Lower Airway Dysbiosis Affects Lung Cancer Progression

• Published in: Cancer discovery Vol. 11; no. 2; pp. 293 - 307
• Main Authors: Tsay, Jun-Chieh J., Wu, Benjamin G., Sulaiman, Imran, Gershner, Katherine, Schluger, Rosemary, Li, Yonghua, Yie, Ting-An, Meyn, Peter, Olsen, Evan, Perez, Luisannay, Franca, Brendan, Carpenito, Joseph, Iizumi, Tadasu, El-Ashmawy, Mariam, Badri, Michelle, Morton, James T., Shen, Nan, He, Linchen, Michaud, Gaetane, Rafeq, Samaan, Bessich, Jamie L., Smith, Robert L., Sauthoff, Harald, Felner, Kevin, Pillai, Ray, Zavitsanou, Anastasia-Maria, Koralov, Sergei B., Mezzano, Valeria, Loomis, Cynthia A., Moreira, Andre L., Moore, William, Tsirigos, Aristotelis, Heguy, Adriana, Rom, William N., Sterman, Daniel H., Pass, Harvey I., Clemente, Jose C., Li, Huilin, Bonneau, Richard, Wong, Kwok-Kin, Papagiannakopoulos, Thales, Segal, Leopoldo N.
• Format: Journal Article
• Language: English
• Published: United States 01.02.2021
• Subjects: Adenocarcinoma - complications; Adenocarcinoma - microbiology; Adenocarcinoma - mortality; Adenocarcinoma - secondary; Animals; Cohort Studies; Disease Models, Animal; Disease Progression; Dysbiosis - complications; Female; Humans; Lung Neoplasms - complications; Lung Neoplasms - microbiology; Lung Neoplasms - mortality; Lung Neoplasms - pathology; Mice; Mice, Transgenic; Microbiota; Neoplasm Metastasis; Neoplasm Staging; New York; Proportional Hazards Models; Survival Analysis; New York
• ISSN: 2159-8274; 2159-8290; 2159-8290
• DOI: 10.1158/2159-8290.CD-20-0263

In lung cancer, enrichment of the lower airway microbiota with oral commensals commonly occurs, and models support that some of these bacteria can trigger host transcriptomic signatures associated with carcinogenesis. Here, we show that this lower airway dysbiotic signature was more prevalent in the...