Region-specific metabolic alterations in the brain of the APP/PS1 transgenic mice of Alzheimer's disease

• Published in: Biochimica et biophysica acta Vol. 1842; no. 12; pp. 2395 - 2402
• Main Authors: González-Domínguez, Raúl, García-Barrera, Tamara, Vitorica, Javier, Gómez-Ariza, José Luis
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.12.2014
• Subjects: Alzheimer Disease - genetics; Alzheimer Disease - metabolism; Alzheimer's disease; Amyloid beta-Protein Precursor - genetics; Amyloid beta-Protein Precursor - metabolism; Animals; APP/PS1 mouse; Brain - metabolism; Cerebellum - metabolism; Cerebral Cortex - metabolism; Chromatography, High Pressure Liquid - methods; Disease Models, Animal; Gas Chromatography-Mass Spectrometry - methods; Hippocampus - metabolism; Humans; Metabolic Networks and Pathways - genetics; Metabolomics; Metabolomics - methods; Mice, Inbred C57BL; Mice, Transgenic; Multivariate Analysis; Mutation; Neostriatum - metabolism; Olfactory Bulb - metabolism; Pathology; Presenilin-1 - genetics; Presenilin-1 - metabolism; Region-specific alteration; Spectrometry, Mass, Electrospray Ionization - methods; APP; Metabolomics; GC–MS; AD; APP/PS1 mouse; PLS-DA; Region-specific alteration; PS1; PCA; Pathology; QC; TG; UPLC–MS; VIP; WT; Alzheimer's disease

Alzheimer's disease (AD) is the most common neurodegenerative disorder worldwide, but its etiology is still not completely understood. The identification of underlying pathological mechanisms is becoming increasingly important for the discovery of biomarkers and therapies, for which metabolomic...