Oxytocin in the anterior cingulate cortex attenuates neuropathic pain and emotional anxiety by inhibiting presynaptic long-term potentiation

• Published in: Cell reports (Cambridge) Vol. 36; no. 3; p. 109411
• Main Authors: Li, Xu-Hui, Matsuura, Takanori, Xue, Man, Chen, Qi-Yu, Liu, Ren-Hao, Lu, Jing-Shan, Shi, Wantong, Fan, Kexin, Zhou, Zhaoxiang, Miao, Zhuang, Yang, Jiale, Wei, Sara, Wei, Feng, Chen, Tao, Zhuo, Min
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 20.07.2021
• Subjects: Analgesics - pharmacology; Animals; anterior cingulate cortex; Anti-Anxiety Agents - pharmacology; anxiety; Anxiety - physiopathology; Behavior, Animal - drug effects; Calcium - metabolism; Chronic Pain - pathology; Chronic Pain - physiopathology; Emotions - drug effects; Female; Gyrus Cinguli - drug effects; Gyrus Cinguli - pathology; Gyrus Cinguli - physiopathology; inhibitory transmission; Interneurons - drug effects; Light; long-term potentiation; Long-Term Potentiation - drug effects; Male; Mice; Mice, Inbred C57BL; Microinjections; Nerve Tissue - drug effects; Nerve Tissue - pathology; Nerve Tissue - physiopathology; Neural Inhibition - drug effects; Neuralgia - complications; Neuralgia - pathology; Neuralgia - physiopathology; neuropathic pain; oxytocin; Oxytocin - administration & dosage; Oxytocin - pharmacology; Paraventricular Hypothalamic Nucleus - drug effects; Paraventricular Hypothalamic Nucleus - pathology; Paraventricular Hypothalamic Nucleus - physiopathology; Presynaptic Terminals - drug effects; Presynaptic Terminals - pathology; Receptors, G-Protein-Coupled - metabolism; Receptors, GABA-A - metabolism; Receptors, Oxytocin - genetics; Receptors, Oxytocin - metabolism; Signal Transduction - drug effects; Synaptic Transmission - drug effects; Up-Regulation - drug effects; anxiety; oxytocin; neuropathic pain; anterior cingulate cortex; inhibitory transmission; long-term potentiation

Oxytocin is a well-known neurohypophysial hormone that plays an important role in behavioral anxiety and nociception. Two major forms of long-term potentiation, presynaptic LTP (pre-LTP) and postsynaptic LTP (post-LTP), have been characterized in the anterior cingulate cortex (ACC). Both pre-LTP and...