-3
10.1016/j.celrep.2015.05.036
10.1084/jem.20102419
10.1038/ncb3276
10.1152/physrev.00041.2008
10.21105/joss.00861
ContentType Journal Article
Copyright The Author(s) 2022
2022. The Author(s).
The Author(s) 2022. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Copyright_xml – notice: The Author(s) 2022
– notice: 2022. The Author(s).
– notice: The Author(s) 2022. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
DBID C6C
AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
3V.
7QO
7QP
7QR
7T5
7TK
7TM
7TO
7U9
7X7
7XB
88E
8FD
8FE
8FH
8FI
8FJ
8FK
ABUWG
AEUYN
AFKRA
AZQEC
BBNVY
BENPR
BHPHI
CCPQU
DWQXO
FR3
FYUFA
GHDGH
GNUQQ
H94
HCIFZ
K9.
LK8
M0S
M1P
M7N
M7P
P64
PHGZM
PHGZT
PJZUB
PKEHL
PPXIY
PQEST
PQGLB
PQQKQ
PQUKI
PRINS
RC3
7X8
5PM
DOI 10.1038/s41422-022-00615-z
DatabaseName Springer Nature OA Free Journals
CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
ProQuest Central (Corporate)
Biotechnology Research Abstracts
Calcium & Calcified Tissue Abstracts
Chemoreception Abstracts
Immunology Abstracts
Neurosciences Abstracts
Nucleic Acids Abstracts
Oncogenes and Growth Factors Abstracts
Virology and AIDS Abstracts
ProQuest Health & Medical Collection (NC LIVE)
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
Technology Research Database
ProQuest SciTech Collection
ProQuest Natural Science Collection
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest One Sustainability (subscription)
ProQuest Central UK/Ireland
ProQuest Central Essentials
Biological Science Collection
ProQuest Central
Natural Science Collection
ProQuest One Community College
ProQuest Central
Engineering Research Database
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
AIDS and Cancer Research Abstracts
SciTech Premium Collection
ProQuest Health & Medical Complete (Alumni)
Biological Sciences
ProQuest Health & Medical Collection
PML(ProQuest Medical Library)
Algology Mycology and Protozoology Abstracts (Microbiology C)
Biological Science Database
Biotechnology and BioEngineering Abstracts
ProQuest Central Premium
ProQuest One Academic
ProQuest Health & Medical Research Collection
ProQuest One Academic Middle East (New)
ProQuest One Health & Nursing
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Applied & Life Sciences
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
Genetics Abstracts
MEDLINE - Academic
PubMed Central (Full Participant titles)
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
ProQuest Central Student
Oncogenes and Growth Factors Abstracts
ProQuest Central Essentials
Nucleic Acids Abstracts
SciTech Premium Collection
ProQuest Central China
ProQuest One Applied & Life Sciences
ProQuest One Sustainability
Health Research Premium Collection
Natural Science Collection
Health & Medical Research Collection
Biological Science Collection
Chemoreception Abstracts
ProQuest Central (New)
ProQuest Medical Library (Alumni)
Virology and AIDS Abstracts
ProQuest Biological Science Collection
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
Biological Science Database
Neurosciences Abstracts
ProQuest Hospital Collection (Alumni)
Biotechnology and BioEngineering Abstracts
ProQuest Health & Medical Complete
ProQuest One Academic UKI Edition
Engineering Research Database
ProQuest One Academic
Calcium & Calcified Tissue Abstracts
ProQuest One Academic (New)
Technology Research Database
ProQuest One Academic Middle East (New)
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
ProQuest One Health & Nursing
ProQuest Natural Science Collection
ProQuest Central
ProQuest Health & Medical Research Collection
Genetics Abstracts
Biotechnology Research Abstracts
Health and Medicine Complete (Alumni Edition)
ProQuest Central Korea
Algology Mycology and Protozoology Abstracts (Microbiology C)
AIDS and Cancer Research Abstracts
ProQuest SciTech Collection
ProQuest Medical Library
Immunology Abstracts
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList
ProQuest Central Student
CrossRef
MEDLINE
MEDLINE - Academic
Database_xml – sequence: 1
  dbid: C6C
  name: Springer Nature OA Free Journals
  url: http://www.springeropen.com/
  sourceTypes: Publisher
– sequence: 2
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 3
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 4
  dbid: BENPR
  name: ProQuest Central
  url: https://www.proquest.com/central
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Biology
EISSN 1748-7838
EndPage 348
ExternalDocumentID PMC8975889
35079138
10_1038_s41422_022_00615_z
Genre Journal Article
GroupedDBID ---
-01
-0A
-Q-
-SA
-S~
0R~
29B
2WC
36B
39C
3V.
4.4
406
53G
5GY
5VR
5XA
5XB
6J9
70F
7X7
88E
8FE
8FH
8FI
8FJ
92E
92I
92M
9D9
9DA
AACDK
AAHBH
AANZL
AASML
AATNV
AAXDM
AAYZH
AAZLF
ABAKF
ABAWZ
ABJNI
ABUWG
ABZZP
ACAOD
ACGFO
ACGFS
ACIWK
ACKTT
ACMJI
ACPRK
ACRQY
ACZOJ
ADBBV
ADFRT
ADHDB
AEFQL
AEJRE
AEMSY
AENEX
AESKC
AEUYN
AEVLU
AEXYK
AFBBN
AFKRA
AFRAH
AFSHS
AFUIB
AGHAI
AGQEE
AHMBA
AHSBF
AIGIU
AILAN
AJRNO
ALFFA
ALIPV
ALMA_UNASSIGNED_HOLDINGS
AMYLF
AOIJS
AXYYD
BAWUL
BBNVY
BENPR
BHPHI
BKKNO
BPHCQ
BVXVI
C1A
C6C
CAG
CAJEA
CCEZO
CCPQU
CCVFK
CHBEP
COF
CS3
CW9
DIK
DNIVK
DPUIP
DU5
E3Z
EBLON
EBS
EE.
EIOEI
EJD
EMB
EMOBN
F5P
FA0
FDQFY
FERAY
FIGPU
FIZPM
FSGXE
FYUFA
GX1
HCIFZ
HMCUK
HYE
HZ~
IWAJR
JSO
JUIAU
JZLTJ
KQ8
LGEZI
LK8
LOTEE
M1P
M7P
NADUK
NAO
NQJWS
NXXTH
O9-
OK1
P2P
PQQKQ
PROAC
PSQYO
Q--
Q-0
R-A
RNS
RNT
RNTTT
ROL
RPM
RT1
S..
SNX
SNYQT
SOHCF
SOJ
SRMVM
SV3
SWTZT
T8Q
TAOOD
TBHMF
TCJ
TDRGL
TGP
TR2
U1F
U1G
U5A
U5K
UKHRP
WFFXF
XSB
~88
AAYXX
ABBRH
ABDBE
ABFSG
ACMFV
ACSTC
AEZWR
AFDZB
AFHIU
AHWEU
AIXLP
ATHPR
AYFIA
CITATION
PHGZM
PHGZT
CGR
CUY
CVF
ECM
EIF
NPM
7QO
7QP
7QR
7T5
7TK
7TM
7TO
7U9
7XB
8FD
8FK
ABRTQ
AZQEC
DWQXO
FR3
GNUQQ
H94
K9.
M7N
P64
PJZUB
PKEHL
PPXIY
PQEST
PQGLB
PQUKI
PRINS
PUEGO
RC3
7X8
5PM
ID FETCH-LOGICAL-c474t-dedf1f93ccb8d46966a6d1f18a10b3066f8bb57063c7e49a9aa6a6533c5f5fda3
IEDL.DBID C6C
ISSN 1001-0602
1748-7838
IngestDate Thu Aug 21 18:32:42 EDT 2025
Fri Jul 11 07:07:48 EDT 2025
Sat Aug 23 14:50:07 EDT 2025
Wed Feb 19 02:26:10 EST 2025
Thu Apr 24 23:10:17 EDT 2025
Tue Jul 01 03:41:40 EDT 2025
Fri Feb 21 02:38:09 EST 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 4
Language English
License 2022. The Author(s).
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c474t-dedf1f93ccb8d46966a6d1f18a10b3066f8bb57063c7e49a9aa6a6533c5f5fda3
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
ORCID 0000-0002-4280-0562
0000-0003-3530-7259
0000-0002-5189-5268
0000-0002-8953-5284
0000-0002-5497-6178
0000-0002-8625-7717
0000-0001-7875-7087
0000-0002-4731-5945
0000-0001-5278-5522
OpenAccessLink https://www.nature.com/articles/s41422-022-00615-z
PMID 35079138
PQID 2646021130
PQPubID 536307
PageCount 16
ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_8975889
proquest_miscellaneous_2622957759
proquest_journals_2646021130
pubmed_primary_35079138
crossref_citationtrail_10_1038_s41422_022_00615_z
crossref_primary_10_1038_s41422_022_00615_z
springer_journals_10_1038_s41422_022_00615_z
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2022-04-01
PublicationDateYYYYMMDD 2022-04-01
PublicationDate_xml – month: 04
  year: 2022
  text: 2022-04-01
  day: 01
PublicationDecade 2020
PublicationPlace Singapore
PublicationPlace_xml – name: Singapore
– name: England
– name: London
PublicationTitle Cell research
PublicationTitleAbbrev Cell Res
PublicationTitleAlternate Cell Res
PublicationYear 2022
Publisher Springer Singapore
Nature Publishing Group
Publisher_xml – name: Springer Singapore
– name: Nature Publishing Group
References Rybtsov (CR63) 2011; 208
Pitulescu, Schmidt, Benedito, Adams (CR64) 2010; 5
Dzierzak, Speck (CR20) 2008; 9
Takase (CR22) 2012; 120
Lu (CR28) 2004; 432
Islam (CR68) 2014; 11
Adams, Alitalo (CR1) 2007; 8
Simons, Eichmann (CR6) 2015; 116
Corada, Morini, Dejana (CR37) 2014; 34
Qiu (CR87) 2017; 14
Tian (CR7) 2014; 345
Papke, Yanagisawa (CR31) 2014; 37
Beyer, Kelly, Miquerol (CR58) 2011; 49
Anders, Pyl, Huber (CR71) 2015; 31
Bergen, Lange, Peidli, Wolf, Theis (CR85) 2020; 38
Luo (CR43) 2021; 589
Wang (CR54) 2017; 421
Fish, Wythe (CR51) 2015; 244
CR74
Picelli (CR65) 2013; 10
Cao (CR17) 2019; 566
Yue (CR62) 2020; 22
Pu (CR50) 2018; 123
Miquerol (CR59) 2004; 63
Ibarra-Soria (CR26) 2018; 20
Herbert, Stainier (CR2) 2011; 12
Paik (CR14) 2020; 142
Drake, Fleming (CR18) 2000; 95
Wagenseil, Mecham (CR34) 2009; 89
Potente, Makinen (CR3) 2017; 18
Ehling, Adams, Benedito, Adams (CR39) 2013; 140
MacParland (CR47) 2018; 9
Wolf, Angerer, Theis (CR76) 2018; 19
Pijuan-Sala (CR16) 2019; 566
Li (CR23) 2017; 20
Pitulescu (CR41) 2017; 19
Vanlandewijck (CR15) 2018; 554
Fujita (CR8) 2011; 138
Fang (CR42) 2017; 8
Armulik, Genove, Betsholtz (CR44) 2011; 21
Hashimshony, Wagner, Sher, Yanai (CR67) 2012; 2
La Manno (CR49) 2018; 560
Ding, Saunders, Enikolopov, Morrison (CR60) 2012; 481
Levine (CR77) 2015; 162
McGrath (CR25) 2015; 11
Bruzzone, Haefliger, Gimlich, Paul (CR32) 1993; 4
Ramilowski (CR84) 2015; 6
Xu (CR12) 2014; 5
Tripathi (CR79) 2015; 18
Scialdone (CR24) 2016; 535
Lake (CR75) 2016; 352
Hou (CR36) 2020; 30
Durinck, Spellman, Birney, Huber (CR81) 2009; 4
He (CR52) 2016; 109
Faber, Chilian, Deindl, van Royen, Simons (CR5) 2014; 34
Macosko (CR69) 2015; 161
Red-Horse, Siekmann (CR4) 2019; 41
He (CR57) 2017; 23
Bussmann, Wolfe, Siekmann (CR9) 2011; 138
Rasmussen (CR27) 2011; 138
Trapnell, Pachter, Salzberg (CR70) 2009; 25
Butler, Hoffman, Smibert, Papalexi, Satija (CR72) 2018; 36
Wheatley, Isacke, Crossley (CR29) 1993; 119
Kalucka (CR13) 2020; 180
Barnes (CR38) 2011; 108
Li, Pashmforoush, Sucov (CR53) 2012; 361
Haghverdi, Lun, Morgan, Marioni (CR86) 2018; 36
Oberlin, Tavian, Blazsek, Peault (CR45) 2002; 129
Picelli (CR66) 2014; 9
Chu (CR40) 2016; 5
Yu, Wang, Han, He (CR80) 2012; 16
Tirosh (CR83) 2016; 352
Zeng (CR46) 2019; 29
Srinivas (CR61) 2001; 1
Red-Horse, Ueno, Weissman, Krasnow (CR11) 2010; 464
Stuart (CR73) 2019; 177
Zhang (CR88) 2015; 43
Chong, Koo, Xu, Fu, Cleaver (CR21) 2011; 240
Vincent (CR33) 2005; 132
Zilberberg (CR30) 2012; 227
Chen, Schlitzer, Chakarov, Ginhoux, Poidinger (CR48) 2016; 7
Thambyrajah (CR35) 2016; 18
Ntranos, Yi, Melsted, Pachter (CR78) 2019; 16
Hastie, Stuetzle (CR82) 1989; 84
Kelly (CR55) 2021; 128
Walls, Coultas, Rossant, Henkelman (CR19) 2008; 3
Su (CR10) 2018; 559
Han (CR56) 2021; 28
M Ehling (615_CR39) 2013; 140
L Ding (615_CR60) 2012; 481
M Chu (615_CR40) 2016; 5
W Pu (615_CR50) 2018; 123
615_CR74
SA MacParland (615_CR47) 2018; 9
S Durinck (615_CR81) 2009; 4
S Srinivas (615_CR61) 2001; 1
JH Levine (615_CR77) 2015; 162
T Hastie (615_CR82) 1989; 84
K Red-Horse (615_CR4) 2019; 41
SD Vincent (615_CR33) 2005; 132
EZ Macosko (615_CR69) 2015; 161
X Ibarra-Soria (615_CR26) 2018; 20
X Lu (615_CR28) 2004; 432
J Kalucka (615_CR13) 2020; 180
ME Pitulescu (615_CR41) 2017; 19
V Ntranos (615_CR78) 2019; 16
SC Wheatley (615_CR29) 1993; 119
L Haghverdi (615_CR86) 2018; 36
C Xu (615_CR12) 2014; 5
CJ Drake (615_CR18) 2000; 95
S Islam (615_CR68) 2014; 11
H Takase (615_CR22) 2012; 120
R Bruzzone (615_CR32) 1993; 4
M Potente (615_CR3) 2017; 18
M Corada (615_CR37) 2014; 34
G Yu (615_CR80) 2012; 16
X Tian (615_CR7) 2014; 345
J Bussmann (615_CR9) 2011; 138
S Beyer (615_CR58) 2011; 49
G La Manno (615_CR49) 2018; 560
KE McGrath (615_CR25) 2015; 11
B Pijuan-Sala (615_CR16) 2019; 566
J Chen (615_CR48) 2016; 7
ME Pitulescu (615_CR64) 2010; 5
K Red-Horse (615_CR11) 2010; 464
JA Ramilowski (615_CR84) 2015; 6
FA Wolf (615_CR76) 2018; 19
JE Faber (615_CR5) 2014; 34
SP Herbert (615_CR2) 2011; 12
JS Fang (615_CR42) 2017; 8
DT Paik (615_CR14) 2020; 142
A Scialdone (615_CR24) 2016; 535
C Trapnell (615_CR70) 2009; 25
E Oberlin (615_CR45) 2002; 129
J Cao (615_CR17) 2019; 566
I Tirosh (615_CR83) 2016; 352
R Thambyrajah (615_CR35) 2016; 18
CL Papke (615_CR31) 2014; 37
Y Zeng (615_CR46) 2019; 29
T Su (615_CR10) 2018; 559
L He (615_CR52) 2016; 109
L He (615_CR57) 2017; 23
S Hou (615_CR36) 2020; 30
V Bergen (615_CR85) 2020; 38
Y Yue (615_CR62) 2020; 22
S Picelli (615_CR66) 2014; 9
RM Barnes (615_CR38) 2011; 108
T Hashimshony (615_CR67) 2012; 2
L Miquerol (615_CR59) 2004; 63
RH Adams (615_CR1) 2007; 8
RG Kelly (615_CR55) 2021; 128
S Picelli (615_CR65) 2013; 10
M Vanlandewijck (615_CR15) 2018; 554
A Butler (615_CR72) 2018; 36
L Zilberberg (615_CR30) 2012; 227
JE Wagenseil (615_CR34) 2009; 89
X Wang (615_CR54) 2017; 421
X Qiu (615_CR87) 2017; 14
BB Lake (615_CR75) 2016; 352
HM Zhang (615_CR88) 2015; 43
DC Chong (615_CR21) 2011; 240
TL Rasmussen (615_CR27) 2011; 138
S Tripathi (615_CR79) 2015; 18
P Li (615_CR53) 2012; 361
X Han (615_CR56) 2021; 28
S Rybtsov (615_CR63) 2011; 208
JR Walls (615_CR19) 2008; 3
W Luo (615_CR43) 2021; 589
T Stuart (615_CR73) 2019; 177
E Dzierzak (615_CR20) 2008; 9
L Li (615_CR23) 2017; 20
S Anders (615_CR71) 2015; 31
JE Fish (615_CR51) 2015; 244
M Simons (615_CR6) 2015; 116
M Fujita (615_CR8) 2011; 138
A Armulik (615_CR44) 2011; 21
References_xml – volume: 138
  start-page: 1705
  year: 2011
  end-page: 1715
  ident: CR8
  article-title: Assembly and patterning of the vascular network of the vertebrate hindbrain
  publication-title: Development
  doi: 10.1242/dev.058776
– volume: 16
  start-page: 163
  year: 2019
  end-page: 166
  ident: CR78
  article-title: A discriminative learning approach to differential expression analysis for single-cell RNA-seq
  publication-title: Nat. Methods
  doi: 10.1038/s41592-018-0303-9
– volume: 464
  start-page: 549
  year: 2010
  end-page: 553
  ident: CR11
  article-title: Coronary arteries form by developmental reprogramming of venous cells
  publication-title: Nature
  doi: 10.1038/nature08873
– volume: 240
  start-page: 2153
  year: 2011
  end-page: 2165
  ident: CR21
  article-title: Stepwise arteriovenous fate acquisition during mammalian vasculogenesis
  publication-title: Dev. Dyn.
  doi: 10.1002/dvdy.22706
– volume: 49
  start-page: 83
  year: 2011
  end-page: 91
  ident: CR58
  article-title: Inducible Cx40-Cre expression in the cardiac conduction system and arterial endothelial cells
  publication-title: Genesis
  doi: 10.1002/dvg.20687
– volume: 36
  start-page: 411
  year: 2018
  end-page: 420
  ident: CR72
  article-title: Integrating single-cell transcriptomic data across different conditions, technologies, and species
  publication-title: Nat. Biotechnol.
  doi: 10.1038/nbt.4096
– volume: 566
  start-page: 496
  year: 2019
  end-page: 502
  ident: CR17
  article-title: The single-cell transcriptional landscape of mammalian organogenesis
  publication-title: Nature
  doi: 10.1038/s41586-019-0969-x
– ident: CR74
– volume: 29
  start-page: 881
  year: 2019
  end-page: 894
  ident: CR46
  article-title: Tracing the first hematopoietic stem cell generation in human embryo by single-cell RNA sequencing
  publication-title: Cell Res.
  doi: 10.1038/s41422-019-0228-6
– volume: 361
  start-page: 116
  year: 2012
  end-page: 124
  ident: CR53
  article-title: Mesodermal retinoic acid signaling regulates endothelial cell coalescence in caudal pharyngeal arch artery vasculogenesis
  publication-title: Dev. Biol.
  doi: 10.1016/j.ydbio.2011.10.018
– volume: 18
  start-page: 723
  year: 2015
  end-page: 735
  ident: CR79
  article-title: Meta- and orthogonal integration of influenza “OMICs” data defines a role for UBR4 in virus budding
  publication-title: Cell Host Microbe
  doi: 10.1016/j.chom.2015.11.002
– volume: 11
  start-page: 163
  year: 2014
  end-page: 166
  ident: CR68
  article-title: Quantitative single-cell RNA-seq with unique molecular identifiers
  publication-title: Nat. Methods
  doi: 10.1038/nmeth.2772
– volume: 8
  start-page: 464
  year: 2007
  end-page: 478
  ident: CR1
  article-title: Molecular regulation of angiogenesis and lymphangiogenesis
  publication-title: Nat. Rev. Mol. Cell Biol.
  doi: 10.1038/nrm2183
– volume: 41
  start-page: e1800198
  year: 2019
  ident: CR4
  article-title: Veins and Arteries Build Hierarchical Branching Patterns Differently: Bottom-Up versus Top-Down
  publication-title: BioEssays
  doi: 10.1002/bies.201800198
– volume: 3
  start-page: e2853
  year: 2008
  ident: CR19
  article-title: Three-dimensional analysis of vascular development in the mouse embryo
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0002853
– volume: 566
  start-page: 490
  year: 2019
  end-page: 495
  ident: CR16
  article-title: A single-cell molecular map of mouse gastrulation and early organogenesis
  publication-title: Nature
  doi: 10.1038/s41586-019-0933-9
– volume: 20
  start-page: 127
  year: 2018
  end-page: 134
  ident: CR26
  article-title: Defining murine organogenesis at single-cell resolution reveals a role for the leukotriene pathway in regulating blood progenitor formation
  publication-title: Nat. Cell Biol.
  doi: 10.1038/s41556-017-0013-z
– volume: 25
  start-page: 1105
  year: 2009
  end-page: 1111
  ident: CR70
  article-title: TopHat: discovering splice junctions with RNA-Seq
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btp120
– volume: 95
  start-page: 1671
  year: 2000
  end-page: 1679
  ident: CR18
  article-title: Vasculogenesis in the day 6.5 to 9.5 mouse embryo
  publication-title: Blood
  doi: 10.1182/blood.V95.5.1671.005k39_1671_1679
– volume: 421
  start-page: 108
  year: 2017
  end-page: 117
  ident: CR54
  article-title: Endothelium in the pharyngeal arches 3, 4 and 6 is derived from the second heart field
  publication-title: Dev. Biol.
  doi: 10.1016/j.ydbio.2016.12.010
– volume: 123
  start-page: 86
  year: 2018
  end-page: 99
  ident: CR50
  article-title: Genetic targeting of organ-specific blood vessels
  publication-title: Circ. Res.
  doi: 10.1161/CIRCRESAHA.118.312981
– volume: 109
  start-page: 419
  year: 2016
  end-page: 430
  ident: CR52
  article-title: Genetic lineage tracing discloses arteriogenesis as the main mechanism for collateral growth in the mouse heart
  publication-title: Cardiovasc. Res.
  doi: 10.1093/cvr/cvw005
– volume: 140
  start-page: 3051
  year: 2013
  end-page: 3061
  ident: CR39
  article-title: Notch controls retinal blood vessel maturation and quiescence
  publication-title: Development
  doi: 10.1242/dev.093351
– volume: 9
  start-page: 171
  year: 2014
  end-page: 181
  ident: CR66
  article-title: Full-length RNA-seq from single cells using Smart-seq2
  publication-title: Nat. Protoc.
  doi: 10.1038/nprot.2014.006
– volume: 142
  start-page: 1848
  year: 2020
  end-page: 1862
  ident: CR14
  article-title: Single-cell RNA sequencing unveils unique transcriptomic signatures of organ-specific endothelial cells.
  publication-title: Circulation
  doi: 10.1161/CIRCULATIONAHA.119.041433
– volume: 2
  start-page: 666
  year: 2012
  end-page: 673
  ident: CR67
  article-title: CEL-Seq: single-cell RNA-Seq by multiplexed linear amplification
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2012.08.003
– volume: 162
  start-page: 184
  year: 2015
  end-page: 197
  ident: CR77
  article-title: Data-driven phenotypic dissection of AML reveals progenitor-like cells that correlate with prognosis
  publication-title: Cell
  doi: 10.1016/j.cell.2015.05.047
– volume: 481
  start-page: 457
  year: 2012
  end-page: 462
  ident: CR60
  article-title: Endothelial and perivascular cells maintain haematopoietic stem cells
  publication-title: Nature
  doi: 10.1038/nature10783
– volume: 161
  start-page: 1202
  year: 2015
  end-page: 1214
  ident: CR69
  article-title: Highly parallel genome-wide expression profiling of individual cells using nanoliter droplets
  publication-title: Cell
  doi: 10.1016/j.cell.2015.05.002
– volume: 345
  start-page: 90
  year: 2014
  end-page: 94
  ident: CR7
  article-title: Vessel formation. De novo formation of a distinct coronary vascular population in neonatal heart
  publication-title: Science
  doi: 10.1126/science.1251487
– volume: 8
  year: 2017
  ident: CR42
  article-title: Shear-induced Notch-Cx37-p27 axis arrests endothelial cell cycle to enable arterial specification
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-017-01742-7
– volume: 20
  start-page: 891
  year: 2017
  end-page: 892
  ident: CR23
  article-title: Single-cell RNA-seq analysis maps development of human germline cells and gonadal niche interactions
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2017.05.009
– volume: 16
  start-page: 284
  year: 2012
  end-page: 287
  ident: CR80
  article-title: Y. clusterProfiler: an R package for comparing biological themes among gene clusters
  publication-title: OMICS
  doi: 10.1089/omi.2011.0118
– volume: 554
  start-page: 475
  year: 2018
  end-page: 480
  ident: CR15
  article-title: A molecular atlas of cell types and zonation in the brain vasculature
  publication-title: Nature
  doi: 10.1038/nature25739
– volume: 227
  start-page: 3828
  year: 2012
  end-page: 3836
  ident: CR30
  article-title: Specificity of latent TGF-beta binding protein (LTBP) incorporation into matrix: role of fibrillins and fibronectin
  publication-title: J. Cell Physiol.
  doi: 10.1002/jcp.24094
– volume: 138
  start-page: 4801
  year: 2011
  ident: CR27
  article-title: ER71 directs mesodermal fate decisions during embryogenesis
  publication-title: Development
  doi: 10.1242/dev.070912
– volume: 34
  start-page: 1854
  year: 2014
  end-page: 1859
  ident: CR5
  article-title: A brief etymology of the collateral circulation
  publication-title: Arterioscler Thromb. Vasc. Biol.
  doi: 10.1161/ATVBAHA.114.303929
– volume: 180
  start-page: 764
  year: 2020
  end-page: 779.e720
  ident: CR13
  article-title: Single-cell transcriptome atlas of murine endothelial cells
  publication-title: Cell
  doi: 10.1016/j.cell.2020.01.015
– volume: 432
  start-page: 179
  year: 2004
  end-page: 186
  ident: CR28
  article-title: The netrin receptor UNC5B mediates guidance events controlling morphogenesis of the vascular system
  publication-title: Nature
  doi: 10.1038/nature03080
– volume: 12
  start-page: 551
  year: 2011
  end-page: 564
  ident: CR2
  article-title: Molecular control of endothelial cell behaviour during blood vessel morphogenesis
  publication-title: Nat. Rev. Mol. Cell Biol.
  doi: 10.1038/nrm3176
– volume: 119
  start-page: 295
  year: 1993
  end-page: 306
  ident: CR29
  article-title: Restricted expression of the hyaluronan receptor, CD44, during postimplantation mouse embryogenesis suggests key roles in tissue formation and patterning
  publication-title: Development
  doi: 10.1242/dev.119.2.295
– volume: 4
  start-page: 7
  year: 1993
  end-page: 20
  ident: CR32
  article-title: Connexin40, a component of gap junctions in vascular endothelium, is restricted in its ability to interact with other connexins
  publication-title: Mol. Biol. Cell
  doi: 10.1091/mbc.4.1.7
– volume: 129
  start-page: 4147
  year: 2002
  end-page: 4157
  ident: CR45
  article-title: Blood-forming potential of vascular endothelium in the human embryo
  publication-title: Development
  doi: 10.1242/dev.129.17.4147
– volume: 5
  start-page: e21032
  year: 2016
  ident: CR40
  article-title: Angiopoietin receptor Tie2 is required for vein specification and maintenance via regulating COUP-TFII
  publication-title: Elife
  doi: 10.7554/eLife.21032
– volume: 559
  start-page: 356
  year: 2018
  end-page: 362
  ident: CR10
  article-title: Single-cell analysis of early progenitor cells that build coronary arteries
  publication-title: Nature
  doi: 10.1038/s41586-018-0288-7
– volume: 244
  start-page: 391
  year: 2015
  end-page: 409
  ident: CR51
  article-title: The molecular regulation of arteriovenous specification and maintenance
  publication-title: Dev. Dyn.
  doi: 10.1002/dvdy.24252
– volume: 352
  start-page: 1586
  year: 2016
  end-page: 1590
  ident: CR75
  article-title: Neuronal subtypes and diversity revealed by single-nucleus RNA sequencing of the human brain
  publication-title: Science
  doi: 10.1126/science.aaf1204
– volume: 560
  start-page: 494
  year: 2018
  end-page: 498
  ident: CR49
  article-title: RNA velocity of single cells
  publication-title: Nature
  doi: 10.1038/s41586-018-0414-6
– volume: 138
  start-page: 1717
  year: 2011
  end-page: 1726
  ident: CR9
  article-title: Arterial-venous network formation during brain vascularization involves hemodynamic regulation of chemokine signaling
  publication-title: Development
  doi: 10.1242/dev.059881
– volume: 6
  year: 2015
  ident: CR84
  article-title: A draft network of ligand-receptor-mediated multicellular signalling in human
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms8866
– volume: 4
  start-page: 1184
  year: 2009
  end-page: 1191
  ident: CR81
  article-title: Mapping identifiers for the integration of genomic datasets with the R/Bioconductor package biomaRt
  publication-title: Nat. Protoc.
  doi: 10.1038/nprot.2009.97
– volume: 37
  start-page: 142
  year: 2014
  end-page: 149
  ident: CR31
  article-title: Fibulin-4 and fibulin-5 in elastogenesis and beyond: Insights from mouse and human studies
  publication-title: Matrix Biol.
  doi: 10.1016/j.matbio.2014.02.004
– volume: 19
  year: 2018
  ident: CR76
  article-title: SCANPY: large-scale single-cell gene expression data analysis
  publication-title: Genome Biol.
  doi: 10.1186/s13059-017-1382-0
– volume: 352
  start-page: 189
  year: 2016
  end-page: 196
  ident: CR83
  article-title: Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq
  publication-title: Science
  doi: 10.1126/science.aad0501
– volume: 19
  start-page: 915
  year: 2017
  end-page: 927
  ident: CR41
  article-title: Dll4 and Notch signalling couples sprouting angiogenesis and artery formation
  publication-title: Nat. Cell Biol.
  doi: 10.1038/ncb3555
– volume: 7
  year: 2016
  ident: CR48
  article-title: Mpath maps multi-branching single-cell trajectories revealing progenitor cell progression during development
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms11988
– volume: 1
  start-page: 4
  year: 2001
  ident: CR61
  article-title: Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus
  publication-title: BMC Dev. Biol.
  doi: 10.1186/1471-213X-1-4
– volume: 10
  start-page: 1096
  year: 2013
  end-page: 1098
  ident: CR65
  article-title: Smart-seq2 for sensitive full-length transcriptome profiling in single cells
  publication-title: Nat. Methods
  doi: 10.1038/nmeth.2639
– volume: 21
  start-page: 193
  year: 2011
  end-page: 215
  ident: CR44
  article-title: Pericytes: developmental, physiological, and pathological perspectives, problems, and promises
  publication-title: Dev. Cell
  doi: 10.1016/j.devcel.2011.07.001
– volume: 18
  start-page: 477
  year: 2017
  end-page: 494
  ident: CR3
  article-title: Vascular heterogeneity and specialization in development and disease
  publication-title: Nat. Rev. Mol. Cell Biol.
  doi: 10.1038/nrm.2017.36
– volume: 22
  start-page: 332
  year: 2020
  end-page: 340
  ident: CR62
  article-title: Long-term, in toto live imaging of cardiomyocyte behaviour during mouse ventricle chamber formation at single-cell resolution
  publication-title: Nat. Cell Biol.
  doi: 10.1038/s41556-020-0475-2
– volume: 43
  start-page: D76
  year: 2015
  end-page: D81
  ident: CR88
  article-title: AnimalTFDB 2.0: a resource for expression, prediction and functional study of animal transcription factors
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gku887
– volume: 5
  year: 2014
  ident: CR12
  article-title: Arteries are formed by vein-derived endothelial tip cells
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms6758
– volume: 63
  start-page: 77
  year: 2004
  end-page: 86
  ident: CR59
  article-title: Architectural and functional asymmetry of the His-Purkinje system of the murine heart
  publication-title: Cardiovasc. Res.
  doi: 10.1016/j.cardiores.2004.03.007
– volume: 28
  start-page: 1160
  year: 2021
  end-page: 1176 e1167
  ident: CR56
  article-title: A suite of new Dre recombinase drivers markedly expands the ability to perform intersectional genetic targeting
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2021.01.007
– volume: 5
  start-page: 1518
  year: 2010
  end-page: 1534
  ident: CR64
  article-title: Inducible gene targeting in the neonatal vasculature and analysis of retinal angiogenesis in mice
  publication-title: Nat. Protoc.
  doi: 10.1038/nprot.2010.113
– volume: 31
  start-page: 166
  year: 2015
  end-page: 169
  ident: CR71
  article-title: HTSeq-a Python framework to work with high-throughput sequencing data
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btu638
– volume: 177
  start-page: 1888
  year: 2019
  end-page: 1902.e1821
  ident: CR73
  article-title: Comprehensive integration of single-cell data
  publication-title: Cell
  doi: 10.1016/j.cell.2019.05.031
– volume: 14
  start-page: 979
  year: 2017
  end-page: 982
  ident: CR87
  article-title: Reversed graph embedding resolves complex single-cell trajectories
  publication-title: Nat. Methods
  doi: 10.1038/nmeth.4402
– volume: 34
  start-page: 2372
  year: 2014
  end-page: 2377
  ident: CR37
  article-title: Signaling pathways in the specification of arteries and veins
  publication-title: Arterioscler Thromb. Vasc. Biol.
  doi: 10.1161/ATVBAHA.114.303218
– volume: 132
  start-page: 1315
  year: 2005
  end-page: 1325
  ident: CR33
  article-title: The zinc finger transcriptional repressor Blimp1/Prdm1 is dispensable for early axis formation but is required for specification of primordial germ cells in the mouse
  publication-title: Development
  doi: 10.1242/dev.01711
– volume: 128
  start-page: 360
  year: 2021
  end-page: 362
  ident: CR55
  article-title: Integrating matrix signals during arch artery morphogenesis
  publication-title: Circ. Res.
  doi: 10.1161/CIRCRESAHA.121.318669
– volume: 589
  start-page: 437
  year: 2021
  end-page: 441
  ident: CR43
  article-title: Arterialization requires the timely suppression of cell growth
  publication-title: Nature
  doi: 10.1038/s41586-020-3018-x
– volume: 84
  start-page: 502
  year: 1989
  end-page: 516
  ident: CR82
  article-title: Principal curves
  publication-title: J. Am. Statist. Assoc.
  doi: 10.1080/01621459.1989.10478797
– volume: 535
  start-page: 289
  year: 2016
  end-page: 293
  ident: CR24
  article-title: Resolving early mesoderm diversification through single-cell expression profiling
  publication-title: Nature
  doi: 10.1038/nature18633
– volume: 108
  start-page: 940
  year: 2011
  end-page: 949
  ident: CR38
  article-title: Hand2 loss-of-function in Hand1-expressing cells reveals distinct roles in epicardial and coronary vessel development
  publication-title: Circ. Res.
  doi: 10.1161/CIRCRESAHA.110.233171
– volume: 36
  start-page: 421
  year: 2018
  end-page: 427
  ident: CR86
  article-title: Batch effects in single-cell RNA-sequencing data are corrected by matching mutual nearest neighbors
  publication-title: Nat. Biotechnol.
  doi: 10.1038/nbt.4091
– volume: 9
  start-page: 129
  year: 2008
  end-page: 136
  ident: CR20
  article-title: Of lineage and legacy: the development of mammalian hematopoietic stem cells
  publication-title: Nat. Immunol.
  doi: 10.1038/ni1560
– volume: 9
  year: 2018
  ident: CR47
  article-title: Single cell RNA sequencing of human liver reveals distinct intrahepatic macrophage populations
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-018-06318-7
– volume: 116
  start-page: 1712
  year: 2015
  end-page: 1724
  ident: CR6
  article-title: Molecular controls of arterial morphogenesis
  publication-title: Circ. Res.
  doi: 10.1161/CIRCRESAHA.116.302953
– volume: 120
  start-page: 914
  year: 2012
  end-page: 923
  ident: CR22
  article-title: Genome-wide identification of endothelial cell-enriched genes in the mouse embryo
  publication-title: Blood
  doi: 10.1182/blood-2011-12-398156
– volume: 23
  start-page: 1488
  year: 2017
  end-page: 1498
  ident: CR57
  article-title: Enhancing the precision of genetic lineage tracing using dual recombinases
  publication-title: Nat. Med.
  doi: 10.1038/nm.4437
– volume: 30
  start-page: 376
  year: 2020
  end-page: 392
  ident: CR36
  article-title: Embryonic endothelial evolution towards first hematopoietic stem cells revealed by single-cell transcriptomic and functional analyses
  publication-title: Cell Res.
  doi: 10.1038/s41422-020-0300-2
– volume: 38
  start-page: 1408
  year: 2020
  end-page: 1414
  ident: CR85
  article-title: Generalizing RNA velocity to transient cell states through dynamical modeling
  publication-title: Nat. Biotechnol.
  doi: 10.1038/s41587-020-0591-3
– volume: 11
  start-page: 1892
  year: 2015
  end-page: 1904
  ident: CR25
  article-title: Distinct sources of hematopoietic progenitors emerge before HSCs and provide functional blood cells in the mammalian embryo
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2015.05.036
– volume: 208
  start-page: 1305
  year: 2011
  end-page: 1315
  ident: CR63
  article-title: Hierarchical organization and early hematopoietic specification of the developing HSC lineage in the AGM region
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.20102419
– volume: 18
  start-page: 21
  year: 2016
  end-page: 32
  ident: CR35
  article-title: GFI1 proteins orchestrate the emergence of haematopoietic stem cells through recruitment of LSD1
  publication-title: Nat. Cell Biol.
  doi: 10.1038/ncb3276
– volume: 89
  start-page: 957
  year: 2009
  end-page: 989
  ident: CR34
  article-title: Vascular extracellular matrix and arterial mechanics
  publication-title: Physiol. Rev.
  doi: 10.1152/physrev.00041.2008
– volume: 28
  start-page: 1160
  year: 2021
  ident: 615_CR56
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2021.01.007
– volume: 9
  start-page: 171
  year: 2014
  ident: 615_CR66
  publication-title: Nat. Protoc.
  doi: 10.1038/nprot.2014.006
– volume: 123
  start-page: 86
  year: 2018
  ident: 615_CR50
  publication-title: Circ. Res.
  doi: 10.1161/CIRCRESAHA.118.312981
– volume: 132
  start-page: 1315
  year: 2005
  ident: 615_CR33
  publication-title: Development
  doi: 10.1242/dev.01711
– volume: 559
  start-page: 356
  year: 2018
  ident: 615_CR10
  publication-title: Nature
  doi: 10.1038/s41586-018-0288-7
– volume: 20
  start-page: 891
  year: 2017
  ident: 615_CR23
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2017.05.009
– volume: 129
  start-page: 4147
  year: 2002
  ident: 615_CR45
  publication-title: Development
  doi: 10.1242/dev.129.17.4147
– volume: 8
  start-page: 464
  year: 2007
  ident: 615_CR1
  publication-title: Nat. Rev. Mol. Cell Biol.
  doi: 10.1038/nrm2183
– volume: 10
  start-page: 1096
  year: 2013
  ident: 615_CR65
  publication-title: Nat. Methods
  doi: 10.1038/nmeth.2639
– volume: 14
  start-page: 979
  year: 2017
  ident: 615_CR87
  publication-title: Nat. Methods
  doi: 10.1038/nmeth.4402
– volume: 11
  start-page: 1892
  year: 2015
  ident: 615_CR25
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2015.05.036
– volume: 31
  start-page: 166
  year: 2015
  ident: 615_CR71
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btu638
– volume: 535
  start-page: 289
  year: 2016
  ident: 615_CR24
  publication-title: Nature
  doi: 10.1038/nature18633
– volume: 464
  start-page: 549
  year: 2010
  ident: 615_CR11
  publication-title: Nature
  doi: 10.1038/nature08873
– volume: 421
  start-page: 108
  year: 2017
  ident: 615_CR54
  publication-title: Dev. Biol.
  doi: 10.1016/j.ydbio.2016.12.010
– volume: 208
  start-page: 1305
  year: 2011
  ident: 615_CR63
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.20102419
– volume: 18
  start-page: 723
  year: 2015
  ident: 615_CR79
  publication-title: Cell Host Microbe
  doi: 10.1016/j.chom.2015.11.002
– volume: 25
  start-page: 1105
  year: 2009
  ident: 615_CR70
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btp120
– volume: 5
  year: 2014
  ident: 615_CR12
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms6758
– volume: 8
  year: 2017
  ident: 615_CR42
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-017-01742-7
– volume: 566
  start-page: 490
  year: 2019
  ident: 615_CR16
  publication-title: Nature
  doi: 10.1038/s41586-019-0933-9
– volume: 21
  start-page: 193
  year: 2011
  ident: 615_CR44
  publication-title: Dev. Cell
  doi: 10.1016/j.devcel.2011.07.001
– volume: 16
  start-page: 284
  year: 2012
  ident: 615_CR80
  publication-title: OMICS
  doi: 10.1089/omi.2011.0118
– volume: 5
  start-page: 1518
  year: 2010
  ident: 615_CR64
  publication-title: Nat. Protoc.
  doi: 10.1038/nprot.2010.113
– volume: 63
  start-page: 77
  year: 2004
  ident: 615_CR59
  publication-title: Cardiovasc. Res.
  doi: 10.1016/j.cardiores.2004.03.007
– volume: 36
  start-page: 411
  year: 2018
  ident: 615_CR72
  publication-title: Nat. Biotechnol.
  doi: 10.1038/nbt.4096
– volume: 29
  start-page: 881
  year: 2019
  ident: 615_CR46
  publication-title: Cell Res.
  doi: 10.1038/s41422-019-0228-6
– volume: 23
  start-page: 1488
  year: 2017
  ident: 615_CR57
  publication-title: Nat. Med.
  doi: 10.1038/nm.4437
– volume: 116
  start-page: 1712
  year: 2015
  ident: 615_CR6
  publication-title: Circ. Res.
  doi: 10.1161/CIRCRESAHA.116.302953
– volume: 16
  start-page: 163
  year: 2019
  ident: 615_CR78
  publication-title: Nat. Methods
  doi: 10.1038/s41592-018-0303-9
– volume: 554
  start-page: 475
  year: 2018
  ident: 615_CR15
  publication-title: Nature
  doi: 10.1038/nature25739
– volume: 161
  start-page: 1202
  year: 2015
  ident: 615_CR69
  publication-title: Cell
  doi: 10.1016/j.cell.2015.05.002
– volume: 352
  start-page: 189
  year: 2016
  ident: 615_CR83
  publication-title: Science
  doi: 10.1126/science.aad0501
– volume: 36
  start-page: 421
  year: 2018
  ident: 615_CR86
  publication-title: Nat. Biotechnol.
  doi: 10.1038/nbt.4091
– volume: 140
  start-page: 3051
  year: 2013
  ident: 615_CR39
  publication-title: Development
  doi: 10.1242/dev.093351
– volume: 177
  start-page: 1888
  year: 2019
  ident: 615_CR73
  publication-title: Cell
  doi: 10.1016/j.cell.2019.05.031
– volume: 180
  start-page: 764
  year: 2020
  ident: 615_CR13
  publication-title: Cell
  doi: 10.1016/j.cell.2020.01.015
– volume: 432
  start-page: 179
  year: 2004
  ident: 615_CR28
  publication-title: Nature
  doi: 10.1038/nature03080
– volume: 3
  start-page: e2853
  year: 2008
  ident: 615_CR19
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0002853
– volume: 7
  year: 2016
  ident: 615_CR48
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms11988
– volume: 566
  start-page: 496
  year: 2019
  ident: 615_CR17
  publication-title: Nature
  doi: 10.1038/s41586-019-0969-x
– volume: 22
  start-page: 332
  year: 2020
  ident: 615_CR62
  publication-title: Nat. Cell Biol.
  doi: 10.1038/s41556-020-0475-2
– volume: 41
  start-page: e1800198
  year: 2019
  ident: 615_CR4
  publication-title: BioEssays
  doi: 10.1002/bies.201800198
– volume: 49
  start-page: 83
  year: 2011
  ident: 615_CR58
  publication-title: Genesis
  doi: 10.1002/dvg.20687
– volume: 43
  start-page: D76
  year: 2015
  ident: 615_CR88
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gku887
– volume: 138
  start-page: 1705
  year: 2011
  ident: 615_CR8
  publication-title: Development
  doi: 10.1242/dev.058776
– volume: 589
  start-page: 437
  year: 2021
  ident: 615_CR43
  publication-title: Nature
  doi: 10.1038/s41586-020-3018-x
– volume: 9
  year: 2018
  ident: 615_CR47
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-018-06318-7
– volume: 34
  start-page: 1854
  year: 2014
  ident: 615_CR5
  publication-title: Arterioscler Thromb. Vasc. Biol.
  doi: 10.1161/ATVBAHA.114.303929
– volume: 6
  year: 2015
  ident: 615_CR84
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms8866
– volume: 4
  start-page: 1184
  year: 2009
  ident: 615_CR81
  publication-title: Nat. Protoc.
  doi: 10.1038/nprot.2009.97
– ident: 615_CR74
  doi: 10.21105/joss.00861
– volume: 227
  start-page: 3828
  year: 2012
  ident: 615_CR30
  publication-title: J. Cell Physiol.
  doi: 10.1002/jcp.24094
– volume: 138
  start-page: 4801
  year: 2011
  ident: 615_CR27
  publication-title: Development
  doi: 10.1242/dev.070912
– volume: 19
  start-page: 915
  year: 2017
  ident: 615_CR41
  publication-title: Nat. Cell Biol.
  doi: 10.1038/ncb3555
– volume: 128
  start-page: 360
  year: 2021
  ident: 615_CR55
  publication-title: Circ. Res.
  doi: 10.1161/CIRCRESAHA.121.318669
– volume: 34
  start-page: 2372
  year: 2014
  ident: 615_CR37
  publication-title: Arterioscler Thromb. Vasc. Biol.
  doi: 10.1161/ATVBAHA.114.303218
– volume: 109
  start-page: 419
  year: 2016
  ident: 615_CR52
  publication-title: Cardiovasc. Res.
  doi: 10.1093/cvr/cvw005
– volume: 481
  start-page: 457
  year: 2012
  ident: 615_CR60
  publication-title: Nature
  doi: 10.1038/nature10783
– volume: 244
  start-page: 391
  year: 2015
  ident: 615_CR51
  publication-title: Dev. Dyn.
  doi: 10.1002/dvdy.24252
– volume: 20
  start-page: 127
  year: 2018
  ident: 615_CR26
  publication-title: Nat. Cell Biol.
  doi: 10.1038/s41556-017-0013-z
– volume: 2
  start-page: 666
  year: 2012
  ident: 615_CR67
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2012.08.003
– volume: 18
  start-page: 21
  year: 2016
  ident: 615_CR35
  publication-title: Nat. Cell Biol.
  doi: 10.1038/ncb3276
– volume: 38
  start-page: 1408
  year: 2020
  ident: 615_CR85
  publication-title: Nat. Biotechnol.
  doi: 10.1038/s41587-020-0591-3
– volume: 138
  start-page: 1717
  year: 2011
  ident: 615_CR9
  publication-title: Development
  doi: 10.1242/dev.059881
– volume: 560
  start-page: 494
  year: 2018
  ident: 615_CR49
  publication-title: Nature
  doi: 10.1038/s41586-018-0414-6
– volume: 37
  start-page: 142
  year: 2014
  ident: 615_CR31
  publication-title: Matrix Biol.
  doi: 10.1016/j.matbio.2014.02.004
– volume: 162
  start-page: 184
  year: 2015
  ident: 615_CR77
  publication-title: Cell
  doi: 10.1016/j.cell.2015.05.047
– volume: 12
  start-page: 551
  year: 2011
  ident: 615_CR2
  publication-title: Nat. Rev. Mol. Cell Biol.
  doi: 10.1038/nrm3176
– volume: 18
  start-page: 477
  year: 2017
  ident: 615_CR3
  publication-title: Nat. Rev. Mol. Cell Biol.
  doi: 10.1038/nrm.2017.36
– volume: 142
  start-page: 1848
  year: 2020
  ident: 615_CR14
  publication-title: Circulation
  doi: 10.1161/CIRCULATIONAHA.119.041433
– volume: 240
  start-page: 2153
  year: 2011
  ident: 615_CR21
  publication-title: Dev. Dyn.
  doi: 10.1002/dvdy.22706
– volume: 30
  start-page: 376
  year: 2020
  ident: 615_CR36
  publication-title: Cell Res.
  doi: 10.1038/s41422-020-0300-2
– volume: 89
  start-page: 957
  year: 2009
  ident: 615_CR34
  publication-title: Physiol. Rev.
  doi: 10.1152/physrev.00041.2008
– volume: 1
  start-page: 4
  year: 2001
  ident: 615_CR61
  publication-title: BMC Dev. Biol.
  doi: 10.1186/1471-213X-1-4
– volume: 119
  start-page: 295
  year: 1993
  ident: 615_CR29
  publication-title: Development
  doi: 10.1242/dev.119.2.295
– volume: 352
  start-page: 1586
  year: 2016
  ident: 615_CR75
  publication-title: Science
  doi: 10.1126/science.aaf1204
– volume: 19
  year: 2018
  ident: 615_CR76
  publication-title: Genome Biol.
  doi: 10.1186/s13059-017-1382-0
– volume: 4
  start-page: 7
  year: 1993
  ident: 615_CR32
  publication-title: Mol. Biol. Cell
  doi: 10.1091/mbc.4.1.7
– volume: 95
  start-page: 1671
  year: 2000
  ident: 615_CR18
  publication-title: Blood
  doi: 10.1182/blood.V95.5.1671.005k39_1671_1679
– volume: 108
  start-page: 940
  year: 2011
  ident: 615_CR38
  publication-title: Circ. Res.
  doi: 10.1161/CIRCRESAHA.110.233171
– volume: 11
  start-page: 163
  year: 2014
  ident: 615_CR68
  publication-title: Nat. Methods
  doi: 10.1038/nmeth.2772
– volume: 84
  start-page: 502
  year: 1989
  ident: 615_CR82
  publication-title: J. Am. Statist. Assoc.
  doi: 10.1080/01621459.1989.10478797
– volume: 120
  start-page: 914
  year: 2012
  ident: 615_CR22
  publication-title: Blood
  doi: 10.1182/blood-2011-12-398156
– volume: 9
  start-page: 129
  year: 2008
  ident: 615_CR20
  publication-title: Nat. Immunol.
  doi: 10.1038/ni1560
– volume: 361
  start-page: 116
  year: 2012
  ident: 615_CR53
  publication-title: Dev. Biol.
  doi: 10.1016/j.ydbio.2011.10.018
– volume: 5
  start-page: e21032
  year: 2016
  ident: 615_CR40
  publication-title: Elife
  doi: 10.7554/eLife.21032
– volume: 345
  start-page: 90
  year: 2014
  ident: 615_CR7
  publication-title: Science
  doi: 10.1126/science.1251487
SSID ssj0025451
Score 2.5565152
Snippet Arteriogenesis rather than unspecialized capillary expansion is critical for restoring effective circulation to compromised tissues in patients. Deciphering...
SourceID pubmedcentral
proquest
pubmed
crossref
springer
SourceType Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 333
SubjectTerms 13/1
13/31
13/51
14/32
631/136
631/80
64/110
64/60
Angiogenesis
Animals
Biomedical and Life Sciences
Capillaries
Cell Biology
Cell Differentiation
Computer applications
Embryogenesis
Embryonic growth stage
Endothelial Cells
Heterogeneity
Humans
Life Sciences
Mammals
Mice
Neovascularization, Pathologic
Recombinase
Transcriptomics
SummonAdditionalLinks – databaseName: ProQuest Health & Medical Collection (NC LIVE)
  dbid: 7X7
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1LT9wwEB5REFIvVcuroRQZiRtYJMSJ7VNVIdAKCU4g7S1y_BArsdltd2lVfn1nnGRXC4JDTp487PnimbE_zwAc17Wxqfaay3BecJGrwJVyOXfOaGO8NDJWibi5LQf34npYDLsFt1lHq-znxDhRu4mlNfIzNNwl2iOccn9Mf3GqGkW7q10JjQ-wQanLCNVyuAy40DuIAVekDZXE5Nlvj5mrs5mgxQ9OXPZo1fnzqmF65W2-Jk2-2DmNBunqM3zqPEn2s1X9F1jzzRZstrUl_23D04CILhPEh0dHm40a5htHx60eEXGM1utnzDSO_R05j69AVbM_MV8riyxPFOpOaLL2JCPzlAqZ9cxV5pZsI3r42IzHiOQduL-6vLsY8K7GArdCijl33oUs6NzaWjkMlcvSlC4LmTJZWmM4UQZV14VER8ZKLzQpECXQR7RFKIIz-S6sN5PGfwXmU2cEVa3WVgsrhMnqgBLepejTlDZLIOsHuLJdAnKqg_FYxY3wXFWtUqqULlJK9ZzAyeKeaZt-413pg15vVfcrzqolcBI4WjTjT0QjbRqPA4syVNVcykInsNeqefG6HD1mneUqAbkCgIUAJehebWlGDzFRt9IYjSl85mkPleVnvd2L_fd78Q0-nkfYEnvoANbnv5_8d3SM5vVhRP9_5MoOLA
  priority: 102
  providerName: ProQuest
Title Heterogeneity in endothelial cells and widespread venous arterialization during early vascular development in mammals
URI https://link.springer.com/article/10.1038/s41422-022-00615-z
https://www.ncbi.nlm.nih.gov/pubmed/35079138
https://www.proquest.com/docview/2646021130
https://www.proquest.com/docview/2622957759
https://pubmed.ncbi.nlm.nih.gov/PMC8975889
Volume 32
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1La9wwEB7yoNBL6btO00WF3lpRay1b0rFdEpZCQykN7M3IetCFrBO6m4bk13dGfoRt2kIPPnksyZqR9Y38zQzAm6axLjfBcBWnJZeFjlxrX3DvrbE2KKtSlYjPJ9X8VH5alIsdmA6xMIm0n1Japs_0wA57v5Z0WMGJe552YX6zC_uUup0crlk1G50sRATJyUpUoYrYOwddaLn-Qxvbm9EdhHmXKPnb39K0CR0_hAc9emQfuvE-gp3QPoZ7XT3J6ydwOSdyyznaREBwzZYtC62nEKsztDJGZ_RrZlvPrpY-YBeoXvYz5WhlidmJQn1UJuuiF1mg9MdsYKsyf8swosZXdrVC630Kp8dH32Zz3tdV4E4queE--CiiKZxrtEf3uKps5UUU2oq8QReiirppSoXgxakgDSkNJRAXujKW0dviGey15214ASzk3kqqVG2ckU5KK5qIEsHniGMqJzIQwwTXrk86TrUvzur087vQdaeUOqeLlFLfZPB2fOaiS7nxT-nDQW91v_zWNaI8VL3A_TmD1-NtXDg007YNOLEoQ5XMlSpNBs87NY_dFYiSjSh0BmrLAEYBSsq9faddfk_JubVBD0xjm-8GU7kd1t_f4uD_xF_C_WkyY2IQHcLe5sdleIXgaNNMYFct1AT2Px6dfPk6SWvjFyS4Dv0
linkProvider Springer Nature
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9QwEB6VIgQXxLOkFDASnMBqsnFi-4AQAqotfZxaaW_B8UOs1M0WdkvV_ih-IzNOsqulorce9pRZJ_GMPd_E38wAvKlrY1PtNZdhUHCRq8CVcjl3zmhjvDQydok4OCyHx-LbqBitwZ8-F4Zolf2eGDdqN7X0jXwbHXeJ_gi33I-nPzl1jaLT1b6FRmsWe_7iHEO22YfdL6jft4PBztejz0PedRXgVkgx5867kAWdW1srh8FhWZrSZSFTJktrBNBlUHVdSHTdVnqh6ZFRAlGRLUIRnMlx3FtwGx1vSsGeHC0DPEQjMcCLNKWSmEObbVq72p4J-tjCiTsfUQS_XHWEV9DtVZLmPye10QHuPID7HXJln1pTewhrvnkEd9pelheP4WxIxJop2qNHYM_GDfONo_SuE7RwRucDM2Yax87HzuMt0LTY71gflkVWKQp1GaGszZxknkovs54py9yS3USDT8xkgivnCRzfyOw_hfVm2vhnwHzqjKAu2dpqYYUwWR1QwrsUMVRpswSyfoIr2xU8p74bJ1U8eM9V1SqlSulHSqkuE3i3-M9pW-7jWumtXm9Vt_Rn1dJQE3i9uIyLlmbaNB4nFmWoi7qUhU5go1Xz4nY5InSd5SoBuWIACwEqCL56pRn_iIXBlcboT-GY73tTWT7W_99i8_q3eAV3h0cH-9X-7uHec7g3iCZMzKUtWJ__OvMvEJTN65dxJTD4ftNL7y9vtExf
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9NAEB6VVCAuiDcuBRYJTmDFjtfe9QEhoI1SClGFqNSbu96HiNQ4bZNStT-NX8fM-hGFit56yMmTtb0zs_ON99sZgDdlqXSU2zwUbpCGPJEulNIkoTEqV8oKJXyXiO_jbLTPvx6kB2vwpz0LQ7TKdk30C7WZafpG3sfAnWE8wiW37xpaxN7W8OPxSUgdpGintW2nUZvIrr04x_Rt_mFnC3X9djAYbv_8MgqbDgOh5oIvQmONi12eaF1Kg4lilqnMxC6WKo5KBNOZk2WZCgzjWlie0-OjBCIknbrUGZXguLdgXVBW1IP1z9vjvR9duofYxKd7nrSUEY9ooz7kLvtzTp9eQmLSe0wRXq6GxStY9ypl8599Wx8Oh_fhXoNj2afa8B7Amq0ewu26s-XFIzgbEc1mhtZpEeazScVsZeiw1xHaO6PdgjlTlWHnE2PxFmho7LevFss8xxSFmvOhrD5HySwVYmYtb5aZJdeJBp-q6RT96DHs38j8P4FeNavsM2A2MopTz-xc51xzruLSoYQ1ESKqTMcBxO0EF7opf05dOI4Kvw2fyKJWShHRj5RSXAbwrvvPcV3841rpzVZvRbMQzIul2QbwuruMLkwzrSqLE4sy1FNdiDQP4Gmt5u52CeL1PE5kAGLFADoBKg--eqWa_PJlwmWOuaDEMd-3prJ8rP-_xcb1b_EK7qDbFd92xrvP4e7AWzDRmDahtzg9sy8QoS3Kl40rMDi8ae_7C22JUfo
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Heterogeneity+in+endothelial+cells+and+widespread+venous+arterialization+during+early+vascular+development+in+mammals&rft.jtitle=Cell+research&rft.au=Hou%2C+Siyuan&rft.au=Li%2C+Zongcheng&rft.au=Dong%2C+Ji&rft.au=Gao%2C+Yun&rft.date=2022-04-01&rft.issn=1748-7838&rft.eissn=1748-7838&rft.volume=32&rft.issue=4&rft.spage=333&rft_id=info:doi/10.1038%2Fs41422-022-00615-z&rft.externalDBID=NO_FULL_TEXT
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1001-0602&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1001-0602&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1001-0602&client=summon