Finnish Parkinson’s disease study integrating protein-protein interaction network data with exome sequencing analysis

• Published in: Scientific reports Vol. 9; no. 1; pp. 18865 - 8
• Main Authors: Siitonen, Ari, Kytövuori, Laura, Nalls, Mike A., Gibbs, Raphael, Hernandez, Dena G., Ylikotila, Pauli, Peltonen, Markku, Singleton, Andrew B., Majamaa, Kari
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 11.12.2019; Nature Publishing Group
• Subjects: 45/23; 45/43; 631/114/2784; 631/208/514/2254; 631/553/2710; 692/617/375/1718; Exome Sequencing; Female; Finland; Genetic Predisposition to Disease; Humanities and Social Sciences; Humans; Male; Movement disorders; multidisciplinary; Neurodegenerative diseases; Parkinson Disease - genetics; Parkinson's disease; Polymorphism, Single Nucleotide; Protein interaction; Protein Interaction Maps; Proteins; Science; Science (multidisciplinary); Finland

Variants associated with Parkinson’s disease (PD) have generally a small effect size and, therefore, large sample sizes or targeted analyses are required to detect significant associations in a whole exome sequencing (WES) study. Here, we used protein-protein interaction (PPI) information on 36 gene...