Stage-Specific Regulation of Reprogramming to Induced Pluripotent Stem Cells by Wnt Signaling and T Cell Factor Proteins

• Published in: Cell reports (Cambridge) Vol. 3; no. 6; pp. 2113 - 2126
• Main Authors: Ho, Ritchie, Papp, Bernadett, Hoffman, Jackson A., Merrill, Bradley J., Plath, Kathrin
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 27.06.2013; Elsevier
• Subjects: Animals; Gene Expression Regulation, Developmental; Induced Pluripotent Stem Cells - cytology; Induced Pluripotent Stem Cells - metabolism; Mice; T Cell Transcription Factor 1 - genetics; T Cell Transcription Factor 1 - metabolism; Wnt Signaling Pathway

Wnt signaling is intrinsic to mouse embryonic stem cell self-renewal. Therefore, it is surprising that reprogramming of somatic cells to induced pluripotent stem cells (iPSCs) is not strongly enhanced by Wnt signaling. Here, we demonstrate that active Wnt signaling inhibits the early stage of reprog...