Scanning Acoustic Microscopy and Time-Resolved Fluorescence Spectroscopy for Characterization of Atherosclerotic Plaques

Atherosclerotic plaques constitute the primary cause of heart attack and stroke. However, we still lack a clear identification of the plaques. Here, we evaluate the feasibility of scanning acoustic microscopy (SAM) and time-resolved fluorescence spectroscopy (TRFS) in atherosclerotic plaque characte...

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Published inScientific reports Vol. 8; no. 1; pp. 14378 - 11
Main Authors Bilen, Bukem, Gokbulut, Belkis, Kafa, Ulku, Heves, Emre, Inci, Mehmet Naci, Unlu, Mehmet Burcin
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 26.09.2018
Nature Publishing Group
Subjects
639/766/747
692/53/2421
Acoustics
Arteriosclerosis
Atherosclerosis
Calcification
Centenarians
Collagen
Fluorescence
Fluorescence spectroscopy
Humanities and Social Sciences
Microscopy
multidisciplinary
Myocardial infarction
Plaques
Quantum dots
Scanning
Science
Science (multidisciplinary)
Spectroscopy
Spectrum analysis
Scanning Acoustic Microscopy (SAM)
Quantum Dots
Collagen-rich Regions
Time-resolved Fluorescence Spectroscopy (TRFS)
Acoustic Impedance Values
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Abstract Atherosclerotic plaques constitute the primary cause of heart attack and stroke. However, we still lack a clear identification of the plaques. Here, we evaluate the feasibility of scanning acoustic microscopy (SAM) and time-resolved fluorescence spectroscopy (TRFS) in atherosclerotic plaque characterization. We perform dual-modality microscopic imaging of the human carotid atherosclerotic plaques. We first show that the acoustic impedance values are statistically higher in calcified regions compared with the collagen-rich areas. We then use CdTe/CdS quantum dots for imaging the atherosclerotic plaques by TRFS and show that fluorescence lifetime values of the quantum dots in collagen-rich areas are notably different from the ones in calcified areas. In summary, both modalities are successful in differentiating the calcified regions from the collagen-rich areas within the plaques indicating that these techniques are confirmatory and may be combined to characterize atherosclerotic plaques in the future.
AbstractList Atherosclerotic plaques constitute the primary cause of heart attack and stroke. However, we still lack a clear identification of the plaques. Here, we evaluate the feasibility of scanning acoustic microscopy (SAM) and time-resolved fluorescence spectroscopy (TRFS) in atherosclerotic plaque characterization. We perform dual-modality microscopic imaging of the human carotid atherosclerotic plaques. We first show that the acoustic impedance values are statistically higher in calcified regions compared with the collagen-rich areas. We then use CdTe/CdS quantum dots for imaging the atherosclerotic plaques by TRFS and show that fluorescence lifetime values of the quantum dots in collagen-rich areas are notably different from the ones in calcified areas. In summary, both modalities are successful in differentiating the calcified regions from the collagen-rich areas within the plaques indicating that these techniques are confirmatory and may be combined to characterize atherosclerotic plaques in the future.
Abstract Atherosclerotic plaques constitute the primary cause of heart attack and stroke. However, we still lack a clear identification of the plaques. Here, we evaluate the feasibility of scanning acoustic microscopy (SAM) and time-resolved fluorescence spectroscopy (TRFS) in atherosclerotic plaque characterization. We perform dual-modality microscopic imaging of the human carotid atherosclerotic plaques. We first show that the acoustic impedance values are statistically higher in calcified regions compared with the collagen-rich areas. We then use CdTe/CdS quantum dots for imaging the atherosclerotic plaques by TRFS and show that fluorescence lifetime values of the quantum dots in collagen-rich areas are notably different from the ones in calcified areas. In summary, both modalities are successful in differentiating the calcified regions from the collagen-rich areas within the plaques indicating that these techniques are confirmatory and may be combined to characterize atherosclerotic plaques in the future.
ArticleNumber 14378
Author Kafa, Ulku
Unlu, Mehmet Burcin
Bilen, Bukem
Gokbulut, Belkis
Heves, Emre
Inci, Mehmet Naci
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/30258115$$D View this record in MEDLINE/PubMed
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Issue 1
Keywords Scanning Acoustic Microscopy (SAM)
Quantum Dots
Collagen-rich Regions
Time-resolved Fluorescence Spectroscopy (TRFS)
Acoustic Impedance Values
Language English
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SSID ssj0000529419
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Snippet Atherosclerotic plaques constitute the primary cause of heart attack and stroke. However, we still lack a clear identification of the plaques. Here, we...
Abstract Atherosclerotic plaques constitute the primary cause of heart attack and stroke. However, we still lack a clear identification of the plaques. Here,...
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proquest
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Publisher
StartPage 14378
SubjectTerms 639/766/747
692/53/2421
Acoustics
Arteriosclerosis
Atherosclerosis
Calcification
Centenarians
Collagen
Fluorescence
Fluorescence spectroscopy
Humanities and Social Sciences
Microscopy
multidisciplinary
Myocardial infarction
Plaques
Quantum dots
Scanning
Science
Science (multidisciplinary)
Spectroscopy
Spectrum analysis
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Title Scanning Acoustic Microscopy and Time-Resolved Fluorescence Spectroscopy for Characterization of Atherosclerotic Plaques
URI https://link.springer.com/article/10.1038/s41598-018-32788-2
https://www.ncbi.nlm.nih.gov/pubmed/30258115
https://www.proquest.com/docview/2112602107
https://search.proquest.com/docview/2113281543
https://pubmed.ncbi.nlm.nih.gov/PMC6158264
Volume 8
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