Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses

• Published in: Science translational medicine Vol. 9; no. 396
• Main Authors: Sheahan, Timothy P, Sims, Amy C, Graham, Rachel L, Menachery, Vineet D, Gralinski, Lisa E, Case, James B, Leist, Sarah R, Pyrc, Krzysztof, Feng, Joy Y, Trantcheva, Iva, Bannister, Roy, Park, Yeojin, Babusis, Darius, Clarke, Michael O, Mackman, Richard L, Spahn, Jamie E, Palmiotti, Christopher A, Siegel, Dustin, Ray, Adrian S, Cihlar, Tomas, Jordan, Robert, Denison, Mark R, Baric, Ralph S
• Format: Journal Article
• Language: English
• Published: United States 28.06.2017
• Subjects: Alanine - analogs & derivatives; Alanine - metabolism; Alanine - pharmacokinetics; Alanine - pharmacology; Alanine - toxicity; Animals; Antiviral Agents - metabolism; Antiviral Agents - pharmacokinetics; Antiviral Agents - pharmacology; Antiviral Agents - toxicity; Callithrix; Cell Line; Coronavirus - drug effects; Epidemics; Epithelial Cells - virology; Humans; Lung - pathology; Mice; Ribonucleotides - metabolism; Ribonucleotides - pharmacokinetics; Ribonucleotides - pharmacology; Ribonucleotides - toxicity; Virus Replication - drug effects; Zoonoses - epidemiology; Zoonoses - prevention & control; Zoonoses - virology

Emerging viral infections are difficult to control because heterogeneous members periodically cycle in and out of humans and zoonotic hosts, complicating the development of specific antiviral therapies and vaccines. Coronaviruses (CoVs) have a proclivity to spread rapidly into new host species causi...